Compounds最新文献_第8页

Hybrid or Component?—Schiff Base Complexes and Laccase 混合式还是组件式?-希夫碱配合物和漆酶

Compounds Pub Date : 2022-11-01 DOI: 10.3390/compounds2040025

T. Akitsu

引用次数: 1

Extraction of Polyphenolic and Volatile Compounds from Cistus creticus Using Deep Eutectic Solvents and Pulsed Electric Fields 深共晶溶剂和脉冲电场法提取山茱萸中多酚类和挥发性化合物

Compounds Pub Date : 2022-11-01 DOI: 10.3390/compounds2040026

D. Palaiogiannis, V. Athanasiadis, Eleni Bozinou, Theodoros G. Chatzimitakos, D. Makris, S. Lalas

{"title":"Extraction of Polyphenolic and Volatile Compounds from Cistus creticus Using Deep Eutectic Solvents and Pulsed Electric Fields","authors":"D. Palaiogiannis, V. Athanasiadis, Eleni Bozinou, Theodoros G. Chatzimitakos, D. Makris, S. Lalas","doi":"10.3390/compounds2040026","DOIUrl":"https://doi.org/10.3390/compounds2040026","url":null,"abstract":"To date, many studies have been published, aiming to extract bioactive compounds from plants. Lately, research focuses on maximizing the extraction yield, using environmentally friendly techniques and solvents. In this study, the extraction of polyphenolic compounds from Cistus creticus is discussed. Extraction of the compounds has been carried out with water and ethanol, employing the most common approach. To further enhance the extraction yield, the usage of four deep eutectic solvents (DESs) has also been examined. In an effort to further enhance the extraction yield, pulsed electric fields have also been employed. According to the results, it was evident that the use of DESs made of glycerol: choline chloride (2:1) increased the extraction yield by 75%, compared to extraction with water. Moreover, the use of pulsed electric fields enhanced the extraction yield of the common approach, by up to 70%. When pulsed electric fields and DESs were combined, the extraction yield increased by 14%, compared to the use of DESs only. Finally, the extract was analyzed for its content in volatile compounds, and it was found that new compounds could be extracted with the use of DESs.","PeriodicalId":10621,"journal":{"name":"Compounds","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76505212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Assessing Antipsoriatic Effects of Bitter Pu’er Tea and Its Three Major Compounds, Strictinin, Theacrine and Epigallocatechin Gallate, in Imiquimod-Treated Mice 苦普洱茶及其三种主要化合物——缩紧素、茶碱和没食子儿茶素没食子酸酯对吡喹莫德治疗小鼠的抗银屑病作用

Compounds Pub Date : 2022-11-01 DOI: 10.3390/compounds2040024

Pei-Yi Lin, Cian-Fen Jhuo, Nan-hei Lin, Wen-Ying Chen, J. Tzen

{"title":"Assessing Antipsoriatic Effects of Bitter Pu’er Tea and Its Three Major Compounds, Strictinin, Theacrine and Epigallocatechin Gallate, in Imiquimod-Treated Mice","authors":"Pei-Yi Lin, Cian-Fen Jhuo, Nan-hei Lin, Wen-Ying Chen, J. Tzen","doi":"10.3390/compounds2040024","DOIUrl":"https://doi.org/10.3390/compounds2040024","url":null,"abstract":"Psoriasis is a chronic inflammatory skin disease with hyperproliferation and aberrant differentiation of keratinocytes in association with the elevation of interleukin-17A (IL-17A) and IL-23 levels. In an animal model, psoriasis-like dermatitis was induced on the shaved dorsal skin of BALB/c mice by topical application of imiquimod (IMQ), a synthetic ligand of Toll-like receptor 7. Administration of bitter Pu’er tea significantly reduced psoriasis-like dermatitis in IMQ-treated mice, including a reduction in dorsal skin lesions, splenomegaly and the mRNA expression levels of IL-17A and IL-23. To examine putative antipsoriatic constituents, three major compounds in bitter Pu’er tea, strictinin, theacrine and epigallocatechin gallate (EGCG), were separately given as supplements to IMQ-treated mice. The results showed that all the three compounds attenuated the severity of psoriasis by reducing epidermal thickness. Only theacrine significantly attenuated splenomegaly. All the three compounds inhibited the expression of IL-23 mRNA in the skin as well as reduced the content of IL-17A+CD4+ T cells in the spleen, and strictinin was found to be relatively effective. It seemed that the antipsoriatic activity of bitter Pu’er tea was attributed to the additive effects of its multiple active compounds.","PeriodicalId":10621,"journal":{"name":"Compounds","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77170702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Influence of Secondary Interactions on Structural Diversity between a Pair of Halogen-Bonded Co-Crystals Containing Isosteric Donors 二次相互作用对含等构给体的卤素键共晶结构多样性的影响

Compounds Pub Date : 2022-10-28 DOI: 10.3390/compounds2040023

H. Krueger, Nicole M. Shapiro, E. Bosch, D. Unruh, R. Groeneman

引用次数: 2

Traditional Chinese Medicines and Prescriptions Brought from China to Japan by a Monk (Jianzhen, Japanese: Ganjin): A Historical Review 由僧人(简真，日文:甘津)从中国传入日本的中药和方剂:历史回顾

Compounds Pub Date : 2022-10-18 DOI: 10.3390/compounds2040022

Shihui Liu, Toshihiko Matsuo, C. Matsuo, Takumi Abe

{"title":"Traditional Chinese Medicines and Prescriptions Brought from China to Japan by a Monk (Jianzhen, Japanese: Ganjin): A Historical Review","authors":"Shihui Liu, Toshihiko Matsuo, C. Matsuo, Takumi Abe","doi":"10.3390/compounds2040022","DOIUrl":"https://doi.org/10.3390/compounds2040022","url":null,"abstract":"(1) Background: Japanese Kampo medicine has its origin in ancient Chinese medicine. In 742, a Tang Dynasty monk named Jianzhen (Ganjin) was invited by Japanese clerics to visit Japan and teach commandments in Buddhism. Because of the dangers of the voyage and also other obstacles, he took 11 years to reach Japan on the sixth voyage and he was blind when he arrived in Japan. He was the first person in China to go to Japan to establish the Buddhism commandments, and he was also the first person in Japan to directly teach traditional Chinese medicine. Until now, there have been few reports in English about the details of the Chinese herbal medicines he brought to Japan, including the types of herbal medicines, pharmacological activities, and formulations. In the review, we systematically and comprehensively summarized Jianzhen’s life from the standpoint of his medical and pharmaceutical knowledge and the types and pharmacological activities of Chinese herbal medicines and prescriptions that were brought to Japan by Jianzhen; (2) Methods: A review was made on the relevant literature written by Chinese, Japanese, and English languages regarding the medical and pharmacological knowledge of Jianzhen, the 36 Chinese herbal medicines brought to Japan by Jianzhen, and the pharmacological and therapeutic effects of these 36 herbal medicines, as well as their formulations; (3) Results: The review of the literature proved that Jianzhen’s prescriptions served as a basis for current herbal medicines (Kampo) in Japan. In the process of the literature search, we found a book entitled Jianshangren (Holy Priest Jianzhen)’s Secret Prescription, which recorded the complete prescription of the 36 traditional Chinese medicines Jianzhen brought to Japan; (4) Conclusions: Jianzhen is one of the ancestors of traditional Chinese medicine/Kampo medicine, and he brought traditional Chinese medicine and medical books to Japan for patients. He made important contributions to the development of traditional Chinese medicine in Japan.","PeriodicalId":10621,"journal":{"name":"Compounds","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84033260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational Study on the Conformational Preferences of Neutral, Protonated and Deprotonated Glycine Dimers 中性、质子化和去质子化甘氨酸二聚体构象偏好的计算研究

Compounds Pub Date : 2022-10-12 DOI: 10.3390/compounds2040021

M. Pita, R. Mosquera

{"title":"Computational Study on the Conformational Preferences of Neutral, Protonated and Deprotonated Glycine Dimers","authors":"M. Pita, R. Mosquera","doi":"10.3390/compounds2040021","DOIUrl":"https://doi.org/10.3390/compounds2040021","url":null,"abstract":"A conformational analysis has been carried out for monoprotonated, unprotonated and deprotonated glycine dimers in the gas phase and an aqueous solution. MP2/6-311++(d,p), B3LYP/6-311++(d,p) and M06/6-311++(d,p) optimizations were performed for more than 200 initial conformations comprising nonionic (COOH–CH2–NH2) (N) and zwitterionic (COO−–CH2–NH3+) (Z) structures for neutral monomers. All the methods indicate that Z monomers are preferred over N ones for the neutral and deprotonated dimers in aqueous solutions, whereas the reverse trend is observed in the gas phase (including also protonated dimers). NC and ZC structures coexist in aqueous solutions for the protonated glycine dimer. The preferred geometries are significantly different depending on the media and total dimer charge. Moreover, several minima display close energies in each series (media and total dimer charge). New conformers, not previously reported, are found to be significantly populated in those conformational mixtures. Dimers containing Z monomers are associated with larger absolute solvation energies and are more prone than N-containing ones to experience protonation and deprotonation in the gas phase, whereas the reverse trend is observed in the aqueous solution. The Quantum Theory of Atoms in Molecules (QTAIM) analysis reveals that uncharged dimers display trifling electron density transfer between monomers, whereas it is significant in anionic and cationic dimers.","PeriodicalId":10621,"journal":{"name":"Compounds","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84361977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of KCl Addition on First Hydrogenation Kinetics of TiFe KCl加成对TiFe首次加氢动力学的影响

Compounds Pub Date : 2022-10-06 DOI: 10.3390/compounds2040020

J. Manna, J. Huot

引用次数: 2

Feature Papers in Compounds 化合物专题论文

Compounds Pub Date : 2022-10-01 DOI: 10.3390/compounds2040019

J. Mejuto

引用次数: 1

Waste-Glycerol as a Precursor for Carbon Materials: An Overview 废甘油作为碳材料的前驱体:综述

Compounds Pub Date : 2022-09-16 DOI: 10.3390/compounds2030018

M. Batista, Sílvia Carvalho, Renato Carvalho, M. Pinto, J. Pires

引用次数: 2

Ethnomedicinal, Phytochemistry and Antiviral Potential of Turmeric (Curcuma longa) 姜黄(Curcuma longa)的民族医药、植物化学和抗病毒潜力

Compounds Pub Date : 2022-08-26 DOI: 10.3390/compounds2030017

B. B. Srivastava, A. Ripanda, Hossein Miraji Mwanga

{"title":"Ethnomedicinal, Phytochemistry and Antiviral Potential of Turmeric (Curcuma longa)","authors":"B. B. Srivastava, A. Ripanda, Hossein Miraji Mwanga","doi":"10.3390/compounds2030017","DOIUrl":"https://doi.org/10.3390/compounds2030017","url":null,"abstract":"Turmeric (Curcuma longa) has been a famous root crop for its medicinal properties since pre-historical times. Lack of effective therapeutics for most viral diseases, higher cost of some antiviral therapies, and the emergence of antiviral drug resistance are increasingly reported. Drug resistance is predicted to be a leading cause of mortality globally by 2050, thus requiring intervention. The need for effective natural antiviral compounds to mitigate viral diseases, such as curcumin, calls for further studies. Curcumin, a primary curcuminoid compound, has demonstrated a broad activity as an antiviral agent. Due to the need to overcome drug resistance to chemically synthesised drugs, the best option is to improve and adapt the use of natural antiviral agents. The antiviral potential of curcumin is hindered by its solubility and bioavailability. Recently, different techniques, such as the preparation of curcumin carbon quantum dots, have been used to improve curcumin antiviral activity. Therefore, the current review aims to assess curcumin’s benefits as a natural antiviral agent and techniques to improve its medicinal activity. Future use of curcumin will aid in mitigating viral diseases, including resistant strain, hence sustainability of the entire community. In this case, research and innovation are required to improve the solubility and bioavailability of curcumin for medical uses.","PeriodicalId":10621,"journal":{"name":"Compounds","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75343080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8