Assessment of thyroid-associated ophthalmopathy activity using corrected standardised uptake value maximum (SUVmax) and uptake ratios from 99Tcm-diethylene triamine pentaacetic acid single photon emission computed tomography/computed tomography (99Tcm-DTPA SPECT/CT) imaging

IF 2.1 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical radiology Pub Date : 2025-05-06 DOI:10.1016/j.crad.2025.106946

J. Sun , L. Ma , M. Wang , X. Yuan

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引用次数: 0

Abstract

Aim

This study evaluated the utility of corrected maximum standardized uptake value (SUVmax) in assessing thyroid-associated ophthalmopathy (TAO) activity through 99Tcm-diethylene triamine pentaacetic acid (99Tcm-DTPA) SPECT/CT imaging.

Materials and Methods

A total of 166 orbits from 83 TAO patients were analyzed, alongside 22 orbits from 11 healthy controls. Participants were cate gorized into active (CAS ≥ 3), inactive (CAS <3), and control groups based on the clinical activity score (CAS). Corrected SUVmax and uptake ratios (UR) were quantitatively measured using Q.Metrix software. Statistical analyses, including Kruskale-Wallis tests, Spearman correlations, and ROC curve evaluations, were employed to examine group differences and diagnostic performance.

Results

The corrected SUVmax and UR values were significantly higher in the active group compared to inactive and control groups (P<0.001). Corrected SUVmax demonstrated strong reproducibility (ICC = 0.958) and a positive correlation with CAS (rs = 0.537, P<0.001), outperforming UR in consistency (ICC = 0.632). ROC analysis revealed that the corrected SUVmax threshold of 10.440 offered 70.7% sensitivity and 82.1% specificity for predicting TAO activity. UR exhibited comparable diagnostic performance but with reduced reproducibility.

Conclusion

These findings highlight corrected SUVmax as a robust and reliable parameter for quantifying TAO inflammatoryactivity. Its strong correlation with CAS and high interobserver agreement establish its potential for clinical use in guiding TAO treatment and monitoring disease progression. Further multicenter studies are warranted to validate these findings and expand clinical applications.

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使用99tcm -二乙烯三胺五乙酸单光子发射计算机断层扫描/计算机断层扫描（99Tcm-DTPA SPECT/CT）成像的校正标准最大摄取值（SUVmax）和摄取比率评估甲状腺相关眼病活动性

目的通过99tcm -二乙烯三胺五乙酸（99Tcm-DTPA） SPECT/CT成像，评价校正最大标准化摄取值（SUVmax）在评估甲状腺相关眼病（TAO）活性中的应用价值。材料与方法分析83例TAO患者的166个眼窝及11例健康对照者的22个眼窝。根据临床活动评分（CAS）将参与者分为活动组（CAS≥3）、非活动组（CAS <3）和对照组。校正后的SUVmax和摄取比（UR）用Q.Metrix软件定量测量。统计分析，包括Kruskale-Wallis检验、Spearman相关性和ROC曲线评估，用于检查组间差异和诊断表现。结果运动组校正后的SUVmax和UR值明显高于不运动组和对照组（P<0.001）。校正后的SUVmax具有较强的重复性（ICC = 0.958），与CAS呈正相关（rs = 0.537, P<0.001），一致性优于UR （ICC = 0.632）。ROC分析显示，修正后的SUVmax阈值为10.440，预测TAO活性的敏感性为70.7%，特异性为82.1%。UR具有类似的诊断性能，但可重复性较低。结论：修正后的SUVmax是量化TAO炎症活性的可靠参数。它与CAS的强相关性和高度的观察者间一致性确定了它在指导TAO治疗和监测疾病进展方面的临床应用潜力。需要进一步的多中心研究来验证这些发现并扩大临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical radiology 医学-核医学

CiteScore

4.70

自引率

3.80%

发文量

528

审稿时长

76 days

期刊介绍： Clinical Radiology is published by Elsevier on behalf of The Royal College of Radiologists. Clinical Radiology is an International Journal bringing you original research, editorials and review articles on all aspects of diagnostic imaging, including: • Computed tomography • Magnetic resonance imaging • Ultrasonography • Digital radiology • Interventional radiology • Radiography • Nuclear medicine Papers on radiological protection, quality assurance, audit in radiology and matters relating to radiological training and education are also included. In addition, each issue contains correspondence, book reviews and notices of forthcoming events.