Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders最新文献

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Relationship Between Serum Vitamin D Level and Disease Severity in Rheumatoid Arthritis. 类风湿关节炎患者血清维生素D水平与疾病严重程度的关系
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2023-01-01 DOI: 10.1177/11795441231182997
Farhang Soltani Bajestani, Nasim Khajavian, Davoud Salarbashi, Mojtaba Kafili, Fatemeh Ashori, Jafar Hajavi
{"title":"Relationship Between Serum Vitamin D Level and Disease Severity in Rheumatoid Arthritis.","authors":"Farhang Soltani Bajestani,&nbsp;Nasim Khajavian,&nbsp;Davoud Salarbashi,&nbsp;Mojtaba Kafili,&nbsp;Fatemeh Ashori,&nbsp;Jafar Hajavi","doi":"10.1177/11795441231182997","DOIUrl":"https://doi.org/10.1177/11795441231182997","url":null,"abstract":"<p><strong>Background and objective: </strong>Rheumatoid arthritis is an autoimmune disease that causes joint pain and reduces daily activities. The aim of this study was to evaluate the serum of vitamin D and its relationship with the severity of the disease in patients with rheumatoid arthritis referred to Allameh Hehlool hospital in Gonabad.</p><p><strong>Design and methods: </strong>This cross-sectional-analytical study was performed on 92 patients referred to the rheumatology clinic of Allameh Behlool Gonabad Hospital in 2021. After obtaining the permission of the ethics committee, the samples were selected based on the desired criteria. Serum vitamin D levels in patients were measured, and data were collected using a patient information checklist and DAS28-CRP activity questionnaire. Data were analyzed using SPSS software version 16 and using statistically appropriate tests at a significance level less than 5%.</p><p><strong>Results: </strong>The mean age of the patients was 53.05 ± 12.33 years and most of them (58.7%) were women. Serum vitamin D level was sufficient in 65.2% of patients and the severity of the disease was in the remission in 48.9% of them. The results of chi-square test showed a significant relationship between serum vitamin D levels and disease severity in patients (<i>P</i> < .001).</p><p><strong>Conclusions: </strong>Serum vitamin D levels were inversely related to disease severity and in most patients with severe disease severity, serum vitamin D levels were inadequate. vitamin D supplementation is recommended in patients with rheumatoid arthritis.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"16 ","pages":"11795441231182997"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/cd/10.1177_11795441231182997.PMC10331176.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10300875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Hughes-Stovin Syndrome: An Experience of Management of 3 Cases From a Tertiary Health Care Centre. 休斯-斯托文综合征:三级医疗中心3例的管理经验。
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2023-01-01 DOI: 10.1177/11795441231168648
Girija Sachdev, Sandeep Yadav, Canchi Balakrishnan, Rishabh Nanavati
{"title":"Hughes-Stovin Syndrome: An Experience of Management of 3 Cases From a Tertiary Health Care Centre.","authors":"Girija Sachdev,&nbsp;Sandeep Yadav,&nbsp;Canchi Balakrishnan,&nbsp;Rishabh Nanavati","doi":"10.1177/11795441231168648","DOIUrl":"https://doi.org/10.1177/11795441231168648","url":null,"abstract":"<p><p>Three young males with Hugh-Stovin's syndrome presented with cough, haemoptysis, fever, raised inflammatory markers, and pulmonary artery aneurysm. Only one had recurrent oral ulcers suggestive of Behcet's disease, and none were HLA B51 positive. All responded well to immunosuppression but eventually needed either an endovascular procedure or surgery.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"16 ","pages":"11795441231168648"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/98/10.1177_11795441231168648.PMC10185861.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9484342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adult-Onset Still's Disease in an Elderly Patient Presenting as Aseptic Meningitis: A Case Report. 以无菌性脑膜炎为表现的老年成人发病斯蒂尔氏病1例报告
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2023-01-01 DOI: 10.1177/11795441231195636
Ujjwol Risal, Krishna Dhungana, Mrikchhya Ghimire
{"title":"Adult-Onset Still's Disease in an Elderly Patient Presenting as Aseptic Meningitis: A Case Report.","authors":"Ujjwol Risal,&nbsp;Krishna Dhungana,&nbsp;Mrikchhya Ghimire","doi":"10.1177/11795441231195636","DOIUrl":"https://doi.org/10.1177/11795441231195636","url":null,"abstract":"<p><p>Adult-onset Still's disease (AOSD) is a rare auto-inflammatory disease of unknown origin characterized mainly by fever, arthritis, and a rash. Aseptic meningitis is a rare complication of AOSD and is seen most commonly in young adults. Here, we report a case of AOSD in a 78-year female with fever and altered sensorium with lymphocyte predominant pleocytosis in the cerebrospinal fluid who was initially managed as tubercular meningitis. Adult-onset Still's disease was diagnosed as there was no response to antitubercular drugs even after 3 months and based on persistent fever, inflammatory arthritis, rash, and highly raised inflammatory markers.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"16 ","pages":"11795441231195636"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4f/25/10.1177_11795441231195636.PMC10460291.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10166642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases? 全血细胞计数图能告诉我们更多关于风湿病活动的信息吗?
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2022-04-01 DOI: 10.1177/11795441221089182
Sara I. Taha, S. Samaan, R. Ibrahim, Nouran M. Moustafa, E. El-Sehsah, Mariam K. Youssef
{"title":"Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?","authors":"Sara I. Taha, S. Samaan, R. Ibrahim, Nouran M. Moustafa, E. El-Sehsah, Mariam K. Youssef","doi":"10.1177/11795441221089182","DOIUrl":"https://doi.org/10.1177/11795441221089182","url":null,"abstract":"Background: In clinical practice, distinguishing disease activity in patients with rheumatological illnesses is challenging. Objectives: We aimed to investigate clinical associations of hemogram-derived indices, namely: red cell distribution width (RDW), mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) with disease activity in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS). Methods: In 250 patients with rheumatological disease and 100 healthy age-matched controls, we investigated disease activity scores and indicators and evaluated their association with hemogram-derived indices values. Results: Compared with the control group, RDW, MPV, and PLR significantly increased (P < .001) in the three studied disorders (RA, SLE, and AS), but LMR dramatically decreased. SII was considerably higher in RA and AS patients compared with controls but not in SLE patients. On the other hand, NLR rose dramatically in SLE patients compared with controls (P = .043), but did not change much in RA and AS patients (P > .05). RDW and MPV showed significant changes (P < .001) in the three studied diseases (RA, SLE, and AS) according to disease activity. They significantly increased across worsening activity scores. Only in the SLE group, PLR was significantly increased with disease activity (P < .001), while LMR showed a significant decrease (P = .016). Conclusions: Clinicians must pay close attention to complete blood count (CBC) analysis and its various derived ratios to better characterize the activity of rheumatological disorders and anticipate the disease course and prognosis.","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"2 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78291603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Effect of Prophylactic Dose of Trimethoprim-Sulfamethoxazole on Serum Creatinine in Japanese Patients With Connective Tissue Diseases 甲氧苄啶-磺胺甲恶唑预防剂量对日本结缔组织病患者血清肌酐的影响
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2022-03-01 DOI: 10.1177/11795441221085141
R. Kawato, R. Rokutanda, M. Okada, M. Matsushita, K. Yamaji, N. Tamura
{"title":"Effect of Prophylactic Dose of Trimethoprim-Sulfamethoxazole on Serum Creatinine in Japanese Patients With Connective Tissue Diseases","authors":"R. Kawato, R. Rokutanda, M. Okada, M. Matsushita, K. Yamaji, N. Tamura","doi":"10.1177/11795441221085141","DOIUrl":"https://doi.org/10.1177/11795441221085141","url":null,"abstract":"Objectives: At normal doses of trimethoprim-sulfamethoxazole (TMP/SMX), trimethoprim inhibits tubular creatinine secretion, leading to a rapid but reversible increase in serum creatinine (SCr). Although patients with connective tissue diseases are often in the state of immunosuppression and TMP/SMX is an important prophylactic drug, clinicians often have to stop or reduce the dosage due to concerns regarding its effect on renal function. This study aimed to evaluate the effect of a prophylactic dose of TMP/SMX on SCr in Japanese patients with connective tissue diseases, the extent of SCr level elevation and the independent risk factors for creatinine elevation. Methods: A retrospective cohort study was undertaken. Participants included patients with connective tissue diseases who were treated with a prophylactic dose of TMP/SMX between 2004 and 2018. Using single and multiple regression analyses, the risk factors that affected SCr elevation were evaluated. Results: A total of 262 patients, females, n = 181; age, median (range) = 59 (19-89) years, were included. The median baseline SCr level before treatment was 0.62 (0.16-2.1) mg/dL. The median SCr elevation value was 0.07 (−0.54 to 0.84) mg/dL in 4 weeks after TMP/SMX initiation. Five (2%) participants had ⩾0.3 mg/dL SCr elevation. Multiple regression analyses, including age, baseline SCr, diuretic use, nonsteroidal anti-inflammatory drug use and diabetes mellitus, indicated that baseline SCr and advanced age were independent risk factors of SCr elevation. Conclusions: These results demonstrated that baseline SCr and advanced age were associated with SCr elevation by a prophylactic dose of TMP/SMX. However, a prophylactic dose of TMP/SMX rarely elevated the SCr level significantly. Therefore, other causes can be considered if patients show an SCr elevation ⩾0.3 mg/dL.","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"9 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84224208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colchicine May Interfere With the Efficacy of the Adenoviral Vector–Based Vaccine for COVID-19 秋水仙碱可能干扰基于腺病毒载体的COVID-19疫苗的疗效
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2022-03-01 DOI: 10.1177/11795441221081061
Cheng-Wei Lin
{"title":"Colchicine May Interfere With the Efficacy of the Adenoviral Vector–Based Vaccine for COVID-19","authors":"Cheng-Wei Lin","doi":"10.1177/11795441221081061","DOIUrl":"https://doi.org/10.1177/11795441221081061","url":null,"abstract":"Under the ongoing COVID-19 pandemic, vaccines have become the crucial players to reduce the spread of the infection. Among them, the ChAdOx1 nCoV-19 vaccine is an adenoviral vector vaccine with an overall efficacy of 70.4% in protection. The engineered adenovirus contains the SARS-CoV-2 spike protein gene and pushes its DNA into the vaccinated cell’s nucleus and subsequently, the spike protein can be made. During vaccination, the genome transition of adenovirus is influenced by the architecture and dynamics of the microtubule. Colchicine can alter microtubule dynamics by suppressing microtubule dynamics at lower concentrations and inducing depolymerization of microtubules at higher concentrations. Accordingly, the delivery of the genome to the vaccinated cell’s nucleus by the adenoviral vector could be hindered under the presence of colchicine. Nevertheless, colchicine is a common medication for gout therapy worldwide, and though not recommended by guidelines, colchicine has even been taken into consideration as a possible therapeutic option for COVID-19 infection. Given the above reasons and the worldwide use of colchicine, the impact of colchicine on the efficacy of the COVID-19 vaccine via adenoviral vector should be viewed cautiously.","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"8 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75530366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis 一种天然口服营养补充剂的成分及其在治疗骨关节炎中的作用
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2022-01-01 DOI: 10.1177/11795441211063365
K. Bharat, N. Manhas, James Gutcho, Joshua Lin, S. Bhattacharyya, Robertus Kounang
{"title":"Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis","authors":"K. Bharat, N. Manhas, James Gutcho, Joshua Lin, S. Bhattacharyya, Robertus Kounang","doi":"10.1177/11795441211063365","DOIUrl":"https://doi.org/10.1177/11795441211063365","url":null,"abstract":"Osteoarthritis is a prevalent degenerative disease affecting a large portion of the world’s aging population. Currently, nonsteroidal anti-inflammatory drugs and acetaminophen are first-line medications for treating osteoarthritis patients’ pain. However, several studies have noted that while these medications control pain they do not halt progressive degeneration and tend to have an unfavorable side-effect profile with prolonged use. Recently, due to their more favorable side-effect profiles, herbal alternatives for controlling osteoarthritis symptoms and for alleviating the progression of the disease are being increasingly studied. Synogesic is a newly developed herbal supplement blend by renowned orthopedic surgeons and physiatrists consisting of turmeric, rutin, ginger root, vitamin C, vitamin D, and boswellia extracts. A study by Sharkey et al. has commented on the efficacy of the blend on the patients with knee osteoarthritis. So far, a review on the ingredients of the blend has not yet carried outbeen. By exploring prominent literature databases including PubMed and ScienceDirect, our aim is to write a narrative review to explore the individual ingredients of this blend and delve into their characteristics, as well as the most recent literature on their mechanism and efficacy in patients with osteoarthritis. Through this, we hope to inform clinicians and patients alike on relevant up-to-date research on the supplement and provide insight on the potential for this supplement for alleviating the disease course of patients with osteoarthritis.","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"29 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91371726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Representation Rate and Management of Gout for Patients Discharged From Emergency Departments in Illawarra Shoalhaven Local Health District. Illawarra Shoalhaven地方卫生区急诊科出院患者痛风的代表率和管理。
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2022-01-01 DOI: 10.1177/11795441221097351
Aravinthan Loganathan, Arupam Raman, Natalia Berlinski, John Riordan
{"title":"Representation Rate and Management of Gout for Patients Discharged From Emergency Departments in Illawarra Shoalhaven Local Health District.","authors":"Aravinthan Loganathan,&nbsp;Arupam Raman,&nbsp;Natalia Berlinski,&nbsp;John Riordan","doi":"10.1177/11795441221097351","DOIUrl":"https://doi.org/10.1177/11795441221097351","url":null,"abstract":"<p><strong>Introduction: </strong>The estimated prevalence of gout in Western societies is 2.7% to 6.7%. In Australia, there have been increasing rates of hospitalisations for gout flares. Urate-lowering therapy (ULT) is effective in reducing urate burden, which can prevent gout flares and destructive arthropathy. This study assessed the representation rate of patients presenting to the Emergency Department (ED) with crystal arthropathy and the utilisation of ULT in the community for patients with a pre-existing history of gout.</p><p><strong>Methods: </strong>A retrospective review of electronic records of patients presenting to the ED from the Illawarra Shoalhaven Local Health District was performed. Patients included were coded as per the 10th revision of the International Classification of Diseases coding for crystal arthropathy.</p><p><strong>Results: </strong>In all, 18.8% of all crystal arthropathy encounters to the ED were repeat presentations. Of the 70% of patients with a history of gout, only 30.8% were on ULT.</p><p><strong>Discussion: </strong>Despite evidence-based recommendations for a 'treat-to-target' approach, most patients with a previous history of gout were not on ULT. One in five encounters were re-presentations for crystal arthropathy. Effective adherence to treatment guidelines may reduce the number of repeat encounters for gout flare in the ED.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"15 ","pages":"11795441221097351"},"PeriodicalIF":2.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/a3/10.1177_11795441221097351.PMC9134409.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10244883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Prevalence of Osteoporosis Among Iranian Postmenopausal Women: A Systematic Review and Meta-analysis 伊朗绝经后妇女骨质疏松症患病率:系统回顾和荟萃分析
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2022-01-01 DOI: 10.1177/11795441211072471
Tayebeh Eghbali, K. Abdi, Mahboubeh Nazari, E. Mohammadnejad, Reza Ghanei Gheshlagh
{"title":"Prevalence of Osteoporosis Among Iranian Postmenopausal Women: A Systematic Review and Meta-analysis","authors":"Tayebeh Eghbali, K. Abdi, Mahboubeh Nazari, E. Mohammadnejad, Reza Ghanei Gheshlagh","doi":"10.1177/11795441211072471","DOIUrl":"https://doi.org/10.1177/11795441211072471","url":null,"abstract":"Objectives: Osteoporosis is the most common metabolic bone disease. It is considered the silent epidemic, with high prevalence after menopause, in the current time. Different studies conducted in Iran have reported different prevalence. The present systematic review and meta-analysis aims to estimate the overall prevalence of osteoporosis in Iranian postmenopausal women. Methods: The national scientific databases Scientific Information Database and MagIran and the international scientific databases PubMed, Web of Science, and Scopus were searched for related articles without any time limitation. The keywords osteopenia, osteoporosis, post menopause, OP, bone mineral density, and Iran along with their combinations were used in the search. The inconsistency in the data was examined using I2 test. The data were analyzed using the meta-analysis method and the random-effects model in Stata software, version 14. Results: The analysis of 26 articles with a sample size of 6735 showed that the prevalence of osteoporosis and osteopenia in Iranian postmenopausal women is, respectively, 33.70% (95% CI [confidence interval]: 22.68-44.73) and 47.60% (95% CI: 32.88-62.32). The pooled prevalence of osteoporosis in the spine and in the femur bone was 31.99% and 15.93%, respectively. Also, the prevalence of osteopenia in the spine and in the femur bone was 22.48% and 39.88%, respectively. Conclusion: Osteoporosis and osteopenia are highly prevalent in Iranian postmenopausal women to the extent that one-third of women suffer from osteoporosis and nearly half of them suffer from osteopenia. It seems essential to teach a healthy lifestyle to these women to reduce the prevalence of these issues.","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"112 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78667975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A Retrospective Observational Cohort Study of Periprosthetic Hip Infection Treated by one-stage Method Including Cases With Bone Graft Reconstruction 一期法治疗人工髋关节周围感染的回顾性观察队列研究,包括骨移植重建病例
IF 2.6
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2022-01-01 DOI: 10.1177/11795441221090344
Ricardo Issler Unfried, L. F. Krause, Helen Minussi Cezimbra, L. Pacheco, João Alberto Larangeira, T. Ribeiro
{"title":"A Retrospective Observational Cohort Study of Periprosthetic Hip Infection Treated by one-stage Method Including Cases With Bone Graft Reconstruction","authors":"Ricardo Issler Unfried, L. F. Krause, Helen Minussi Cezimbra, L. Pacheco, João Alberto Larangeira, T. Ribeiro","doi":"10.1177/11795441221090344","DOIUrl":"https://doi.org/10.1177/11795441221090344","url":null,"abstract":"Purpose: Prosthetic joint infection (PJI) is a devastating complication that can affect hip arthroplasty. Its treatment is extremely difficult, and issues regarding the optimal treatment remain unanswered. This study intended to show the effectiveness of the one-stage treatment of PJI. Materials and Methods: A retrospective observational cohort study performed from July 2014- August 2018. All patients with suspected PJI were included. Major and minor criteria developed by the International Consensus on Periprosthetic Joint Infection (ICPJI) was used to define infection. Laboratory tests and image exams were performed, and all patients were followed for at least 2 years. Outcomes: Success rate (2018 ICPJI definition to success) in treatment of PJI using one-stage revision method. Clinical and functional outcomes defined by Harris Hip Score (HHS). Results: Thirty-one patients were screened and 18 analyzed. 69.85 ± 9.76 years was the mean age. Mean follow-up time was 63.84 ± 18.55 months. Ten patients had acetabular defects and required bone graft reconstruction. Sixteen patients were classified as Tier 1, 1 as Tier 3D, and as 1 Tier 3E. Almost 90% of patients submitted to one-stage revision with acetabulum graft reconstruction were free of infection. The overall infection survival rate was 78.31±6.34 months. Candida albicans and sinus tract were statistically significant in univariate Cox’s analysis. The predictor of one-stage revision surgery failure that remained final Cox’s regression model was C. albicans (hazard ratio [HR]: 4.47). Conclusion: Treatment through one-stage revision surgery associated with 6 months of antimicrobial is a viable option with acceptable results even when bone graft reconstruction is necessary. C. albicans was a strong predictor of failure in this cohort.","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"1 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75569126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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