Soft Matter最新文献_第10页

Advanced polymeric systems for colon drug delivery: from experimental models to market applications 用于结肠给药的先进聚合物系统：从实验模型到市场应用。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-01-13 DOI: 10.1039/D4SM01222D

R. Crispino, E. Lagreca, A. Procopio, R. D’Auria, B. Corrado, S. La Manna, V. Onesto and C. Di Natale

{"title":"Advanced polymeric systems for colon drug delivery: from experimental models to market applications","authors":"R. Crispino, E. Lagreca, A. Procopio, R. D’Auria, B. Corrado, S. La Manna, V. Onesto and C. Di Natale","doi":"10.1039/D4SM01222D","DOIUrl":"10.1039/D4SM01222D","url":null,"abstract":"In recent years, nano and micro drug delivery systems targeting the colon have gained more attention due to increasing interest in treating colon diseases such as colorectal cancer and inflammatory bowel disease, i.e., Crohn's disease and ulcerative colitis. Usually, nanocarriers are exploited for their enhanced permeability properties, allowing higher penetration effects and bioavailability, while microcarriers are primarily used for localized and sustained release. In bowel diseases, carriers must go into a delicate environment with a strict balance of gut bacteria (e.g., colon), and natural or biodegradable polymers capable of ensuring lower toxicity are preferred. However, these systems are primarily delivered orally, so the carrier must go through the whole gastrointestinal tract, where it encounters significant pH fluctuations, different mucus layers, several enzymes, and a long transit time. For this reason, various approaches have been explored and evaluated, especially using pH-responsive and time-dependent systems. This review provides an overview of the contemporary methodologies employed in orally administered nano- and microparticles for colon delivery, encompassing both in vivo and in vitro investigations. It evaluates their strengths, weaknesses, constraints, and potential enhancements, leveraging mathematical and microfluidic models. Furthermore, it focuses explicitly on systems that have already reached the market and are presently employed in treating severe colon diseases.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 5","pages":" 792-818"},"PeriodicalIF":2.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pinch-off dynamics of emulsion filaments before and after polymerization of the internal phase† 内相聚合前后乳液细丝的掐断动力学。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-01-13 DOI: 10.1039/D4SM00618F

Parisa Bazazi and Howard A. Stone

{"title":"Pinch-off dynamics of emulsion filaments before and after polymerization of the internal phase†","authors":"Parisa Bazazi and Howard A. Stone","doi":"10.1039/D4SM00618F","DOIUrl":"10.1039/D4SM00618F","url":null,"abstract":"The capillary break-up of complex fluid filaments occurs in many scientific and industrial applications, particularly in bio-printing where both liquid and polymerized droplets exist in the fluid. The simultaneous presence of fluid and solid particles within a carrier fluid and their interactions lead to deviations in the filament break-up from the well-established capillary breakup dynamics of single-phase liquids. To examine the significance of the dispersed phase and the internal interactions between liquid droplets and solid particles, we prepare emulsions through photopolymerization and conduct experimental investigations into the pinch-off dynamics of fluid filaments, focusing on the impact of varying concentrations of liquid droplets (before polymerization) and polymerized droplets. Despite the increase in bulk viscosity due to the presence of polymerized droplets in the fluid and their aggregation, the results show that polymerization significantly reduces the length of the fluid filament before breakup, thus shortening the duration of pinch-off. We investigate two categories of complex fluids, characterized by their droplet sizes: (i) sub-micrometer droplets and (ii) droplets with an average diameter of 50 micrometers. In emulsions containing sub-micrometer droplets, the individual droplet contributions remain undetectable during capillary breakup, and the measured pinch-off dynamics predominantly reflect the bulk shear viscosity or viscoelasticity of the system. This is due to the droplet sizes falling below our imaging resolution. In contrast, emulsions with larger polymerized droplets exhibit behavior analogous to single-phase carrier fluids: once the filament's length equals the droplet diameter, the droplets are expelled. Concurrently, larger liquid droplets are deformed and elongated along the flow direction. Our study highlights the effect of mixing liquid and polymerized droplets on the capillary breakup dynamics of fluid filaments, providing insights to formulate 3D printing inks.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 7","pages":" 1296-1307"},"PeriodicalIF":2.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Boundaries and cross-linking densities modulate domain sizes of polydomain nematic elastomers† 边界和交联密度调节多畴向列弹性体的畴尺寸。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-01-13 DOI: 10.1039/D4SM01419G

Takuya Ohzono, Kaoru Katoh and Nariya Uchida

{"title":"Boundaries and cross-linking densities modulate domain sizes of polydomain nematic elastomers†","authors":"Takuya Ohzono, Kaoru Katoh and Nariya Uchida","doi":"10.1039/D4SM01419G","DOIUrl":"10.1039/D4SM01419G","url":null,"abstract":"When nematic liquid crystal elastomers (LCEs) crosslinked at their isotropic phase are quenched to the nematic phase, they show polydomain patterns, in which nematic microdomains with different orientations self-organize into a three-dimensional mosaic with characteristic correlation patterns. The orientational correlation length of the domain, which is usually in the micrometer range, is believed to emerge as a result of a competition between liquid crystalline ordering and frozen network inhomogeneity. Although polydomain patterns show potentials as the basic platform for optical, memory, and mechanical devices, no study exists regarding how they are modulated by experimentally accessible parameters. Here, using confocal polarized fluorescence microscopy, we study the effects of a solid-wall or open boundary on the domain size in conjunction with effects of cross-linking density. The LCE bounded by solid glass shows reduced domain size near the boundary. In contrast, increased domain size appears at the free surface. With increasing cross-linking density, the domain size decreases, also exhibiting the boundary effects. Guided by theoretical considerations, the results are explained by a picture that the effective strength of the inhomogeneity frozen in the polymer network, i.e., the effective disorder strength, varies depending on the cross-linking density and constrained states at boundaries. The results offer the first experimental approach to global and local modulation of the polydomain pattern in nematic LCEs.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 6","pages":" 1233-1240"},"PeriodicalIF":2.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipophilic molecular rotor to assess the viscosity of oil core in nano-emulsion droplets† 亲脂分子转子评价纳米乳液滴中油芯的粘度。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-01-13 DOI: 10.1039/D4SM01234H

Mohamed Elhassan, Carla Faivre, Halina Anton, Guillaume Conzatti, Pascal Didier, Thierry Vandamme, Alteyeb S. Elamin, Mayeul Collot and Nicolas Anton

{"title":"Lipophilic molecular rotor to assess the viscosity of oil core in nano-emulsion droplets†","authors":"Mohamed Elhassan, Carla Faivre, Halina Anton, Guillaume Conzatti, Pascal Didier, Thierry Vandamme, Alteyeb S. Elamin, Mayeul Collot and Nicolas Anton","doi":"10.1039/D4SM01234H","DOIUrl":"10.1039/D4SM01234H","url":null,"abstract":"Characterization of nanoscale formulations is a continuous challenge. Size, morphology and surface properties are the most common characterizations. However, physicochemical properties inside the nanoparticles, like viscosity, cannot be directly measured. Herein, we propose an original approach to measuring dynamic viscosity using a lipidic molecular rotor solubilized in the core of nano-formulations. These molecules undergo conformational changes in response to viscosity variations, leading to observable changes in fluorescence intensity and lifetime, able to sense the volume properties of dispersed nano-domains. The lipophilic molecular rotor (BOPIDY derivatives) was specifically synthesized and characterized as oil viscosity sensing in large volumes. A second part of the study compares these results with rBDP-Toco in nano-emulsions. The objective is to evaluate the impact of the formulation, droplet size and composition on the viscosity of the droplet's core. The lipophilic rotor showed a universal behavior whatever the oil composition, giving a master curve. Applied to nano-formulations, it reveals the viscosity inside the nano-emulsion droplets, enabling the detection of slight variations between reference oil samples and the nano-formulated ones. This new tool opens the way to the fine characterization of complex colloids and multi-domain nano and micro systems, potentially applied to hybrid materials and biomaterials.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 6","pages":" 1212-1224"},"PeriodicalIF":2.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/sm/d4sm01234h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ formation of ultrahigh molecular weight polymers in highly concentrated electrolytes and their physicochemical properties† 高浓度电解液中超高分子量聚合物的原位形成及其物理化学性质。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-01-10 DOI: 10.1039/D4SM01248H

Yuji Kamiyama, Takeshi Ueki and Ryota Tamate

引用次数: 0

Spatiotemporal pattern formation of membranes induced by surface molecular binding/unbinding† 表面分子结合/脱结合诱导的膜时空模式形成。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-01-10 DOI: 10.1039/D4SM01277A

Hiroshi Noguchi

引用次数: 0

Self-assembly of chromatic patchy particles with tetrahedrally arranged patches† 带有四面体排列的斑块的彩色斑块粒子的自组装。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-01-10 DOI: 10.1039/D4SM01210K

Dariusz Tarasewicz, Edyta Raczyłło, Wojciech Rżysko and Łukasz Baran

引用次数: 0

Flow environment affects nutrient transport in soft plant roots 流动环境影响植物软根养分的输送。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-01-10 DOI: 10.1039/D4SM01083C

Sumit Kumar Mehta, Anirudha Talukdar, Suraj Panja, Jinmay Kalita, Somchai Wongwises and Pranab Kumar Mondal

{"title":"Flow environment affects nutrient transport in soft plant roots","authors":"Sumit Kumar Mehta, Anirudha Talukdar, Suraj Panja, Jinmay Kalita, Somchai Wongwises and Pranab Kumar Mondal","doi":"10.1039/D4SM01083C","DOIUrl":"10.1039/D4SM01083C","url":null,"abstract":"This work estimates Michaelis–Menten kinetics parameters for nutrient transport under varying flow rates in the soft roots of Indian mustard (Brassica juncea) using a plant fluidic device. To find the metallic components within the roots, inductively coupled plasma mass spectrometry (ICP-MS) analysis was performed. The flow rate-dependent metabolic changes were examined using Raman spectral analysis. In addition, three-dimensional numerical simulations were conducted to assess mechanical stresses resulting from the concentration difference that enhances osmotic pressure and flow loading at the root–liquid interface. Convection, the primary mode of nutrient transport in flowing media, was observed to reduce nutrient uptake at higher flow rates. In contrast, diffusion became more prevalent in areas where the complex root structure restricted the flow field. The concentration gradient between the upstream and downstream regions of the root caused nutrient diffusion from downstream to upstream. As seen, an increase in flow rate resulted in a decrease in root length due to the reduction of advantageous metabolites, which led to lower average mechanical stress and osmotic pressure loading. Additionally, osmotic pressure at the root–liquid interface was found to increase over time. Numerical simulations revealed that the average internal mechanical stress was substantially greater when osmotic pressure was considered. This emphasizes the importance of accounting for osmotic pressure when assessing mechanical stress in roots. This study uses a fluidic device that replicates hydroponic conditions for the first time in order to evaluate the convection-dependent Michaelis–Menten kinetics of nutrient uptake in plant roots.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 7","pages":" 1269-1285"},"PeriodicalIF":2.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical feedback links cell division and dynamics in growing cell collectives 机械反馈将细胞分裂和生长中的细胞群动力学联系起来。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-01-10 DOI: 10.1039/D4SM01230E

Sumit Sinha, Xin Li, Abdul N. Malmi-Kakkada and D. Thirumalai

{"title":"Mechanical feedback links cell division and dynamics in growing cell collectives","authors":"Sumit Sinha, Xin Li, Abdul N. Malmi-Kakkada and D. Thirumalai","doi":"10.1039/D4SM01230E","DOIUrl":"10.1039/D4SM01230E","url":null,"abstract":"Local stresses in a tissue, a collective property, regulate cell division and apoptosis. In turn, cell growth and division induce active stresses in the tissue. As a consequence, there is a feedback between cell growth and local stresses. However, how the cell dynamics depend on local stress-dependent cell division and the feedback strength is not understood. Here, we probe the consequences of stress-mediated growth and cell division on cell dynamics using agent-based simulations of a two-dimensional growing tissue. We discover a rich dynamical behavior of individual cells, ranging from jamming (mean square displacement, Δ(t) ∼ tα with α less than unity), to hyperdiffusion (α > 2) depending on cell division rate and the strength of the mechanical feedback. Strikingly, Δ(t) is determined by the tissue growth law, which quantifies cell proliferation, measuring the number of cells N(t) as a function of time. The growth law (N(t) ∼ tλ at long times) is regulated by the critical pressure that controls the strength of the mechanical feedback and the ratio between cell division-apoptosis rates. We show that λ ∼ α, which implies that higher growth rate leads to a greater degree of cell migration. The variations in cell motility are linked to the emergence of highly persistent forces extending over several cell cycle times. Our predictions are testable using cell-tracking imaging techniques.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" 6","pages":" 1170-1179"},"PeriodicalIF":2.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

α-Synuclein interaction with POPC/POPS vesicles† α-突触核蛋白与POPC/POPS囊泡的相互作用。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-01-09 DOI: 10.1039/D4SM01036A

Marija Dubackic, Veronica Lattanzi, Yun Liu, Michael Haertlein, Juliette M. Devos, Emma Sparr, Sara Linse and Ulf Olsson

引用次数: 0