Adjusting morphologies of wound dressing by transferring skin textures through electrospinning technology

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications Pub Date : 2025-04-09 DOI:10.1016/j.colcom.2025.100835

Huidan Wei , Jing Wen , Sai Yan , Han Zhang , Yuan Liu , Yuhan Xia , Jidong Li , Ran Cao , Meifang Zhu

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Abstract

Surface topography and mechanical properties of wound dressing significantly influence cell behavior and tissue regeneration process. Skin has unique textures, which are often overlooked in the preparation of wound dressings. Herein, we fabricated biomimetic wound dressings by transferring the surface textures of skin through electrospinning technology. Specifically, the top and bottom surface of pig skin employed as substrates for the collection of electrospinning nanofibers composed of polylactic acid and gelatin (PLLA/GL). Due to the existence of hair on the top surface of pig skin, the transferred nanofiber membrane (skin-top) exhibited scattered small pores (∼50 μm). In contrast, the transferred nanofiber membrane with aluminum foil (Al) as substrate displayed a smooth surface. Benefit from the unique surface properties of skin, the skin-based nanofiber membrane demonstrated improved roughness and enhanced air permeability. Specifically, skin-top based wound dressing showed the best performance in promoting wound healing, including enhanced epithelialization and collagen deposition.

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来源期刊

Colloid and Interface Science Communications Materials Science-Materials Chemistry

CiteScore

9.40

自引率

6.70%

发文量

125

审稿时长

43 days

期刊介绍： Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.