Clinical Journal of Gastroenterology最新文献_第7页

A case of relapsed pan-colonic ulcerative colitis accompanied with gastroduodenal lesions immediately after COVID-19. 新冠肺炎感染后立即复发性泛结肠溃疡性结肠炎伴胃十二指肠病变1例。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-03-01 DOI: 10.1007/s12328-025-02107-0

Katsuya Endo, Tomonori Satoh, Yuki Yoshino, Shiho Kondo, Yoko Kawakami, Daisuke Fukushi, Atsuko Takasu, Takayuki Kogure, Morihisa Hirota, Kennichi Satoh

{"title":"A case of relapsed pan-colonic ulcerative colitis accompanied with gastroduodenal lesions immediately after COVID-19.","authors":"Katsuya Endo, Tomonori Satoh, Yuki Yoshino, Shiho Kondo, Yoko Kawakami, Daisuke Fukushi, Atsuko Takasu, Takayuki Kogure, Morihisa Hirota, Kennichi Satoh","doi":"10.1007/s12328-025-02107-0","DOIUrl":"https://doi.org/10.1007/s12328-025-02107-0","url":null,"abstract":"Some patients with ulcerative colitis (UC) suffer from complicated UC-associated upper gastrointestinal lesions. However, the trigger of these lesions has not been clarified. Herein, we present a 28-year-old man with relapsed pan-colonic UC accompanied by gastroduodenal lesions immediately after contracting coronavirus disease 2019 (COVID-19). In this patient, UC relapsed approximately 7 days after the COVID-19 onset, despite being in remission for 3 years. The patient also developed symptoms such as epigastric pain and nausea on day 19 of COVID-19. The endoscopic and pathologic findings of the stomach and duodenum closely resembled colorectal lesions of UC; accordingly, we diagnosed the patient with UC-associated gastroduodenal lesions. Corticosteroids were significantly effective in the colorectal and upper gastrointestinal lesions, leading to remission. This report is the first to describe UC-associated upper GI lesions that developed right after COVID-19 infection. Therefore, COVID-19 can be a possible trigger of UC-associated upper gastrointestinal lesion. Further studies are needed to understand the relationship between the onset of UC or UC-associated upper GI lesions and COVID-19.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of chronic hepatitis B complicated by systemic sarcoidosis that regressed following nucleos(t)ide analog therapy. 慢性乙型肝炎合并全身性结节病1例，经核苷类似物治疗后病情消退。

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Clinical Journal of Gastroenterology Pub Date : 2025-02-26 DOI: 10.1007/s12328-025-02105-2

Shigeaki Semba, Yuji Teraoka, Hiroki Kamada, Naohiro Kato, Takeshi Mizumoto, Yuzuru Tamaru, Tsuyoshi Hatakeyama, Atsushi Yamaguchi, Hirotaka Kouno, Shigeto Yoshida

{"title":"A case of chronic hepatitis B complicated by systemic sarcoidosis that regressed following nucleos(t)ide analog therapy.","authors":"Shigeaki Semba, Yuji Teraoka, Hiroki Kamada, Naohiro Kato, Takeshi Mizumoto, Yuzuru Tamaru, Tsuyoshi Hatakeyama, Atsushi Yamaguchi, Hirotaka Kouno, Shigeto Yoshida","doi":"10.1007/s12328-025-02105-2","DOIUrl":"https://doi.org/10.1007/s12328-025-02105-2","url":null,"abstract":"Herein, we report the case of a 75-year-old woman with systemic sarcoidosis complicated by chronic hepatitis B. She presented with high fever and fatigue, with imaging studies revealing multiple tumor nodules in the liver and spleen, along with generalized lymphadenopathy, leading to her admission to our hospital for further evaluation and treatment. Blood tests revealed chronic hepatitis B, and nucleoside analog therapy with entecavir was initiated before the sarcoidosis diagnosis. A liver biopsy confirmed sarcoidosis, and treatment continued without steroid use. Significant improvement in symptoms and tumor size reduction were observed within weeks. After 6 months of treatment, positron emission tomography/computed tomography showed further regression of the liver and spleen tumors, with no symptom recurrence. Given the rarity of sarcoidosis complicated by chronic hepatitis B, this case suggests that controlling hepatitis B virus infection with nucleos(t)ide analogs might improve sarcoidosis symptoms without steroid use. The immunologic mechanisms underlying this cooccurrence remain unclear, and such cases are extremely rare. Therefore, this case may contribute to the understanding and management of sarcoidosis in patients with concurrent chronic hepatitis B.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of esophageal squamous cell carcinoma with epidermization showing a unique morphology. 一例形态独特的表皮化食管鳞状细胞癌。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-10-18 DOI: 10.1007/s12328-024-02042-6

Jyunichi Mizuno, Yuji Urabe, Hikaru Nakahara, Ken Yamashita, Yuichi Hiyama, Hidehiko Takigawa, Akira Ishikawa, Toshio Kuwai, Takao Hinoi, Shiro Oka

{"title":"A case of esophageal squamous cell carcinoma with epidermization showing a unique morphology.","authors":"Jyunichi Mizuno, Yuji Urabe, Hikaru Nakahara, Ken Yamashita, Yuichi Hiyama, Hidehiko Takigawa, Akira Ishikawa, Toshio Kuwai, Takao Hinoi, Shiro Oka","doi":"10.1007/s12328-024-02042-6","DOIUrl":"10.1007/s12328-024-02042-6","url":null,"abstract":"An 80-year-old woman with a history of endoscopic balloon dilation for esophageal stricture caused by accidental ingestion of caustic soda during infancy presented with dysphagia. Upper gastrointestinal endoscopy revealed a 10-cm-long, highly white, elevated lesion with a feathered appearance. This lesion was determined to be the cause of dysphagia and was completely resected via endoscopic submucosal dissection. Histopathological examination revealed a thick keratin layer on the surface of the stratified squamous epithelium, with a prominent granular layer underneath and some areas showing nuclear atypia. The lesion was diagnosed as a well-differentiated squamous cell carcinoma, pT1a-LPM, derived from epidermoid metaplasia. Cancer genome analysis revealed mutations in TP53 as well as amplification of MYC, FGFR1, chromosome 7, and chromosome 20q. This case suggests that epidermoid metaplasia caused by chronic irritation from an esophageal stricture may have been exacerbated by the dilation procedure.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"23-28"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic dilemma: a collision of pancreatic neuroendocrine tumor G3 and adenocarcinoma with extensive fibrosis. 诊断难题：胰腺神经内分泌肿瘤 G3 和腺癌并发广泛纤维化。

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Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-11-10 DOI: 10.1007/s12328-024-02057-z

Daichi Hayashi, Masashi Yamamoto, Dai Nakamatsu, Kengo Matsumoto, Koji Fukui, Shiro Adachi, Tsutomu Nishida

{"title":"Diagnostic dilemma: a collision of pancreatic neuroendocrine tumor G3 and adenocarcinoma with extensive fibrosis.","authors":"Daichi Hayashi, Masashi Yamamoto, Dai Nakamatsu, Kengo Matsumoto, Koji Fukui, Shiro Adachi, Tsutomu Nishida","doi":"10.1007/s12328-024-02057-z","DOIUrl":"10.1007/s12328-024-02057-z","url":null,"abstract":"An 82-year-old man presented with intermittent abdominal pain and elevated liver enzymes. Blood tests showed normal levels of tumor markers (CEA, CA19-9, NSE). Contrast-enhanced computed tomography (CE-CT) revealed a 20 mm hypovascular mass in the pancreatic head. Magnetic resonance imaging indicated low intensity on both T1- and T2-weighted images and high intensity on diffusion-weighted images. Endoscopic ultrasonography visualized an irregular hypoechoic mass. Initially, it was diagnosed as pancreatic ductal adenocarcinoma (PDAC) based on imaging. Subsequent histopathological analysis via endoscopic ultrasound-guided fine-needle aspiration revealed a neuroendocrine tumor (NET). The preoperative diagnosis was changed to a pancreatic NET grade1. Consequently, a pancreaticoduodenectomy was performed. Histopathological examination of the resected specimen unveiled a mixed tumor-NET-Grade1/Grade3 and invasive PDAC. No clear transition between the NETs and PDAC was observed. The high grade of NET with significant fibrosis contributed to decreased enhancement of CE-CT. Finally, we diagnosed this case as a pancreatic collision tumor involving both NET and PDAC components, with lymph node metastases attributed to the NET components. In this case, achieving an accurate preoperative diagnosis was challenging despite utilizing both imaging and biopsy diagnostics. This unique case underscores the difficulties encountered in the preoperative assessment of mixed tumors.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"224-229"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

S-1/irinotecan/oxaliplatin chemotherapy achieved a pathological complete remission in advanced pancreatic carcinoma. S-1/伊立替康/奥沙利铂化疗实现了晚期胰腺癌的病理完全缓解。

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Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-11-06 DOI: 10.1007/s12328-024-02055-1

Ru Chen, Tomohisa Iwai, Hiroshi Tajima, Kai Adachi, Kosuke Okuwaki, Masafumi Watanabe, Taro Hanaoka, Akihiro Tamaki, Yusuke Kumamoto, Chika Kusano

{"title":"S-1/irinotecan/oxaliplatin chemotherapy achieved a pathological complete remission in advanced pancreatic carcinoma.","authors":"Ru Chen, Tomohisa Iwai, Hiroshi Tajima, Kai Adachi, Kosuke Okuwaki, Masafumi Watanabe, Taro Hanaoka, Akihiro Tamaki, Yusuke Kumamoto, Chika Kusano","doi":"10.1007/s12328-024-02055-1","DOIUrl":"10.1007/s12328-024-02055-1","url":null,"abstract":"Chemotherapy has been developed for many years for malignancies, including advanced pancreatic cancer, downsizing the primary site, thereby enabling complete cure with the combination of conversion surgery. Pathological complete remission from operation samples was usually identified as a promising indication for a good prognosis for many carcinomas. Several case reports consisting of pathological complete remission after chemotherapy application have been reported but no case of pathological complete remission that resulted from successful extensive resection by surgery after S-1, irinotecan, and oxaliplatin (SIROX) chemotherapy. A 48-year-old male patient was hospitalized due to abdominal pain which turned out to be a 25 mm-sized advanced uncinate process of pancreatic cancer with possible duodenum invasion and hepatic metastasis. The tumor had decreased after administering 23 sessions of modified SIROX chemotherapy, and he underwent pylorus-preserving pancreaticoduodenectomy with portal vein resection. He was successfully managed with conservative treatment and discharged 12 days postoperatively despite his postoperative weakness. He had been taking S-1 pills for 6 months and until now, 3 years postoperatively, with no relapse. The final pathology reported complete tumor regression. Therefore, we emphasize the oncologic significance of chemotherapy in the uncinate process of pancreatic cancer and the potential role of conversion surgery.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"220-223"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arsenic and young liver: a case report of hepatic steatosis due to arsenic toxicity. 砷与年轻的肝脏：砷中毒导致肝脂肪变性的病例报告。

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Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-10-08 DOI: 10.1007/s12328-024-02045-3

Cindy Khanh Nguyen, Meagan Alvarado, Won Jae Huh, Jennifer Batisti

引用次数: 0

A case of pancreatic fistula with disruption of the inferior branch of the pancreatic duct caused by a pancreatic stent after endoscopic papillectomy. 一例内镜乳头切除术后胰腺支架导致胰管下支中断的胰腺瘘。

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Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-11-22 DOI: 10.1007/s12328-024-02067-x

Yoshihisa Takada, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Kota Uetsuki, Hiroki Kawashima

{"title":"A case of pancreatic fistula with disruption of the inferior branch of the pancreatic duct caused by a pancreatic stent after endoscopic papillectomy.","authors":"Yoshihisa Takada, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Kota Uetsuki, Hiroki Kawashima","doi":"10.1007/s12328-024-02067-x","DOIUrl":"10.1007/s12328-024-02067-x","url":null,"abstract":"A 73-year-old man underwent upper gastrointestinal endoscopy for abdominal pain, which revealed an ampullary adenoma with no obvious extension into the bile or pancreatic ducts. Endoscopic papillectomy (EP) was performed and a 5-Fr 5-cm stent was placed in the pancreatic duct. The patient developed acute pancreatitis on postoperative day (POD) 1 and contrast-enhanced computed tomography performed on POD 2 revealed that the proximal end of the stent had migrated into the retroperitoneum, forming a pancreatic fistula. Stent removal and endoscopic nasopancreatic drainage were performed and the pancreatitis rapidly improved. The tumor was completely resected and after approximately three years of follow-up, no tumor recurrence or acute pancreatitis was observed.Retrospectively, the inferior branch of the pancreatic duct was prominent on pancreatography at the time of EP and the proximal end of the stent had dislocated into the inferior branch. The stent subsequently moved proximally, which could have caused pancreatitis and pancreatic fistula. The morphology of the pancreatic duct should be carefully monitored during stenting. Selecting a stent that matches each patient's specific pancreatic duct morphology may help physicians minimize the risk of adverse outcomes.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"169-175"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of JAK inhibitors in adult eosinophilic colitis with atopic dermatitis; four cases report. JAK抑制剂治疗成人嗜酸性结肠炎伴特应性皮炎的疗效观察报告4例。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-12-12 DOI: 10.1007/s12328-024-02080-0

Hiroshi Matsumto, Momoyo Sasahira, Yasuhito Fujimoto, Shogen Yo, Akiko Shiotani

{"title":"The efficacy of JAK inhibitors in adult eosinophilic colitis with atopic dermatitis; four cases report.","authors":"Hiroshi Matsumto, Momoyo Sasahira, Yasuhito Fujimoto, Shogen Yo, Akiko Shiotani","doi":"10.1007/s12328-024-02080-0","DOIUrl":"10.1007/s12328-024-02080-0","url":null,"abstract":"We herein present four cases of Eosinophilic colitis (EoC) in adult patients who were successfully treated with a Janus kinase (JAK) inhibitor. Case 1 is a 23-year-old female who was treated with baricitinib (BAR, 4 mg, once a day) for atopic dermatitis (AD). Colonoscopy (CS) initially did not reveal any significant abnormalities. However, she underwent another CS when she underwent a food challenge test involving wheat without baricitinib medication. During this procedure, the CS subsequently leading to her diagnosis of EoC based on eosinophil infiltration. Case 2 is a 26-year-old man whereas Case 3 is a 40-year-old man. Both patients were started on upadacitinib (UPA, 15 mg, once daily) for the treatment of AD. Their abdominal symptoms improved, and colonic histology revealed the disappearance of eosinophils. Case 4, on the other hand, is a 29-year-old woman who was also started on UPA (15 mg, once daily). Her skin lesions and abdominal symptoms also improved within 2 weeks. To the best of our knowledge, this is the first novel clinical observational case report on the efficacy of JAK inhibitors in treating adult patients with both EoC and AD.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"100-106"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstructive jaundice caused by an abdominal tuberculous mass lesion. 腹部结核性肿块病变引起的阻塞性黄疸。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-11-28 DOI: 10.1007/s12328-024-02070-2

Wilson Jing Peng Liu, Michael Yulong Wu, Matthew Zaborowski, Eugene Ng

{"title":"Obstructive jaundice caused by an abdominal tuberculous mass lesion.","authors":"Wilson Jing Peng Liu, Michael Yulong Wu, Matthew Zaborowski, Eugene Ng","doi":"10.1007/s12328-024-02070-2","DOIUrl":"10.1007/s12328-024-02070-2","url":null,"abstract":"Tuberculosis is a global epidemic infection that typically presents with symptoms affecting the respiratory system. Abdominal tuberculosis is an uncommon manifestation, occurring in only 5% of tuberculosis cases globally and can present with a broad range of vague symptoms that mimic other biliary and pancreatic pathologies. We report a case of a 36-year-old woman presenting with jaundice and biliary obstruction secondary to abdominal tuberculosis. Computed tomography and magnetic resonance cholangiopancreatography revealed a loculated retroperitoneal mass abutting the pancreatic head and duodenum with associated common bile duct dilatation. Endoscopic ultrasound demonstrated an ulcerated mass in the duodenum which was biopsied. Necrotising granulomas were identified on histology and the biopsied tissue was positive on tuberculosis polymerase chain reaction testing. Thus, extrapulmonary abdominal tuberculosis was diagnosed. The patient was commenced on a 6-month course of rifampicin, isoniazid, pyrazinamide and ethambutol treatment and demonstrated complete response to medical therapy. Abdominal tuberculosis can be difficult to diagnose but should remain an important differential to be considered for patients with previous travel or residence in endemic areas presenting with gastrointestinal symptoms. Prompt diagnosis and treatment can prevent unnecessary procedures, complications and death in patients with biliary obstruction caused by abdominal tuberculosis.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"202-207"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laparoscopic transhiatal surgery based on high-resolution manometric evaluation of epiphrenic esophageal diverticulum. 基于高分辨率测压法评估虹膜上食管憩室的腹腔镜经食管手术。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-10-30 DOI: 10.1007/s12328-024-02056-0

Ryoma Taketo, Katsuhiro Ogawa, Tomotaka Shibata, Atsuro Fujinaga, Tomonori Akagi, Shigeo Ninomiya, Yoshitake Ueda, Hidefumi Shiroshita, Tsuyoshi Etoh, Masafumi Inomata

{"title":"Laparoscopic transhiatal surgery based on high-resolution manometric evaluation of epiphrenic esophageal diverticulum.","authors":"Ryoma Taketo, Katsuhiro Ogawa, Tomotaka Shibata, Atsuro Fujinaga, Tomonori Akagi, Shigeo Ninomiya, Yoshitake Ueda, Hidefumi Shiroshita, Tsuyoshi Etoh, Masafumi Inomata","doi":"10.1007/s12328-024-02056-0","DOIUrl":"10.1007/s12328-024-02056-0","url":null,"abstract":"Epiphrenic esophageal diverticulum is rare and often associated with abnormalities of esophageal motility. Here, we report a case of a patient diagnosed with high-resolution manometry as having epiphrenic esophageal diverticulum with esophagogastric junction outflow obstruction, which were successfully treated with laparoscopic transhiatal surgery. A 59-year-old woman presented to our hospital for treatment of a symptomatic epiphrenic esophageal diverticulum. An esophagogram revealed a left epiphrenic diverticulum measuring 50 mm. High-resolution manometry showed a high integrated relaxation pressure of 35.6 mmHg (> 26 mmHg) and preserved esophageal peristalsis. A chest computed tomography scan showed no external compression of the distal esophagus. Therefore, we diagnosed an epiphrenic esophageal diverticulum with esophagogastric junction outflow obstruction according to the Chicago Classification v3.0. Laparoscopic transhiatal diverticulectomy, planned and selective myotomy, and Dor fundoplication were performed. We performed myotomy just on the esophageal side and did not perform gastric myotomy. The postoperative course was uneventful, and the postoperative esophagogram showed smooth passage of contrast without leakage or stenosis. High-resolution manometry showed a normal integrated relaxation pressure (11.6 mmHg) at three months after surgery. Because an epiphrenic esophageal diverticulum is frequently associated with esophageal motility disorder, not only morphologic but also functional and appropriate treatment must be considered.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"37-42"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0