Colloid and Interface Science Communications最新文献_第9页

A new method for measuring fast aggregation rate based on the growth of the colloidal aggregate size 基于胶体聚集体尺寸增长的快速聚集率测量新方法

IF 4.5 3区材料科学

Colloid and Interface Science Communications Pub Date : 2023-12-26 DOI: 10.1016/j.colcom.2023.100764

Xiaoan Zhao , Shenghua Xu , Hongwei Zhou

引用次数: 0

Structural, chemical and biological properties of SiO2-CaO-Er2O3 flexible ceramic nanofibers for biomedical applications 用于生物医学应用的 SiO2-CaO-Er2O3 柔性陶瓷纳米纤维的结构、化学和生物特性

IF 4.5 3区材料科学

Colloid and Interface Science Communications Pub Date : 2023-12-26 DOI: 10.1016/j.colcom.2023.100763

Lihuan Wang, Feng Gan, Jinpeng Mo, Jing Zhao, Xi Yu, Hui Yu

{"title":"Structural, chemical and biological properties of SiO2-CaO-Er2O3 flexible ceramic nanofibers for biomedical applications","authors":"Lihuan Wang, Feng Gan, Jinpeng Mo, Jing Zhao, Xi Yu, Hui Yu","doi":"10.1016/j.colcom.2023.100763","DOIUrl":"https://doi.org/10.1016/j.colcom.2023.100763","url":null,"abstract":"<div><p>Rare earth-doped bioactive ceramics are promising biomaterials due to their unique optical properties, biocompatibility, antioxidants, and antibacterial activity. In this study, a series of SiO<sub>2</sub>-CaO-Er<sub>2</sub>O<sub>3</sub> nanofiber mats were fabricated by sol-gel electrospinning. The morphology, flexibility, physicochemical and biological properties of the nanofibers were investigated. The flexibility of the nanofiber mats containing 5 and 10 wt% of Er<sub>2</sub>O<sub>3</sub> was better than that of samples without or with >10 wt% Er<sub>2</sub>O<sub>3</sub>. The chemical property assay indicated that addition of Er can lead to changes in the degree of crystallinity and the degree of silica network polymerization, which further affect the flexibility. Photoluminescent spectra showed that the Er-doped nanofibers exist green and near infrared emissions. The <em>in vitro</em> bio experiments demonstrated that Er-doped nanofibers present excellent biocompatibility, and the mineralization experiment demonstrated that Er-doped nanofibers present favorable mineralization activity. Therefore, these SiO<sub>2</sub>-CaO-Er<sub>2</sub>O<sub>3</sub> flexible nanofibers may be promising candidates for biomedical applications.</p></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"58 ","pages":"Article 100763"},"PeriodicalIF":4.5,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215038223000705/pdfft?md5=e7760d081f0f2deeb7d0d30780794e06&pid=1-s2.0-S2215038223000705-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139050458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-healing coating with the ability to mark damaged locations, based on electrospun photothermal fibers and AIE agents 基于电纺光热纤维和 AIE 药剂的可标记受损位置的自修复涂层

IF 4.5 3区材料科学

Colloid and Interface Science Communications Pub Date : 2023-12-23 DOI: 10.1016/j.colcom.2023.100762

Rui Ding , Xue-qi Zhang , Jing Lv , Xuan Liang , An-lan Ji , Yu-chen Zhang , Jie Fu , Xiao Lv , Lan Yao , Sheng-ying Yang , Guo-qing Mao , Heng Yang , Jie Liu , Hai-bin Yu

{"title":"Self-healing coating with the ability to mark damaged locations, based on electrospun photothermal fibers and AIE agents","authors":"Rui Ding , Xue-qi Zhang , Jing Lv , Xuan Liang , An-lan Ji , Yu-chen Zhang , Jie Fu , Xiao Lv , Lan Yao , Sheng-ying Yang , Guo-qing Mao , Heng Yang , Jie Liu , Hai-bin Yu","doi":"10.1016/j.colcom.2023.100762","DOIUrl":"https://doi.org/10.1016/j.colcom.2023.100762","url":null,"abstract":"<div><p>The anti-corrosion coatings based on core-sheath fibers prepared by electrospinning methods are developed for the indication and repair of large-scale damage to coatings. The cores are the composite fluorescent agents composed of AIE-gens and CHEF-gens, which exhibit strong fluorescence characteristics sensitive to corrosion due to the CHEF and FRET effects. The composite fluorescent agents provided information about the location of damages when the coatings, with the fibers as the core materials, are damaged. The sheaths are photothermal materials, composed of photothermal responsive acid doped polyaniline and shape memory polyurethane. The photothermal properties of acid doped polyaniline, under the irradiation of an infrared laser, contributes to heating in the damaged areas. The softened and activated polyurethane simultaneously lead to interpenetration and entanglement of molecular chains at the closed damage sites, resulting in complete repair of the damaged coatings.</p></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"58 ","pages":"Article 100762"},"PeriodicalIF":4.5,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215038223000699/pdfft?md5=7021d0beb7e508ab2d1ea5df55718681&pid=1-s2.0-S2215038223000699-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139033966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ noble metal-ion modified TiO2 rutile nanobars with highly exposed {110} facets: Synthesis, structure, and catalytic properties 具有高暴露{110}面的原位贵金属离子修饰 TiO2 金红石纳米棒：合成、结构和催化特性

IF 4.5 3区材料科学

Colloid and Interface Science Communications Pub Date : 2023-12-12 DOI: 10.1016/j.colcom.2023.100761

Shihui Jiao , Mingyu Shang , Yan Chen , Guangsheng Pang

{"title":"In situ noble metal-ion modified TiO2 rutile nanobars with highly exposed {110} facets: Synthesis, structure, and catalytic properties","authors":"Shihui Jiao , Mingyu Shang , Yan Chen , Guangsheng Pang","doi":"10.1016/j.colcom.2023.100761","DOIUrl":"https://doi.org/10.1016/j.colcom.2023.100761","url":null,"abstract":"<div><p>The in situ anchoring of metal elements on the surface of nanomaterials is a state-of-the-art technology that can significantly enhance the performance of materials. We have successfully fabricated noble metal-ion modified rutile TiO<sub>2</sub> nanobars, which exhibit exceptional catalytic activity in both H<sub>2</sub> generation and CO oxidation. Firstly, we synthesized Ti<sup>3+</sup> self-doped rutile TiO<sub>2-x</sub> nanobars by a simple solvothermal method using Zn as a reductant, resulting in highly crystalline structures with a significant proportion of (110) surfaces. The reduced nanobars chemically absorb the noble metal cations with the addition of a solution of a noble metal salt in the absence of light to form in situ noble metal-ion modified catalysts. TiO<sub>2</sub> nanobars with 1 wt% Pt<sup>2+</sup> and Pd<sup>2+</sup> exhibited excellent performance in photocatalytic H<sub>2</sub> generation from water and low temperature CO oxidation. Moreover, the samples modified with low noble metal ions (0.1 wt%) also show effective activity in H<sub>2</sub> generation.</p></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"58 ","pages":"Article 100761"},"PeriodicalIF":4.5,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215038223000687/pdfft?md5=3f562e60fada4b77e2d0ebf908c108d9&pid=1-s2.0-S2215038223000687-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138570721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-icing and weatherability study of superhydrophobic titanium metal matrix composites surface 超疏水钛基复合材料表面的抗冰性和耐候性研究

IF 4.5 3区材料科学

Colloid and Interface Science Communications Pub Date : 2023-12-05 DOI: 10.1016/j.colcom.2023.100759

Cui Jing , Wang Yifan , Wang Chengxuan , Yang Guangfeng

{"title":"Anti-icing and weatherability study of superhydrophobic titanium metal matrix composites surface","authors":"Cui Jing , Wang Yifan , Wang Chengxuan , Yang Guangfeng","doi":"10.1016/j.colcom.2023.100759","DOIUrl":"https://doi.org/10.1016/j.colcom.2023.100759","url":null,"abstract":"<div><p>Superhydrophobic surfaces have received much attention from academia and industry for their promising applications, which can significantly expand the comprehensive performance of composite materials. Thus, this paper demonstrated a low-cost and simple method to fabricate arrays of micro−/nano-structure surfaces similar to rice leaves through laser micro texturing, modified with polydimethylsiloxane (PDMS) to produce physicochemically coupling texture hydrophobic surfaces, and then investigate the surface's resistance to ice and weathering under environmental damage. After tens of circulating for coagulation and thawing frost and shocking of water, the surface can remain hydrophobic, while the hydrophobic groups and structures on the surface can remain hydrophobic under hundreds of times of stripping and friction, which shows good weather ability. In summary, a practical reference for titanium metal matrix composite surfaces is provided, realizing superhydrophobicity and ice suppression functions and expanding its scenario applications.</p></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"58 ","pages":"Article 100759"},"PeriodicalIF":4.5,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215038223000663/pdfft?md5=463372bbf4600402f7822435afdf87f0&pid=1-s2.0-S2215038223000663-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138483929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GO nanosheets inhibit the proliferation of hPDLCs by covering the membrane to block the EGFR-AKT signaling pathway 氧化石墨烯纳米片通过覆盖膜阻断EGFR-AKT信号通路来抑制hpdlc的增殖

IF 4.5 3区材料科学

Colloid and Interface Science Communications Pub Date : 2023-11-01 DOI: 10.1016/j.colcom.2023.100746

Hui Xue , Zhibing Tang , Ping Li , Lin Zhao , Guangxin Duan , Ling Wen

{"title":"GO nanosheets inhibit the proliferation of hPDLCs by covering the membrane to block the EGFR-AKT signaling pathway","authors":"Hui Xue , Zhibing Tang , Ping Li , Lin Zhao , Guangxin Duan , Ling Wen","doi":"10.1016/j.colcom.2023.100746","DOIUrl":"https://doi.org/10.1016/j.colcom.2023.100746","url":null,"abstract":"<div><p>Graphene-based materials show potential applications in dentistry due to their outstanding physicochemical properties. However, the use of graphene and its derivatives increases their exposure risk to periodontal cells. This study aimed to evaluate the cytotoxicity caused by graphene in periodontal cells and clarify the potential molecular mechanism. Through a series of experiments, we isolated human periodontal ligament cells (hPDLCs) and subsequently investigated the cytotoxic behaviors and related signaling pathway through which graphene oxide (GO) nanohseets injured hPDLCs. Our findings illustrated that the cytotoxicity of GO against hPDLCs was derived from the covering of GO nanosheets on the membrane surface, which blocked the phosphorylation of epidermal growth factor receptor on the membrane. It further inhibited the activation of the serine/threonine kinase signaling pathway that promoted the proliferation and cycle progression of cells. This study revealed the toxic behavior of GO nanosheets to oral cells and elucidated the potential molecular mechanism, thereby providing theoretical guidance for the safe application of graphene-based materials in dentistry.</p></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"57 ","pages":"Article 100746"},"PeriodicalIF":4.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215038223000535/pdfft?md5=8c5c9b00abddec70e4904d34e1fc49cd&pid=1-s2.0-S2215038223000535-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91986475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

pH-responsive nanofiber membranes for superior controlled release of poorly water-soluble drug and its release mechanism study ph响应纳米纤维膜对难水溶性药物的优异控释及其释放机制研究

IF 4.5 3区材料科学

Colloid and Interface Science Communications Pub Date : 2023-11-01 DOI: 10.1016/j.colcom.2023.100750

Changmi Wu, Haotian Ren, Yanan Zhang, Danfeng Jian, Yujie Gao, Jindan Wu

{"title":"pH-responsive nanofiber membranes for superior controlled release of poorly water-soluble drug and its release mechanism study","authors":"Changmi Wu, Haotian Ren, Yanan Zhang, Danfeng Jian, Yujie Gao, Jindan Wu","doi":"10.1016/j.colcom.2023.100750","DOIUrl":"https://doi.org/10.1016/j.colcom.2023.100750","url":null,"abstract":"<div><p>Antibiotics delivery using dressings is an effective manner to treat chronic infected wounds, but it still faces the challenge of uncontrolled drug release. To address this issue, we developed pH-responsive electrospun nanofibers for controlled release of poorly water-soluble antibiotics. Specifically, the drug-loaded electrospun nanofibers were fabricated via coaxial electrospinning technique, with polycaprolactone (PCL) and drug acting as the core and pH-responsive acrylic copolymer Eudragit L100–55 serving as the sheath layer. Under alkaline conditions, all drugs release rapidly due to the dissolution of Eudragit L100–55, and first-order model well fits the release behavior. In contrast, the sheath layer swells under acidic conditions, causing poorly water-soluble drugs to be firmly trapped. Moreover, the drug-loaded nanofibers display completely different antibacterial activities due to distinct drug release behaviors under alkaline or acidic conditions. The current pH-responsive nanofibers shows superior controllability of poorly water-soluble drug release, revealing great prospects for treating chronic infected wounds.</p></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"57 ","pages":"Article 100750"},"PeriodicalIF":4.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215038223000572/pdfft?md5=fe87c257368eb0bc9e0b1560a530f828&pid=1-s2.0-S2215038223000572-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92136012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scalable processing parameters to fabricate silicon elastomer microparticles using a blade-free planetary mixer with a thixotropic medium 可扩展的工艺参数，以制造硅弹性体微粒使用无叶片的行星混合器与触变介质

IF 4.5 3区材料科学

Colloid and Interface Science Communications Pub Date : 2023-11-01 DOI: 10.1016/j.colcom.2023.100756

Jeongwook Ko , Han-Bok Seo , Jihee Lee, Sang Yup Kim, Seung-Yop Lee

{"title":"Scalable processing parameters to fabricate silicon elastomer microparticles using a blade-free planetary mixer with a thixotropic medium","authors":"Jeongwook Ko , Han-Bok Seo , Jihee Lee, Sang Yup Kim, Seung-Yop Lee","doi":"10.1016/j.colcom.2023.100756","DOIUrl":"https://doi.org/10.1016/j.colcom.2023.100756","url":null,"abstract":"<div><p>The development of biomedical devices and soft robotics has spurred the utilization of silicone elastomers. Converting these polymers into particulates is increasingly important for their application to advanced materials and processes. However, the highly viscous nature of silicone resins, resulting from their long polymer chains, makes it challenging to fabricate them as particulates. Recently, a blade-free planetary mixer has been used to effectively emulsify viscous resins in a thixotropic medium. However, the particle fabrication process has not yet been examined to gain full control over the produced microparticles. This study presents key processing parameters for the fabrication of silicone elastomer microparticles in a sodium alginate medium using a blade-free planetary mixer. The experimental results show that stirring speed, stirring time, and medium concentration are the determining factors for controlling the particle size distribution. The variation in particle size by parameters exhibits differences depending on the viscous-to-elastic transition of the medium.</p></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"57 ","pages":"Article 100756"},"PeriodicalIF":4.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215038223000638/pdfft?md5=3bb831385f9de4a4c4aa1efad58c7e2e&pid=1-s2.0-S2215038223000638-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136697141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress in biodegradation of microplastics by Aspergillus sp. in aquatic environments 水生环境中曲霉降解微塑料的研究进展

IF 4.5 3区材料科学

Colloid and Interface Science Communications Pub Date : 2023-11-01 DOI: 10.1016/j.colcom.2023.100754

Afsaneh Esmaeili Nasrabadi , Bahman Ramavandi , Ziaeddin Bonyadi

{"title":"Recent progress in biodegradation of microplastics by Aspergillus sp. in aquatic environments","authors":"Afsaneh Esmaeili Nasrabadi , Bahman Ramavandi , Ziaeddin Bonyadi","doi":"10.1016/j.colcom.2023.100754","DOIUrl":"https://doi.org/10.1016/j.colcom.2023.100754","url":null,"abstract":"<div><p>The potential of <em>Aspergillus</em> sp. for plastic biodegradation is a promising approach for environmentally friendly waste management. Various research studies have been conducted to optimize conditions that enhance the biodegradation of plastics and to understand the genetic basis of <em>Aspergillus</em> species. By performing this investigation, we discussed the role of various species of <em>Aspergillus</em> sp. in the decomposition of plastic polymers. Most <em>Aspergillus</em> sp. grow within the pH range of 4 to 6. 37.5% of the studies showed that <em>Aspergillus</em> sp. grows optimally at 30 °C. Scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) tests were used in 34.61% and 32.69% of the different studies, respectively. It has been observed that fungi can biodegrade polymers more effectively within a size range of 20–100 μm. Most studies (34.21%) have focused on the biodegradation of polymers within 21 to 30 days. The highest percentage of studies (44%) focused on the biodegradation of low-density polyethylene (LDPE) by various <em>Aspergillus</em> sp. The dominant <em>Aspergillus</em> sp., including <em>A. niger</em>, <em>A. flavus</em>, and <em>A. oryzae</em>, play a significant role in the biodegradation of microplastics. Enzymes such as laccase, esterase, peroxidase, lipase, and urease play crucial roles in the degradation of plastics. Laccase utilizes oxygen to generate reactive oxygen species, breaking polymer chains. Esterase cleaves polymers into fragments, while peroxidase generates radicals for polymer degradation. Lipases and urease also contribute to the degradation of specific plastic substrates. In general, it can be said that this fungal species has been successful in effectively degrading various polymers.</p></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"57 ","pages":"Article 100754"},"PeriodicalIF":4.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215038223000614/pdfft?md5=3e50ec34f0af1ccd625d6495495ad8c9&pid=1-s2.0-S2215038223000614-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134656325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pH-responsive nanocarrier synergistically activate tumor immunotherapy by promoting pyroptosis and immune checkpoint blocking ph反应性纳米载体通过促进焦亡和免疫检查点阻断协同激活肿瘤免疫治疗

IF 4.5 3区材料科学

Colloid and Interface Science Communications Pub Date : 2023-11-01 DOI: 10.1016/j.colcom.2023.100751

Xiaopin Hua , Xiuli Zhang , Qiaohua Peng , Juanhong Wu , Sangsang Tang , Chenxi Lin , Jian Shen

{"title":"A pH-responsive nanocarrier synergistically activate tumor immunotherapy by promoting pyroptosis and immune checkpoint blocking","authors":"Xiaopin Hua , Xiuli Zhang , Qiaohua Peng , Juanhong Wu , Sangsang Tang , Chenxi Lin , Jian Shen","doi":"10.1016/j.colcom.2023.100751","DOIUrl":"https://doi.org/10.1016/j.colcom.2023.100751","url":null,"abstract":"<div><p>Tumor immunotherapy has developed rapidly in recent years, with good curative effects and minimal side effects, but it is restricted by the poor tumor immunogenicity. Metformin, a clinical drug used worldwide, has been found to have a novel role in inducing tumor pyroptosis, which in turn promotes tumor to releases inflammatory substances and improve tumor immunogenicity. Nevertheless, it requires a higher dosage for cancer treatment compared to conventional chemotherapy medications, thereby exhibiting pronounced side effects. Within the context of this specific study, we developed a pH-responsive nanocarrier (MT NPs) that can simultaneously deliver metformin as a pyroptosis inducer and Toripalimab as an anti-programmed cell death (PD)-1 monoclonal antibody for the purpose of cancer immunotherapy. Once the nanodrugs reached the acidic tumor microenvironment, their structures were degraded due to hydrophilic transformation caused by segment protonation. Furthermore, the MT NPs released the metformin and Toripalimab to synergistically promote tumor immunity, resulting in significantly improved therapeutic outcomes, potentially leading to successful tumor eradication.</p></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"57 ","pages":"Article 100751"},"PeriodicalIF":4.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215038223000584/pdfft?md5=2dd6301d043b0b82d5c00d48fb3a2ebb&pid=1-s2.0-S2215038223000584-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138396165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0