Soft Matter最新文献_第4页

Microneedle arrays coated with Middle East respiratory syndrome coronavirus DNA vaccine via electrospray deposition.

IF 2.9 3区化学

Soft Matter Pub Date : 2025-03-28 DOI: 10.1039/d4sm01322k

Sarah H Park, Isha R Shah, Nandita C Jhumur, Yaxin Mo, Shalaka Tendolkar, Emran O Lallow, Jerry W Shan, Jeffrey D Zahn, Joel N Maslow, Assimina A Pelegri, Hao Lin, David I Shreiber, Jonathan P Singer

{"title":"Microneedle arrays coated with Middle East respiratory syndrome coronavirus DNA vaccine via electrospray deposition.","authors":"Sarah H Park, Isha R Shah, Nandita C Jhumur, Yaxin Mo, Shalaka Tendolkar, Emran O Lallow, Jerry W Shan, Jeffrey D Zahn, Joel N Maslow, Assimina A Pelegri, Hao Lin, David I Shreiber, Jonathan P Singer","doi":"10.1039/d4sm01322k","DOIUrl":"https://doi.org/10.1039/d4sm01322k","url":null,"abstract":"Microneedle arrays have been shown to be a minimally invasive method of transdermal drug delivery. However, methods to coat these arrays often require a reservoir of the active ingredient, leading to unused and wasted material. Electrospray deposition is a targeted coating method that offers a competitive alternative for coating microneedles. By architecting the charge landscape of the setup, this technology can achieve coating deposition efficiencies nearing 100%, with little to no material wasted during the coating process. A Middle East respiratory syndrome coronavirus DNA vaccine was used as the model material to assess deposition efficiency as well as the efficacy of fragile biological materials subjected to electrospray deposition. Trehalose and polystyrene-block-polyacrylic acid were used as excipients to encourage coating dispersion. These coatings were inserted into Sprague Dawley rats where the antigen was subsequently detected and located using immunohistochemistry. Both coatings, with and without excipients, showed that protein expression is achieved after the vaccine is subjected to electrospray, however, the presence of excipients qualitatively leads to a more disperse diffusion profile. Further, this work demonstrates the capability of electrospray deposition as a highly efficient method to coat microneedles for transdermal drug delivery.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kovacs-like memory effect in a sheared colloidal glass: role of non-affine flows†

IF 2.9 3区化学

Soft Matter Pub Date : 2025-03-28 DOI: 10.1039/D4SM01514B

Maitri Mandal, Abhishek Ghadai, Rituparno Mandal and Sayantan Majumdar

{"title":"Kovacs-like memory effect in a sheared colloidal glass: role of non-affine flows†","authors":"Maitri Mandal, Abhishek Ghadai, Rituparno Mandal and Sayantan Majumdar","doi":"10.1039/D4SM01514B","DOIUrl":"10.1039/D4SM01514B","url":null,"abstract":"Memory effect reflects a system's ability to encode, retain and retrieve information about its past. Such effects are essentially an out-of-equilibrium phenomenon providing insight into the complex structural and dynamical behavior of the system. Kovacs effect is one such memory effect that is traditionally associated with thermal history. Although studies on the Kovacs-like memory effect have been extended to mechanical perturbations such as compression–decompression, whether such effects can also be observed under volume-conserving perturbations like shear, remains unclear. Combining experiments, simulations and linear response theory we demonstrate Kovacs-like memory effect in a sheared colloidal glass. Moreover, we explore the influence of non-linear perturbations and establish a correlation between the deviation from linear response prediction and microscopic non-affine flows generated due to such large deformations in affecting the memory effect. Our study not only extends Kovacs-like memory effect in the domain of volume-conserving mechanical perturbations, it also highlights the importance of the nature of underlying microscopic flows in controlling the bulk stress relaxation, affecting the Kovacs-like memory effect in amorphous materials.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 15","pages":" 2958-2966"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How does a polymer glass resist fatigue crack growth?†

IF 2.9 3区化学

Soft Matter Pub Date : 2025-03-28 DOI: 10.1039/D4SM01521E

Christine Heera Ahn, Zheqi Chen, Xianyang Bao and Zhigang Suo

引用次数: 0

Mesoscopic study of smart dendritic-polymeric micelles for the removal of hormonal contraceptives from polluted aqueous environments

IF 2.9 3区化学

Soft Matter Pub Date : 2025-03-27 DOI: 10.1039/D5SM00272A

César Soto-Figueroa, Tomas Galicia-Garcia, Armando Sebastián Pérez-Rodríguez, María del Rosario Rodríguez-Hidalgo and Luis Vicente

{"title":"Mesoscopic study of smart dendritic-polymeric micelles for the removal of hormonal contraceptives from polluted aqueous environments","authors":"César Soto-Figueroa, Tomas Galicia-Garcia, Armando Sebastián Pérez-Rodríguez, María del Rosario Rodríguez-Hidalgo and Luis Vicente","doi":"10.1039/D5SM00272A","DOIUrl":"10.1039/D5SM00272A","url":null,"abstract":"The ability of new smart dendritic-polymeric micelles (Boltorn-H40-P(NPAM)-P(NIPAM)) to extract hormonal contraceptives from polluted aqueous environments was investigated using dissipative particle dynamics (DPD) simulations and coarse-grained models. Mesoscopic results indicated that these dendritic-polymeric micelles exhibit stimulus sensitivity at two low critical solution temperatures (LCST's). Thermal scans revealed that the micelles generate distinct temperature-dependent miscibility intervals: below the LCST, a thermodynamically stable micellar system is formed, while above the LCST, the system loses miscibility through a cloud point, resulting in hydrophobic particles with a complex conformational structure, comprising a dendritic core and a polymeric shell that double encapsulates the hydrophobic core. The removal process of two hormonal contraceptives, drospirenone and 17α-ethinylestradiol, using Boltorn-H40-P(NPAM)-P(NIPAM) micelles involved two consecutive stages: (I) loading the contraceptive molecules into the dendritic core below the LCST, and (II) separating the contraceptive molecules via a cloud point above the LCST. Finally, all the stages involved in the removal of hormonal contraceptives from polluted aqueous environments were explored in detail.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 15","pages":" 2923-2934"},"PeriodicalIF":2.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of substrate mechanics in osmotic biofilm spreading†

IF 2.9 3区化学

Soft Matter Pub Date : 2025-03-27 DOI: 10.1039/D4SM01463D

Anthony Pietz, Karin John and Uwe Thiele

{"title":"The role of substrate mechanics in osmotic biofilm spreading†","authors":"Anthony Pietz, Karin John and Uwe Thiele","doi":"10.1039/D4SM01463D","DOIUrl":"10.1039/D4SM01463D","url":null,"abstract":"Bacteria invade surfaces by forming dense colonies encased in a polymer matrix. Successful settlement of founder bacteria, early microcolony development and later macroscopic spreading of these biofilms on surfaces rely on complex physical mechanisms. Recent data show that on soft hydrogels, substrate rigidity is an important determinant for biofilm initiation and spreading, through mostly unknown mechanisms. Using a thermodynamically consistent thin-film approach for suspensions on soft elastic surfaces supplemented with biomass production we investigate in silico the role of substrate softness in the osmotic spreading of biofilms. We show that on soft substrates with an imposed osmotic pressure spreading is considerably slowed down and may be completely halted depending on the biomass production rate. We find that the critical slowing down of biofilm spreading on soft surfaces is caused by a reduced osmotic influx of solvent into the biofilm at the edges, which results from the thermodynamic coupling between substrate deformation and interfacial forces. By linking substrate osmotic pressure and mechanical softness through scaling laws, our simple model semi-quantitatively captures a range of experimentally observed biofilm spreading dynamics on hydrogels with different architectures, underscoring the importance of inherent substrate properties in the spreading process.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 15","pages":" 2935-2945"},"PeriodicalIF":2.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/sm/d4sm01463d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sub-Newtonian coalescence dynamics in shear-thickening non-Brownian colloidal droplets.

IF 2.9 3区化学

Soft Matter Pub Date : 2025-03-27 DOI: 10.1039/d4sm01389a

M V R Sudheer, Sarath Chandra Varma, Aloke Kumar, Udita U Ghosh

{"title":"Sub-Newtonian coalescence dynamics in shear-thickening non-Brownian colloidal droplets.","authors":"M V R Sudheer, Sarath Chandra Varma, Aloke Kumar, Udita U Ghosh","doi":"10.1039/d4sm01389a","DOIUrl":"https://doi.org/10.1039/d4sm01389a","url":null,"abstract":"Recent investigations into coalescence dynamics of complex fluid droplets revealed the existence of sub-Newtonian behaviour in polymeric fluids (elastic and shear thinning). We hypothesize that such delayed coalescence or sub-Newtonian coalescence dynamics may be extended to the general class of shear thickening fluids. To investigate this, droplets of aqueous corn-starch suspensions were chosen and their coalescence in the sessile-pendant configuration was probed by real-time high-speed imaging. Temporal evolution of the neck (growth) during coalescence was quantified as a function of suspended particle weight fraction, ϕw. The necking behavior was found to evolve as the power-law relation, R = atb, where R is the neck radius, with exponent b ≤ 0.5, implying that it is a subset of the generic sub-Newtonian coalescence. Furthermore, the coalescence dynamics could be demarcated into two distinct regimes, b ∼ 0.5 and b < 0.5, where the emergence of visco-elastic pinch-off response was observed in the latter regime. The particle fraction demarcating these regimes, designated as the critical particle weight fraction, ϕw ∼ ϕc > 0.35, also coincides with the existence of 'jamming' and 'flowing' regions within the neck during viscoelastic pinch-off of cornstarch suspensions (Roché et al., Phys. Rev. Lett., 2011, 107, 134503). We also propose a simplistic theoretical model that captures the observed delay in coalescence dynamics implicitly through altered suspension viscosity stemming from increased particle content.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coarse-grained molecular dynamics simulations of slide-ring gels under finite deformation: influence of sliding ring rearrangement on softness and extensibility.

IF 2.9 3区化学

Soft Matter Pub Date : 2025-03-26 DOI: 10.1039/d5sm00003c

Yusuke Yasuda, Takeyoshi Masumoto, Koichi Mayumi, Masatoshi Toda, Hideaki Yokoyama, Hiroshi Morita, Kohzo Ito

{"title":"Coarse-grained molecular dynamics simulations of slide-ring gels under finite deformation: influence of sliding ring rearrangement on softness and extensibility.","authors":"Yusuke Yasuda, Takeyoshi Masumoto, Koichi Mayumi, Masatoshi Toda, Hideaki Yokoyama, Hiroshi Morita, Kohzo Ito","doi":"10.1039/d5sm00003c","DOIUrl":"https://doi.org/10.1039/d5sm00003c","url":null,"abstract":"Slide-ring (SR) gels are a class of polymer gels known for their unique softness, toughness, and high extensibility. The defining structural feature of SR gels is their figure-of-eight-shaped slidable cross-links, whose sliding dynamics are believed to underpin their mechanical properties. However, the relationship between the sliding mechanics and observed mechanical behavior of SR gels remains unclear because their structure differs considerably from those of conventional fixed cross-link gels and vulcanized rubbers. In this work, we employed coarse-grained molecular dynamics simulations to investigate the mechanical behavior of SR gels up to large deformation. By visualizing the correlated distribution of network strand orientation and stress loading, we found that SR gels under strain exhibit uniform chain orientation and efficient stress dispersion throughout the network, in contrast to gels with fixed cross-links, which display regions of highly oriented and heavily stressed chains. Furthermore, we observed that the distribution of network-strand length changes under deformation, indicating that chains are reconfigured into shorter and longer sections during stretching. Notably, we demonstrated that the finite network-strand length (Nmax) determines the finite extensibility of SR gels, corresponding to the maximum elongation ratio (λmax). These findings provide new insights into the molecular mechanisms driving the high extensibility and toughness of SR gels and offer valuable guidance for designing SR gels with tailored mechanical properties.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybridization of colloidal handlebodies with singular defects and topological solitons in chiral liquid crystals.

IF 2.9 3区化学

Soft Matter Pub Date : 2025-03-26 DOI: 10.1039/d5sm00014a

Jun-Yong Lee, Asha Kumari, Ye Yuan, Mykola Tasinkevych, Ivan I Smalyukh

{"title":"Hybridization of colloidal handlebodies with singular defects and topological solitons in chiral liquid crystals.","authors":"Jun-Yong Lee, Asha Kumari, Ye Yuan, Mykola Tasinkevych, Ivan I Smalyukh","doi":"10.1039/d5sm00014a","DOIUrl":"https://doi.org/10.1039/d5sm00014a","url":null,"abstract":"Topology can manifest itself in colloids when quantified by invariants like Euler characteristics of nonzero-genus colloidal surfaces, albeit spherical colloidal particles are most often studied, and colloidal particles with complex topology are rarely considered. On the other hand, singular defects and topological solitons often define the physical behavior of the molecular alignment director fields in liquid crystals. Interestingly, nematic liquid crystalline dispersions of colloidal particles allow for probing the interplay between topologies of surfaces and fields, but only a limited number of such cases have been explored so far. Here, we study the hybridization of topological solitons, singular defects, and topologically nontrivial colloidal particles with the genus of surfaces different from zero in a chiral nematic liquid crystal phase. Hybridization occurs when distortions separately induced by colloidal particles and LC solitons overlap, leading to energy minimization-driven redistribution of director field deformations and defects. As a result, hybrid director configurations emerge, combining topological features from both components. We uncover a host of director field configurations complying with topological theorems, which can be controlled by applying electric fields. Rotational and translational dynamics arise due to the nonreciprocal evolution of the director fields in response to alternating electric fields of different frequencies. These findings help define a platform for controlling topologically hyper-complex colloidal structures and dynamics with electrically reconfigurable singular defects and topological solitons induced by colloidal handlebodies.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Wet spinning of sodium carboxymethyl cellulose-sodium caseinate hydrogel fibres: relationship between rheology and spinnability.

IF 2.9 3区化学

Soft Matter Pub Date : 2025-03-26 DOI: 10.1039/d5sm90047f

Lathika Vaniyan, Pallab Kumar Borah, Galina E Pavlovskaya, Nick Terrill, Joshua E S J Reid, Michael Boehm, Philippe Prochasson, Reed A Nicholson, Stefan Baier, Gleb E Yakubov

引用次数: 0

Increased water presence in phospholipid fluid bilayers upon addition of lysolipids†

IF 2.9 3区化学

Soft Matter Pub Date : 2025-03-26 DOI: 10.1039/D4SM01211A

Fernanda Alvarado Galindo, Joachim Venzmer, Najet Mahmoudi, Michael Gradzielski and Ingo Hoffmann

{"title":"Increased water presence in phospholipid fluid bilayers upon addition of lysolipids†","authors":"Fernanda Alvarado Galindo, Joachim Venzmer, Najet Mahmoudi, Michael Gradzielski and Ingo Hoffmann","doi":"10.1039/D4SM01211A","DOIUrl":"10.1039/D4SM01211A","url":null,"abstract":"In spite of the numerous studies dealing with the interaction between lipid membranes and surfactants at subsolubilizing membrane concentrations, quantifying detailed bilayer structure, as for instance pore formation, on phospholipid bilayers upon addition of single chain lipids continues to be a challenge. Herein, we analyze the effects of lysophosphatidylcholine (18 : 1 LPC or lysolipid) on soybean phosphatidylcholine (SPC) extruded liposomes, where vesicles containing additional LPC exhibit approximately a 10% reduction in size as indicated by dynamic light scattering experiments. Most importantly, we benefit from the non-perturbing nature of small-angle neutron scattering (SANS) measurements to determine the degree of water incorporation presumably through the surfactant stabilized pores along the fluid bilayers. Model-free analysis of SANS curves reveals that the membrane part of the pure SPC vesicles contain 3.3% v of water. As the lysolipid is added to the dispersion, the volume fraction of water counted into the lipid membrane (<img>) increases to 15–20%. Finally, assuming <img> to be equivalent to the volume fraction of pores within the bilayers we estimate the pore size and density.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 16","pages":" 3117-3124"},"PeriodicalIF":2.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/sm/d4sm01211a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0