Clinical Journal of Gastroenterology最新文献_第8页

Non-cirrhotic portal-splenic-mesenteric vein thrombosis unmasking JAK2 V617F-positive polycythemia vera. 非肝硬化门脉-脾-肠系膜静脉血栓揭示JAK2 v617f阳性真性红细胞增多症。

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2026-03-23 DOI: 10.1007/s12328-026-02306-3

Tomoki Otake, Masamichi Kimura, Koji Nishikawa, Jun Imamura, Kiminori Kimura

{"title":"Non-cirrhotic portal-splenic-mesenteric vein thrombosis unmasking JAK2 V617F-positive polycythemia vera.","authors":"Tomoki Otake, Masamichi Kimura, Koji Nishikawa, Jun Imamura, Kiminori Kimura","doi":"10.1007/s12328-026-02306-3","DOIUrl":"https://doi.org/10.1007/s12328-026-02306-3","url":null,"abstract":"Non-cirrhotic splanchnic venous thrombosis (SVT) can occur in myeloproliferative neoplasms. We report the case of a 69-year-old man who presented with a 2-week history of epigastric pain and was found to have simultaneous portal, splenic, and superior mesenteric vein thromboses in the absence of cirrhosis or malignancy on contrast-enhanced computed tomography. Laboratory testing revealed elevated haemoglobin/haematocrit with a low-normal mean corpuscular volume (83 fL), biochemical evidence of iron restriction, and an inappropriately low serum erythropoietin level. On further testing, JAK2 V617F was positive, and bone marrow findings supported the diagnosis of polycythemia vera (PV). This presentation is compatible with an iron-deficiency-modified PV phenotype (sometimes referred to as \"masked PV\"), in which iron restriction can attenuate or obscure typical erythrocytosis, and extensive non-cirrhotic SVT effectively unmasked the underlying clonal disorder. Edoxaban 30 mg once daily (body weight < 60 kg) was initiated without interruption or bleeding, and therapeutic phlebotomy was initiated to control the hematocrit. Follow-up computed tomography on day 78 demonstrated marked thrombus reduction with partial re-opacification of the main portal vein, and the patient continued to have a stable clinical course. This case highlights triple-site, non-cirrhotic SVT as a potential presenting feature of PV and supports early JAK2 V617F and erythropoietin testing, coupled with parallel anticoagulation and PV-directed management, in unexplained non-cirrhotic SVT.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An extremely rare case of stercoral colitis with a subsequent benign stricture: preoperative thin endoscopic assessment to optimize surgical extent. 一例极为罕见的后珊瑚结肠炎并发良性狭窄：术前薄内窥镜评估以优化手术范围。

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2026-03-23 DOI: 10.1007/s12328-026-02310-7

Haruka Miyazaki, Kentaro Tominaga, Itsuo Nagayama, Kazuya Takahashi, Satoshi Ikarashi, Hiroteru Kamimura, Hideaki Sugino, Yoshifumi Shimada, Toshifumi Wakai, Shuji Terai

{"title":"An extremely rare case of stercoral colitis with a subsequent benign stricture: preoperative thin endoscopic assessment to optimize surgical extent.","authors":"Haruka Miyazaki, Kentaro Tominaga, Itsuo Nagayama, Kazuya Takahashi, Satoshi Ikarashi, Hiroteru Kamimura, Hideaki Sugino, Yoshifumi Shimada, Toshifumi Wakai, Shuji Terai","doi":"10.1007/s12328-026-02310-7","DOIUrl":"https://doi.org/10.1007/s12328-026-02310-7","url":null,"abstract":"Stercoral obstructive colitis is a rare but potentially life-threatening condition that often progresses to septic shock or colonic necrosis. Optimal management strategies, balancing conservative stabilization with surgical timing and extent, remain unclear. We present the case of an 81-year-old man who presented with obstipation, abdominal pain, hematochezia, and shock (blood pressure: 74/59 mmHg, lactate level: 8.1 mmol/L). Computed tomography showed diffuse fecal loading without signs of necrosis or perforation. Aggressive conservative therapy (manual disimpaction, fluids, and antibiotics) achieved stabilization. During recovery, a 30 cm benign stricture developed from the left transverse colon to the rectosigmoid colon. This is the first documented case in which thin endoscopic mapping was used to traverse the stenotic segment, delineate ulcer-scar changes, and tattoo healthy mucosa, enabling limited left hemicolectomy with primary anastomosis and stoma avoidance. Histological examination revealed severe submucosal fibrosis with chronic inflammatory cell and eosinophil infiltration, indicating reparative phase changes. Therefore, thin endoscopic assessment after stabilization can optimize surgical planning and reduce invasive management in patients with stercoral obstructive colitis and postinflammatory strictures.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful treatment of β-catenin-positive, immune checkpoint inhibitor-resistant tumor in a case of multicentric hepatocellular carcinoma. 成功治疗一例多中心肝细胞癌中β-连环蛋白阳性、免疫检查点抑制剂耐药的肿瘤

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2026-03-21 DOI: 10.1007/s12328-025-02266-0

Hirotaka Nomiya, Hidetaka Matsuda, Takuto Nosaka, Yu Akazawa, Tomoko Tanaka, Kazuto Takahashi, Tatsushi Naito, Masahiro Ohtani, Yoshiaki Imamura, Yasunari Nakamoto

引用次数: 0

Acute-on-chronic liver failure triggered by postpartum variceal bleeding in a patient with alcohol-associated liver disease. 酒精相关性肝病患者产后静脉曲张出血引发的急性慢性肝衰竭

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2026-03-18 DOI: 10.1007/s12328-026-02307-2

Yoshiaki Kobayashi, Takefumi Kimura, Tomoo Yamazaki, Takanobu Iwadare, Kosuke Sonoda, Yasuhiro Tanaka, Tadanobu Nagaya

引用次数: 0

Gastric outlet obstruction secondary to Peutz-Jeghers syndrome successfully managed by polypectomy. 胃出口梗阻继发Peutz-Jeghers综合征成功地处理息肉切除术。

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2026-03-17 DOI: 10.1007/s12328-026-02308-1

Riho Takeda, Toshiki Nakamura, Masamichi Sato, Kiyoaki Yabe, Kenji Hosoi, Kentaro Matsuoka, Hiroshi Futagawa, Hiroshi Sakakibara

{"title":"Gastric outlet obstruction secondary to Peutz-Jeghers syndrome successfully managed by polypectomy.","authors":"Riho Takeda, Toshiki Nakamura, Masamichi Sato, Kiyoaki Yabe, Kenji Hosoi, Kentaro Matsuoka, Hiroshi Futagawa, Hiroshi Sakakibara","doi":"10.1007/s12328-026-02308-1","DOIUrl":"https://doi.org/10.1007/s12328-026-02308-1","url":null,"abstract":"Peutz-Jeghers syndrome (PJS) is a genetic disorder characterized by the development of hamartomatous polyps throughout the gastrointestinal tract but primarily in the small bowel. Gastric outlet obstruction (GOO) due to PJS polyps is rare in childhood. The optimal treatment of large, gastric polyps in PJS remains unclear. We report herein the case of a 1-year-old, male patient who was treated endoscopically for GOO caused by a massive PJS polyp. The patient had a history of frequent non-bilious vomiting and melena. Gastrointestinal bleeding was suspected, prompting an abdominal ultrasound and a gastrointestinal series. The ultrasound revealed mucosal lesions in the stomach, and a contrast meal indicated a possible gastrointestinal obstruction. Endoscopy led to the diagnosis of gastric obstruction secondary to a massive PJS polyp. After carefully excluding malignancy, the polyp was excised via snare polypectomy. The present case demonstrated that gastric polyps in PJS can present with symptoms even at a young age and that abdominal ultrasound and gastrointestinal series are valuable tools for diagnosing GOO due to gastric polyps. While open surgery is typically considered for polyps causing GOO, endoscopic resection can be a safe and effective alternative.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of cryopyrin-associated periodic syndrome presenting with abdominal symptoms due to a novel mutation NLRP3 p.Ile257Met. NLRP3 p.p ile257met突变引起的低温霉素相关周期性综合征的腹部症状一例。

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2026-03-17 DOI: 10.1007/s12328-026-02293-5

Yo Komatsu, Tomofumi Oizumi, Shun-Ichi Yanai, Yumiko Kobayashi, Shin-Ya Nishio, Shin-Ichi Usami, Takayuki Matsumoto

引用次数: 0

Successful management and 10-year survival of a rectal neuroendocrine tumor with rare systemic metastases via a non-portal venous pathway. 直肠神经内分泌肿瘤经非门静脉途径转移的成功治疗和10年生存率。

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2026-03-17 DOI: 10.1007/s12328-026-02295-3

Shigeru Horiguchi, Kazuyuki Matsumoto, Kazuya Miyamoto, Akihiro Matsumi, Hiroyuki Terasawa, Yuki Fujii, Kosei Takagi, Takashi Kuise, Takehiro Tanaka, Motoyuki Otsuka

引用次数: 0

Delayed diagnosis of acquired hemophilia a complicating hepatocellular carcinoma: a rare case of hepatectomy following atezolizumab and bevacizumab therapy. 获得性血友病并发肝细胞癌的延迟诊断：阿特唑单抗和贝伐单抗治疗后肝切除术的罕见病例。

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2026-03-17 DOI: 10.1007/s12328-026-02297-1

Shun Nakamura, Takashi Masuda, Wataru Miyoshino, Yuiko Nagasawa, Masahiro Kawamura, Yoko Kawano, Hiroomi Takayama, Teijiro Hirashita, Yuichi Endo, Masafumi Inomata

引用次数: 0

Thoracoscopic biopsy should be considered for pulmonary nodules with the halo sign during immunotherapy for hepatocellular carcinoma. 在肝细胞癌的免疫治疗中，胸腔镜活检应考虑有晕征的肺结节。

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2026-03-14 DOI: 10.1007/s12328-026-02305-4

Yoichi Asano, Satoru Iwamoto, Yuki Yamazaki, Ryosuke Kaku, Kunio Hamanaka, Koki Moriyoshi, Shin'ichi Miyamoto

引用次数: 0

Diffuse duodenitis in a patient with ulcerative colitis who was successfully treated with upadacitinib. 溃疡性结肠炎患者弥漫性十二指肠炎，upadacitinib治疗成功。

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2026-03-09 DOI: 10.1007/s12328-026-02304-5

Ryosuke Murata, Yoshiki Okita, Shunsuke Urayoshi, Yusuke Yoshikane, Yuriko Uomi, Misaki Nakamura, Yuhei Umeda, Mikio Kawamura, Yuji Toiyama, Hayato Nakagawa

引用次数: 0