Comparative Biochemistry and Physiology C-toxicology & Pharmacology最新文献

{"title":"Toxic effects of polystyrene and polyethylene microplastics on the zebrafish cardiovascular system and their differential mechanisms","authors":"Qingzheng Liu ,&nbsp;Feifei Yan ,&nbsp;Haoran Liu ,&nbsp;Jing Zhang ,&nbsp;Jidong Zhang","doi":"10.1016/j.cbpc.2025.110353","DOIUrl":"10.1016/j.cbpc.2025.110353","url":null,"abstract":"<div><div>This study investigated the toxic effects of polystyrene (PS) and polyethylene (PE) microplastics on the cardiovascular systems of zebrafish, as well as the differences in their mechanisms. Using a larval zebrafish (<em>Danio rerio</em>) model, we systematically evaluate the effects of the two microplastics on growth and development, oxidative stress, myocardial cell number and structure, histopathological changes, cell apoptosis, and gene expression via physiological parameter measurements, histopathological analysis, and molecular biological techniques. The experimental results showed that PS exerted a more significant inhibitory effect on body weight, whereas PE had a more marked inhibitory effect on body length. Both substances caused a dose-dependent decrease in heart rate, induced oxidative stress, aggravated myocardial damage and fibrosis and activated inflammatory responses. Additionally, PS and PE microplastics exhibit differences in their toxic mechanisms. PS enhances toxicity primarily through the adsorption capacity of its rigid benzene ring structures. While PE, due to its strong hydrophobicity, tends to accumulate more readily in myocardial tissue and exacerbate cell apoptosis via physical damage pathways. This study is the first to compare the differential mechanisms of cardiovascular toxicity between PS and PE microplastics in zebrafish, providing scientific evidence for environmental risk assessment and human health protection related to microplastics.</div></div>","PeriodicalId":10602,"journal":{"name":"Comparative Biochemistry and Physiology C-toxicology & Pharmacology","volume":"299 ","pages":"Article 110353"},"PeriodicalIF":4.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyridaben-induced biochemical and molecular stress in Daphnia magna","authors":"Gülüzar Atli ,&nbsp;Yusuf Sevgiler ,&nbsp;Serdar Kilercioglu","doi":"10.1016/j.cbpc.2025.110350","DOIUrl":"10.1016/j.cbpc.2025.110350","url":null,"abstract":"<div><div>Pyridaben (PDB) is a widely used acaricide in agriculture, classified as highly toxic to aquatic life (H400, H410; USEPA) because it inhibits mitochondrial complex I. This study aimed to evaluate the subacute toxicity of PDB (0.20–0.80 TU for 48 h) in the model organism <em>Daphnia magna</em> using an integrated molecular and biochemical multi-biomarker approach. To the best of our knowledge, this is the first comprehensive study to integrate molecular and biochemical markers related to oxidative stress and osmoregulation in assessing subacute PDB toxicity in <em>D. magna</em> using the Integrated Biomarker Response index (IBR). PDB exposure altered antioxidant system dynamics, with decreased SOD and GPX activities, increased CAT and GST activities, and elevated GSH and TBARS levels. The increase in Ca²⁺-ATPase activity was positively correlated with antioxidant enzymes, suggesting an adaptive osmoregulatory response to oxidative stress. Reduced total protein levels were negatively correlated with most of the biomarkers. At the molecular level, while the expression of oxidative stress-related genes decreased, <em>miR-153</em> was significantly upregulated, showing a negative correlation with these genes but a positive correlation with other biomarker levels. The results revealed significant and interrelated alterations at both biochemical and molecular levels, and IBR analysis demonstrated that responses were notably triggered at 0.35 TU, with maximal effects observed at concentrations of 0.50 TU and above. These findings provide new insights into the ecological risk of PDB, supporting the use of multi-biomarker approaches for environmental monitoring, as well as elucidating molecular pathways underlying the adaptive responses of aquatic organisms to stress.</div></div>","PeriodicalId":10602,"journal":{"name":"Comparative Biochemistry and Physiology C-toxicology & Pharmacology","volume":"299 ","pages":"Article 110350"},"PeriodicalIF":4.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significantly enhanced effects of heavy metals on the toxicity, bioconcentration and biomagnification under combined exposure","authors":"Qian Cheng ,&nbsp;Jin Zhang ,&nbsp;Bi-ya Dai ,&nbsp;Xin-yue Wang ,&nbsp;Guang-zhen Ji ,&nbsp;Yuan-fan Zhao","doi":"10.1016/j.cbpc.2025.110346","DOIUrl":"10.1016/j.cbpc.2025.110346","url":null,"abstract":"<div><div>Heavy metal (HM) co-contamination is prevalent in the aquatic ecosystems and often induces complex combined effects such as synergism or antagonism, bioconcentration and biomagnification on the food-chain organisms, which is threatening the survival of living creatures and even to human health. However, the combined effects of HMs under combined exposure on the aquatic food chains still remain poorly understood. Therefore, toxic responses, bioconcentration and biomagnification of four typical HMs, lead (Pb), cadmium (Cd), nickel (Ni) and zinc (Zn), were systematically investigated under different combined exposure conditions. Results demonstrated that combined toxicity significantly exceeded single-metal effects and increased with component number, following the order: quaternary &gt; ternary &gt; binary &gt; single. The Cd<img>Ni combination exhibited the strongest toxicity at 96 h (pEC₅₀ = 4.15), confirming significant synergistic. Further analysis of the reactive oxygen species (ROS) production, membrane integrity, and chlorophyll <em>a</em> and b contents demonstrated that HM interactions disrupt redox balance and photosynthetic function, amplifying toxicity. Under the combined exposure, HMs were readily bioconcentrated in <em>Chlorella pyrenoidosa</em> and transferred to <em>Daphnia magna</em>. Notably, Cd showed clear biomagnification under single-metal exposure. As the number and complexity of metal components increased, biomagnification factor values for both Cd and Ni further increased. Cd and Ni exhibited stronger trophic magnification effects, indicating that Cd and Ni may be the key drivers of combined toxicity and biomagnification. All the findings in this study will provide the basic reference for the ecological risk assessment of compound contamination of multiple HMs.</div></div>","PeriodicalId":10602,"journal":{"name":"Comparative Biochemistry and Physiology C-toxicology & Pharmacology","volume":"299 ","pages":"Article 110346"},"PeriodicalIF":4.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145027505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-level tetrabromobisphenol A (TBBPA) exposure disrupts early embryonic architecture: molecular impacts on dorsoventral patterning","authors":"Kanchaka Senarath Pathirajage ,&nbsp;Rosemaria Serradimigni ,&nbsp;Copeland R. Johnson ,&nbsp;Sunil Sharma ,&nbsp;Christopher Chouinard ,&nbsp;Subham Dasgupta","doi":"10.1016/j.cbpc.2025.110348","DOIUrl":"10.1016/j.cbpc.2025.110348","url":null,"abstract":"<div><div>Tetrabromobisphenol A (TBBPA), a widely used flame retardant in textiles and electronics, poses toxicological risks through both environmental and indoor exposures. Biomonitoring studies have detected significant TBBPA levels in prenatal environments, including cord blood, raising concerns about developmental impacts. Using zebrafish as a model, this study addresses critical gaps in understanding how developmental TBBPA exposures perturb regulatory pathways that govern dorsoventral patterning. Embryos were exposed at 0.75- or 6-h post-fertilization (hpf) and phenotyped at 24 hpf, with tissue uptake quantified by LC-MS. At 24 hpf, embryos exhibited concentration-dependent ventralization characterized by loss of dorsal structures. Whole-mount immunohistochemistry revealed concentration-dependent alterations in dorsoventral, cell adhesion, and germ layer markers, indicating disruptions in cell migration and germ layer integrity. At later stages, even nontoxic exposures led to craniofacial and hematopoietic defects, linking early molecular perturbations to downstream developmental abnormalities. Although the phenotypes strongly resembled BMP pathway overactivation, co-exposure with the BMP inhibitor dorsomorphin failed to rescue the defects, suggesting involvement of alternative mechanisms. Collectively, these findings demonstrate that TBBPA disrupts proteins critical for cell migration, fate specification, and germ layer formation at environmentally relevant concentrations, fundamentally altering embryonic physiology prior to organogenesis and inducing systemic changes in tissue development.</div></div>","PeriodicalId":10602,"journal":{"name":"Comparative Biochemistry and Physiology C-toxicology & Pharmacology","volume":"299 ","pages":"Article 110348"},"PeriodicalIF":4.3,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial light at night disrupts fertility in Drosophila melanogaster","authors":"Margherita Martelli ,&nbsp;Raffaella Lazzarini ,&nbsp;Francesco Piva ,&nbsp;Gianmaria Salvio ,&nbsp;Alessandro Ciarloni ,&nbsp;Lory Santarelli ,&nbsp;Massimo Bracci","doi":"10.1016/j.cbpc.2025.110349","DOIUrl":"10.1016/j.cbpc.2025.110349","url":null,"abstract":"<div><div>Artificial light at night (ALAN) can disrupt numerous biological processes, and is increasingly studied in animal models. Here, we evaluated the impact of red and blue ALAN on <em>Drosophila melanogaster,</em> focusing on fertility, development, circadian rhythms, and gene expression. All results were compared to those of a control group maintained under a 12 h white light/12 h dark cycle.</div><div>Red ALAN exposure increased the number of eggs laid but reduced the hatching rate and shortened the larval period. Conversely, blue ALAN led to fewer eggs laid, fewer emerging adults, and lower hatching success. Significant alterations in circadian rhythm and the sleep–wake cycle were observed in flies exposed to both red and blue ALAN, including a reduction in mean locomotor activity over 24 h and during the daytime period, increased sleep duration during the day, and reduced sleep duration at night. Effects were more pronounced under blue ALAN, which disrupted circadian rhythm by eliminating morning and evening activity peaks and increasing nocturnal activity. Gene expression analyses revealed that red ALAN upregulated <em>ecdysone-induced protein 74EF</em> (<em>E74</em>) and the <em>ecdysone receptor</em> (<em>EcR</em>) expression in adults, while <em>juvenile hormone binding protein 1</em> (<em>Jhbp1</em>) was elevated under both light conditions. In larvae, both ALAN spectra increased expression of <em>E74</em> and <em>Jhbp1</em>.</div><div>These findings demonstrate that red and blue ALAN can significantly disrupt fertility and development in <em>Drosophila melanogaster</em>. Given the rising prevalence of light pollution and night-shift work, further studies are needed to investigate ALAN-related reproductive impairments in other animals, including vertebrates and humans.</div></div>","PeriodicalId":10602,"journal":{"name":"Comparative Biochemistry and Physiology C-toxicology & Pharmacology","volume":"299 ","pages":"Article 110349"},"PeriodicalIF":4.3,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fisetin modulates fluoride induced osteochondral toxicity in zebrafish larvae","authors":"Harsheema Ottappilakkil ,&nbsp;Grace Helena Yesudas ,&nbsp;Theeksha Sreedharan ,&nbsp;Ekambaram Perumal","doi":"10.1016/j.cbpc.2025.110351","DOIUrl":"10.1016/j.cbpc.2025.110351","url":null,"abstract":"<div><div>Excessive fluoride (F⁻) exposure, particularly during early development, poses a significant risk to skeletal integrity by disrupting bone homeostasis through oxidative stress and altered mineralization. While F⁻ induced oxidative stress is well documented, studies investigating the role of natural antioxidants in mitigating F⁻ induced osteochondral toxicity remain limited. Hence, the present study investigated the osteomodulatory effect of fisetin (Fis) against F⁻ toxicity in zebrafish larvae. Fis (15 μM) was exposed to zebrafish larvae at 3 days post fertilization (dpf) for 24 h, followed by 72 h exposure to 25 ppm sodium fluoride (NaF). F⁻ accumulation, oxidant (ROS, LPO, NO, PCC) and antioxidant (SOD, CAT, GSH) levels, cartilage (alcian blue staining), skeletal (alizarin red staining, hydroxyproline content, ALP activity) markers, and expression of osteochondral genes <em>(sox9b, runx2b, ocn, osx, col1a1, alp, rankl, and opg)</em> were assessed in control and treated larvae. F⁻ exposure significantly elevated oxidative stress, disrupted craniofacial cartilage morphology, and induced premature ossification, alongside altered expression of osteogenic and resorptive markers<em>.</em> Remarkably, Fis pretreatment effectively reduced F⁻ accumulation, restored redox homeostasis, preserved cartilage architecture, and normalized mineral deposition. Gene expression analysis further confirmed that Fis modulated key regulators of osteogenesis, chondrogenesis, and bone resorption, underscoring its osteoprotective role. Collectively, these findings demonstrate that Fis confers protection against F⁻ induced osteochondral toxicity by attenuating oxidative stress, supporting bone matrix development, and regulating genes essential for bone homeostasis.</div></div>","PeriodicalId":10602,"journal":{"name":"Comparative Biochemistry and Physiology C-toxicology & Pharmacology","volume":"299 ","pages":"Article 110351"},"PeriodicalIF":4.3,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of short-term exposure to environmentally relevant pesticides mixture on morphological alterations, oxidative-nitrative stress biomarkers, cellular apoptosis, and antioxidant expression in kidneys of goldfish","authors":"Esmirna Cantu ,&nbsp;Md Saydur Rahman","doi":"10.1016/j.cbpc.2025.110337","DOIUrl":"10.1016/j.cbpc.2025.110337","url":null,"abstract":"<div><div>Chemical stressors are pervasive, affecting both terrestrial and aquatic environments. The continual influx of these toxins is damaging ecosystems and the organisms that inhabit them. The abundance of environmental toxins makes aquatic habitats inhospitable for aquatic life. These chemical stressors consistently disrupt the life processes of aquatic organisms, particularly their physiological functions. This study examined on the effects of environmentally relevant pesticides mixture (low-dose and high-dose: S-metolachlor: 2.4 go/L, 12 μg/L; linuron: 2.0 μg/L, 10 μg/L; isoproturon: 1.2 μg/L, 6.0 μg/L; tebucanozole: 1.2 μg/L, 6.0 μg/L; aclonifen: 0.8 μg/L, 4.0 μg/L; atrazine: 0.4 μg/L, 2.0 μg/L; pendimethalin: 0.4 μg/L, 2.0 μg/L, and azinphos-methyl: 0.8 μg/L, 4.0 μg/L) on tissue morphology, cellular apoptosis, and nitrotyrosine protein (NTP), dinitrophenyl protein (DNP), renin, superoxide dismutase (SOD), and catalase (CAT) expression in the kidneys of goldfish (<em>Carassius auratus</em>) exposed for one week under controlled laboratory conditions. Histopathological analysis revealed severe tissue damage in the kidneys, while silver staining identified melano-macrophage centers, and immunohistochemistry and real-time PCR shed light on the expression of molecular biomarkers in these tissues. Exposure to pesticide mixtures caused fish to exhibit glomerular shrinkage, enlargement of Bowman's space, and degradation of glomerular cells. Moreover, the expression of renin, DNP, NTP, SOD, and apoptotic nuclei increased in kidney tissues, while CAT expression decreased. Overall, our findings indicate that exposure of goldfish to an environmentally relevant pesticide mixture leads to increased cellular damage and altered osmoregulatory and antioxidant enzyme expressions, which may impair physiological functions, including growth, reproduction, and development in teleost fish.</div></div>","PeriodicalId":10602,"journal":{"name":"Comparative Biochemistry and Physiology C-toxicology & Pharmacology","volume":"299 ","pages":"Article 110337"},"PeriodicalIF":4.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of pulse exposures to road salt at various stages of early development in rainbow trout (Oncorhynchus mykiss)","authors":"Carley E. Winter ,&nbsp;Clare L. Kilgour ,&nbsp;Colin J. Brauner ,&nbsp;Patricia M. Schulte ,&nbsp;Chris M. Wood","doi":"10.1016/j.cbpc.2025.110334","DOIUrl":"10.1016/j.cbpc.2025.110334","url":null,"abstract":"<div><div>Salmonids spawn in freshwater streams including those in urban areas that are impacted by human activities. In the Vancouver region of British Columbia, Canada, the extensive use of road salt (primarily NaCl) is associated with frequent 24-h “pulses” of salt in streams, some of which may exceed the provincial acute guideline for maximum chloride concentrations (600 mg L⁻¹ Cl⁻) by up to 11-fold. For some salmonids, road salting coincides with critical developmental stages, as many species spawn between October and January. We explored the concentration-dependent effects of a 24-h salt pulse (600–9600 mg L⁻¹ Cl⁻) on salmonid development using rainbow trout (<em>Oncorhynchus mykiss</em>). Salt pulses were imposed at one of three developmental time points: &lt;1 h post-fertilization, the eyed-stage or 7 days post-hatch. Significant mortality occurred only in the &lt;1 h post-fertilization treatment, at 2400, 4800 and 9600 mg L⁻¹ Cl⁻, all environmentally relevant salt concentrations. Significant differences in whole-embryo ion concentrations at the end of the salt exposure and at the eyed-stage (17 days post-salt exposure) indicated lasting ionoregulatory effects on embryos. Co-exposure to CaCO₃ during the salt pulse, at a level that increased dissolved Ca²⁺ by 2-to 3-fold in the ion poor Vancouver water, greatly reduced mortality and altered whole-embryo ion levels. These findings support the need for site-specific water quality guidelines, as toxicity varies with water's ionic composition. This research also highlights the need for improved road salting practices to reduce salt contamination and its potential adverse effects on developing salmonids.</div></div>","PeriodicalId":10602,"journal":{"name":"Comparative Biochemistry and Physiology C-toxicology & Pharmacology","volume":"299 ","pages":"Article 110334"},"PeriodicalIF":4.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-system toxicity of lead (Pb) in Procambarus clarkii: Integrated analysis of tissue damage, immune dysfunction, oxidative stress, and microbial dysbiosis via multi-omics approaches","authors":"Lang Zhang ,&nbsp;Ziwei Song ,&nbsp;Qiuying Qin ,&nbsp;Li He ,&nbsp;Juan Tian ,&nbsp;Yali Yu ,&nbsp;Yingchun Mu ,&nbsp;Liqi Zhong ,&nbsp;Zongbin Cui ,&nbsp;Jinhua Gan","doi":"10.1016/j.cbpc.2025.110331","DOIUrl":"10.1016/j.cbpc.2025.110331","url":null,"abstract":"<div><div>The element lead (Pb) exhibits significant toxicity throughout aquatic habitats. Crustaceans sit at the top of the aquatic food chain and therefore are especially susceptible to Pb-associated toxicity. Nevertheless, there is limited information on the crustaceans exposed to Pb. Hence, in this study, the acute Pb-mediated alterations of histopathology, hepatopancreas transcriptome, and gut microbiomes of <em>Procambarus clarkii</em> (<em>P. clarkii</em>) were performed. Pb exposure caused hepatopancreas damage (lumen dilatation, epithelial vacuolization) and intestinal lesions (disrupted lamina propria and epithelium). RNA-seq revealed differentially expressed genes (DEGs) in the hepatopancreas, including immune-related (PGRMC1, TAK1, CDC42, USP2), oxidation-reduction-related (XDH, G6PD, CYP4C1, CYP6K1, CYP9E2), and ion transport genes (TNC2, LETM1, ABCA1/3/10), suggesting Pb disrupts immunity, oxidation-reduction balance, and ion homeostasis. Additionally, examination of the bacterial 16S rRNA gene demonstrated that Pb induced a significantly reduction in both the diversity and abundance of bacteria, resulting in a notable perturbation in the composition of the gut microbiome. The exposure to Pb resulted in significant alterations in 4 phyla and 13 genera. The findings indicated that the presence of Pb might impede the capacity to synthesis of amylases, glucose assimilation, chitin degradation, and antibacterial activity. Taken together, the results of our study provided insights into the multiple mechanisms underlying Pb toxicity in aquatic crustaceans, encompassing tissue, cellular, molecular, and microbial levels.</div></div>","PeriodicalId":10602,"journal":{"name":"Comparative Biochemistry and Physiology C-toxicology & Pharmacology","volume":"298 ","pages":"Article 110331"},"PeriodicalIF":4.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How microplastics influence the health and microbiota of aquatic invertebrates: A review","authors":"Haksoo Jeong ,&nbsp;Zhou Yang ,&nbsp;Jae-Seong Lee","doi":"10.1016/j.cbpc.2025.110333","DOIUrl":"10.1016/j.cbpc.2025.110333","url":null,"abstract":"<div><div>Concern about microplastics (MPs) in aquatic ecosystems, and their hazardous effects on aquatic organisms and microbiota in particular, is growing globally. Previous reviews focused on the impact of MPs on biological responses and microbial alterations in fish. The impacts of MPs on other aquatic organisms (mainly invertebrates) remain poorly understood. This review concentrates on the effects of MPs on aquatic organisms other than fish. First, we describe an important microscopic ecosystem associated with MPs and its function in aquatic systems. Second, we elucidate the latest trends in relevant research and experimental designs. We also discuss the toxicity of MPs in various biological and molecular responses, microbial changes, and the relationship between host health and microbiota in aquatic organisms. Last, we examine the combined effects of MPs, climate change, and pollutants on microbiota and hosts. This review provides an overall research background for MPs and microbiota in aquatic ecosystems and suggests future research directions.</div></div>","PeriodicalId":10602,"journal":{"name":"Comparative Biochemistry and Physiology C-toxicology & Pharmacology","volume":"299 ","pages":"Article 110333"},"PeriodicalIF":4.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}