Electrospun biosensors for biomarker detection

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications Pub Date : 2024-01-29 DOI:10.1016/j.colcom.2024.100767

Jinli Zhou , Junjie Zheng , Chenxiao Wang , Ge Zhang , Hongying Yang , Fan Xiong , Mengzhao Fan , Zheng Wang , Yunfei Li , Chaoran Yang

{"title":"Electrospun biosensors for biomarker detection","authors":"Jinli Zhou , Junjie Zheng , Chenxiao Wang , Ge Zhang , Hongying Yang , Fan Xiong , Mengzhao Fan , Zheng Wang , Yunfei Li , Chaoran Yang","doi":"10.1016/j.colcom.2024.100767","DOIUrl":null,"url":null,"abstract":"<div><p>Biosensors based on electrospun nanofibers have found extensive applications in the field of biomarker detection. Nanofibers, owing to their advantages such as porosity, high surface area, and significant loading capacity, play a crucial role in immobilizing recognition elements, directly interacting with target analytes, enhancing antibody fixation positions, and improving the activity and lifespan of biomolecules. This, in turn, enables the high sensitivity and selectivity detection of major disease biomarkers. This review begins by summarizing the structure and processing methods of electrospun nanofiber biosensors, followed by an overview of the physical, chemical detection, and immobilization patterns in biomarker detection. Subsequently, a brief retrospective analysis of the research progress in biomarker detection is presented. Additionally, the application of electrospun nanofiber biosensors in various disease areas, including cancer, cardiovascular, neurological, metabolic, and infectious diseases, is discussed based on biomedical classifications. Finally, the challenges faced by electrospun nanofiber biosensors in biomarker detection are summarized, and the future directions for the development of electrospun nanofiber biosensors are highlighted</p></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"59 ","pages":"Article 100767"},"PeriodicalIF":4.7000,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215038224000025/pdfft?md5=d013c7ccaaffaeb9eae773a7c00d80d3&pid=1-s2.0-S2215038224000025-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloid and Interface Science Communications","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2215038224000025","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Biosensors based on electrospun nanofibers have found extensive applications in the field of biomarker detection. Nanofibers, owing to their advantages such as porosity, high surface area, and significant loading capacity, play a crucial role in immobilizing recognition elements, directly interacting with target analytes, enhancing antibody fixation positions, and improving the activity and lifespan of biomolecules. This, in turn, enables the high sensitivity and selectivity detection of major disease biomarkers. This review begins by summarizing the structure and processing methods of electrospun nanofiber biosensors, followed by an overview of the physical, chemical detection, and immobilization patterns in biomarker detection. Subsequently, a brief retrospective analysis of the research progress in biomarker detection is presented. Additionally, the application of electrospun nanofiber biosensors in various disease areas, including cancer, cardiovascular, neurological, metabolic, and infectious diseases, is discussed based on biomedical classifications. Finally, the challenges faced by electrospun nanofiber biosensors in biomarker detection are summarized, and the future directions for the development of electrospun nanofiber biosensors are highlighted

Abstract Image

查看原文本刊更多论文

用于生物标记检测的电纺生物传感器

基于电纺纳米纤维的生物传感器已在生物标记物检测领域得到广泛应用。纳米纤维具有多孔性、高比表面积和高负载能力等优点，在固定识别元件、直接与目标分析物相互作用、增强抗体固定位置以及提高生物分子的活性和寿命方面发挥着重要作用。这反过来又能实现对主要疾病生物标志物的高灵敏度和选择性检测。本综述首先概述了电纺纳米纤维生物传感器的结构和加工方法，然后概述了生物标记物检测中的物理、化学检测和固定模式。随后，简要回顾分析了生物标记物检测的研究进展。此外，还根据生物医学分类讨论了电纺纳米纤维生物传感器在癌症、心血管、神经、代谢和传染病等不同疾病领域的应用。最后，总结了电纺纳米纤维生物传感器在生物标记物检测中面临的挑战，并强调了电纺纳米纤维生物传感器的未来发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Colloid and Interface Science Communications Materials Science-Materials Chemistry

CiteScore

9.40

自引率

6.70%

发文量

125

审稿时长

43 days

期刊介绍： Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.