A case of esophageal squamous cell carcinoma with epidermization showing a unique morphology.

IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY

Clinical Journal of Gastroenterology Pub Date : 2024-10-18 DOI:10.1007/s12328-024-02042-6

Jyunichi Mizuno, Yuji Urabe, Hikaru Nakahara, Ken Yamashita, Yuichi Hiyama, Hidehiko Takigawa, Akira Ishikawa, Toshio Kuwai, Takao Hinoi, Shiro Oka

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引用次数: 0

Abstract

An 80-year-old woman with a history of endoscopic balloon dilation for esophageal stricture caused by accidental ingestion of caustic soda during infancy presented with dysphagia. Upper gastrointestinal endoscopy revealed a 10-cm-long, highly white, elevated lesion with a feathered appearance. This lesion was determined to be the cause of dysphagia and was completely resected via endoscopic submucosal dissection. Histopathological examination revealed a thick keratin layer on the surface of the stratified squamous epithelium, with a prominent granular layer underneath and some areas showing nuclear atypia. The lesion was diagnosed as a well-differentiated squamous cell carcinoma, pT1a-LPM, derived from epidermoid metaplasia. Cancer genome analysis revealed mutations in TP53 as well as amplification of MYC, FGFR1, chromosome 7, and chromosome 20q. This case suggests that epidermoid metaplasia caused by chronic irritation from an esophageal stricture may have been exacerbated by the dilation procedure.

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一例形态独特的表皮化食管鳞状细胞癌。

一名 80 岁的妇女曾因婴儿期误食烧碱导致食道狭窄而接受过内镜下球囊扩张术，术后出现吞咽困难。上消化道内镜检查发现一个 10 厘米长、高度白色、隆起的病变，外观呈羽毛状。该病灶被确定为导致吞咽困难的原因，并通过内镜粘膜下剥离完全切除。组织病理学检查显示，分层鳞状上皮表面有一层厚厚的角质层，下面有一层突出的颗粒层，部分区域出现核不典型性。病变被诊断为分化良好的鳞状细胞癌，pT1a-LPM，源于表皮变性。癌症基因组分析显示，TP53发生了突变，MYC、FGFR1、7号染色体和20q染色体也发生了扩增。该病例表明，食管狭窄的慢性刺激引起的表皮化生可能因扩张手术而加剧。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Journal of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

2.00

自引率

0.00%

发文量

182

期刊介绍： The journal publishes Case Reports and Clinical Reviews on all aspects of the digestive tract, liver, biliary tract, and pancreas. Critical Case Reports that show originality or have educational implications for diagnosis and treatment are especially encouraged for submission. Personal reviews of clinical gastroenterology are also welcomed. The journal aims for quick publication of such critical Case Reports and Clinical Reviews.