Soft Matter最新文献_第4页

Impact of rheology on formation of oil-in-liquid metal emulsions†

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-29 DOI: 10.1039/D4SM01361A

Shreyas Kanetkar, Sai P. Peri, Husain Mithaiwala, Febby Krisnadi, Michael D. Dickey, Matthew D. Green, Robert Y. Wang and Konrad Rykaczewski

引用次数: 0

Comparative evaluation of melt- vs. solution-printed poly(ε-caprolactone)/hydroxyapatite scaffolds for bone tissue engineering applications.

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-29 DOI: 10.1039/d4sm01197j

Hadis Gharacheh, Alperen Abaci, Keven Alkhoury, Ediha Choudhury, Chya-Yan Liaw, Shawn A Chester, Murat Guvendiren

{"title":"Comparative evaluation of melt- vs. solution-printed poly(ε-caprolactone)/hydroxyapatite scaffolds for bone tissue engineering applications.","authors":"Hadis Gharacheh, Alperen Abaci, Keven Alkhoury, Ediha Choudhury, Chya-Yan Liaw, Shawn A Chester, Murat Guvendiren","doi":"10.1039/d4sm01197j","DOIUrl":"10.1039/d4sm01197j","url":null,"abstract":"Material extrusion-based three-dimensional (3D) printing is a widely used manufacturing technology for fabricating scaffolds and devices in bone tissue engineering (BTE). This technique involves two fundamentally different extrusion approaches: solution-based and melt-based printing. In solution-based printing, a polymer solution is extruded and solidifies via solvent evaporation, whereas in melt-based printing, the polymer is melted at elevated temperatures and solidifies as it cools post-extrusion. Solution-based printing can also be enhanced to generate micro/nano-scale porosity through phase separation by printing the solution into a nonsolvent bath. The choice of the printing method directly affects scaffold properties and the biological response of stem cells. In this study, we selected polycaprolactone (PCL), a biodegradable polymer frequently used in BTE, blended with hydroxyapatite (HA) nanoparticles, a bioceramic known for promoting bone formation, to investigate the effects of the printing approach on scaffold properties and performance in vitro using human mesenchymal stem cells (hMSCs). Our results showed that while both printing methods produced scaffolds with similar strut and overall scaffold dimensions, solvent-based printing resulted in porous struts, higher surface roughness, lower stiffness, and increased crystallinity compared to melt-based printing. Although stem cell viability and proliferation were not significantly influenced by the printing approach, melt-printed scaffolds promoted a more spread morphology and exhibited pronounced vinculin staining. Furthermore, composite scaffolds outperformed their neat counterparts, with melt-printed composite scaffolds significantly enhancing bone formation. This study highlights the critical role of the printing process in determining scaffold properties and performance, providing valuable insights for optimizing scaffold design in BTE.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probing the binding mode and interactions of proteinase K and glutathione: molecular simulation and experiments†

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-29 DOI: 10.1039/D4SM01039F

Yuan Yang, Bianxiang Zhang and Jian Zhang

{"title":"Probing the binding mode and interactions of proteinase K and glutathione: molecular simulation and experiments†","authors":"Yuan Yang, Bianxiang Zhang and Jian Zhang","doi":"10.1039/D4SM01039F","DOIUrl":"10.1039/D4SM01039F","url":null,"abstract":"Proteinase K, a serine protease from Tritirachium album Limber, is crucial in research due to its potent proteolytic activity, which relies on conformational stability and substrate affinity. Glutathione (GSH), an essential intracellular antioxidant, regulates various physiological processes by interacting with proteins, influencing their stability and function. Despite the importance of both proteinase K and GSH, their potential interaction remains unexplored. Understanding this interaction could uncover new regulatory mechanisms affecting proteinase K, with significant implications for research and therapeutic applications. In this study, we systematically investigated the binding of GSH to proteinase K using a comprehensive approach in which theoretical and experimental methods mutually validate each other. Molecular docking determined the binding mode and the interaction mechanism of proteinase K and GSH. Molecular dynamics (MD) simulations revealed that GSH binding significantly improved the stability of proteinase K, affirming the binding process was spontaneous, with hydrogen bonds and van der Waals forces emerging as the predominant contributors throughout the interaction. At the same time, the fluorescence spectrum and circular dichroism spectrum confirmed the interaction mechanism between GSH and proteinase K, as well as the conformational changes of proteinase K induced by GSH binding. We believe this study could offer valuable insights for future research into the structure and binding dynamics of other protein–ligand complexes under physiological conditions.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 48","pages":" 9654-9663"},"PeriodicalIF":2.9,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collective motion of energy depot active disks. 能量仓库活动盘的集体运动。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-27 DOI: 10.1039/d4sm00785a

Juan Pablo Miranda, Demian Levis, Chantal Valeriani

引用次数: 0

Nanogels with tailored hydrophobicity and their behavior at air/water interfaces†

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-27 DOI: 10.1039/D4SM01186D

Ruiguang Cui, Maret Ickler, Johannes Menath, Nicolas Vogel and Daniel Klinger

{"title":"Nanogels with tailored hydrophobicity and their behavior at air/water interfaces†","authors":"Ruiguang Cui, Maret Ickler, Johannes Menath, Nicolas Vogel and Daniel Klinger","doi":"10.1039/D4SM01186D","DOIUrl":"10.1039/D4SM01186D","url":null,"abstract":"The interfacial behavior of micro-/nanogels is governed to a large extent by the hydrophobicity of their polymeric network. Prevailing studies to examine this influence mostly rely on external stimuli like temperature or pH to modulate the particle hydrophobicity. Here, a sudden transition between hydrophilic and hydrophobic state prevents systematic and gradual modulation of hydrophobicity. This limits detailed correlations between interfacial behavior and network hydrophobicity. To address this challenge, we introduce a nanogel platform that allows accurate tuning of hydrophobicity on a molecular level. For this, via post-functionalization of active ester-based particles, we prepare poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) nanogels as a hydrophilic benchmark and introduce gradually varied amounts of hydrophobic propyl or dodecyl moieties to increase the nanogel hydrophobicity. We study the deformation and arrangement of these particles at an air/water interface and correlate the results with quantitative measures for nanogel hydrophobicity. We observe that increasing hydrophobicity of nanogels, either by increasing the hydrophobic moiety ratio or the alkyl chain length, leads to decreased particle deformability and aggregation of an interfacially-adsorbed monolayer. Contrary to what may be intuitively assumed, these changes are not gradual, but rather occur suddenly above a threshold in hydrophobicity. Our study further shows that the effect of hydrophobicity affects the nanogel properties differently in bulk and when adsorbed at liquid interfaces. Thus, this study establishes the transition of interfacial behavior between soft gel-like particles to a solid spherical morphology triggered by the increase in hydrophobicity.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 1","pages":" 100-112"},"PeriodicalIF":2.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/sm/d4sm01186d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of layered carbon nitride/titanium-based metal skeleton materials and study on their electrorheological properties†

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-27 DOI: 10.1039/D4SM01247J

Liangkun Chen, Xiang Ji, Haochun Yan, Liyue Wang, Yusheng Lin, Baoxiang Wang and Chuncheng Hao

{"title":"Preparation of layered carbon nitride/titanium-based metal skeleton materials and study on their electrorheological properties†","authors":"Liangkun Chen, Xiang Ji, Haochun Yan, Liyue Wang, Yusheng Lin, Baoxiang Wang and Chuncheng Hao","doi":"10.1039/D4SM01247J","DOIUrl":"10.1039/D4SM01247J","url":null,"abstract":" Background: as an intelligent material, electrorheological fluids (ERFs) comprise a suspension system consisting of dielectric particles and/or their composites dispersed in an insulating liquid. In this article, MOF/g-C3N4 composite nanoparticles were successfully synthesized and demonstrated an excellent ER effect. Methods: first, the precursor for g-C3N4 was synthesized using a high-temperature calcination method, followed by the in situ synthesis of MIL-125 (MOF-Ti) on the surface of layered graphitic carbon nitride using a solvothermal approach. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses were used to reveal the presence of numerous MOF particles deposited onto the surfaces of layered g-C3N4 nanosheets. X-ray powder diffraction confirmed the growth of MOF particles on the g-C3N4 precursor. The chemical composition and states were characterized through Fourier-transform infrared (FT-IR) spectroscopy and X-ray photoelectron (XPS) analyses. Additionally, BET analysis indicated the presence of abundant pore structures in the MOF/g-C3N4 composite nanoparticles. Results: lastly, rheological and dielectric properties were investigated. The ER behavior demonstrated their excellent performance, with a 10 wt% mass fraction suspension of the MOF/g-C3N4-0.4 based composite material and dimethyl silicone oil exhibiting a yield stress of 300 Pa at 2 kV mm−1.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 1","pages":" 87-99"},"PeriodicalIF":2.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional hybrid poly(ester-urethane)urea/resveratrol electrospun nanofibers for a potential vascularizing matrix†

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-26 DOI: 10.1039/D4SM00937A

Chen Liang, Yanan Wang, Renliang Zhao, Juan Du, Jin Yao, Atta ur Rehman Khan, Youwei Zhu, Huitang Xia and Tonghe Zhu

{"title":"Multifunctional hybrid poly(ester-urethane)urea/resveratrol electrospun nanofibers for a potential vascularizing matrix†","authors":"Chen Liang, Yanan Wang, Renliang Zhao, Juan Du, Jin Yao, Atta ur Rehman Khan, Youwei Zhu, Huitang Xia and Tonghe Zhu","doi":"10.1039/D4SM00937A","DOIUrl":"10.1039/D4SM00937A","url":null,"abstract":"The challenges for clinical application of small-diameter vascular graft are mainly acute/chronic thrombosis, inadequate endothelialization, intimal hyperplasia caused by inflammation, oxidative stress, and the mismatch of mechanical compliance after transplantation. How to construct an effective regenerative microenvironment through a material with uniform dispersion of active components is the premise of maintaining patency of a vascular graft. In this study, we have compounded poly(ester-urethane)urea (PEUU) with various optimized concentrations of resveratrol (Res) by homogeneous emulsion blending, followed by electrospinning into the hybrid PEUU/Res nanofibers (P/R-0, P/R-0.5, P/R-1.0, and P/R-1.5). Then the microstructure, surface wettability, mechanical properties, degradation, Res sustained release properties, hemocompatibility, and cytocompatibility of P/R were evaluated comprehensively. The results indicate that Res can be gradually released from the P/R, and both the hydrophilicity and antioxidant ability of the nanofiber gradually increase with the increase of Res content. Moreover, with the increase of Res, the viability and proliferation behavior of HUVECs were significantly improved. Meanwhile, tube formation and migration experiments showed that Res promoted the formation of a neovascularization network. In brief, it is concluded that P/R-1.0 is the optimal candidate with a uniform microstructure, moderate wettability, optimized mechanical properties, reliable hemocompatibility and cytocompatibility, and strongest ability to promote endothelial growth for the vascularizing matrix.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 1","pages":" 55-67"},"PeriodicalIF":2.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crowding effects on the structure and rheology of ultrasoft PNIPAM–PEGMA copolymer microgels†

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-26 DOI: 10.1039/D4SM01103A

Gavino Bassu, Jacopo Vialetto, José Ruiz-Franco, Andrea Scotti, Judith E. Houston, Jitendra Mata, Emanuela Zaccarelli and Marco Laurati

{"title":"Crowding effects on the structure and rheology of ultrasoft PNIPAM–PEGMA copolymer microgels†","authors":"Gavino Bassu, Jacopo Vialetto, José Ruiz-Franco, Andrea Scotti, Judith E. Houston, Jitendra Mata, Emanuela Zaccarelli and Marco Laurati","doi":"10.1039/D4SM01103A","DOIUrl":"10.1039/D4SM01103A","url":null,"abstract":"We investigate the link between the internal microstructure of poly(N-isopropylacrylamide)–poly(ethylene glycol) methyl ether methacrylate (PNIPAM–PEGMA) microgels, their bulk moduli and the rheological response and structural arrangement in dense suspensions. The low degree of crosslinking combined with the increased hydrophilicity induced by the presence of PEGMA results in a diffuse, star-like density profile of the particle and very low values of the bulk modulus in dilute conditions, as determined by small angle neutron scattering (SANS). The ultrasoft nature of the particle is reflected in the changes of the structural arrangement in dense suspensions, which evidence a strong deswelling and a sharp rise of the bulk modulus at moderate packing fractions. At larger packings the single particle morphology and softness saturate, and we observe a structural transition from a dispersion-like to a hydrogel-like behavior. The transition is also reflected in the rheological response in the form of a two-step yielding at large packing fractions, characteristic of systems in which a network structure is present. Our results demonstrate that a knowledge of the internal structure and mechanics of individual microgels is needed to determine and tune the properties of dense suspensions, and optimize their response for applications in biomedicine and as filtration systems.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 1","pages":" 68-76"},"PeriodicalIF":2.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/sm/d4sm01103a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical model for the motion and interaction of two-dimensional active nematic defects†

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-26 DOI: 10.1039/D4SM00956H

Cody D. Schimming, C. J. O. Reichhardt and C. Reichhardt

{"title":"Analytical model for the motion and interaction of two-dimensional active nematic defects†","authors":"Cody D. Schimming, C. J. O. Reichhardt and C. Reichhardt","doi":"10.1039/D4SM00956H","DOIUrl":"10.1039/D4SM00956H","url":null,"abstract":"We develop an approximate, analytical model for the velocity of defects in active nematics by combining recent results for the velocity of topological defects in nematic liquid crystals with the flow field generated from individual defects in active nematics. Importantly, our model takes into account the long-range interactions between defects that result from the flows they produce as well as the orientational coupling between defects inherent in nematics. Our work complements previous studies of active nematic defect motion by introducing a linear approximation that allows us to treat defect interactions as two-body interactions and incorporates the hydrodynamic screening length as a tuning parameter. We show that the model can analytically predict bound states between two +1/2 winding number defects, effective attraction between two −1/2 defects, and the scaling of a critical unbinding length between ±1/2 defects with activity. The model also gives predictions for the trajectories of defects, such as the scattering of +1/2 defects by −1/2 defects at a critical impact parameter that depends on activity. In the presence of circular confinement, the model predicts a braiding motion for three +1/2 defects that was recently seen in experiments, as well as stable and ergodic trajectories for four or more defects.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 1","pages":" 122-136"},"PeriodicalIF":2.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Composite of knitted fabric and soft matrix. I. Crack growth in the course direction† 针织物与软基体的复合材料。I. 裂纹沿走向生长。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-26 DOI: 10.1039/D4SM01114G

Fengkai Liu, Xi Chen, Zhigang Suo and Jingda Tang

{"title":"Composite of knitted fabric and soft matrix. I. Crack growth in the course direction†","authors":"Fengkai Liu, Xi Chen, Zhigang Suo and Jingda Tang","doi":"10.1039/D4SM01114G","DOIUrl":"10.1039/D4SM01114G","url":null,"abstract":"A composite of a knitted fabric and a soft matrix enables applications that require low stiffness and high crack resistance. Examples include heart valves and stretchable strain sensors. Here we study processes of crack growth in such a composite under monotonic and cyclic stretch. We fabricate a composite using a knitted fabric of nylon yarn and an elastomer matrix of polycarbonate urethane. We precut a sample with a crack, monotonically stretch the sample, and observe the growth of the crack. The crack grows in the matrix as the yarn slips and breaks. The stretch is converted to energy release rate G. We identify two critical energy release rates, GA and GB. When G < GA, the yarn does not slip, and the crack does not grow in the matrix. When GA < G < GB, the yarn slips but does not break, and the crack grows in the matrix stably and arrests when the stretch stops increasing. When G = GB, the yarn slips and breaks, while the crack grows unstably. When the sample is subject to cyclic stretch, we observe analogous behavior of crack growth and arrest, as well as yarn slip and yarn break. However, the two critical values, Ga and Gb, are much smaller than the corresponding values under monotonic stretch.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 48","pages":" 9614-9621"},"PeriodicalIF":2.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0