Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders最新文献

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Patient-Reported Outcome Measures for Patients with Upper Extremity Arthritis: Overview of Systematic Reviews. 上肢关节炎患者的患者报告结果测量:系统综述。
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2023-12-06 eCollection Date: 2023-01-01 DOI: 10.1177/11795441231213887
Armaghan Dabbagh, Christina Ziebart, Rochelle Furtado, Eleni C Boutsikari, Joy C MacDermid
{"title":"Patient-Reported Outcome Measures for Patients with Upper Extremity Arthritis: Overview of Systematic Reviews.","authors":"Armaghan Dabbagh, Christina Ziebart, Rochelle Furtado, Eleni C Boutsikari, Joy C MacDermid","doi":"10.1177/11795441231213887","DOIUrl":"https://doi.org/10.1177/11795441231213887","url":null,"abstract":"<p><strong>Background: </strong>Arthritis leads to disabilities impacting patients' physical and mental health.</p><p><strong>Objective: </strong>To synthesize the evidence on measurement properties of the patient-reported outcome measures (PROMs) for people with upper extremity arthritis.</p><p><strong>Design: </strong>Overview of systematic reviews (SRs).</p><p><strong>Methods: </strong>We performed an electronic search of 6 databases to retrieve SRs looking at any measurement property related to PROMs for people with upper extremity arthritis. Two authors rated the risk of bias (ROB) of the included SRs using AMSTAR. We extracted data on measurement properties from each SR.</p><p><strong>Results: </strong>From 6 included SRs, 6 PROMs (Arthritis Impact Measurement Scale [AIMS], AIMS-2, AIMS-Short Form, Cedars-Sinai Health-Related Quality of Life for Rheumatoid Arthritis (CSHQ-RA), Revised CSHQ-RA, and Influence of Rheumatic Disease on General Health and Lifestyle) were evaluated in 2 or more SRs. The ROB of the included SRs ranged from moderate to high. Low- to moderate-quality evidence was found of good construct and criterion validity, acceptable content validity, and good responsiveness of the AIMS. We found low- to moderate-quality evidence of good internal consistency, test-retest reliability, and construct validity of the CSHQ-RA.</p><p><strong>Conclusion: </strong>We found a moderate to high ROB in the included SRs on the upper extremity PROMs for patients with arthritis. More evidence was specific to upper extremity arthritis in measures not in common use versus well-validated measures used in upper extremity conditions and recommended in current core sets. These factors suggest an urgent need for additional research to improve the scope and quality of evidence before recommendations can be made specific to patients with arthritis.</p><p><strong>Registration number: </strong>on PROSPERO CRD 42019137491.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"16 ","pages":"11795441231213887"},"PeriodicalIF":2.6,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10702415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spondyloarthropathies That Mimic Ankylosing Spondylitis: A Narrative Review. 类似强直性脊柱炎的脊椎关节病:叙述回顾。
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2023-01-01 DOI: 10.1177/11795441231186822
Mina Tanios, Bradley Brickman, Jordan Norris, Sreeram Ravi, Emre Eren, Cade McGarvey, David J Morris, Hossein Elgafy
{"title":"Spondyloarthropathies That Mimic Ankylosing Spondylitis: A Narrative Review.","authors":"Mina Tanios,&nbsp;Bradley Brickman,&nbsp;Jordan Norris,&nbsp;Sreeram Ravi,&nbsp;Emre Eren,&nbsp;Cade McGarvey,&nbsp;David J Morris,&nbsp;Hossein Elgafy","doi":"10.1177/11795441231186822","DOIUrl":"https://doi.org/10.1177/11795441231186822","url":null,"abstract":"<p><p>Ankylosing spondylitis is the most common type of seronegative inflammatory spondyloarthropathy often presenting with low back or neck pain, stiffness, kyphosis and fractures that are initially missed on presentation; however, there are other spondyloarthropathies that may present similarly making it a challenge to establish the correct diagnosis. Here, we will highlight the similarities and unique features of the epidemiology, pathophysiology, presentation, radiographic findings, and management of seronegative inflammatory and metabolic spondyloarthropathies as they affect the axial skeleton and mimic ankylosing spondylitis. Seronegative inflammatory spondyloarthropathies such as psoriatic arthritis, reactive arthritis, noninflammatory spondyloarthropathies such as diffuse idiopathic skeletal hyperostosis, and ochronotic arthritis resulting from alkaptonuria can affect the axial skeleton and present with symptoms similar those of ankylosing spondylitis. These similarities can create a challenge for providers as they attempt to identify a patient's condition. However, there are characteristic radiographic findings and laboratory tests that may help in the differential diagnosis. Axial presentations of seronegative inflammatory, non-inflammatory, and metabolic spondyloarthropathies occur more often than previously thought. Identification of their associated symptoms and radiographic findings are imperative to effectively diagnose and properly manage patients with these diseases.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"16 ","pages":"11795441231186822"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/c8/10.1177_11795441231186822.PMC10391685.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10308346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sarcoidosis Mimicking a Malignant Metastatic Disease. 结节病模拟恶性转移性疾病。
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2023-01-01 DOI: 10.1177/11795441221145937
Georges El Hasbani, Nagi El Saghir, Hicham Moukaddam, Lama Farhat, Nina Shabb, Imad Uthman
{"title":"Sarcoidosis Mimicking a Malignant Metastatic Disease.","authors":"Georges El Hasbani,&nbsp;Nagi El Saghir,&nbsp;Hicham Moukaddam,&nbsp;Lama Farhat,&nbsp;Nina Shabb,&nbsp;Imad Uthman","doi":"10.1177/11795441221145937","DOIUrl":"https://doi.org/10.1177/11795441221145937","url":null,"abstract":"<p><p>Sarcoidosis can have pulmonary and extrapulmonary clinical manifestations depending on the organ of involvement. Because multiple organs are involved by the disease, sarcoid can mimic metastatic diseases. Whenever clinical and radiological clues of metastasis are present, differentials other than cancer should not be missed. Herein, we present a case of a middle aged gentleman who presented to the oncology clinic for 1-month history of low back pain associated with a dry cough along with radiological findings of metastatic disease involving the lungs, liver, lymph nodes, axial spine, and adrenal gland. A biopsy of the liver lesion showed non-caseating granuloma. Elevated blood levels of angiotensin-converting enzyme confirmed the diagnosis of sarcoidosis.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"16 ","pages":"11795441221145937"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/b5/10.1177_11795441221145937.PMC10160796.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9423558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Unforeseen Outcome of COVID-19: The Triggering of Adult-Onset Still's Disease. COVID-19的一个不可预见的结果:引发成人发病的斯蒂尔斯病。
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2023-01-01 DOI: 10.1177/11795441231161640
Hasan Alzuhaily, Seba Mohamad, Lama Alsalloum, Safaa Al-Sayed
{"title":"An Unforeseen Outcome of COVID-19: The Triggering of Adult-Onset Still's Disease.","authors":"Hasan Alzuhaily,&nbsp;Seba Mohamad,&nbsp;Lama Alsalloum,&nbsp;Safaa Al-Sayed","doi":"10.1177/11795441231161640","DOIUrl":"https://doi.org/10.1177/11795441231161640","url":null,"abstract":"<p><strong>Background: </strong>Adult-onset Still's disease (AOSD) is a rare auto-inflammatory disorder with unknown etiology by which an infectious trigger is usually responsible for the onset of the disease. It is diagnosed by exclusion when certain clinical, biochemical, and radiological criteria are met after excluding all other potential causes. Besides, SARS‑CoV‑2 infection is increasingly being reported to have autoimmune complications. In the literature, 3 AOSD cases have been reported to be triggered by SARS‑CoV‑2 infection and here we report the fourth.</p><p><strong>Case presentation: </strong>A 24-year-old female doctor suffered from fever, sore throat, and mild cough a few days after a shift in the COVID-19 ward. A week later, she developed polyarthritis, salmon-colored rash, and high-grade fever, and the laboratory findings were indicating an inflammatory syndrome. COVID-19 IgM antibodies were positive indicating recent infection. After running a battery of tests, infectious, neoplastic, and rheumatic causes of these symptoms that persisted for about 50 days were excluded which led to a diagnosis of AOSD after fulfilling its criteria with subsequent treatment with methylprednisolone. Drastic improvement was achieved with no recurrence until the date of reporting.</p><p><strong>Conclusion: </strong>This case presents a new consequence of COVID-19 and adds to the emerging cumulative experiences with this disease. We encourage health care professionals to report such cases to further understand the nature of this infection and its possible outcomes.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"16 ","pages":"11795441231161640"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/85/3a/10.1177_11795441231161640.PMC10067467.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9626504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Revealing the Effect of Spinopelvic Alignment on Hip Disorders. 揭示脊柱骨盆对髋关节疾病的影响。
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2023-01-01 DOI: 10.1177/11795441231191790
Zafer Soydan, Emru Bayramoglu, Okyar Altas, Cengiz Şen
{"title":"Revealing the Effect of Spinopelvic Alignment on Hip Disorders.","authors":"Zafer Soydan,&nbsp;Emru Bayramoglu,&nbsp;Okyar Altas,&nbsp;Cengiz Şen","doi":"10.1177/11795441231191790","DOIUrl":"https://doi.org/10.1177/11795441231191790","url":null,"abstract":"<p><strong>Background: </strong>Hip osteoarthritis (HOA) is a growing burden and one of the leading causes of hip pain. The relationship between the HOA and the alignment of the spinopelvic region has been intensively studied, however the issue remains controversial. Spinopelvic imbalance, HOA, and dysplasia were investigated in relation to sagittal spinopelvic parameters in this study.</p><p><strong>Methods: </strong>We collected computerized tomography (CT) topograms of the pelvis or abdomen from 380 patients. In antero-posterior (AP) topograms, Tonnis grading, center-edge angle (CEA) and Sharp's acetabular angle (AA) measurements were performed on each patient. Lateral topograms were used to evaluate the following spinopelvic parameters for each patient: pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), sacral table angle (STA), lumbar lordosis (LL), proximal lumbar lordosis (PLL), distal lumbar lordosis (DLL), and PI-LL difference. Initially, the cohort was divided into two subgroups based on whether or not they had HOA. Then, they were divided into two subgroups based on whether or not they had dysplasia. Ultimately, it was divided in half based on the PI-LL imbalance. Statistical analyses were conducted to determine the likely correlations between the spinopelvic parameters of these subgroups. In addition, the correlations between spinopelvic parameters were investigated.</p><p><strong>Results: </strong>There were 380 patients evaluated. We found no association between HOA or dysplasia and spinopelvic parameters. In addition, there was no association between PI-LL imbalance and HOA or dysplasia.</p><p><strong>Conclusion: </strong>There was no difference in constant PI and STA angle, besides other variable parameters, between groups having HOA and dysplasia or not. PI-LL imbalance has no effect on HOA and dysplasia.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"16 ","pages":"11795441231191790"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/9c/10.1177_11795441231191790.PMC10493047.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10589121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disordered Eating and Body Image Concerns in Young Adult Women With Scoliosis. 年轻成年女性脊柱侧凸患者饮食失调与身体形象的关系。
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2023-01-01 DOI: 10.1177/11795441231166010
Christine A Limbers, Amy Baskin, L Adelyn Cohen
{"title":"Disordered Eating and Body Image Concerns in Young Adult Women With Scoliosis.","authors":"Christine A Limbers,&nbsp;Amy Baskin,&nbsp;L Adelyn Cohen","doi":"10.1177/11795441231166010","DOIUrl":"https://doi.org/10.1177/11795441231166010","url":null,"abstract":"<p><strong>Background: </strong>Researchers have called for more investigation into disordered eating behaviors in females with scoliosis.</p><p><strong>Objective: </strong>The objective of the current study was to assess the associations between body image concerns, disease-specific indicators of scoliosis (ie, age of diagnosis, having undergone bracing treatment, being told by a physician your scoliosis required surgery, having a spinal fusion), quality of life, and disordered eating in a sample of young adult women diagnosed with idiopathic scoliosis during adolescence.</p><p><strong>Design: </strong>This study was cross-sectional in design.</p><p><strong>Methods: </strong>Participants were 177 young adult women ages 18 to 30 years diagnosed with idiopathic scoliosis by a physician who completed questionnaires online.</p><p><strong>Results: </strong>Undergoing bracing treatment (<i>r</i> = -.440; <i>P</i> < .001), greater age at scoliosis diagnosis (<i>r</i> = .563; <i>P</i> < .001), being told scoliosis required surgery (<i>r</i> = -.196; <i>P</i> < .050), annual income (<i>r</i> = .306; <i>P</i> < .001), level of education (<i>r</i> = .228; <i>P</i> < .010), and race/ethnicity (<i>r</i> = -.213; <i>P</i> < .050) were associated with the EDE-Q Global Score. The Body Shape Questionnaire Total Score and EDE-Q Global Score (<i>r</i> = .848; <i>P</i> < .001) and EDE-Q Weight Concern Score (<i>r</i> = .813; <i>P</i> < .001) were associated. The strongest correlations between the EDE-Q and the SRS-22-Revised Subscales were generally evidenced on the SRS-22-Revised Mental Health Subscale (<i>r</i>s ranged from -.200 to -.371; <i>P</i> < .001). After controlling for annual income, highest level of education, undergoing bracing treatment, and age of scoliosis diagnosis, the Body Shape Questionnaire Total Score was significantly correlated with the EDE-Q Eating Concern Score (standardized beta coefficient = .618; <i>P</i> < .001).</p><p><strong>Conclusions: </strong>These findings underscore the importance of assessing body image concerns in young adult women with scoliosis experiencing disordered eating as this information may provide valuable information relevant to treatment planning.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"16 ","pages":"11795441231166010"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/f8/10.1177_11795441231166010.PMC10134120.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9448958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Relationship Between Serum Vitamin D Level and Disease Severity in Rheumatoid Arthritis. 类风湿关节炎患者血清维生素D水平与疾病严重程度的关系
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2023-01-01 DOI: 10.1177/11795441231182997
Farhang Soltani Bajestani, Nasim Khajavian, Davoud Salarbashi, Mojtaba Kafili, Fatemeh Ashori, Jafar Hajavi
{"title":"Relationship Between Serum Vitamin D Level and Disease Severity in Rheumatoid Arthritis.","authors":"Farhang Soltani Bajestani,&nbsp;Nasim Khajavian,&nbsp;Davoud Salarbashi,&nbsp;Mojtaba Kafili,&nbsp;Fatemeh Ashori,&nbsp;Jafar Hajavi","doi":"10.1177/11795441231182997","DOIUrl":"https://doi.org/10.1177/11795441231182997","url":null,"abstract":"<p><strong>Background and objective: </strong>Rheumatoid arthritis is an autoimmune disease that causes joint pain and reduces daily activities. The aim of this study was to evaluate the serum of vitamin D and its relationship with the severity of the disease in patients with rheumatoid arthritis referred to Allameh Hehlool hospital in Gonabad.</p><p><strong>Design and methods: </strong>This cross-sectional-analytical study was performed on 92 patients referred to the rheumatology clinic of Allameh Behlool Gonabad Hospital in 2021. After obtaining the permission of the ethics committee, the samples were selected based on the desired criteria. Serum vitamin D levels in patients were measured, and data were collected using a patient information checklist and DAS28-CRP activity questionnaire. Data were analyzed using SPSS software version 16 and using statistically appropriate tests at a significance level less than 5%.</p><p><strong>Results: </strong>The mean age of the patients was 53.05 ± 12.33 years and most of them (58.7%) were women. Serum vitamin D level was sufficient in 65.2% of patients and the severity of the disease was in the remission in 48.9% of them. The results of chi-square test showed a significant relationship between serum vitamin D levels and disease severity in patients (<i>P</i> < .001).</p><p><strong>Conclusions: </strong>Serum vitamin D levels were inversely related to disease severity and in most patients with severe disease severity, serum vitamin D levels were inadequate. vitamin D supplementation is recommended in patients with rheumatoid arthritis.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"16 ","pages":"11795441231182997"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/cd/10.1177_11795441231182997.PMC10331176.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10300875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Hughes-Stovin Syndrome: An Experience of Management of 3 Cases From a Tertiary Health Care Centre. 休斯-斯托文综合征:三级医疗中心3例的管理经验。
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2023-01-01 DOI: 10.1177/11795441231168648
Girija Sachdev, Sandeep Yadav, Canchi Balakrishnan, Rishabh Nanavati
{"title":"Hughes-Stovin Syndrome: An Experience of Management of 3 Cases From a Tertiary Health Care Centre.","authors":"Girija Sachdev,&nbsp;Sandeep Yadav,&nbsp;Canchi Balakrishnan,&nbsp;Rishabh Nanavati","doi":"10.1177/11795441231168648","DOIUrl":"https://doi.org/10.1177/11795441231168648","url":null,"abstract":"<p><p>Three young males with Hugh-Stovin's syndrome presented with cough, haemoptysis, fever, raised inflammatory markers, and pulmonary artery aneurysm. Only one had recurrent oral ulcers suggestive of Behcet's disease, and none were HLA B51 positive. All responded well to immunosuppression but eventually needed either an endovascular procedure or surgery.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"16 ","pages":"11795441231168648"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/98/10.1177_11795441231168648.PMC10185861.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9484342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adult-Onset Still's Disease in an Elderly Patient Presenting as Aseptic Meningitis: A Case Report. 以无菌性脑膜炎为表现的老年成人发病斯蒂尔氏病1例报告
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2023-01-01 DOI: 10.1177/11795441231195636
Ujjwol Risal, Krishna Dhungana, Mrikchhya Ghimire
{"title":"Adult-Onset Still's Disease in an Elderly Patient Presenting as Aseptic Meningitis: A Case Report.","authors":"Ujjwol Risal,&nbsp;Krishna Dhungana,&nbsp;Mrikchhya Ghimire","doi":"10.1177/11795441231195636","DOIUrl":"https://doi.org/10.1177/11795441231195636","url":null,"abstract":"<p><p>Adult-onset Still's disease (AOSD) is a rare auto-inflammatory disease of unknown origin characterized mainly by fever, arthritis, and a rash. Aseptic meningitis is a rare complication of AOSD and is seen most commonly in young adults. Here, we report a case of AOSD in a 78-year female with fever and altered sensorium with lymphocyte predominant pleocytosis in the cerebrospinal fluid who was initially managed as tubercular meningitis. Adult-onset Still's disease was diagnosed as there was no response to antitubercular drugs even after 3 months and based on persistent fever, inflammatory arthritis, rash, and highly raised inflammatory markers.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"16 ","pages":"11795441231195636"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4f/25/10.1177_11795441231195636.PMC10460291.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10166642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases? 全血细胞计数图能告诉我们更多关于风湿病活动的信息吗?
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2022-04-01 DOI: 10.1177/11795441221089182
Sara I. Taha, S. Samaan, R. Ibrahim, Nouran M. Moustafa, E. El-Sehsah, Mariam K. Youssef
{"title":"Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?","authors":"Sara I. Taha, S. Samaan, R. Ibrahim, Nouran M. Moustafa, E. El-Sehsah, Mariam K. Youssef","doi":"10.1177/11795441221089182","DOIUrl":"https://doi.org/10.1177/11795441221089182","url":null,"abstract":"Background: In clinical practice, distinguishing disease activity in patients with rheumatological illnesses is challenging. Objectives: We aimed to investigate clinical associations of hemogram-derived indices, namely: red cell distribution width (RDW), mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) with disease activity in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS). Methods: In 250 patients with rheumatological disease and 100 healthy age-matched controls, we investigated disease activity scores and indicators and evaluated their association with hemogram-derived indices values. Results: Compared with the control group, RDW, MPV, and PLR significantly increased (P < .001) in the three studied disorders (RA, SLE, and AS), but LMR dramatically decreased. SII was considerably higher in RA and AS patients compared with controls but not in SLE patients. On the other hand, NLR rose dramatically in SLE patients compared with controls (P = .043), but did not change much in RA and AS patients (P > .05). RDW and MPV showed significant changes (P < .001) in the three studied diseases (RA, SLE, and AS) according to disease activity. They significantly increased across worsening activity scores. Only in the SLE group, PLR was significantly increased with disease activity (P < .001), while LMR showed a significant decrease (P = .016). Conclusions: Clinicians must pay close attention to complete blood count (CBC) analysis and its various derived ratios to better characterize the activity of rheumatological disorders and anticipate the disease course and prognosis.","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"2 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78291603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
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