{"title":"Smart self-assembled nanomedicine for ferroptotic tumor therapy","authors":"Chen Liang , Tian Zhang , Qingming Zhang , Xiaozhou Mou","doi":"10.1016/j.colcom.2025.100829","DOIUrl":null,"url":null,"abstract":"<div><div>Featured by iron-dependent lipid peroxidation, ferroptosis is increasingly recognized as a prominent route for programmed tumor therapy. However, the adaptivity, complexity, and heterogeneity of tumors hamper the performance of ferroptotic tumor therapies. Recent advances in molecularly self-assembled nanomedicine show promise in rejuvenating ferroptotic tumor therapies by leveraging the principles of molecular self-assembly (MSA). This review first sketches the basis of ferroptosis and MSA. Subsequently, representative nanoplatforms are discussed to elucidate how MSA can be devised, either in vitro or in vivo, to improve the precision, efficacy, and biosafety of ferroptotic tumor therapies. Finally, considerations and future perspectives toward clinical translation of molecularly self-assembled ferroptosis nanomedicine are addressed.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100829"},"PeriodicalIF":4.7000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloid and Interface Science Communications","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2215038225000135","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Featured by iron-dependent lipid peroxidation, ferroptosis is increasingly recognized as a prominent route for programmed tumor therapy. However, the adaptivity, complexity, and heterogeneity of tumors hamper the performance of ferroptotic tumor therapies. Recent advances in molecularly self-assembled nanomedicine show promise in rejuvenating ferroptotic tumor therapies by leveraging the principles of molecular self-assembly (MSA). This review first sketches the basis of ferroptosis and MSA. Subsequently, representative nanoplatforms are discussed to elucidate how MSA can be devised, either in vitro or in vivo, to improve the precision, efficacy, and biosafety of ferroptotic tumor therapies. Finally, considerations and future perspectives toward clinical translation of molecularly self-assembled ferroptosis nanomedicine are addressed.
期刊介绍:
Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.