Cold Spring Harbor perspectives in biology最新文献

Mechanisms of Alternative Lengthening of Telomeres. 端粒替代性延长的机制

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2025-01-07 DOI: 10.1101/cshperspect.a041690

Roderick J O'Sullivan, Roger A Greenberg

引用次数: 0

Calculating Relatedness: A Pedigree of Definitions. 计算亲缘关系：定义谱系

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2025-01-07 DOI: 10.1101/cshperspect.a041667

Matishalin Patel, J Arvid Ågren

引用次数: 0

Satellite Glial Cells: No Longer the Most Overlooked Glia. 卫星胶质细胞：卫星胶质细胞：不再是最被忽视的胶质细胞

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2025-01-07 DOI: 10.1101/cshperspect.a041367

Susan J Birren, Lisa V Goodrich, Rosalind A Segal

引用次数: 0

Understanding the Influence of Host Radiation on Symbiont Speciation through Parasites of Species Flocks. 通过种群寄生虫了解宿主辐射对共生体物种变异的影响

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2025-01-07 DOI: 10.1101/cshperspect.a041450

Maarten P M Vanhove, Nikol Kmentová, Christel Faes, Jorge M O Fernandes, Christoph Hahn, Niel Hens, Antoine Pariselle, Stephan Koblmüller

{"title":"Understanding the Influence of Host Radiation on Symbiont Speciation through Parasites of Species Flocks.","authors":"Maarten P M Vanhove, Nikol Kmentová, Christel Faes, Jorge M O Fernandes, Christoph Hahn, Niel Hens, Antoine Pariselle, Stephan Koblmüller","doi":"10.1101/cshperspect.a041450","DOIUrl":"10.1101/cshperspect.a041450","url":null,"abstract":"(Adaptive) radiations have attracted evolutionary biologists for a long time as ideal model systems to study patterns and processes of often rapid speciation. However, whereas a wealth of (sometimes already genome-scale) data is available for host radiations, very few studies target the patterns of diversification in their symbionts, even though they would be excellent models to study symbiont speciation. Our review summarizes what little is known about general patterns of symbiont diversification in often iconic adaptive host radiations and to what extent these patterns are dependent on the evolutionary trajectories of their hosts. We identify research gaps that need to be addressed in the future and discuss the potential of approaches not yet typically used in these study systems, such as epidemiological disease modeling and new omics technologies, for significantly advancing our understanding of these complex eco-evolutionary relationships.","PeriodicalId":10494,"journal":{"name":"Cold Spring Harbor perspectives in biology","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perisynaptic Schwann Cells: Guardians of Neuromuscular Junction Integrity and Function in Health and Disease. 突触周围许旺细胞：健康和疾病中神经肌肉接头完整性和功能的守护者

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2025-01-07 DOI: 10.1101/cshperspect.a041362

Thomas W Gould, Chien-Ping Ko, Hugh Willison, Richard Robitaille

引用次数: 0

Telomere Dynamics in Zebrafish Aging and Disease. 斑马鱼衰老和疾病的端粒动力学。

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-12-18 DOI: 10.1101/cshperspect.a041696

Miguel Godinho Ferreira

引用次数: 0

Maintaining Telomeres without Telomerase in Drosophila: Novel Mechanisms and Rapid Evolution to Save a Genus. 果蝇在没有端粒酶的情况下维持端粒：拯救一个属的新机制和快速进化。

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-12-18 DOI: 10.1101/cshperspect.a041708

Stefano Cacchione, Giovanni Cenci, Anne-Marie Dion-Côté, Daniel A Barbash, Grazia Daniela Raffa

{"title":"Maintaining Telomeres without Telomerase in Drosophila: Novel Mechanisms and Rapid Evolution to Save a Genus.","authors":"Stefano Cacchione, Giovanni Cenci, Anne-Marie Dion-Côté, Daniel A Barbash, Grazia Daniela Raffa","doi":"10.1101/cshperspect.a041708","DOIUrl":"https://doi.org/10.1101/cshperspect.a041708","url":null,"abstract":"Telomere maintenance is crucial for preventing the linear eukaryotic chromosome ends from being mistaken for DNA double-strand breaks, thereby avoiding chromosome fusions and the loss of genetic material. Unlike most eukaryotes that use telomerase for telomere maintenance, Drosophila relies on retrotransposable elements-specifically HeT-A, TAHRE, and TART (collectively referred to as HTT)-which are regulated and precisely targeted to chromosome ends. Drosophila telomere protection is mediated by a set of fast-evolving proteins, termed terminin, which bind to chromosome termini without sequence specificity, balancing DNA damage response factors to avoid erroneous repair mechanisms. This unique telomere capping mechanism highlights an alternative evolutionary strategy to compensate for telomerase loss. The modulation of recombination and transcription at Drosophila telomeres offers insights into the diverse mechanisms of telomere maintenance. Recent studies at the population level have begun to reveal the architecture of telomere arrays, the diversity among the HTT subfamilies, and their relative frequencies, aiming to understand whether and how these elements have evolved to reach an equilibrium with the host and to resolve genetic conflicts. Further studies may shed light on the complex relationships between telomere transcription, recombination, and maintenance, underscoring the adaptive plasticity of telomeric complexes across eukaryotes.","PeriodicalId":10494,"journal":{"name":"Cold Spring Harbor perspectives in biology","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telomere Protection in Stem Cells. 干细胞的端粒保护。

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-12-18 DOI: 10.1101/cshperspect.a041686

Marta Markiewicz-Potoczny, Eros Lazzerini Denchi

引用次数: 0

Life and Death without Telomerase: The Saccharomyces cerevisiae Model. 没有端粒酶的生与死：酿酒酵母模型。

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-12-18 DOI: 10.1101/cshperspect.a041699

Veronica Martinez-Fernandez, Aurélia Barascu, Maria Teresa Teixeira

{"title":"Life and Death without Telomerase: The Saccharomyces cerevisiae Model.","authors":"Veronica Martinez-Fernandez, Aurélia Barascu, Maria Teresa Teixeira","doi":"10.1101/cshperspect.a041699","DOIUrl":"https://doi.org/10.1101/cshperspect.a041699","url":null,"abstract":"Saccharomyces cerevisiae, a model organism in telomere biology, has been instrumental in pioneering a comprehensive understanding of the molecular processes that occur in the absence of telomerase across eukaryotes. This exploration spans investigations into telomere dynamics, intracellular signaling cascades, and organelle-mediated responses, elucidating their impact on proliferative capacity, genome stability, and cellular variability. Through the lens of budding yeast, numerous sources of cellular heterogeneity have been identified, dissected, and modeled, shedding light on the risks associated with telomeric state transitions, including the evasion of senescence. Moreover, the unraveling of the intricate interplay between the nucleus and other organelles upon telomerase inactivation has provided insights into eukaryotic evolution and cellular communication networks. These contributions, akin to milestones achieved using budding yeast, such as the discovery of the cell cycle, DNA damage checkpoint mechanisms, and DNA replication and repair processes, have been of paramount significance for the telomere field. Particularly, these insights extend to understanding replicative senescence as an anticancer mechanism in humans and enhancing our understanding of eukaryotes' evolution.","PeriodicalId":10494,"journal":{"name":"Cold Spring Harbor perspectives in biology","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Hybridization in Species Formation and Persistence. 杂交在物种形成和持续存在中的作用。

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2024-12-02 DOI: 10.1101/cshperspect.a041445

Joshua V Peñalba, Anna Runemark, Joana I Meier, Pooja Singh, Guinevere O U Wogan, Rosa Sánchez-Guillén, James Mallet, Sina J Rometsch, Mitra Menon, Ole Seehausen, Jonna Kulmuni, Ricardo J Pereira

{"title":"The Role of Hybridization in Species Formation and Persistence.","authors":"Joshua V Peñalba, Anna Runemark, Joana I Meier, Pooja Singh, Guinevere O U Wogan, Rosa Sánchez-Guillén, James Mallet, Sina J Rometsch, Mitra Menon, Ole Seehausen, Jonna Kulmuni, Ricardo J Pereira","doi":"10.1101/cshperspect.a041445","DOIUrl":"10.1101/cshperspect.a041445","url":null,"abstract":"Hybridization, or interbreeding between different taxa, was traditionally considered to be rare and to have a largely detrimental impact on biodiversity, sometimes leading to the breakdown of reproductive isolation and even to the reversal of speciation. However, modern genomic and analytical methods have shown that hybridization is common in some of the most diverse clades across the tree of life, sometimes leading to rapid increase of phenotypic variability, to introgression of adaptive alleles, to the formation of hybrid species, and even to entire species radiations. In this review, we identify consensus among diverse research programs to show how the field has progressed. Hybridization is a multifaceted evolutionary process that can strongly influence species formation and facilitate adaptation and persistence of species in a rapidly changing world. Progress on testing this hypothesis will require cooperation among different subdisciplines.","PeriodicalId":10494,"journal":{"name":"Cold Spring Harbor perspectives in biology","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0