Soft Matter最新文献_第4页

Src kinase slows collective rotation of confined epithelial cell monolayers. Src激酶可减缓封闭上皮细胞单层的集体旋转。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-15 DOI: 10.1039/d4sm00827h

Nastassia Pricoupenko, Flavia Marsigliesi, Philippe Marcq, Carles Blanch-Mercader, Isabelle Bonnet

{"title":"Src kinase slows collective rotation of confined epithelial cell monolayers.","authors":"Nastassia Pricoupenko, Flavia Marsigliesi, Philippe Marcq, Carles Blanch-Mercader, Isabelle Bonnet","doi":"10.1039/d4sm00827h","DOIUrl":"https://doi.org/10.1039/d4sm00827h","url":null,"abstract":"Collective cell migration is key during development, wound healing, and metastasis and relies on coordinated cell behaviors at the group level. Src kinase is a key signalling protein for the physiological functions of epithelia, as it regulates many cellular processes, including adhesion, motility, and mechanotransduction. Its overactivation is associated with cancer aggressiveness. Here, we take advantage of optogenetics to precisely control Src activation in time and show that its pathological-like activation slows the collective rotation of epithelial cells confined into circular adhesive patches. We interpret velocity, force, and stress data during period of non-activation and period of activation of Src thanks to a hydrodynamic description of the cell assembly as a polar active fluid. Src activation leads to a 2-fold decrease in the ratio of polar angle to friction, which could result from increased adhesiveness at the cell-substrate interface. Measuring internal stress allows us to show that active stresses are subdominant compared to traction forces. Our work reveals the importance of fine-tuning the level of Src activity for coordinated collective behaviors.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interfacial viscoelasticity in oscillating drops of cyclodextrin-surfactant aqueous solution: experiments and theory. 环糊精-表面活性剂水溶液振荡液滴中的界面粘弹性：实验与理论。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-14 DOI: 10.1039/d4sm01007h

J Roberto Romero-Arias, Alberto S Luviano, Miguel Costas, Aurora Hernández-Machado, Rafael A Barrio

引用次数: 0

Co-assembly of cellulose nanocrystals and gold nanorods: insights from molecular dynamics modelling. 纤维素纳米晶体与金纳米棒的共组装：分子动力学建模的启示。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-14 DOI: 10.1039/d4sm00871e

Jiaxin Hou, William Sampson, Ahu Gümrah Dumanli

引用次数: 0

Hydrogel-based 3D fabrication of multiple replicas with varying sizes and materials from a single template via iterative shrinking. 基于水凝胶的三维制造技术，通过迭代收缩，从单一模板中制造出多个不同尺寸和材料的复制品。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-14 DOI: 10.1039/d4sm00835a

Eunseok Heo, Hye Been Koo, Jun Chang Yang, In Cho, Hyun-Hee Lee, Yong-Jin Yoon, Steve Park, Jae-Byum Chang

{"title":"Hydrogel-based 3D fabrication of multiple replicas with varying sizes and materials from a single template via iterative shrinking.","authors":"Eunseok Heo, Hye Been Koo, Jun Chang Yang, In Cho, Hyun-Hee Lee, Yong-Jin Yoon, Steve Park, Jae-Byum Chang","doi":"10.1039/d4sm00835a","DOIUrl":"https://doi.org/10.1039/d4sm00835a","url":null,"abstract":"3D printing technologies have been widely used for the rapid prototyping of 3D structures, but their application in a broader context has been hampered by their low printing throughput. For the same structures to be produced in a variety of sizes and materials, each must be printed separately, which increases time and cost. Replicating 3D-printed structures in a variety of sizes using a molding process with size-tunable molds could be a solution, but it has only been applied to simple structures, such as those with tapered or vertical profiles. This work demonstrates the generation of multiple replicas of varying sizes and materials from a single 3D-printed template with complex geometries by using molds made of stretchable hydrogel that shrink isotropically. We optimize hydrogel compositions to synthesize a hydrogel that is highly stretchable and shrinks isotropically in all directions. The high stretchability of this hydrogel allows for the removal of complex 3D-printed templates from hydrogel molds. The cavities of the hydrogel molds are then filled with polycaprolactone (PCL) and dried at 80 °C. As the hydrogel shrinks due to drying, the melted PCL fragments completely fill the cavities. The entire process can be repeated to produce multiple replicas in a variety of sizes and materials. Replicas that are one-tenth of the size of the original printed template can be produced. Finally, we demonstrate how our method can be used to reduce the size of interconnected geometries, which would be impossible to achieve using traditional molding processes.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling nematic phase main-chain liquid crystal elastomer synthesis, mechanics, and thermal actuation via coarse-grained molecular dynamics. 通过粗粒度分子动力学模拟向列相主链液晶弹性体的合成、力学和热致动。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-14 DOI: 10.1039/d4sm00528g

Nicolas Herard, Raja Annapooranan, Todd Henry, Martin Kröger, Shengqiang Cai, Nicholas Boechler, Yelena Sliozberg

{"title":"Modeling nematic phase main-chain liquid crystal elastomer synthesis, mechanics, and thermal actuation via coarse-grained molecular dynamics.","authors":"Nicolas Herard, Raja Annapooranan, Todd Henry, Martin Kröger, Shengqiang Cai, Nicholas Boechler, Yelena Sliozberg","doi":"10.1039/d4sm00528g","DOIUrl":"https://doi.org/10.1039/d4sm00528g","url":null,"abstract":"This paper presents a coarse-grained molecular dynamics simulation study of the synthesis, mechanics, and thermal actuation of nematic phase main-chain liquid crystal elastomers (LCEs), a type of soft, temperature-responsive, polymeric actuating material. The simulations herein model the crosslinking, mechanical stretching, and additional crosslinking synthesis process, following which, the simulated LCE exhibits a direction-dependent thermal actuation and mechanical response. The thermal actuation response shows good qualitative agreement with experimental results, including the variation of a global order parameter that describes the orientation of the mesogen domains comprising the LCE. The mechanical response due to applied deformation shows less agreement, but manifests the key features observed in experiments on LCEs, namely soft strain and hyperelasticity that is present when loaded perpendicularly and in-line, respectively, to the mesogen alignment direction. We also present a topological analysis of the simulated LCEs, which, in conjunction with the simulated thermomechanical responses, allows us to infer the relative contribution of entanglements and chemical crosslinks on those responses. We suggest that the model proposed herein will help enable improved LCE formulations via mechanistic insights that can be gained via the use of such a relatively computationally inexpensive coarse-grained molecular dynamics model, which may be of further value to application areas including soft robotics, bio-mimicking devices, artificial muscles, and adaptive materials.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding polymer-colloid gels: a solvent perspective using low-field NMR. 了解聚合物胶体凝胶：利用低场核磁共振的溶剂视角。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-13 DOI: 10.1039/d4sm01098a

Léo Hervéou, Gauthier Legrand, Thibaut Divoux, Guilhem P Baeza

引用次数: 0

Enhanced gravitational trapping of bottom-heavy Janus particles over parallel microgrooves. 在平行微槽上增强底重 Janus 粒子的引力捕获。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-13 DOI: 10.1039/d4sm00989d

Yan Wen, Jiayu Liu, Wei Wang, Pik-Yin Lai, Penger Tong

{"title":"Enhanced gravitational trapping of bottom-heavy Janus particles over parallel microgrooves.","authors":"Yan Wen, Jiayu Liu, Wei Wang, Pik-Yin Lai, Penger Tong","doi":"10.1039/d4sm00989d","DOIUrl":"https://doi.org/10.1039/d4sm00989d","url":null,"abstract":"We report a systematic study on the barrier-crossing dynamics of bottom-heavy self-propelled particles (SPPs) over a one-dimensional periodic potential landscape U0(x), which is fabricated on a microgroove-patterned polydimethylsiloxane (PDMS) substrate. From the measured steady-state probability density function (PDF) P(x;F0) of the SPPs with different self-propulsion forces F0, we find that the escape dynamics of slow-rotating SPPs over the periodic potential U0(x) can be well described by an activity-dependent potential Ũ0(x;F0) under the fixed angle approximation. A theoretical model is developed to include the effects of the gravitational-torque-induced alignment on the polar angle θ and the hydrodynamic wall alignment on the azimuthal angle φ as well as their influence on the self-propulsion speed v0. By introducing a proper average of the activity-dependent potential Ũ0(x;F0) over all possible particle orientations, our model explains the enhanced trapping effect on the bottom-heavy Janus particles. The obtained theoretical results are in good agreement with both the experimental and active Brownian particle simulation results. This work thus provides a thermodynamics description of the non-equilibrium barrier crossing of the Janus particles with nonuniform angular distributions over periodic potentials.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Percolation transitions in a binary mixture of active Brownian particles with different softness. 具有不同软度的活性布朗粒子二元混合物中的渗流转变。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-12 DOI: 10.1039/d4sm00981a

Monika Sanoria, Raghunath Chelakkot, Amitabha Nandi

{"title":"Percolation transitions in a binary mixture of active Brownian particles with different softness.","authors":"Monika Sanoria, Raghunath Chelakkot, Amitabha Nandi","doi":"10.1039/d4sm00981a","DOIUrl":"https://doi.org/10.1039/d4sm00981a","url":null,"abstract":"Homogeneous active Brownian particle (ABP) systems with purely repulsive interactions are considered to exhibit a simple phase behavior, but various physical attributes of active entities can lead to variation in the collective dynamics. Recent studies have shown that even homogeneous ABPs exhibit complex behavior due to an interplay between particle softness and motility. However, the heterogeneity in the composition of ABPs has not been explored yet. In this paper, we study the structural properties of a binary mixture of ABPs with different particle softness by varying the relative softness and composition. We found that upon varying the motility parameter, the system underwent a motility-induced phase separation (MIPS) followed by a percolation transition similar to the homogeneous systems. However, we observed a novel feature: the formation of a space-filling structure made of particles with higher stiffness, within the dense cluster of MIPS containing both types of particles. Our systematic analysis shows that this structure formation occurs only if the difference in softness of both types of particles is sufficiently large. Furthermore, the presence of a non-linear scaling for different compositions of binary ABPs suggests that there is a complex relationship between the composition and the structural properties. Our study demonstrates that the composition heterogeneity of ABPs can lead to complex phase behavior.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of active agent motility on SIRS epidemiological dynamics. 活性病原体运动对 SIRS 流行动态的影响。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-12 DOI: 10.1039/d4sm00864b

R Kailasham, Aditya S Khair

引用次数: 0

Biomimetic mineralization of positively charged silica nanoparticles templated by thermoresponsive protein micelles: applications to electrostatic assembly of hierarchical and composite superstructures. 以热膨胀蛋白胶束为模板的带正电的二氧化硅纳米粒子的仿生矿化：应用于分层和复合超结构的静电组装。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-11 DOI: 10.1039/d4sm00907j

Nada Y Naser, William C Wixson, Helen Larson, Brandi M Cossairt, Lilo D Pozzo, François Baneyx

{"title":"Biomimetic mineralization of positively charged silica nanoparticles templated by thermoresponsive protein micelles: applications to electrostatic assembly of hierarchical and composite superstructures.","authors":"Nada Y Naser, William C Wixson, Helen Larson, Brandi M Cossairt, Lilo D Pozzo, François Baneyx","doi":"10.1039/d4sm00907j","DOIUrl":"https://doi.org/10.1039/d4sm00907j","url":null,"abstract":"High information content building blocks offer a path toward the construction of precision materials by supporting the organization and reconfiguration of organic and inorganic components through engineered functions. Here, we combine thermoresponsiveness with biomimetic mineralization by fusing the Car9 silica-binding dodecapeptide to the C-terminus of the (VPGVG)54 elastin-like polypeptide (ELP). Using small angle X-ray scattering, we show that the short Car9 cationic block is sufficient to promote the conversion of disordered unimers into 30 nm micelles comprising about 150 proteins, 5 °C above the transition temperature of the ELP. While both species catalyze self-limiting silica precipitation, micelles template the mineralization of highly monodisperse (62 nm) nanoparticles, while unimers yield larger polydisperse species. Strikingly, and unlike traditional synthetic silica, these particles exhibit a positive surface charge, likely due to cationic Car9 sidechains projecting from their surface. Capitalizing on the high monodispersity and positive charge of the micelle-templated products, we use smaller silica and gold particles bearing a native negative charge to create a variety of superstructures via electrostatic co-assembly. This simple biomimetic route to positively charged silica eliminates the need for multiple precursors or surface modifications and enables the rapid creation of single-material and composite architectures in which components of different sizes or compositions are well dispersed and integrated.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0