神经退行性疾病中的胶质细胞

IF 6.9 2区生物学 Q1 CELL BIOLOGY

Cold Spring Harbor perspectives in biology Pub Date : 2024-09-16 DOI:10.1101/cshperspect.a041375

Gerard Crowley, David Attwell, Hemali Phatnani, Harald Sontheimer, Soyon Hong

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引用次数: 0

摘要

人们越来越清楚地认识到，以神经为中心的神经退行性变的主流观点已有百年历史，但不足以解释为什么某些神经元会退化，尤其是随着年龄的增长。对患者群体的基因研究以及对动物模型的机理和功能研究共同表明，非神经元细胞，尤其是神经胶质细胞，在神经变性中扮演的角色不仅仅是旁观者。在人的一生中，神经元的功能和稳态受神经胶质细胞的调节，随着年龄的增长，神经胶质细胞的功能变得更加重要。本综述重点介绍神经胶质细胞在神经退行性变中作用的主要新概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Glia in Neurodegenerative Disease

It is becoming increasingly clear that the dominant, century-old neurocentric view of neurodegeneration is insufficient to explain why certain neurons degenerate, in particular with aging. Genetic studies in patient populations as well as mechanistic and functional studies in animal models altogether implicate nonneuronal cells, especially glia, to play more than bystander roles in neurodegeneration. Throughout the life span, neuronal function and homeostasis are modulated by glia, the functions of which become even more critical with aging. This review highlights key emerging concepts of the role of glia in neurodegeneration.

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来源期刊

Cold Spring Harbor perspectives in biology CELL BIOLOGY-

CiteScore

15.00

自引率

1.40%

发文量

审稿时长

3-8 weeks

期刊介绍： Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.