Zhanglong Huang , Shiwei Ding , Lili Zhong, Chenxi Liu, Xiaofei Li, Dan He
{"title":"Tumor-targeted hybrid micelles enable ROS-responsive CO release and synergistic chemo–gas antitumor therapy","authors":"Zhanglong Huang , Shiwei Ding , Lili Zhong, Chenxi Liu, Xiaofei Li, Dan He","doi":"10.1016/j.colcom.2025.100862","DOIUrl":"10.1016/j.colcom.2025.100862","url":null,"abstract":"<div><div>Combination therapy holds great promise for enhancing antitumor efficacy by achieving tumor-targeted and sequentially synergistic cytotoxicity. We developed a tumor-targeted hybrid micellar nanoplatform that co-delivers the chemotherapeutic agent pemetrexed (PEM) and carbon monoxide (CO) for synergistic chemo-gas therapy. PEM and Fe₃(CO)₁₂ were covalently conjugated to D-α-tocopheryl polyethylene glycol succinate (TPGS), yielding two amphiphilic prodrugs—TPGS-PEM and TPGS-CO—which were co-assembled into hybrid micelles. The presence of PEM enabled folate receptor-mediated active targeting, resulting in efficient uptake by 4T1 breast cancer cells. Intracellular esterase-catalyzed cleavage of the ester bond released PEM, which elevated reactive oxygen species (ROS) levels. The increase in ROS triggered site-specific CO release from the Fe–CO complex. This sequential mechanism enabled a cascade of tumor-selective chemotherapy and gas therapy, leading to enhanced apoptosis and reduced tumor proliferation. The hybrid micelles exhibited superior tumor suppression, reduced systemic toxicity, and prolonged survival in tumor-bearing mice.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"69 ","pages":"Article 100862"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guannan Zhang , Hailiang Zhang , Rong Li , Ying Lu , Qinying Shi , Xin Yang , Jianbo Song
{"title":"Corrigendum to ‘Photo-Sono activated fluorine-doped titanium-based bone implants for rapid osteosarcoma eradication and bacterial infection elimination’ [Colloid and Interface Science Communications 60 (2024) 100783/COLCOM-D-23-00244]","authors":"Guannan Zhang , Hailiang Zhang , Rong Li , Ying Lu , Qinying Shi , Xin Yang , Jianbo Song","doi":"10.1016/j.colcom.2025.100859","DOIUrl":"10.1016/j.colcom.2025.100859","url":null,"abstract":"","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"69 ","pages":"Article 100859"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145576089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wei Liu , Yue Zhu , Teng Chen , Zuhua Wang , Shuang Yan , Yuxin Pang
{"title":"Green preparation of nanoemulsion of Cinnamomum burmanni (Nees et T.Nees) blume essential oil loaded with cinnamaldehyde and evaluation of its antibacterial, anti-inflammatory, antioxidant and wound healing activities","authors":"Wei Liu , Yue Zhu , Teng Chen , Zuhua Wang , Shuang Yan , Yuxin Pang","doi":"10.1016/j.colcom.2025.100858","DOIUrl":"10.1016/j.colcom.2025.100858","url":null,"abstract":"<div><div><em>Cinnamomum burmanni</em> (Nees & T. Nees) Blume oil (CBO) and cinnamaldehyde (CA) are natural compounds with promising wound healing. However, their application is limited by volatility. In this study, a tea saponin (TS)-stabilized nanoemulsion (CBO-TS NEs) was developed under conditions: 1 % CBO, 3 mg/mL TS, and 2 min of ultrasonication at 260 W. The CBO-TS NEs exhibited a particle size of 140.27 ± 3.11 nm and good stability under various conditions. After loading CA (10 μL) into CBO-TS NEs, the particle size becomes 156 ± 2.66 nm, and the transdermal delivery efficiency of CA was enhanced. The CACBO-TS NEs demonstrated notable anti-inflammatory and antioxidant activities, promoted the migration of L929 cells, and exhibited broad-spectrum antimicrobial efficacy. In vivo experimental results indicated that the CACBO-TS NEs achieved superior wound healing outcomes, underscoring a synergistic therapeutic effect between CBO and CA, highlighting the considerable application potential of CACBO-TS NEs for wound healing.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"69 ","pages":"Article 100858"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuhou Yang , Jiacheng Lei , Shuxiang Zhang , Yizhou Xu , Dongdong Tong , Qiang Wei , Changsheng Zhao
{"title":"Fabrication of antifouling coatings through 4-benzoylbenzoic acid-mediated dextran grafting","authors":"Shuhou Yang , Jiacheng Lei , Shuxiang Zhang , Yizhou Xu , Dongdong Tong , Qiang Wei , Changsheng Zhao","doi":"10.1016/j.colcom.2025.100855","DOIUrl":"10.1016/j.colcom.2025.100855","url":null,"abstract":"<div><div>Antifouling coatings based on natural polymers demonstrate significant advantages in biocompatibility over traditional chemical coatings, showing broad application prospects for biomedical device surface modifications. In this work, a hydrogel coating was fabricated by grafting 4-benzoylbenzoic acid onto dextran to mediate its embedding into the substrate surface, thereby immobilizing the hydroxyl groups of dextran on the substrate to form a dense hydrophilic layer. We systematically characterized the protein adsorption resistance and cell adhesion resistance of this coating strategy, and utilized these properties to achieve tumor malignancy screening of cancer cells. The coating with the most stable antifouling performance (benzophenone-dextran, 8.3–11.6 % grafting rate) was subsequently applied to PES membrane surfaces, demonstrating excellent anticoagulant properties and hemocompatibility.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"69 ","pages":"Article 100855"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pengjia Yan , Wenbo He , Xin Du , Wenxiu Hou , Miao Luo , Changwei Tan , Jinling Luo , Xiaoqian Jiang , Ji Qiu , Ling Bai , Guoqing Pan
{"title":"A sugar-responsive dynamic biointerface for the regulation of cell adhesion and macrophage polarization behavior","authors":"Pengjia Yan , Wenbo He , Xin Du , Wenxiu Hou , Miao Luo , Changwei Tan , Jinling Luo , Xiaoqian Jiang , Ji Qiu , Ling Bai , Guoqing Pan","doi":"10.1016/j.colcom.2025.100860","DOIUrl":"10.1016/j.colcom.2025.100860","url":null,"abstract":"<div><div>Here we report a new strategy for the functionalization of soft polyacrylamide (PAM) hydrogels with a sugar-responsive dynamic biointerface, offering a more accurate mimicry of the cellular microenvironment for cell dynamic adhesion and macrophage polarization. This dynamic platform shows the potential for recapitulating the physiological stiffness of various human tissues, enabling the modulation of cell behaviors through a natural biofeedback mechanism.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"69 ","pages":"Article 100860"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145324860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis and characterization of structurally variable bola type crown ether-ferrocene surfactant vesicles","authors":"Wei Li, Yuji Jinbo, Tatsuro Kijima","doi":"10.1016/j.colcom.2025.100857","DOIUrl":"10.1016/j.colcom.2025.100857","url":null,"abstract":"<div><div>Bola-type ferrocene surfactants with terminal 18-crown-6-ether groups were synthesized. Despite showing no improvement in activity over the monosubstituted analog, they exhibited a very low critical aggregation concentration (0.06 mM). Glucose encapsulation and SAXS confirmed vesicle formation with an internal aqueous phase, enabling controlled release via potassium ion complexation.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"69 ","pages":"Article 100857"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Denaturation and graphitization of albumin molecules induced by mechanical shear stress via in-situ point contact","authors":"Jiachen Chen, Heng Liu, Xiangdong Tian, Yu Yan","doi":"10.1016/j.colcom.2025.100853","DOIUrl":"10.1016/j.colcom.2025.100853","url":null,"abstract":"<div><div>Many well functioned explants have shown that a gaphitized tribofilm formed on the bearing surfaces providing excellent lubrication effects, greatly improves the longevity and service safety of the joint prosthesis. Tribofilms are generally believed to be generated from protein molecules in the pseudo-synovial fluid. In this study, a modified atomic force microscopy with an alumina microsphere tip was used to articulate against low-carbon wrought CoCrMo alloy pins in protein solution. We successfully studied the process of tribofilm formation in-situ, with the results demonstrating that a critical compressive stress (>136 MPa) was required for tribofilm formation. Increasing compressive stress reduced tribofilm thickness but expanded its area and increased its modulus. In addition, with prolonged friction, the proteins gradually shifted toward graphitization. This in-situ study revealed that tribofilm growth in the articular prostheses is manifested as the expansion of the coverage area, rather than the continuous increase of thickness.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"68 ","pages":"Article 100853"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gyungbin Ju , Dongwon Kim , Hyungil Lee , Manhee Lee
{"title":"Linear algebraic characterization of particle concentration and size distribution","authors":"Gyungbin Ju , Dongwon Kim , Hyungil Lee , Manhee Lee","doi":"10.1016/j.colcom.2025.100852","DOIUrl":"10.1016/j.colcom.2025.100852","url":null,"abstract":"<div><div>Particle counting and sizing are essential in various fields of science and engineering. Most existing particle characterization methods rely on a rigorous analysis of nonlinear particle–light interactions. Here, we present a novel algebraic approach for counting and sizing colloidal particles. We construct a mathematical vector space in which the scattered signal distributions from the colloidal dispersions form vectors. These vectors are expanded using the basis vectors corresponding to the scattered signal distributions from particles of known sizes. We then determine the expansion coefficients that yield the number concentration as a function of particle size via mathematical optimization. Further, we experimentally evaluate the algebraic optics and find that the formalism accurately recovers the particle size and concentration. Thus, this algebraic method provides a means of quantifying particulate matter in fluids that are highly concentrated and difficult to measure individually and entirely.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"68 ","pages":"Article 100852"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shouguang Wang , Xiaofei Zhang , Dunmin Zhuang , Lina Dong , Bo Li
{"title":"Mn2+-coordinated hyaluronic acid modified nanoparticles for phloretin delivery: Breast cancer treatment","authors":"Shouguang Wang , Xiaofei Zhang , Dunmin Zhuang , Lina Dong , Bo Li","doi":"10.1016/j.colcom.2025.100854","DOIUrl":"10.1016/j.colcom.2025.100854","url":null,"abstract":"<div><h3>Objective</h3><div>Breast cancer remains a global health challenge due to limitations of conventional therapies, such as drug resistance and systemic toxicity. This study aimed to develop a novel synergistic chemo-immunotherapy platform by constructing Mn<sup>2+</sup>-coordinated oxidized hyaluronic acid (OHA)-based nanoparticles co-loaded with phloretin (PHL) (OHA@Lys/PHL Mn<sup>2+</sup>).</div></div><div><h3>Methods</h3><div>A nanosystem was engineered using oxidized hyaluronic acid (OHA) modified with lysine (Lys) to co-encapsulate PHL and Mn<sup>2+</sup> ions. The anti-tumor efficacy was evaluated <em>in vitro</em> (4 T-1 breast cancer cells) and <em>in vivo</em> (4 T-1 tumor-bearing mice), including assessments of proliferation inhibition, apoptosis induction, reactive oxygen species (ROS) accumulation, DNA damage, cGAS-STING pathway activation, and dendritic cell (DC) maturation. Combination therapy with cisplatin (CDDP) was also investigated.</div></div><div><h3>Results</h3><div>OHA@Lys/PHL Mn<sup>2+</sup> achieved 80.3 % cell viability inhibition on 4 T-1 cells. Combined with CDDP, it further suppressed proliferation, induced apoptosis, and enhanced ROS accumulation. Mechanistically, the nanosystem induced DNA double-strand damage and activated the cGAS-STING pathway. <em>In vivo</em>, OHA@Lys/PHL Mn<sup>2+</sup> monotherapy showed significant tumor inhibition (46.4 %, <em>p</em> < 0.001). Combination with CDDP achieved near-complete tumor suppression (86.7 % inhibition) and reduced lung metastasis. The <em>in vivo</em> mechanism results indicated that nanosystem triggered DNA damage, activated cGAS-STING signaling, and significantly promoted DC maturation (48.5 % <em>vs.</em> 28.2 % in controls).</div></div><div><h3>Conclusion</h3><div>This strategy offers a promising and clinically translatable approach for advanced breast cancer treatment.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"68 ","pages":"Article 100854"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144771928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiaojiao Lv , Chong Zhang , Yang Yang , Xinting Dong , Dongming Qi , Jindan Wu
{"title":"One-pot synthesis of catechol-based antibacterial coating for ultra-high molecular weight polyethylene sutures","authors":"Jiaojiao Lv , Chong Zhang , Yang Yang , Xinting Dong , Dongming Qi , Jindan Wu","doi":"10.1016/j.colcom.2025.100844","DOIUrl":"10.1016/j.colcom.2025.100844","url":null,"abstract":"<div><div>Ultra-high molecular weight polyethylene (UHMWPE), a promising material for high-strength sutures in bone repair, faces challenges due to its inert surface, limiting its biomedical applications. A one-pot approach was developed to apply a catechol (CA)/tobramycin (Tob)/poly(sulfobetaine methacrylate) (pSBMA) composite coating onto suture surfaces. During the redox reaction between Tob and CA, hydroxyl radicals were generated, initiating the polymerization of SBMA.The resulting coating not only reduces the surface roughness but also maintains sufficient mechanical strength of the fibers to withstand tissue tension during usage. Furthermore, the sutures exhibited good bactericidal and anti-bacteria adhesion properties, effectively preventing bacterial approaching and adhering, thereby reducing the infection rate at the surgical site. Additionally, the sutures demonstrated excellent biocompatibility and hemocompatibility. In conclusion, the modified UHMWPE fibers hold significant potential for application in orthopedic tissue repair. Moreover, this facile method for fabricating multifunctional coatings may provide new impetus for the development of biomedical materials.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"67 ","pages":"Article 100844"},"PeriodicalIF":4.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144105156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}