Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders最新文献

{"title":"Prevalence of Musculoskeletal Disorders Among Prison Inmates: A Systematic Review and Meta-Analysis.","authors":"Tope Oyelade, Arowosegbe Abayomi, Sulaiman M Almarkhan, Fahad A Salem, Jaber S Alqahtani","doi":"10.1177/11795441261480697","DOIUrl":"https://doi.org/10.1177/11795441261480697","url":null,"abstract":"<p><strong>Background: </strong>MSK (musculoskeletal) disorders (MSDs) significantly limit physical activity and the general quality of life of patients. Prison inmates have poor access to quality health care, which may hinder their rehabilitation journey. This study assessed the prevalence of MSDs among prison inmates.</p><p><strong>Methods: </strong>Electronic databases were searched from inception to July 2025. Studies were screened, and relevant data were extracted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A meta-analysis was conducted using a random-effects model to pool the prevalence of MSDs among inmates. The quality of studies was assessed using the Newcastle-Ottawa Scale, and bias was measured using the funnel plot, the Egger test, and leave-one-out sensitivity analysis.</p><p><strong>Results: </strong>A total of 16 studies were included from 1089 initially retrieved from database searches. A total of 21 536 prison inmates were included in these studies, of which 4016 had MSDs. Pooled prevalence of overall MSDs (diagnosed and self-reported) among prisoners was 25% (95% confidence interval [CI] = 18%-33%). Clinically diagnosed and self-reported MSDs had a prevalence of 18% (95% CI = 13%-24%) and 30% (95% CI = 20%-39%), respectively. The funnel plots and the Egger tests show no publication bias, with sensitivity analyses showing that no single research significantly influences the pooled effect sizes.</p><p><strong>Conclusions: </strong>Musculoskeletal disorders may affect 1 in 4 prison inmates, with associated debilitating effects on both physical and mental health. Given that this population has limited access to quality care and considering that the aim of incarceration is rehabilitation, it is essential to prioritize and address the health effects of MSK disorders among prison inmates.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"19 ","pages":"11795441261480697"},"PeriodicalIF":1.2,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13546466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associated Determinants of Sexual Dysfunctions in Non-Specific Low Back Pain Patients in Cameroon: A Cross-Sectional Study.","authors":"Womsi Tatuegan Ruslaine, Wankeu-Nya Modeste, Mekoulou Ndongo Jerson, Djeumeni Néely Ornéla, Watcho Pierre, Massoma Dieudonné Lembè","doi":"10.1177/11795441261481095","DOIUrl":"10.1177/11795441261481095","url":null,"abstract":"<p><strong>Background: </strong>Non-specific low back pain (NSLBP) is a significant factor involved in the onset of sexual dysfunctions (SDs). However, studies demonstrating the correlation between these 2 conditions are rare. This study aimed to determine the prevalence and factors associated to SDs in patients suffering from NSLBP in Cameroon.</p><p><strong>Method: </strong>A cross-sectional study was conducted among patients suffering from NSLBP in the 3 main town (Yaoundé, Douala and Bafoussam) of Cameroon. Clinical characteristics and sexual activity of these patients were evaluated using validated questionnaires such as the Oswestry Disability Index, the Hospital Anxiety and Depression Scale, the Pain Catastrophizing Scale, the Male sexual Health-Questionnaire, and the Female Sexual Function Index.</p><p><strong>Results: </strong>Data from 409 patients (233 men and 176 women) were collected and included in this study. The overall prevalence of SDs related to NSLBP was 43%. The most affected sexual activity domains were desire (2.7 ± 1.4) and excitement (3.2 ± 1.4) in women. In men, desire (15.2 ± 5.7) and sexual satisfaction (15 ± 6.8) were most affected. Several associations were found between SD in NSLBP patients and some variables such as: overweight (odds ratio [OR] = 1.882, <i>P</i> = .005), female (OR = 1.518, <i>P</i> = .03), pain intensity (OR = 1.365, <i>P</i> = .0001), pain catastrophizing (OR = 1.076, <i>P</i> = .0003), hypoflexibility (OR = 1.029, <i>P</i> = .0009), reduced <i>erector spinae</i> (OR = 0.984, <i>P</i> = .0009), abdominal muscle strength (OR = 0.983, <i>P</i> = .016), depression (OR = 1.177, <i>P < .</i>0001), anxiety (adjusted odds ratio [aOR] = 1.168, <i>P < .</i>0001), and disability (OR = 1.165, <i>P < .</i>0001).</p><p><strong>Conclusion: </strong>The relatively high prevalence of SDs related to NSLBP highlights the close relationship between these 2 conditions and their associated factors in Cameroon. These results highlight many factors that must be taken into account in the management of SDs related to NSLBP.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"19 ","pages":"11795441261481095"},"PeriodicalIF":1.2,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Blood Flow Restriction Therapy in Individuals With Knee Osteoarthritis: Overview of Systematic Reviews.","authors":"Felipe A Machado, Gustavo J Almeida, Francisco R A Santos, Graziella F B Cipriano, Gerson Cipriano, Jefferson R Cardoso, Wagner R Martins","doi":"10.1177/11795441261446451","DOIUrl":"10.1177/11795441261446451","url":null,"abstract":"<p><strong>Background: </strong>Knee osteoarthritis (KOA) is frequently accompanied by quadriceps weakness. Resistance training is recommended, but high-intensity resistance training (HIRT) may be poorly tolerated in some patients, whereas low-intensity resistance training (LIRT) may yield smaller strength gains. Low-intensity blood flow restriction training (LIBFR) has been proposed as a low-load strategy to stimulate muscle adaptations; however, the evidence base has been summarized in multiple systematic reviews with variable conclusions.</p><p><strong>Objective: </strong>To synthesize and appraise the evidence on the efficacy and safety of LIBFR in individuals with KOA through an overview of systematic reviews.</p><p><strong>Methods: </strong>We searched MEDLINE, EMBASE, Cochrane Database, Web of Science, CINAHL, SPORTDiscus, PEDro, Epistemonikos, and gray literature (ProQuest, Global ETD) for systematic reviews of randomized clinical trials comparing LIBFR with LIRT and/or HIRT. Reviews were eligible if they evaluated supervised exercise-based LIBFR delivered ⩾2 to 3 sessions/week for ⩾4 weeks. Two reviewers independently screened, extracted data, and assessed methodological quality (AMSTAR 2). Certainty of evidence was appraised using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) based on KOA-specific quantitative syntheses, applying a hierarchical approach in the presence of overlap across reviews.</p><p><strong>Results: </strong>Eighteen systematic reviews (57 randomized trials; 5656 participants) were included. Compared with LIRT, LIBFR was associated with greater improvements in quadriceps strength (standardized mean difference [SMD] = 0.75; 95% confidence interval [CI] = [0.40 to 1.10]) and muscle hypertrophy (SMD = 0.81; 95% CI = [0.10 to 1.52]), although certainty of evidence was very low. Compared with HIRT, LIBFR was associated with fewer adverse events (risk ratio [RR] = 0.26; 95% CI = [0.09 to 0.72]).Across comparisons, effects on pain and functional outcomes were generally similar, and between-group differences were not consistently observed.</p><p><strong>Conclusions: </strong>The LIBFR may improve quadriceps strength and hypertrophy relative to LIRT and may have a more favorable adverse-event profile than HIRT, but confidence in these estimates is limited by low-/very low-certainty evidence and variability in protocols and reporting. Well-designed, longer-term randomized trials with standardized LIBFR parameters and robust safety reporting are needed to clarify patient-important outcomes.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"19 ","pages":"11795441261446451"},"PeriodicalIF":1.2,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148344186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Musculoskeletal Pain With Foot Type, Plantar Pressure, Physical Activity, Psychosocial Factors, and Daily Living Habits Among Adolescents.","authors":"Yaqi Zhang, Jinzi Yang, Lijuan Li, Yixuan Lin, Beini Wang, Lishuo Shi, Haiqin Jiang, Yuxi Li, Yaoyao Xiao, Jun Liu, Peihui Wu, Yangyang Lin","doi":"10.1177/11795441261448562","DOIUrl":"10.1177/11795441261448562","url":null,"abstract":"<p><strong>Background: </strong>In recent years, musculoskeletal pain (MSP) has gained widespread attention globally and has become a significant public health issue affecting people of all ages, especially those affected by adolescence. Many musculoskeletal problems have a biomechanical origin, often linked to foot type and plantar pressure.</p><p><strong>Objectives: </strong>The aim of this study is to provide new insights into the multifactorial nature of MSP by exploring its associations with foot type, plantar pressure, physical activity, psychosocial factors, and daily living habits in adolescents.</p><p><strong>Design: </strong>A cross-sectional observational study was conducted among adolescents recruited from community and schools in Guangzhou, China.</p><p><strong>Methods: </strong>Chi-square tests and logistic regression analysis were employed to investigate the associations between the prevalence of musculoskeletal pain and various factors, including foot type, plantar pressure, physical activity levels, psychosocial factors, study pressure and daily living habits like sleep duration, sleep quality, and screen time. Given the high prevalence and clinical relevance, we further analyzed factors associated with neck, back, and foot pain.</p><p><strong>Results: </strong>This study included 216 adolescents (15.83 ± 1.05 years). The analysis revealed that physical activity, sleep duration, and study pressure significantly associated with the incidence of neck pain. Emotional symptoms at the threshold or abnormal and poor sleep quality both associated with low back pain. Foot type and plantar pressure did not show statistical significance in association with overall musculoskeletal pain. However, when specific pain sites were examined, foot pain was significantly associated with maximum plantar pressure ⩾ 1000 N/dm², average plantar pressure ⩾ 180 N, and flatfoot or high-arched foot.</p><p><strong>Conclusions: </strong>Our study found that while foot type and plantar pressure were not associated with overall musculoskeletal pain, they were significantly associated with foot pain specifically. Low physical activity, insufficient sleep, and high study pressure were linked to neck pain, while poor sleep quality and emotional symptoms were associated with low back pain. These findings highlight the multifactorial nature of musculoskeletal pain and the need for comprehensive assessments in primary care.</p><p><strong>Clinical trial number: </strong>This study was registered at Chinese Clinical Trials Registry (http://www.chictr.org.cn/) on August 12, 2024. Clinical trial number: ChiCTR2400088109.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"19 ","pages":"11795441261448562"},"PeriodicalIF":1.2,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13254153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Podiatric Treatment in Ledderhose Disease Management.","authors":"Roberto Tedeschi","doi":"10.1177/11795441251392297","DOIUrl":"10.1177/11795441251392297","url":null,"abstract":"<p><p>Ledderhose disease, or plantar fibromatosis, is a rare fibroproliferative disorder affecting the plantar fascia. Conservative management plays a crucial role in alleviating symptoms and maintaining function. This article explores the role of podiatric interventions, including custom orthotics, footwear modifications, manual therapy, and adjunctive modalities such as shockwave therapy. In addition, the role of regenerative medicine and the need for interdisciplinary rehabilitation strategies are discussed. Future research should focus on the efficacy of podiatric treatments and their integration into multidisciplinary care.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"19 ","pages":"11795441251392297"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescription Pattern and Safety of Biologics in Autoimmune Rheumatologic Diseases in Tertiary Care Hospital of Bihar.","authors":"Adil Ali Shakur, Raj Kumar, Raushan Kumar Ranjan, Saajid Hameed, Lalit Mohan","doi":"10.1177/11795441261448563","DOIUrl":"10.1177/11795441261448563","url":null,"abstract":"<p><strong>Background: </strong>Biologics have revolutionized the treatment of autoimmune rheumatologic diseases, but data on their real-world use and safety in resource-limited settings like Bihar, India, are scarce.</p><p><strong>Objectives: </strong>This study aimed to evaluate the prescription patterns and safety profile of biologic disease-modifying antirheumatic drugs (b-DMARDs) in patients with rheumatoid arthritis (RA) at a tertiary care hospital in Bihar.</p><p><strong>Design: </strong>A prospective, observational cohort study conducted over 12 months.</p><p><strong>Methods: </strong>A total of 120 adult patients with RA prescribed b-DMARDs were enrolled. Data on demographic, clinical characteristics, and treatment details were collected. Disease activity (DAS-28-CRP) and functional status (HAQ-DI) were assessed at baseline and 6 months. Adverse events, particularly infections, were recorded and analysed using multivariable logistic regression to identify risk factors.</p><p><strong>Results: </strong>Biologicals were prescribed in 14.93% patients with RA. Adalimumab (49.17%) was the most prescribed b-DMARD, followed by etanercept (28.33%). Methotrexate was the most common concomitant conventional DMARD (85.83%). All b-DMARDs significantly improved DAS-28-CRP and HAQ-DI scores (<i>P</i> < .0001), with adalimumab showing the greatest improvement. Infliximab had the highest infection rate (53.33%), whereas etanercept had the lowest (14.70%). Regression analysis identified infliximab use (adjusted odds ratio [aOR]: 3.27), concomitant corticosteroid use (aOR: 2.74), and the presence of comorbidities (aOR: 2.13) as significant independent risk factors for infection.</p><p><strong>Conclusion: </strong>Biologic disease-modifying antirheumatic drugs are effective in RA, but infection risks vary. Adalimumab and etanercept demonstrated favourable efficacy and safety profiles, respectively. Treatment decisions should be personalized, considering drug-specific risks, corticosteroid co-therapy, and patient comorbidities, especially in resource-constrained settings.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"19 ","pages":"11795441261448563"},"PeriodicalIF":1.2,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13187399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence Assessment of HTLV-1 and Its Related Risk Factors in Patients With Rheumatoid Arthritis in Gonabad in 2023.","authors":"Faeze Tehranian, Farhang Soltani Bajestani, Nasim Khajavian, Jafar Hajavi","doi":"10.1177/11795441261437811","DOIUrl":"10.1177/11795441261437811","url":null,"abstract":"<p><strong>Background: </strong>HTLV-1 infection has been demonstrated to induce both cellular and humoral immune responses, suggesting a probable role in the development and pathogenesis of autoimmune diseases.</p><p><strong>Objectives: </strong>The objective of the present study was to assess the prevalence of antibodies against HTLV-1 and its associated risk factors in patients diagnosed with rheumatoid arthritis who were referred to Allameh Bohlool Gonabadi Hospital in 2023.</p><p><strong>Design: </strong>This study is of a cross-sectional analytical nature. The study population comprised 107 patients diagnosed with rheumatoid arthritis. These patients were referred to the rheumatology clinic of Allameh Bohlool Gonabadi Hospital. The patients were selected for inclusion in the study on a random basis.</p><p><strong>Methods: </strong>The data collection instrument employed in this study was the demographic information checklist and the disease activity and severity questionnaire (Disease Activity Score 28 [DAS28]). A study was conducted to determine the prevalence of HTLV-1. Also, 2 mL of blood was collected from the research units, and then serum was isolated and stored at -20°C. The antibody levels were measured using an enzyme-linked immunosorbent assay (ELISA) kit. Following the collection of the data, it was subjected to analysis using SPSS version 20 software, with the Fisher's exact and independent samples T-tests employed at a significance level of less than 5%.</p><p><strong>Results: </strong>The mean age of the research units was 55.30 ± 12.45 years, and 82.2% of the subjects were female. The activity and severity of the disease were found to be average in 38.3% and 70.1% of the research units, respectively. A total of 2 positive HTLV-1 cases (1.9%) were identified among the study population. The investigation revealed that HTLV-1 infection demonstrated no substantial correlation with disease activity, disease severity, gender, education, history of smoking and alcohol consumption, age, and body mass index (<i>P</i> > .05).</p><p><strong>Conclusion: </strong>The prevalence of HTLV-1 infection among patients diagnosed with rheumatoid arthritis is not significant. Also, in this study, the impact of HTLV-1 infection on the activity and severity of rheumatoid arthritis was not found.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"19 ","pages":"11795441261437811"},"PeriodicalIF":1.2,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid Arthritis Exploratory Survey: Voices of Three Key Stakeholders (Patients, Caregivers, and Health Care Professionals).","authors":"Vandana Chaudhary","doi":"10.1177/11795441261446975","DOIUrl":"10.1177/11795441261446975","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disorder that is associated with reduced quality of life, physical and emotional distress, and financial strain on caregivers and health care systems. Although RA has been thoroughly researched, the psychological effects and lived experiences of patients and caregivers remain underexplored.</p><p><strong>Objectives: </strong>To evaluate the perspectives of patients with RA, caregivers, and health care professionals (HCPs) involved in RA management.</p><p><strong>Design: </strong>Online cross-sectional exploratory survey.</p><p><strong>Methods: </strong>The survey was conducted from December 20, 2024, to January 13, 2025, focusing on patients with RA, caregivers, and HCPs. Individualized questionnaires for each group collected data on disease impact, treatment experiences, mental well-being, and systemic deficiencies. Descriptive statistics were used to analyse and summarize the responses.</p><p><strong>Results: </strong>Out of 25 patient responders, majority were old females, with 60% reporting severe limitations in daily activities and 72% experiencing disrupted sleep and fatigue. Only 20% were satisfied with their treatment plans. Among 23 caregivers, 74% reported negative impacts on relationships and social lives, and 35% lacked adequate knowledge about RA. Of 13 HCPs, most prioritized patient education and identified treatment adherence, financial constraints, and communication gaps as major challenges. Only 46% routinely referred patients to support organizations.</p><p><strong>Conclusion: </strong>The study highlights areas related to patient-centred care, enhanced provider-patient communication, and improved caregiver support. The integration of psychosocial support and education into RA care strategies may support overall care approaches.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"19 ","pages":"11795441261446975"},"PeriodicalIF":1.2,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application Value of Blood Routine-Derived Indices for the Evaluation of Disease Activity in Systemic Lupus Erythematosus.","authors":"Ming Li, Yunfei Li, Lijun Pang, Junjie Chen, Shuangshuang Shang, Chuanbing Huang","doi":"10.1177/11795441261436819","DOIUrl":"10.1177/11795441261436819","url":null,"abstract":"<p><strong>Background: </strong>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organ systems, characterized by heterogeneous pathogenesis, diverse clinical manifestations, prolonged disease course, and substantial morbidity and mortality.</p><p><strong>Objectives: </strong>This study aimed to systematically evaluate the clinical value of 11 hematological indices derived from routine blood tests in assessing disease activity in patients with SLE.</p><p><strong>Design: </strong>This retrospective observational study analyzed the correlation between hematological biomarkers and clinical disease activity indicators in enrolled patients. Receiver-operating characteristic (ROC) curves were employed to evaluate the predictive efficacy of each indicator for disease activity, while binary logistic regression analysis was used to identify independent risk factors influencing disease activity.</p><p><strong>Methods: </strong>Clinical and laboratory data from 100 patients with SLE were retrospectively analyzed. Associations between blood routine-derived indices and disease activity were assessed. Receiver-operating characteristic curves were used to evaluate the predictive performance of these indices for SLE activity, and binary logistic regression analysis was conducted to identify independent risk factors.</p><p><strong>Results: </strong>Compared with healthy controls, patients with SLE exhibited significantly higher levels of platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), aggregated inflammatory systemic index (AISI), derived neutrophil-to-lymphocyte ratio (dNLR), neutrophil-to-lymphocyte-platelet ratio (NLPR), monocyte-to-lymphocyte ratio (MLR), and RDW/PLT ratio (RPR) (all <i>P</i> < .05), whereas HGB/RDW ratio (HBR) was significantly lower. Disease activity was positively correlated with SIRI, SII, AISI, PLR, NLR, dNLR, NLPR, and MLR (<i>P</i> < .05 or <i>P</i> < .01), while mean platelet volume-to-platelet ratio (MPR) and RPR showed significant negative correlations with disease severity. The ROC analysis demonstrated that SIRI, SII, AISI, PLR, NLR, dNLR, NLPR, MLR, RPR, and a combined predictive model effectively discriminated active disease, with the combined model yielding the highest area under the curve (AUC). Among individual indices, SII and NLR showed the strongest predictive performance.</p><p><strong>Conclusion: </strong>Blood routine-derived inflammatory indices, particularly SII and NLR, are effective tools for evaluating disease activity in SLE. After adjustment for potential confounders, elevated SII was identified as an independent risk factor for increased disease activity, highlighting its potential clinical utility in routine assessment of patients with SLE.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"19 ","pages":"11795441261436819"},"PeriodicalIF":1.2,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-6 as a Marker of Joint Damage in Osteoarthritis: A Study of Its Pro-inflammatory Impacts.","authors":"Dwitya Elvira, Dela Hangri Jalmas","doi":"10.1177/11795441261436818","DOIUrl":"10.1177/11795441261436818","url":null,"abstract":"<p><strong>Background: </strong>Osteoarthritis (OA) is a degenerative joint disease characterized by a complex pathophysiology involving inflammatory biomarkers.</p><p><strong>Objectives: </strong>The current study aimed to investigate the correlation between interleukin-6 (IL-6) serum levels and joint space narrowing (JSN) in patients with knee OA.</p><p><strong>Design: </strong>A total of 46 patients clinically diagnosed with knee OA were included in this study.</p><p><strong>Methods: </strong>Joint space narrowing was measured using radiographic examinations, whereas blood serum levels of IL-6 were quantified using enzyme-linked immunosorbent assay. Statistical analysis was performed to determine the relationship between IL-6 and JSN.</p><p><strong>Results: </strong>The average level of IL-6 was 117.61 (67.05) ng/mL, with JSN measurement of 1.76 (1.31) mm. An inverse correlation found between IL-6 levels and the size of the gap joints in patients with knee OA (<i>r</i> = -.298; <i>P</i> = .044).</p><p><strong>Conclusion: </strong>An inverse correlation exists between IL-6 levels and joint impairment in knee OA, suggesting that inflammation plays a crucial role in the progression of the disease.</p>","PeriodicalId":10443,"journal":{"name":"Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders","volume":"19 ","pages":"11795441261436818"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13049335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}