Cold Spring Harbor perspectives in biology最新文献_第9页

Schwann Cell Development and Myelination 许旺细胞的发育和髓鞘化

IF 7.2 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-03-19 DOI: 10.1101/cshperspect.a041360

James Salzer, M. Laura Feltri, Claire Jacob

引用次数: 0

How Important Is Variation in Extrinsic Reproductive Isolation to the Process of Speciation? 外在生殖隔离的变异对物种演化过程有多重要？

IF 7.2 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-03-19 DOI: 10.1101/cshperspect.a041430

Linyi Zhang, Etsuko Nonaka, Megan Higgie, Scott Egan

{"title":"How Important Is Variation in Extrinsic Reproductive Isolation to the Process of Speciation?","authors":"Linyi Zhang, Etsuko Nonaka, Megan Higgie, Scott Egan","doi":"10.1101/cshperspect.a041430","DOIUrl":"https://doi.org/10.1101/cshperspect.a041430","url":null,"abstract":"The strength of reproductive isolation (RI) between two or more lineages during the process of speciation can vary by the ecological conditions. However, most speciation research has been limited to studying how ecologically dependent RI varies among a handful of broadly categorized environments. Very few studies consider the variability of RI and its effects on speciation at finer scales—that is, within each environment due to spatial or temporal environmental heterogeneity. Such variation in RI across time and/or space may inhibit speciation through leaky reproductive barriers or promote speciation by facilitating reinforcement. To investigate this overlooked aspect of speciation research, we conducted a literature review of existing studies of variation in RI in the field and then conducted individual-based simulations to examine how variation in hybrid fitness across time and space affects the degree of gene flow. Our simulations indicate that the presence of variation in hybrid fitness across space and time often leads to an increase in gene flow compared to scenarios where hybrid fitness remains static. This observation can be attributed to the convex relationship between the degree of gene flow and the strength of selection on hybrids. Our simulations also show that the effect of variation in RI on facilitating gene flow is most pronounced when RI, on average, is relatively low. This finding suggests that it could serve as an important mechanism to explain why the completion of speciation is often challenging. While direct empirical evidence documenting variation in extrinsic RI is limited, we contend that it is a prevalent yet underexplored phenomenon. We support this argument by proposing common scenarios in which RI is likely to exhibit variability and thus influence the process of speciation.","PeriodicalId":10494,"journal":{"name":"Cold Spring Harbor perspectives in biology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140165453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Negative Coupling: The Coincidence of Premating Isolating Barriers Can Reduce Reproductive Isolation 负耦合：预产期隔离障碍的巧合可以减少生殖隔离

IF 7.2 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-03-19 DOI: 10.1101/cshperspect.a041435

Thomas G. Aubier, Michael Kopp, Isaac J. Linn, Oscar Puebla, Marina Rafajlović, Maria R. Servedio

{"title":"Negative Coupling: The Coincidence of Premating Isolating Barriers Can Reduce Reproductive Isolation","authors":"Thomas G. Aubier, Michael Kopp, Isaac J. Linn, Oscar Puebla, Marina Rafajlović, Maria R. Servedio","doi":"10.1101/cshperspect.a041435","DOIUrl":"https://doi.org/10.1101/cshperspect.a041435","url":null,"abstract":"Speciation can be mediated by a variety of reproductive barriers, and the interaction among different barriers has often been shown to enhance overall reproductive isolation, a process referred to as “coupling.” Here, we analyze a population genetics model to study the establishment of linkage disequilibrium (LD) among loci involved in multiple premating barriers, an aspect that has received little theoretical attention to date. We consider a simple genetic framework underlying two distinct premating barriers, each encoded by a preference locus and its associated mating trait locus. We show that their interaction can lead to a decrease in overall reproductive isolation relative to a situation with a single barrier, a process we call “negative coupling.” More specifically, in our model, negative coupling results either from sexual selection that reduces divergence at all loci, or from reduced LD that occurs because the presence of many females with “mismatched” preferences causes the mating success of recombinant males to become high. Interestingly, the latter effect may even cause LD among preference loci to become negative when recombination rates among loci are low. We conclude that coincident reproductive barriers may not necessarily reinforce each other, and that the underlying loci may not necessarily develop a positive association.","PeriodicalId":10494,"journal":{"name":"Cold Spring Harbor perspectives in biology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140165428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combining Molecular, Macroevolutionary, and Macroecological Perspectives on the Generation of Diversity 结合分子、宏观进化和宏观生态学视角看多样性的产生

IF 7.2 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-03-19 DOI: 10.1101/cshperspect.a041453

Lindell Bromham

{"title":"Combining Molecular, Macroevolutionary, and Macroecological Perspectives on the Generation of Diversity","authors":"Lindell Bromham","doi":"10.1101/cshperspect.a041453","DOIUrl":"https://doi.org/10.1101/cshperspect.a041453","url":null,"abstract":"Charles Darwin presented a unified process of diversification driven by the gradual accumulation of heritable variation. The growth in DNA databases and the increase in genomic sequencing, combined with advances in molecular phylogenetic analyses, gives us an opportunity to realize Darwin's vision, connecting the generation of variation to the diversification of lineages. The rate of molecular evolution is correlated with the rate of diversification across animals and plants, but the relationship between genome change and speciation is complex: Mutation rates evolve in response to life history and niche; substitution rates are influenced by mutation, selection, and population size; rates of acquisition of reproductive isolation vary between populations; and traits, niches, and distribution can influence diversification rates. The connection between mutation rate and diversification rate is one part of the complex and varied story of speciation, which has theoretical importance for understanding the generation of biodiversity and also practical impacts on the use of DNA to understand the dynamics of speciation over macroevolutionary timescales.","PeriodicalId":10494,"journal":{"name":"Cold Spring Harbor perspectives in biology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140165712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing Large-Scale Human Circuit Development with In Vivo Neuroimaging 用体内神经成像技术表征大规模人体电路发育过程

IF 7.2 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-03-04 DOI: 10.1101/cshperspect.a041496

Tomoki Arichi

引用次数: 0

The Role of Hybridization in Species Formation and Persistence. 杂交在物种形成和持续存在中的作用。

IF 7.2 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-03-04 DOI: 10.1101/cshperspect.a041445

Joshua V Peñalba, Anna Runemark, Joana I Meier, Pooja Singh, Guinevere O U Wogan, Rosa Sánchez-Guillén, James Mallet, Sina J Rometsch, Mitra Menon, Ole Seehausen, Jonna Kulmuni, Ricardo J Pereira

引用次数: 0

Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS) 健康与疾病中的小胶质细胞：中枢神经系统 (CNS) 的综合枢纽

IF 7.2 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-03-04 DOI: 10.1101/cshperspect.a041366

Amanda Sierra, Veronique E. Miron, Rosa C. Paolicelli, Richard M. Ransohoff

引用次数: 0

Protein Design Using Structure-Prediction Networks: AlphaFold and RoseTTAFold as Protein Structure Foundation Models 利用结构预测网络进行蛋白质设计：作为蛋白质结构基础模型的 AlphaFold 和 RoseTTAFold

IF 7.2 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-03-04 DOI: 10.1101/cshperspect.a041472

Jue Wang, Joseph L. Watson, Sidney L. Lisanza

引用次数: 0

The Astrocyte: Metabolic Hub of the Brain 星形胶质细胞大脑的代谢枢纽

IF 7.2 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-03-04 DOI: 10.1101/cshperspect.a041355

L. Felipe Barros, Stefanie Schirmeier, Bruno Weber

引用次数: 0

Remyelination in the Central Nervous System. 中枢神经系统的再髓鞘化

IF 7.2 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-03-01 DOI: 10.1101/cshperspect.a041371

Robin J M Franklin, Benedetta Bodini, Steven A Goldman

{"title":"Remyelination in the Central Nervous System.","authors":"Robin J M Franklin, Benedetta Bodini, Steven A Goldman","doi":"10.1101/cshperspect.a041371","DOIUrl":"10.1101/cshperspect.a041371","url":null,"abstract":"<p><p>The inability of the mammalian central nervous system (CNS) to undergo spontaneous regeneration has long been regarded as a central tenet of neurobiology. However, while this is largely true of the neuronal elements of the adult mammalian CNS, save for discrete populations of granule neurons, the same is not true of its glial elements. In particular, the loss of oligodendrocytes, which results in demyelination, triggers a spontaneous and often highly efficient regenerative response, remyelination, in which new oligodendrocytes are generated and myelin sheaths are restored to denuded axons. Yet remyelination in humans is not without limitation, and a variety of demyelinating conditions are associated with sustained and disabling myelin loss. In this work, we will (1) review the biology of remyelination, including the cells and signals involved; (2) describe when remyelination occurs and when and why it fails, including the consequences of its failure; and (3) discuss approaches for therapeutically enhancing remyelination in demyelinating diseases of both children and adults, both by stimulating endogenous oligodendrocyte progenitor cells and by transplanting these cells into demyelinated brain.</p>","PeriodicalId":10494,"journal":{"name":"Cold Spring Harbor perspectives in biology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10910446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139691425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0