Clinical radiology最新文献

{"title":"Nonrigid temporal registration of multiphase CT pulmonary angiography using low-kV and low contrast: a feasibility study with dual-source CT","authors":"Q.-H. Zhang ,&nbsp;S.-S. Lin ,&nbsp;X. Zhao ,&nbsp;Z. Qin ,&nbsp;H. Ge ,&nbsp;J.-X. Qian ,&nbsp;Y.-C. Wang","doi":"10.1016/j.crad.2025.106916","DOIUrl":"10.1016/j.crad.2025.106916","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to compare the nonrigid temporal registration of multiphase computed tomography pulmonary angiography (CTPA) with single-phase CTPA in terms of radiation dose, contrast agent usage, objective and subjective image quality.</div></div><div><h3>Materials and Methods</h3><div>Consecutive patients suspected of acute pulmonary embolism were prospectively included in this study, and randomly received multiphase or single-phase CTPA. Regarding the contrast media, 15 mL was applied in the multiphase CTPA in comparison with 40 mL applied in the single-phase CTPA. Temporal registration was performed for multiphase CTPA during post-processing. Two experienced radiologists independently evaluated the image quality (IQ) based on objective measurements, subjective impression and diagnostic confidence. Patient demographics, scan parameters and image quality were compared between the two groups.</div></div><div><h3>Results</h3><div>A total of 72 patients were analysed (37 multiphase CTPA and 35 single-phase CTPA). Positive pulmonary embolism was confirmed in five and seven patients, respectively. The two patient groups had similar demographics besides older age in those who underwent single-phase CTPA. Radiation dose and the contrast-to-noise ratio (CNR) were also similar between groups except for the CNR in the right main pulmonary artery. Both readers rated the multiphase CTPA with a statistically superior subjective IQ over the single-phase CTPA. The diagnostics confidence of the two CTPA protocols was similarly rated by one reader and slightly different according to the second reader.</div></div><div><h3>Conclusion</h3><div>The nonrigid temporal registration of multiphase CT pulmonary angiography could offer similar or even better image quality than the single-phase protocol and significantly reduce the amount of contrast usage.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106916"},"PeriodicalIF":2.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased cerebral hemodynamics during the interictal period of migraine and the association with migraine features","authors":"Y. Liu ,&nbsp;A. Sun ,&nbsp;Y. Zhang ,&nbsp;B. Wang ,&nbsp;X. Kuang ,&nbsp;F. Dai ,&nbsp;H. Wang ,&nbsp;J. Ding ,&nbsp;X. Wang","doi":"10.1016/j.crad.2025.106918","DOIUrl":"10.1016/j.crad.2025.106918","url":null,"abstract":"<div><h3>Aim</h3><div>To detect cerebral hemodynamic changes in migraine’s interictal period using 4D flow magnetic resonance imaging (MRI) and explore the relationships between altered hemodynamics and migraine features.</div></div><div><h3>Materials and Methods</h3><div>Twenty-five patients (29 ± 4 years, 22 female) with migraine in the interictal period and twenty-five healthy controls (28 ± 4 years, 20 female) were consecutively enrolled. Migraine features including frequency, duration of migraine history, pain side and degree were collected in migraineurs. 4D flow MRI scan was performed for all subjects. Cross-sectional area, peak systolic through-plane velocity (PSV), average through-plane velocity (V_avg), average blood flow rate (Flow_avg), and average wall shear stress (WSS_avg) in the bilateral middle cerebral artery (MCA) and the posterior cerebral artery (PCA) were measured. Pulsatility index (PI) was calculated from the maximum, minimum and average blood flow velocity. The hemodynamic differences of MCA and PCA in migraineurs and controls were investigated. The relationships between hemodynamic changes and migraine features were further explored.</div></div><div><h3>Results</h3><div>Increased PSV, V_avg and Flow_avg in the MCA, as well as elevated V_avg, Flow_avg and WSS_avg in the PCA, were found among migraine patients. Flow_avg of PCA was significantly correlated with the duration of migraine history (r = 0.46, <em>P</em> = 0.02).</div></div><div><h3>Conclusion</h3><div>Cerebral hemodynamics is significantly elevated in migraineurs during the interictal period of migraine. Notably, the Flow_avg in the PCA is associated with the duration of migraine history.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106918"},"PeriodicalIF":2.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation in paediatric splenic trauma management in adult and combined major trauma centres in England","authors":"H. Sanchez-Lewis ,&nbsp;P. Jenkins ,&nbsp;L. Sorrell ,&nbsp;L. Watkins ,&nbsp;J. Zhong ,&nbsp;J.E. Smith ,&nbsp;V. Allgar ,&nbsp;C. Roobottom ,&nbsp;I. Mccafferty","doi":"10.1016/j.crad.2025.106904","DOIUrl":"10.1016/j.crad.2025.106904","url":null,"abstract":"<div><h3>Aim</h3><div>Treatment options for paediatric splenic injuries include conservative management, splenic embolisation, and splenectomy. Within the UK, in addition to standalone paediatric trauma centres, adult and combined (adult and paediatric) major trauma centres (MTCs) receive traumatically injured children. We describe the treatment of paediatric splenic injuries between 2017 and 2021 in the United Kingdom adult and combined MTCs.</div></div><div><h3>Materials and Methods</h3><div>Data were extracted from the Trauma Audit and Research Network (TARN) for all patients &lt;18 years old with splenic injuries admitted between 01/01/17 and 31/12/21 at adult and combined MTCs. The relationship between injury and centre type, treatment, and outcomes was assessed using chi-squared and Fisher's exact tests.</div></div><div><h3>Results</h3><div>A total of 690 children were included. The median age was 13.9 years (interquartile range: 10.9-16.1), and 78.7% (543/690) of the patients were male. A total of 92.9% (641/690) of patients suffered blunt injuries; 7.1% (49/690) suffered penetrating. Of those known, 69.5% (182/262) were treated in a combined MTC and 30.5% (80/262) at an adult MTC.</div><div>Treatment included: A total of 90.4% (624/690) received conservative management, 5.5% (38/690) underwent splenic embolisation, and 4.1% (28/690) had a splenectomy. Embolisation and splenectomy rates at adult-only MTCs were 8.8% (7/80) and 10% (8/80), respectively, compared to 4.4% (8/182) and 1.6% (3/182) in combined MTCs (<em>P</em> = 0.002). No embolised patients required a subsequent splenectomy. The mortality rates were 8.8% (7/80) in adult and 3.3% (6/182) in combined centres (<em>P</em> = 0.118).</div></div><div><h3>Conclusion</h3><div>Embolisation is performed more (5.5%) than splenectomy (4.1%). Combined MTCs demonstrate superior outcomes and lower intervention rates than adult-only MTCs. These findings should inform strategies to standardise paediatric trauma care within the UK.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106904"},"PeriodicalIF":2.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of MRI findings by pTERT mutation status and the prognostic significance in GBM patients with recurrent lesions","authors":"G. Quan ,&nbsp;C. Wang ,&nbsp;Y. Liu ,&nbsp;T. Yuan","doi":"10.1016/j.crad.2025.106913","DOIUrl":"10.1016/j.crad.2025.106913","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate the MRI characteristics of recurrent glioblastoma (GBM) in relation to telomerase reverse transcriptase-promoter (pTERT) mutation status and their prognostic significance.</div></div><div><h3>Materials and Methods</h3><div>A retrospective analysis was conducted on 80 patients with primary IDH wild-type GBM. MRI features, including conventional and functional imaging, were compared between pTERT mutant and wild-type groups. Cox regression and receiver operating characteristic (ROC) analyses were performed to evaluate survival outcomes and predictive models.</div></div><div><h3>Results</h3><div>Compared to patients with wild-type pTERT (n = 24), those with mutant pTERT (n = 56) were older (p = 0.008) and had shorter overall survival (OS) (p = 0.003). They also exhibited a higher incidence of massive-like enhancement (p = 0.036) and new subependymal enhancement (p = 0.034), lower relative apparent diffusion coefficient (rADC) (p = 0.006), and higher relative cerebral blood volume (rCBV) (p = 0.048) and choline/N-acetyl aspartate ratio (p = 0.033). Multivariate analysis identified new subependymal enhancement (HR = 2.348, p = 0.018) and massive-like enhancement (HR = 2.348, p = 0.018) as independent risk factors for shorter OS. The areas under the ROC curve (AUCs) for predicting poor OS using pTERT mutation status, conventional MRI, and combination models were 0.700, 0.695, and 0.764, respectively. Among the 31 patients with available functional MRI data, the AUCs for prediction using functional MRI, conventional MRI + pTERT mutation status, and the combination model were 0.783, 0.710, and 0.888, respectively.</div></div><div><h3>Conclusions</h3><div>MRI features, particularly subependymal and massive-like enhancements, along with pTERT mutation status, serve as valuable prognostic markers for survival outcomes in recurrent GBM patients. The combination model incorporating MRI characteristics and genetic status enhances predictive accuracy.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106913"},"PeriodicalIF":2.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative chest computed tomography: regional differences in dual-energy-derived virtual vs. true non-contrast scans","authors":"Q.D. Strotzer ,&nbsp;C. Schachner ,&nbsp;L. Scheuermeyer ,&nbsp;F. Raab ,&nbsp;S. Meiler ,&nbsp;M.V. Malfertheiner ,&nbsp;C. Stroszczynski ,&nbsp;O.W. Hamer","doi":"10.1016/j.crad.2025.106912","DOIUrl":"10.1016/j.crad.2025.106912","url":null,"abstract":"<div><h3>Aim</h3><div>Quantitative analysis of chest computed tomography (CT) usually requires non-contrast scans. Multi-energy CT-derived virtual non-contrast (VNC) images may obviate additional true non-contrast (TNC) scans. We aimed to quantitatively compare virtual and true non-contrast images, with a focus on regional differences in pulmonary tissue.</div></div><div><h3>Materials and Methods</h3><div>This bi-center retrospective, IRB-approved study included consecutive patients who received contrast-enhanced dual-energy and non-contrast chest CT scans within one year between April 2018 and December 2022. Scans were co-registered and semi-manually segmented into various volumes of interest: whole lung, center/periphery, ventral/dorsal half and upper/middle/lower third. The mean lung density, high and low attenuation volumes and the lower 15th percentile were computed from the VNC and TNC scans for each volume. Correlation and agreement were assessed using Pearson’s and intraclass correlation coefficients and Bland–Altman analysis. Subgroup analyses involved body mass index and markers of pulmonary emphysema.</div></div><div><h3>Results</h3><div>Forty-eight patients were included (26 females, median age: 63 years, interquartile range: 58–69). Pearson’s and intraclass correlation coefficients &gt; 0.9 demonstrated high correlation and agreement for the mean lung density, low attenuation volume and the lower 15th percentile across the whole lung. The agreement for high attenuation volume was slightly less pronounced (intraclass correlation coefficient, 0.84 [95% confidence interval: 0.73, 0.91]). Regional differences were observed, for example, concerning the mean lung density with mean differences (HU_VNC minus HU_TNC) of -5.71 HU [-11.07, -0.35], 1.62 HU [-2.98, 6.23] and 5.77 HU [-0.47, 12.01] for the upper, middle and lower third, respectively.</div></div><div><h3>Conclusion</h3><div>Although slight regional differences were observed, quantitative analysis can be reliably performed using VNC images.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106912"},"PeriodicalIF":2.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RCR meetings","authors":"","doi":"10.1016/S0009-9260(25)00079-0","DOIUrl":"10.1016/S0009-9260(25)00079-0","url":null,"abstract":"","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"83 ","pages":"Article 106874"},"PeriodicalIF":2.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paid MBP advert: 250120_Thoracic Imaging-CR-210x280-v2","authors":"","doi":"10.1016/S0009-9260(25)00080-7","DOIUrl":"10.1016/S0009-9260(25)00080-7","url":null,"abstract":"","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"83 ","pages":"Article 106875"},"PeriodicalIF":2.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatric sclerotherapy of vascular anomalies of the hand and digits","authors":"C. Mahler ,&nbsp;J. DiFatta ,&nbsp;R. Oser ,&nbsp;J. Huang ,&nbsp;A.J. Gunn ,&nbsp;J. Raja","doi":"10.1016/j.crad.2025.106908","DOIUrl":"10.1016/j.crad.2025.106908","url":null,"abstract":"<div><h3>Aim</h3><div>Vascular anomalies in the hands and digits can cause pain, swelling and restrict the range of motion. Additionally, the small compartments they reside within portend challenges and possible risks in treatment. This study aims to evaluate the safety and efficacy of percutaneous sclerotherapy to treat vascular malformations in the hand and digits in paediatric patients.</div></div><div><h3>Materials and Methods</h3><div>Metrics including size and location characteristics of the anomaly, procedural specifics, technical success, clinical success, and adverse events were recorded and further analysed.</div></div><div><h3>Results</h3><div>Eight paediatric patients (5 males, 3 females) aged 5–17 years (mean 12 years) with vascular anomalies of the hands and digits treated with sclerotherapy were included. Three patients had arteriovenous malformation (AVMs), two venous malformation (VMs), and three venolymphatic malformation (VLMs) based upon imaging. Presenting symptoms included localised pain (n=8), swelling (n=7), decreased range of motion and function (n=3) and distal upper extremity numbness (n=1). Technical success was achieved in all (100%) patients. Seven of the eight patients (87.5%) followed up at six weeks and all reported at least partial reduction of symptoms (100%). Follow-up imaging was available for three patients with all showing decrease in the size of the malformation. There were no intraoperative complications or major adverse events. Three patients (37.5%) reported Society of Interventional Radiology (SIR) grade A/B minor adverse events (swelling [n=3], transient pain [n=3], and poor capillary refill [n=1]). Two patients (25%) benefited with a steroid prescription that successfully abated their symptoms.</div></div><div><h3>Conclusion</h3><div>Sclerotherapy appears to be a safe and effective treatment for vascular malformations in the hand and digits in paediatric patients.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106908"},"PeriodicalIF":2.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous core needle biopsy of 566 peripheral lung lesions: analysis of factors associated with biopsy failure and postprocedural pneumothorax","authors":"J. Yoon ,&nbsp;S. Park ,&nbsp;J.H. Kim ,&nbsp;J.H. Hwang ,&nbsp;C. Park ,&nbsp;S. Park","doi":"10.1016/j.crad.2025.106911","DOIUrl":"10.1016/j.crad.2025.106911","url":null,"abstract":"<div><h3>AIM</h3><div>To evaluate the safety and efficacy of percutaneous transthoracic core needle biopsy (PCNB) for peripheral lung lesions and to identify factors associated with diagnostic failure and occurrence of significant pneumothorax.</div></div><div><h3>MATERIAL AND METHODS</h3><div>Data from 566 PCNB procedures on lung lesions in contact with or adjacent to the visceral pleura at a distance less than 1 cm, performed at a single center between March 2019 and December 2021, were retrospectively reviewed. The electric medical records, including inpatient notes, radiology reports, and procedure reports were reviewed. Procedure details and lesion(s) characteristics were analyzed using univariate and multivariate logistic regression analyses to identify factors associated with diagnostic failure and postprocedural pneumothorax.</div></div><div><h3>RESULTS</h3><div>The technical and diagnostic success rates were 100% and 90.1% (510/566), respectively. Postprocedural pneumothorax occurred in 19.4% (110/566) of patients. The severe adverse events that required prolongation of the hospital admission occurred in 3.4% (19/566). Univariate and multivariate analyses revealed that lesion diameter less than 10 mm (p&lt;0.001) was associated with diagnostic failure, and the transfissural route (p = 0.042) and longer tract length (p = 0.018) were associated with the occurrence of postprocedural pneumothorax.</div></div><div><h3>CONCLUSION</h3><div>PCNB was an effective and safe diagnostic method for peripheral lung lesions, with a high diagnostic success rate and low incidence of postprocedural pneumothorax.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106911"},"PeriodicalIF":2.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and influencing factors of vasovagal reaction in computed tomography (CT)-guided localisation of pulmonary ground-glass nodules prior to video-assisted thoracoscopic surgery","authors":"H.X. Feng ,&nbsp;Z.G. Huang ,&nbsp;H.L. Sun ,&nbsp;Y.Y. Xu ,&nbsp;Y.L. Wang ,&nbsp;B.X. Gao ,&nbsp;C.D. Li ,&nbsp;T.Y. Zhang ,&nbsp;H.Y. Li ,&nbsp;Y.W. Hu","doi":"10.1016/j.crad.2025.106910","DOIUrl":"10.1016/j.crad.2025.106910","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate the incidence, clinical features, and influencing factors of vasovagal reaction (VVR) associated with computed tomography (CT)-guided localisation of pulmonary ground-glass nodules (GGNs) prior to video-assisted thoracoscopic surgery (VATS).</div></div><div><h3>Materials and methods</h3><div>A total of 1303 consecutive patients who underwent CT-guided localisation of GGNs were selected as research subjects. VVR related to CT-guided localisation was defined as the onset of otherwise unexplained transient hypotension and/or relative bradycardia during or after localisation, manifesting as symptoms such as pallor, sweating, nausea, and potentially syncope. Risk factors for VVR were identified through both univariate and multivariate analyses.</div></div><div><h3>Results</h3><div>VVR was observed in 4.5% (58/1,303) of the patients. All VVRs occurred postlocalisation, with 91.4% (53/58) happening between the time patients rose from the CT table and their departure from the CT room. Prodromal symptoms were evident in all VVR cases, with two cases progressing to syncope, each with a brief loss of consciousness lasting less than one minute. Univariate analysis identified significant risk factors for VVR, including patient age, stress level, history of syncope, and the marking of multiple GGNs, as well as marking time. Multivariate logistic regression analysis revealed that patient stress (odds ratio [OR], 20.17; P &lt; 0.001) and a history of syncope (OR, 8.06; P = 0.002) were independent risk factors for VVR.</div></div><div><h3>Conclusion</h3><div>VVR affects approximately 4.5% of patients undergoing CT-guided localisation of GGNs, often manifesting immediately after rising from the CT table. Patient stress and a history of syncope are significantly associated with an increased likelihood of VVR.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106910"},"PeriodicalIF":2.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}