Clinical Journal of Gastroenterology最新文献

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Selective endoscopic nasobiliary drainage to determine the resection range for intraductal papillary neoplasm of the bile duct with an initially indeterminate primary site. 选择性内镜下鼻胆管引流术确定原发部位不确定的胆管内乳头状肿瘤的切除范围。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2026-09-18 DOI: 10.1007/s12328-026-02437-7
Toshihito Ogasawara, Junichi Kaneko, Hideki Izumi, Yosuke Tazawa, Junko Nagata, Shunji Hirose, Hiroyuki Ito, Tomoko Sugiyama, Takuma Tajiri, Takayoshi Suzuki
{"title":"Selective endoscopic nasobiliary drainage to determine the resection range for intraductal papillary neoplasm of the bile duct with an initially indeterminate primary site.","authors":"Toshihito Ogasawara, Junichi Kaneko, Hideki Izumi, Yosuke Tazawa, Junko Nagata, Shunji Hirose, Hiroyuki Ito, Tomoko Sugiyama, Takuma Tajiri, Takayoshi Suzuki","doi":"10.1007/s12328-026-02437-7","DOIUrl":"https://doi.org/10.1007/s12328-026-02437-7","url":null,"abstract":"<p><strong>Background: </strong>Intraductal papillary neoplasm of the bile duct (IPNB) often presents with marked ductal dilatation due to excessive mucin secretion, which can make it challenging to distinguish the primary tumor site from secondary dilatation.</p><p><strong>Case presentation: </strong>An 83-year-old woman presented with obstructive jaundice and bilateral biliary dilatation. Initial imaging, including CT, MRI, and PET-CT, failed to localize the tumor. While the first peroral cholangioscopy (POCS) was unsuccessful due to viscous bile, a second POCS identified a papillary lesion distal to the confluence of the B2 and B3 bile ducts. To determine the appropriate resection range, an endoscopic nasobiliary drainage (ENBD) tube was selectively placed in the right hepatic duct. The drainage of normal-colored, non-viscous bile and subsequent resolution of jaundice suggested that the right-sided dilatation was caused by mucin reflux from the left liver, rather than direct tumor involvement. The patient successfully underwent a curative left hepatectomy, including caudate lobectomy. Histopathology confirmed type 1 IPNB with high-grade atypia (carcinoma in situ) and negative surgical margins.</p><p><strong>Conclusion: </strong>POCS combined with selective ENBD may provide a valuable strategy for determining the surgical extent in mucin-producing IPNB when the primary site is difficult to identify using conventional imaging.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Segmental arterial mediolysis developing during treatment for severe acute pancreatitis. 重度急性胰腺炎治疗过程中出现的节段性动脉介质溶解。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2026-09-18 DOI: 10.1007/s12328-026-02452-8
Kazuki Kobayashi, Natsuyo Yamamoto, Taro Yokoyama, Yuya Hisada, Naoki Akazawa, Chizu Yokoi, Yasushi Kojima, Yasuo Tanaka, Junichi Akiyama, Mikio Yanase
{"title":"Segmental arterial mediolysis developing during treatment for severe acute pancreatitis.","authors":"Kazuki Kobayashi, Natsuyo Yamamoto, Taro Yokoyama, Yuya Hisada, Naoki Akazawa, Chizu Yokoi, Yasushi Kojima, Yasuo Tanaka, Junichi Akiyama, Mikio Yanase","doi":"10.1007/s12328-026-02452-8","DOIUrl":"https://doi.org/10.1007/s12328-026-02452-8","url":null,"abstract":"<p><p>We describe a case of segmental arterial mediolysis that developed during treatment for severe acute pancreatitis. The patient is a 41-year-old male who was hospitalized for severe alcoholic pancreatitis. The clinical course of acute pancreatitis was favorable. On the 10th hospital day, the patient experienced hemorrhagic shock. Contrast-enhanced computed tomography revealed newly developed aneurysms distant from the site of pancreatic inflammation, leading to a diagnosis of segmental arterial mediolysis. The aneurysm suspected of rupture was successfully embolized by catheter intervention, and the subsequent clinical course was favorable.The unruptured aneurysm resolved spontaneously under conservative management. On day 142 after onset, the patient developed headache and vomiting, and imaging revealed an intraventricular hematoma, which was suspected to be associated with segmental arterial mediolysis. To our knowledge, this is the first report describing the relationship between segmental arterial mediolysis and acute pancreatitis. This case underscores the importance of considering segmental arterial mediolysis as a potential cause of intra-abdominal hemorrhage in patients with pancreatitis. Notably, aneurysm formation and rupture occurred within a very short period; no aneurysm was detected on day 3, whereas rupture occurred on day 10. This suggests that aneurysm development in segmental arterial mediolysis may occur within 7 days. Our observation provides valuable clinical insight into the rapid progression of aneurysms in segmental arterial mediolysis and highlights the need for early recognition and prompt management in similar clinical settings.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical resection of a liver metastasis from an ovarian granulosa cell tumor mimicking a simple hepatic cyst. 模仿单纯性肝囊肿的卵巢颗粒细胞瘤的肝转移手术切除。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2026-09-17 DOI: 10.1007/s12328-026-02451-9
Takaomi Seki, Hideki Suzuki, Yoshiyasu Takayama, Satoshi Karino, Kenichiro Araki, Ken Shirabe
{"title":"Surgical resection of a liver metastasis from an ovarian granulosa cell tumor mimicking a simple hepatic cyst.","authors":"Takaomi Seki, Hideki Suzuki, Yoshiyasu Takayama, Satoshi Karino, Kenichiro Araki, Ken Shirabe","doi":"10.1007/s12328-026-02451-9","DOIUrl":"https://doi.org/10.1007/s12328-026-02451-9","url":null,"abstract":"<p><p>A 57-year-old woman underwent follow-up after surgery for a right ovarian granulosa cell tumor. Four years after the initial operation, computed tomography (CT) revealed a hepatic lesion suggestive of a simple hepatic cyst. Given that the lesion showed progressive enlargement, liver biopsy was performed, and recurrent hepatic metastasis from an ovarian granulosa cell tumor was diagnosed. She was administered a combination of paclitaxel and carboplatin (TC regimen), followed by bleomycin, etoposide, and cisplatin; however, disease control was not achieved, and para-aortic lymph node metastasis was suspected. As chemotherapy was considered ineffective, surgical resection was planned. Para-aortic lymph node metastasis was confirmed, and para-aortic lymph node dissection was performed, followed by left lateral sectionectomy and partial hepatectomy of segments 5 and 7/8. At 1 year and 4 months postoperatively, CT revealed three cystic hepatic lesions with para-aortic lymphadenopathy, deemed unresectable. TC chemotherapy was ineffective, and the patient died 5 years and 7 months after hepatectomy. Hepatic metastases from ovarian granulosa cell tumors may mimic simple hepatic cysts on imaging. Hepatic recurrence may differ from pelvic recurrence in clinical behavior, and hepatectomy may have a role in patients in whom macroscopic complete resection or symptom relief can be expected, although its survival benefit remains unproven.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Non-cirrhotic hepatocellular carcinoma during Crohn's disease therapy with azathioprine : possible involvement of focal hepatocyte glycogenosis in hepatocarcinogenesis. 更正:用硫唑嘌呤治疗克罗恩病期间的非肝硬化肝细胞癌:肝癌发生过程中可能涉及局灶性肝细胞糖原形成。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2026-09-16 DOI: 10.1007/s12328-026-02449-3
Hiroto Fujii, Koji Sawada, Nobuhiro Ueno, Katsuyoshi Ando, Kyozo Izumi, Hidemi Hayashi, Yu Ota, Manami Hayashi, Hideki Yokoo, Mikihiro Fujiya
{"title":"Correction: Non-cirrhotic hepatocellular carcinoma during Crohn's disease therapy with azathioprine : possible involvement of focal hepatocyte glycogenosis in hepatocarcinogenesis.","authors":"Hiroto Fujii, Koji Sawada, Nobuhiro Ueno, Katsuyoshi Ando, Kyozo Izumi, Hidemi Hayashi, Yu Ota, Manami Hayashi, Hideki Yokoo, Mikihiro Fujiya","doi":"10.1007/s12328-026-02449-3","DOIUrl":"https://doi.org/10.1007/s12328-026-02449-3","url":null,"abstract":"","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent non-toxic megacolon in ulcerative colitis: a case report of broad disruption and scar replacement of the muscularis propria. 溃疡性结肠炎持续性无毒性巨结肠:固有肌层广泛破坏及瘢痕置换1例。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2026-09-14 DOI: 10.1007/s12328-026-02450-w
Makoto Uchino, Tsunehiko Maruyama, Chiaki Tanaka, Yusuke Ozawa, Reiji Nozaki, Tatsuya Oda, Mika Takasu, Akari Tomita, Hiroshi Kashimura, Haruo Ohtani
{"title":"Persistent non-toxic megacolon in ulcerative colitis: a case report of broad disruption and scar replacement of the muscularis propria.","authors":"Makoto Uchino, Tsunehiko Maruyama, Chiaki Tanaka, Yusuke Ozawa, Reiji Nozaki, Tatsuya Oda, Mika Takasu, Akari Tomita, Hiroshi Kashimura, Haruo Ohtani","doi":"10.1007/s12328-026-02450-w","DOIUrl":"https://doi.org/10.1007/s12328-026-02450-w","url":null,"abstract":"<p><p>Ulcerative colitis-associated colonic dilatation is clinically important because it may progress to perforation or toxic megacolon. However, surgical decision-making is difficult when systemic toxicity is absent. An 83-year-old woman with long-standing pancolitis-type ulcerative colitis was admitted with worsening bloody diarrhea and abdominal pain. Despite high-dose corticosteroids and infliximab, computed tomography revealed marked colonic dilatation predominantly involving the transverse colon. Although she had anemia, she did not meet the Jalan criteria for toxic megacolon because she lacked high fever, marked tachycardia, leukocytosis, and additional signs of systemic deterioration. Serial abdominal radiographs showed progressive dilatation from approximately 70 mm to 95 mm despite intensive medical therapy. Surgery was selected after multidisciplinary reassessment. Histopathological examination revealed deep ulceration with erosion, broad disruption of the muscularis propria, and scar replacement in the dilated segment, indicating severe structural bowel-wall injury. No major postoperative complications occurred, although rehabilitation transfer was required because of decreased activities of daily living. This case suggests that persistent or progressive colonic dilatation in ulcerative colitis, even without systemic toxicity, may reflect advanced mural injury and should prompt repeated surgical assessment based on serial radiological findings.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aggressive hepatic carcinoma consistent with cholangioblastic cholangiocarcinoma treated with liver transplantation: a retrospectively reclassified case. 肝移植治疗侵袭性肝癌合并胆管母细胞胆管癌一例回顾性再分类。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2026-09-14 DOI: 10.1007/s12328-026-02448-4
Masaaki Hirata, Tu Thanh Nguyen, Takashi Ito, Hironori Shimizu, Yasuhide Takeuchi, Etsuro Hatano, Hironori Haga
{"title":"Aggressive hepatic carcinoma consistent with cholangioblastic cholangiocarcinoma treated with liver transplantation: a retrospectively reclassified case.","authors":"Masaaki Hirata, Tu Thanh Nguyen, Takashi Ito, Hironori Shimizu, Yasuhide Takeuchi, Etsuro Hatano, Hironori Haga","doi":"10.1007/s12328-026-02448-4","DOIUrl":"https://doi.org/10.1007/s12328-026-02448-4","url":null,"abstract":"<p><p>Cholangioblastic cholangiocarcinoma, also known as NIPBL::NACC1 fusion hepatic carcinoma, is an extremely rare and diagnostically challenging hepatic tumor. We report the first case in Japan and the first documented case treated with liver transplantation for this entity, retrospectively reclassified from hepatocellular carcinoma. A 24-year-old woman was found to have a large hepatic mass, with imaging showing a giant heterogeneous right-sided tumor and a separate hypervascular lesion in the left lateral segment. Because the tumor was unresectable, liver transplantation was performed. The explanted liver contained encapsulated tumors showing cystic change and hemorrhage, the largest measuring 22.5 cm. Histologically, the tumor predominantly displayed solid and pseudopapillary growth patterns. Initial immunohistochemistry showed focal positivity for chromogranin A and synaptophysin and absence of hepatocellular markers. Pathologic review 25 years later demonstrated patchy but strong positivity for cytokeratin 19 and inhibin, and the tumor was considered most consistent with cholangioblastic cholangiocarcinoma. Metastatic recurrence developed at 8 months, and the patient died at 28 months after transplantation. This case highlights the heterogeneous features and aggressive behavior of cholangioblastic cholangiocarcinoma. In patients with extensive intrahepatic tumor burden and multifocal disease, liver transplantation may not provide adequate oncologic control, highlighting the importance of accurate diagnosis and therapeutic selection.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of refractory immune checkpoint inhibitor-induced colitis successfully treated with mirikizumab. mirikizumab成功治疗难治性免疫检查点抑制剂诱导结肠炎1例。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2026-09-14 DOI: 10.1007/s12328-026-02444-8
Yuntae Kim, Junko Takei, Atsushi Yoshida, Shino Babaguchi, Hiroko Tsunoda, Naoki Kanomata, Koichi Takagi, Katsuyuki Fukuda
{"title":"A case of refractory immune checkpoint inhibitor-induced colitis successfully treated with mirikizumab.","authors":"Yuntae Kim, Junko Takei, Atsushi Yoshida, Shino Babaguchi, Hiroko Tsunoda, Naoki Kanomata, Koichi Takagi, Katsuyuki Fukuda","doi":"10.1007/s12328-026-02444-8","DOIUrl":"https://doi.org/10.1007/s12328-026-02444-8","url":null,"abstract":"<p><strong>Background: </strong>Immune checkpoint inhibitor-induced colitis (ICIC) is a common and clinically significant adverse event associated with immune checkpoint inhibitor (ICI) use. Although corticosteroids are used as first-line therapy and infliximab or vedolizumab is recommended for steroid-refractory cases, some patients fail to respond to these treatments and optimal management remains unclear.</p><p><strong>Case presentation: </strong>A 76-year-old woman with triple-negative breast cancer (cT2N0M0, Stage IIA) received neoadjuvant chemotherapy, including pembrolizumab, according to the KEYNOTE-522 regimen. After the second cycle, the patient developed watery diarrhea and hematochezia more than 10 times daily. Based on the endoscopic and histopathological findings, ICIC was diagnosed. Treatment with corticosteroids followed by infliximab led to a clinical response. She subsequently underwent surgery for residual disease; however, colitis relapsed postoperatively. Switching to vedolizumab resulted in a transient response; however, sustained remission was not achieved. Given that ICIC is refractory to corticosteroids, infliximab, and vedolizumab, mirikizumab, a selective anti-interleukin-23 p19 antibody, was initiated, leading to rapid clinical and endoscopic remission. No ICIC relapse or cancer recurrence was observed during the follow-up period of > 500 days after the initiation of mirikizumab.</p><p><strong>Conclusion: </strong>Mirikizumab may be a promising therapeutic option for refractory ICIC, particularly in patients resistant to multiple biological agents.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fatal cerebral gas embolism during endoluminal vacuum therapy for esophageal leak. 食道漏腔内真空治疗中致死性脑气栓塞。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2026-09-14 DOI: 10.1007/s12328-026-02441-x
Adam Mylonakis, Markos Despotidis, Andreas Koutsoumpas, Maria Saridaki, Chrysovalantis Vergadis, Dimitrios Bistarakis, Lampis C Stavrinou, Elizabeth Paramythiotou, Dimitrios Schizas
{"title":"Fatal cerebral gas embolism during endoluminal vacuum therapy for esophageal leak.","authors":"Adam Mylonakis, Markos Despotidis, Andreas Koutsoumpas, Maria Saridaki, Chrysovalantis Vergadis, Dimitrios Bistarakis, Lampis C Stavrinou, Elizabeth Paramythiotou, Dimitrios Schizas","doi":"10.1007/s12328-026-02441-x","DOIUrl":"https://doi.org/10.1007/s12328-026-02441-x","url":null,"abstract":"<p><strong>Background: </strong>Endoluminal vacuum therapy (EndoVAC/EVT) is widely used for managing esophageal anastomotic leaks, with high closure rates and a favorable safety profile compared with stent placement or surgical revision. Serious neurological complications associated with endoVAC treatment appear to be exceptionally rare.</p><p><strong>Case presentation: </strong>We present the case of a 60-year-old patient who underwent open Ivor Lewis esophagectomy for pT2N0 esophageal adenocarcinoma. On postoperative day (POD) 8, fever and leukocytosis developed, and imaging confirmed an intrathoracic anastomotic leak. EVT was initiated on POD 12 with intracavitary sponge placement at - 80 mmHg continuous suction. Seven subsequent exchanges were uneventful, with progressive reduction of the leak cavity. On POD 37, during the eighth exchange using CO₂ insufflation, sudden neurological collapse occurred immediately after sponge removal and irrigation. Brain CT demonstrated extensive intracranial gas within supratentorial and infratentorial compartments, predominantly in the dural venous sinuses, with cerebral edema. The patient died six days later.</p><p><strong>Discussion: </strong>A plausible mechanism was retrograde venous gas embolization via the posterior mediastinum and Batson's plexus, facilitated by direct endoscopic access to the leak cavity. Preventive strategies include minimizing insufflation pressure, gentle irrigation, and careful reassessment of the need for continued intracavitary therapy.</p><p><strong>Conclusions: </strong>This case of fatal cerebral gas embolism during EVT highlights an exceptionally rare and potentially catastrophic complication and the need for procedural vigilance.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enterolith-containing Meckel's diverticulum causing strangulated small bowel obstruction in an older adult: diagnostic implications of transition-point calcification on computed tomography. 含肠石的梅克尔憩室引起老年人绞窄性小肠梗阻:计算机断层扫描过渡点钙化的诊断意义。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2026-09-10 DOI: 10.1007/s12328-026-02443-9
Takumi Yoshimura, Yoshiaki Fujimoto, Takuma Izumi, Rintaro Yoshida, Fumihiko Hirai, Takuya Honboh, Noboru Harada, Seiya Kato, Noriaki Sadanaga, Tomoharu Yoshizumi
{"title":"Enterolith-containing Meckel's diverticulum causing strangulated small bowel obstruction in an older adult: diagnostic implications of transition-point calcification on computed tomography.","authors":"Takumi Yoshimura, Yoshiaki Fujimoto, Takuma Izumi, Rintaro Yoshida, Fumihiko Hirai, Takuya Honboh, Noboru Harada, Seiya Kato, Noriaki Sadanaga, Tomoharu Yoshizumi","doi":"10.1007/s12328-026-02443-9","DOIUrl":"https://doi.org/10.1007/s12328-026-02443-9","url":null,"abstract":"<p><strong>Introduction: </strong>Preoperative diagnosis of Meckel's diverticulum in adults remains challenging because clinical presentation and computed tomography findings are often nonspecific. Enterolith-containing Meckel's diverticulum may present as strangulated small bowel obstruction with calcified lesions near the transition point.</p><p><strong>Case presentation: </strong>An 83-year-old woman without prior abdominal surgery presented with abdominal pain, vomiting, and progressive malaise. Non-contrast computed tomography showed closed-loop small bowel obstruction with two adjacent high-density lesions near the pelvic transition point. Emergency surgery was performed because bowel ischemia was suspected. Laparoscopy was converted to open laparotomy because severe bowel dilatation prevented adequate visualization. A blind-ending diverticulum arising from the antimesenteric border of the distal ileum and containing two enteroliths was identified. The diverticulum twisted around the adjacent ileum, causing strangulation and segmental bowel necrosis. Based on its anatomical configuration, it was considered Meckel's diverticulum. Partial ileal resection was performed. Retrospective review indicated that the high-density lesions corresponded to enteroliths within the diverticulum. The patient was discharged on postoperative day 10 without complications.</p><p><strong>Conclusion: </strong>Meckel's diverticulum should be considered in older adults with strangulated small bowel obstruction without prior laparotomy. Enterolith-like calcifications adjacent to the distal ileal transition point may provide a diagnostic clue when the etiology is unclear preoperatively.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148918837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gallbladder adenosquamous carcinoma with extensive necrosis mimicking gangrenous cholecystitis and liver abscess. 胆囊腺鳞癌伴广泛坏死,类似坏疽性胆囊炎和肝脓肿。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2026-09-06 DOI: 10.1007/s12328-026-02439-5
Marie Sakai, Mayu Uka, Yuri Takemoto, Yuka Ogino, Koichi Yoshimura, Momoka Nagae, Shinichi Shimizu, Yoko Shinno, Takashi Mukai, Takao Hiraki
{"title":"Gallbladder adenosquamous carcinoma with extensive necrosis mimicking gangrenous cholecystitis and liver abscess.","authors":"Marie Sakai, Mayu Uka, Yuri Takemoto, Yuka Ogino, Koichi Yoshimura, Momoka Nagae, Shinichi Shimizu, Yoko Shinno, Takashi Mukai, Takao Hiraki","doi":"10.1007/s12328-026-02439-5","DOIUrl":"https://doi.org/10.1007/s12328-026-02439-5","url":null,"abstract":"<p><p>We report a case of gallbladder adenosquamous carcinoma with characteristic imaging findings. A 78-year-old man was suspected of having gangrenous cholecystitis and liver abscess based on abdominal ultrasonography performed at another hospital. Contrast-enhanced computed tomography revealed a 10-cm hepatic mass contiguous with the gallbladder, with marked internal necrosis and persistent peripheral enhancement. These imaging findings suggested gallbladder adenosquamous or squamous cell carcinoma with hepatic invasion, and needle biopsy revealed both adenocarcinoma and squamous cell carcinoma components, supporting the diagnosis. This case highlights the importance of recognizing marked internal necrosis and aggressive infiltrative growth on imaging in gallbladder adenosquamous carcinoma presenting with imaging features mimicking gangrenous cholecystitis and liver abscess.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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