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An observational study of the prevalence of classic metaphyseal fractures in children with osteogenesis imperfecta in the first two years of life 一项关于两岁前成骨不全儿童典型干骺端骨折发生率的观察性研究
IF 2.1 3区 医学
Clinical radiology Pub Date : 2025-05-17 DOI: 10.1016/j.crad.2025.106964
E. Riley , S. Elgarwany , P. Arundel , N.J. Bishop , A.C. Offiah
{"title":"An observational study of the prevalence of classic metaphyseal fractures in children with osteogenesis imperfecta in the first two years of life","authors":"E. Riley ,&nbsp;S. Elgarwany ,&nbsp;P. Arundel ,&nbsp;N.J. Bishop ,&nbsp;A.C. Offiah","doi":"10.1016/j.crad.2025.106964","DOIUrl":"10.1016/j.crad.2025.106964","url":null,"abstract":"<div><h3>AIM</h3><div>Classic metaphyseal fractures are highly suggestive of inflicted injury. Osteogenesis imperfecta (OI) is an important differential in infants presenting with unexplained fracture(s), and some argue that classic metaphyseal fractures occur accidentally in children with OI. This study sought to assess the prevalence of classic metaphyseal fractures in children with OI during the first 2 years of life.</div></div><div><h3>MATERIALS AND METHODS</h3><div>This was a retrospective observational cohort study of children with OI less than 2 years of age between 01/01/2010 and 31/12/2021. Radiographs and reports were reviewed by two observers. The site and type of fractures were recorded along with other radiological features of OI. Descriptive and inferential statistics were used to analyse the results.</div></div><div><h3>RESULTS</h3><div>There were 109 eligible patients (53 female) who had a total of 3,142 images (1,949 images in those less than 1 year old). There were 87 patients (79.8%) with a total of 462 long bone fractures, of which 386 (83.5%) were diaphyseal and 76 (16.5%) were at the junction of the diaphysis and metaphysis. No classic metaphyseal fractures were identified.</div></div><div><h3>CONCLUSION</h3><div>The absence of classic metaphyseal fractures in this large cohort suggests that OI is rarely, or not at all, associated with such fractures. However, metadiaphyseal fractures, reflecting bone fragility, are common; distinction should be made between ‘classic metaphyseal’ and ‘metadiaphyseal’ fractures to facilitate clinical decision-making. The unspecified term ‘metaphyseal fracture’ should be avoided. Children less than 2 years old with OI and classic metaphyseal fractures should be thoroughly investigated to exclude inflicted injury.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"87 ","pages":"Article 106964"},"PeriodicalIF":2.1,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of perfusion defects parameters in dual-energy computed tomography (CT) pulmonary angiography across arterial phase and venous phase 双能CT肺血管造影在动脉期和静脉期灌注缺陷参数的比较
IF 2.1 3区 医学
Clinical radiology Pub Date : 2025-05-17 DOI: 10.1016/j.crad.2025.106963
X. Sun , W. Xu , X. Liu , J. Long , P. Dou , H. Zhang , A. Sun , S. Zhang , K. Xu , Y. Meng
{"title":"Comparison of perfusion defects parameters in dual-energy computed tomography (CT) pulmonary angiography across arterial phase and venous phase","authors":"X. Sun ,&nbsp;W. Xu ,&nbsp;X. Liu ,&nbsp;J. Long ,&nbsp;P. Dou ,&nbsp;H. Zhang ,&nbsp;A. Sun ,&nbsp;S. Zhang ,&nbsp;K. Xu ,&nbsp;Y. Meng","doi":"10.1016/j.crad.2025.106963","DOIUrl":"10.1016/j.crad.2025.106963","url":null,"abstract":"<div><h3>AIM</h3><div>This study aims to compare dual-energy computed tomography pulmonary angiography (DE-CTPA) perfusion defects (PD) parameters between the arterial (AP) and venous phases (VP).</div></div><div><h3>MATERIALS AND METHODS</h3><div>This retrospective study analysed the database of patients who underwent dual-phase DE-CTPA examinations. The patients were categorised into three groups based on their Qanadli (Q) scores (Group A: Q = 0%, Group B: 0% &lt; Q &lt; 50%, and Group C: Q ≥ 50%). PD parameters, including perfusion defect volume (PDV) and its percentage relative to total lung volume (<sub>Rel</sub>PDV), were derived from the dual-phase DE-CTPA images. Differences in PD parameters were assessed between phases and among the three groups.</div></div><div><h3>Results</h3><div>A total of 81 consecutive patients were included in the study (44 females [54.3%]; mean age: 68.37 ± 13.01 years). <sub>Rel</sub>PDV was significantly higher in the AP compared to the VP (P0.030). Phase comparisons within each group showed no statistically significant differences in PDV between the AP and VP for Group C. However, in Groups A and B, both PDV and <sub>Rel</sub>PDV were higher in the AP than in the VP (all P&lt;0.05). When comparing the three groups, there were no statistically significant differences in PDV or <sub>Rel</sub>PDV for AP. In VP, PDV, and <sub>Rel</sub>PDV increased with higher Q scores, with Group C showing statistically significant differences compared to Groups A and B.</div></div><div><h3>Conclusion</h3><div>The PD parameters of DE-CTPA differed between AP and VP. This study highlights the limitations of relying on iodine maps in AP to estimate lung perfusion.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"87 ","pages":"Article 106963"},"PeriodicalIF":2.1,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The perils of Double-J stent placement: What radiologists must know 双j型支架置入的危险:放射科医生必须知道的
IF 2.1 3区 医学
Clinical radiology Pub Date : 2025-05-16 DOI: 10.1016/j.crad.2025.106956
B. Lucas , C.B.H. Sulay , G.S. Octavius
{"title":"The perils of Double-J stent placement: What radiologists must know","authors":"B. Lucas ,&nbsp;C.B.H. Sulay ,&nbsp;G.S. Octavius","doi":"10.1016/j.crad.2025.106956","DOIUrl":"10.1016/j.crad.2025.106956","url":null,"abstract":"<div><div>The use of ureteral stents has seen a substantial rise in modern urological practice, serving as an indispensable tool in the management of urinary tract obstructions, stone disease, and postoperative drainage. However, their widespread application is accompanied by a high incidence of complications, each with potentially devastating consequences if left unrecognized. Encrustation and stone formation may result in obstruction, necessitating complex retrieval procedures. Stent migration can lead to severe discomfort, infection, and compromised renal function. Infection and pyelonephritis, if undetected, may progress to urosepsis, a life-threatening condition. Additionally, stent fracture and ureteral perforation can precipitate extensive morbidity, sometimes requiring surgical intervention. Given the critical nature of these complications, early detection through imaging is paramount. Radiologists play a pivotal role in diagnosing and characterizing these complications, ensuring timely management. By providing meticulous reporting of stent positioning, encrustation, migration, and associated pathologies, radiologists contribute to preventing severe adverse outcomes. A collaborative approach between urologists and radiologists is essential for optimizing patient care and mitigating the risks associated with prolonged stent placement.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"87 ","pages":"Article 106956"},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RCR meetings 软的会议
IF 2.1 3区 医学
Clinical radiology Pub Date : 2025-05-15 DOI: 10.1016/S0009-9260(25)00153-9
{"title":"RCR meetings","authors":"","doi":"10.1016/S0009-9260(25)00153-9","DOIUrl":"10.1016/S0009-9260(25)00153-9","url":null,"abstract":"","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106948"},"PeriodicalIF":2.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paid MBP advert Paediatrics-CR-210x280_01 付费MBP广告儿科- cr -210x280_01
IF 2.1 3区 医学
Clinical radiology Pub Date : 2025-05-15 DOI: 10.1016/S0009-9260(25)00154-0
{"title":"Paid MBP advert Paediatrics-CR-210x280_01","authors":"","doi":"10.1016/S0009-9260(25)00154-0","DOIUrl":"10.1016/S0009-9260(25)00154-0","url":null,"abstract":"","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106949"},"PeriodicalIF":2.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging pancreatic cancer with [18F]F-AlF-NOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT): distribution patterns and therapeutic implications [18F]F-AlF-NOTA-FAPI-04正电子发射断层扫描/计算机断层扫描(PET/CT)成像胰腺癌:分布模式和治疗意义
IF 2.1 3区 医学
Clinical radiology Pub Date : 2025-05-14 DOI: 10.1016/j.crad.2025.106954
C. Wang , Z. Zhu , L. Xu , W. Li , Y. Liu , H. Wang , Z. Ma , R. Zhang , X. Zhang , J. Yue
{"title":"Imaging pancreatic cancer with [18F]F-AlF-NOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT): distribution patterns and therapeutic implications","authors":"C. Wang ,&nbsp;Z. Zhu ,&nbsp;L. Xu ,&nbsp;W. Li ,&nbsp;Y. Liu ,&nbsp;H. Wang ,&nbsp;Z. Ma ,&nbsp;R. Zhang ,&nbsp;X. Zhang ,&nbsp;J. Yue","doi":"10.1016/j.crad.2025.106954","DOIUrl":"10.1016/j.crad.2025.106954","url":null,"abstract":"<div><h3>AIM</h3><div>This study aimed to evaluate the diagnostic performance of [<sup>18</sup>F]F-AlF-NOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT) in pancreatic cancer by comparing its uptake patterns with other tumour types and analysing intrapancreatic heterogeneity. The study also explored possible causes of physiological pancreatic uptake to aid in distinguishing non-malignant uptake from true pathological lesions and improve diagnostic accuracy.</div></div><div><h3>MATERIALS AND METHODS</h3><div>In this prospective study, 103 treatment-naïve cancer patients (36 pancreatic, 67 nonpancreatic) underwent [<sup>18</sup>F] AlF-NOTA-FAPI-04 PET/CT. Metabolic tumour volume (MTV), standardised uptake values (SUV), and total lesion Fibroblast Activation Protein (FAP) expression (TLF) were analysed. Hierarchical regression and independent t-tests were applied to assess correlations between imaging features and clinicopathological characteristics.</div></div><div><h3>RESULTS</h3><div>Pancreatic cancer exhibited significantly higher SUVmax (16.3 ± 4.4 vs 5.0 ± 4.3, <em>P&lt;0.001</em>), SUVmean (6.3 ± 2.3 vs 1.7 ± 1.2, <em>P&lt;0.001</em>), and TLF (321.5 ± 251.3 vs 89.4 ± 62.1, <em>P&lt;0.001</em>) compared to non-pancreatic tumors. Tumours in the pancreatic head/neck region demonstrated greater [68 G]G-FAPI-04 uptake than body/tail lesions (SUVmean: 7.7 ± 3.1 vs 6.3 ± 2.9, <em>P=0.016</em>). TLF correlated positively with tumour size and stage (F = 2.576, <em>P=0.027</em>). Mild to moderate pancreatic uptake was also observed in a subset of patients with hepatocellular carcinoma, partially correlating with elevated alkaline phosphatase (ALP) levels.</div></div><div><h3>CONCLUSION</h3><div>[<sup>18</sup>F]F-AlF-NOTA-FAPI-04 PET/CT shows high specificity for pancreatic ductal adenocarcinoma, particularly in head/neck tumours. Physiological or nonspecific pancreatic uptake in nonpancreatic malignancies warrants careful interpretation to avoid misdiagnosis.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"87 ","pages":"Article 106954"},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth patterns of true renal artery aneurysms in the current published literature 在目前发表的文献中,真肾动脉瘤的生长模式
IF 2.1 3区 医学
Clinical radiology Pub Date : 2025-05-14 DOI: 10.1016/j.crad.2025.106957
H. Briody , E. Tong , R.J. Lee , G.R. Daly , C. Brosnan , K.P. Sheahan , D.P. Mulholland , M.J. Lee
{"title":"Growth patterns of true renal artery aneurysms in the current published literature","authors":"H. Briody ,&nbsp;E. Tong ,&nbsp;R.J. Lee ,&nbsp;G.R. Daly ,&nbsp;C. Brosnan ,&nbsp;K.P. Sheahan ,&nbsp;D.P. Mulholland ,&nbsp;M.J. Lee","doi":"10.1016/j.crad.2025.106957","DOIUrl":"10.1016/j.crad.2025.106957","url":null,"abstract":"<div><h3>AIM</h3><div>To describe the methods of surveying true renal artery aneurysms (RAAs) and identify the pattern of growth of RAA in the current literature.</div></div><div><h3>MATERIALS AND METHODS</h3><div>A comprehensive electronic database search was performed. The limits applied included full text and English language. The reference lists of included publications were manually searched for further relevant studies. Studies that surveyed RAA on imaging and calculated mean aneurysm growth rates per year were included.</div></div><div><h3>Results</h3><div>Literature review yielded six studies comprising 876 patients and approximately 988 aneurysms. Computed tomography (CT) was the most common imaging modality utilised for evaluation of RAA. Mean initial RAA diameter ranged from 1.21 to 1.6 cm. The combined cohort was followed radiologically for up to a maximum of 142 months and reports a zero percent rupture rate. Mean growth rates were consistently below 0.1 cm/y across the included studies (range: 0.017–0.086 cm/y).</div></div><div><h3>Conclusion</h3><div>The present study highlights a benign course of RAA. The current evidence yields a rupture rate of zero in a combined cohort of approximately 988 aneurysms followed for up to 11 years. Future guidelines should recognise this indolent course and consider rationalisation of RAA surveillance, particularly where initial aneurysm size is well below the threshold for treatment.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"86 ","pages":"Article 106957"},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumour and adipose tissue uptake on 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) predict immunotherapy response in recurrent or metastatic nasopharyngeal carcinoma 肿瘤和脂肪组织对18f -氟脱氧葡萄糖(18F-FDG)正电子发射断层扫描/计算机断层扫描(PET/CT)的摄取预测复发或转移性鼻咽癌的免疫治疗反应
IF 2.1 3区 医学
Clinical radiology Pub Date : 2025-05-14 DOI: 10.1016/j.crad.2025.106959
J. Bao , M. Xiong , M. Zheng , P. Huang , X. Lin
{"title":"Tumour and adipose tissue uptake on 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) predict immunotherapy response in recurrent or metastatic nasopharyngeal carcinoma","authors":"J. Bao ,&nbsp;M. Xiong ,&nbsp;M. Zheng ,&nbsp;P. Huang ,&nbsp;X. Lin","doi":"10.1016/j.crad.2025.106959","DOIUrl":"10.1016/j.crad.2025.106959","url":null,"abstract":"<div><h3>AIM</h3><div>This study evaluated the prognostic value of <sup>18</sup>F-Fluorodeoxyglucose (<sup>18</sup>F-FDG) uptake in tumour and adipose tissue in recurrent or metastatic (R/M) nasopharyngeal carcinoma (NPC) patients treated with immunotherapy.</div></div><div><h3>MATERIALS AND METHODS</h3><div>We retrospectively included 120 patients with R/M NPC treated with PD-1 inhibitors. Maximum standardised uptake value (SUV<sub>max</sub>), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) of all malignant lesions were recorded. Additionally, SUV<sub>max</sub> and SUV<sub>mean</sub> were measured for subcutaneous and visceral adipose tissue (SAT and VAT). The study classified patients who, within six months of immunotherapy, either experienced tumour progression, died, or changed treatment regimens as the nonclinical benefit (non-CB) group, and others as the CB group. The primary endpoints were progression-free survival (PFS) and overall survival (OS).</div></div><div><h3>RESULTS</h3><div>The CB group had significantly lower primary tumour MTV (PT-MTV) (median, 15.8 vs 48.1, <em>P</em>=0.006), PT-TLG (median, 88.7 vs 275.6, <em>P</em>=0.008) and SUV<sub>max</sub>-VAT (median, 0.63 vs 0.77, <em>P</em>=0.047) than non-CB group. More T4 stages (71.4% vs. 41.3%) and lung metastases (42.9% vs 21.7%) were observed in the non-CB group compared to the CB group. Multivariate analysis indicated lung metastases (<em>P</em>=0.002, hazard ratio [HR] = 2.204, 95% confidence interval [CI]: 1.323–3.669) and higher primary tumour burden (<em>P</em>&lt;0.001, HR= 3.379, 95% CI: 1.768–6.460) as independent PFS predictors. Only higher primary tumour burden (<em>P</em>=0.027, HR=2.513, 95% CI: 1.108–5.698) was an independent OS predictor.</div></div><div><h3>CONCLUSION</h3><div>Our study indicates that higher primary tumour burden is associated with poor prognosis for NPC patients undergoing immunotherapy. SUV<sub>max</sub>-VAT may be a promising predictor for immunotherapy response.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"87 ","pages":"Article 106959"},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining conventional magnetic resonance imaging (MRI) parameters with clinicopathologic data for differentiation of the three-tiered human epidermal growth factor receptor 2 (HER2) status in breast cancer 将常规磁共振成像(MRI)参数与临床病理数据相结合,对乳腺癌中三层人表皮生长因子受体2 (HER2)状态的分化进行研究
IF 2.1 3区 医学
Clinical radiology Pub Date : 2025-05-14 DOI: 10.1016/j.crad.2025.106955
W. Liu , C. Liu , Y. Yang , Y. Chen , A. Muhetaier , Z. Lin , Z. Weng , X. Wang , P. Zhang , J. Qin
{"title":"Combining conventional magnetic resonance imaging (MRI) parameters with clinicopathologic data for differentiation of the three-tiered human epidermal growth factor receptor 2 (HER2) status in breast cancer","authors":"W. Liu ,&nbsp;C. Liu ,&nbsp;Y. Yang ,&nbsp;Y. Chen ,&nbsp;A. Muhetaier ,&nbsp;Z. Lin ,&nbsp;Z. Weng ,&nbsp;X. Wang ,&nbsp;P. Zhang ,&nbsp;J. Qin","doi":"10.1016/j.crad.2025.106955","DOIUrl":"10.1016/j.crad.2025.106955","url":null,"abstract":"<div><h3>AIM</h3><div>To assess the three-tiered human epidermal growth factor receptor 2 (HER2) classification of breast cancer (BC) patients based on conventional magnetic resonance imaging (MRI) parameters combined with clinicopathologic data.</div></div><div><h3>MATERIALS AND METHODS</h3><div>211 patients with invasive BC were retrospectively evaluated and divided into the HER2-zero, HER2-low, and HER2-positive BC groups. Patients underwent conventional dynamic contrast-enhanced breast MRI. Radiologists assessed clinicopathologic features and measured the apparent diffusion coefficient (ADC) and haemodynamic parameters to differentiate HER2-zero/-low (n=129) from HER2-positive (n=82) BC (task 1) and then HER2-zero (n=90) from HER2-low (n=57) BC (task 2). Patients were randomly assigned to the training and test sets at a ratio of 7:3. Univariate and multivariate logistic regression analyses were applied to select the most useful predictors. Receiver operating characteristic curve analysis was applied to evaluate the discriminative performance of the models.</div></div><div><h3>RESULTS</h3><div>The ADC and Ki-67 status were independently associated factors both for task 1 (OR: 41.22, 5.68) and task 2 (OR: 0.02, 0.29). The models established combining conventional MRI parameters with clinicopathologic data in the training set for task 1 and task 2 yielded an area under the curve (AUC) of 0.836 and 0.874, respectively, and demonstrated effective prediction in the test set, with the AUC of 0.845 for task 1 and an AUC of 0.805 for task 2, respectively.</div></div><div><h3>CONCLUSION</h3><div>Models combining conventional magnetic resonance imaging (MRI) parameters and clinicopathologic data could be valuable for differentiating BC HER2 expression, which may aid in selecting patients for HER2-targeted therapies in those without fluorescence in situ hybridisation results.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"86 ","pages":"Article 106955"},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epicardial adipose tissue associated with right cardiac chamber remodelling in patients with connective tissue disease evaluated by cardiac magnetic resonance: a cross-sectional study 心外膜脂肪组织与结缔组织疾病患者右心室重构相关的心脏磁共振:一项横断面研究
IF 2.1 3区 医学
Clinical radiology Pub Date : 2025-05-14 DOI: 10.1016/j.crad.2025.106958
Y. Tang , Z. Pan , J. Wen , Z. Yang , D. Tang , Y. Luo , C. Xiang , L. Huang , L. Xia
{"title":"Epicardial adipose tissue associated with right cardiac chamber remodelling in patients with connective tissue disease evaluated by cardiac magnetic resonance: a cross-sectional study","authors":"Y. Tang ,&nbsp;Z. Pan ,&nbsp;J. Wen ,&nbsp;Z. Yang ,&nbsp;D. Tang ,&nbsp;Y. Luo ,&nbsp;C. Xiang ,&nbsp;L. Huang ,&nbsp;L. Xia","doi":"10.1016/j.crad.2025.106958","DOIUrl":"10.1016/j.crad.2025.106958","url":null,"abstract":"<div><h3>AIM</h3><div>The present study aimed to evaluate the relationship between epicardial adipose tissue (EAT) and right cardiac chamber remodelling in connective tissue disease (CTD) patients and to investigate the value of EAT in CTD-associated pulmonary hypertension (CTD-PH) patients.</div></div><div><h3>MATERIALS AND METHODS</h3><div>A total of 134 CTD patients and 64 age- and sex-matched controls who underwent cardiac magnetic resonance (CMR) examination were retrospectively enrolled. Systolic pulmonary arterial pressure (sPAP) measured by transthoracic echocardiography was recorded. Based on combined PH, patients were divided into two subgroups: CTD-PH and CTD-nonPH. Right heart strain parameters and EAT thickness and volume were measured using CVI42 (version 5.13.9, Circle Cardiovascular Imaging Inc., Calgary, Canada). Bootstrapping was used to analyse the mediating effect of right cardiac chamber remodelling between EAT volume index (EATVI) and sPAP in CTD patients. Logistic regression was used to explore the correlations between EAT and CTD-PH.</div></div><div><h3>RESULTS</h3><div>CTD-PH patients had significantly higher EATVI (43.82 [36.00, 61.27] ml/m<sup>2</sup> vs. 30.13 [24.06, 41.38] ml/m<sup>2</sup>, <em>P</em>&lt;0.001) and more pronounced right cardiac chamber remodelling than controls. There was a mediating effect between EAT and pulmonary artery pressure in right ventricular myocardial mass index and right atrial conduit function. Multivariate logistic regression showed that EATVI remained an independent association for CTD-PH after adjustment for clinical factors.</div></div><div><h3>CONCLUSION</h3><div>EAT is significantly increased in CTD-PH patients with more pronounced right cardiac chamber remodelling, which may be one of the valuable parameters for risk stratification of CTD patients.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"87 ","pages":"Article 106958"},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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