Smart self-assembled nanomedicine for ferroptotic tumor therapy

IF 4.7 3区 材料科学 Q2 CHEMISTRY, PHYSICAL
Chen Liang , Tian Zhang , Qingming Zhang , Xiaozhou Mou
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Abstract

Featured by iron-dependent lipid peroxidation, ferroptosis is increasingly recognized as a prominent route for programmed tumor therapy. However, the adaptivity, complexity, and heterogeneity of tumors hamper the performance of ferroptotic tumor therapies. Recent advances in molecularly self-assembled nanomedicine show promise in rejuvenating ferroptotic tumor therapies by leveraging the principles of molecular self-assembly (MSA). This review first sketches the basis of ferroptosis and MSA. Subsequently, representative nanoplatforms are discussed to elucidate how MSA can be devised, either in vitro or in vivo, to improve the precision, efficacy, and biosafety of ferroptotic tumor therapies. Finally, considerations and future perspectives toward clinical translation of molecularly self-assembled ferroptosis nanomedicine are addressed.

Abstract Image

用于肿瘤治疗的智能自组装纳米药物
铁下垂以铁依赖性脂质过氧化为特征,越来越被认为是程序化肿瘤治疗的重要途径。然而,肿瘤的适应性、复杂性和异质性阻碍了铁系肿瘤治疗的表现。分子自组装纳米药物的最新进展表明,利用分子自组装(MSA)的原理,可以使嗜铁性肿瘤的治疗恢复活力。本文首先概述了铁下垂和MSA的基础。随后,本文讨论了具有代表性的纳米平台,以阐明如何在体外或体内设计MSA,以提高铁致肿瘤治疗的准确性、有效性和生物安全性。最后,讨论了分子自组装铁下垂纳米药物临床翻译的考虑和未来前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Colloid and Interface Science Communications
Colloid and Interface Science Communications Materials Science-Materials Chemistry
CiteScore
9.40
自引率
6.70%
发文量
125
审稿时长
43 days
期刊介绍: Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.
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