Clinical Journal of Gastroenterology最新文献_第8页

Thrombotic complications following bariatric surgery: how medical tourism poses challenges to comprehensive care in obesity medicine. 减肥手术后的血栓并发症：医疗旅游如何给肥胖症医学的综合治疗带来挑战。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-10-12 DOI: 10.1007/s12328-024-02047-1

Mandour Omer Mandour, Robert Bakewell, John Ong

引用次数: 0

A small bowel adenocarcinoma harboring a DDR2 mutation in a celiac patient. 一名乳糜泻患者的小肠腺癌携带 DDR2 突变。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-08-08 DOI: 10.1007/s12328-024-02025-7

Ludovica Mollica, Erica Quaquarini, Annalisa Schiepatti, Erica Travaglino, Francesca Antoci, Alessandro Vanoli, Giovanni Arpa, Federico Biagi, Laura Deborah Locati

{"title":"A small bowel adenocarcinoma harboring a DDR2 mutation in a celiac patient.","authors":"Ludovica Mollica, Erica Quaquarini, Annalisa Schiepatti, Erica Travaglino, Francesca Antoci, Alessandro Vanoli, Giovanni Arpa, Federico Biagi, Laura Deborah Locati","doi":"10.1007/s12328-024-02025-7","DOIUrl":"10.1007/s12328-024-02025-7","url":null,"abstract":"We present the case of a 62-year-old man with a history of celiac disease and IgA deficiency, following a strict gluten-free diet that was admitted to our hospital for recurrent abdominal pain, fatigue and melena. Esophagogastroduodenoscopy and colonoscopy with biopsies were normal. A video-capsule endoscopy was performed and revealed a sub-stenosing, vegetating, and bleeding lesion in the first jejunal loop. He underwent laparotomic surgery with resection of the involved segment with loco-regional lymphadenectomy. The pathological report described a poorly differentiated adenocarcinoma of the jejunum, stage IIIA (pT3pN1). Analysis of next-generation sequencing (NGS) of DNA on the surgical sample revealed a likely pathogenetic variant in exon 15 of the DDR2 gene (c.2003G > A) and a TP53 non-frame-shift deletion (c.585_602del). Considering the risk of recurrence, he was candidate to 6 months of adjuvant chemotherapy with platinum salt and fluoropyrimidine. Thirty-eight months after the diagnosis, the patient is still disease free and in good clinical condition. This is the first described case of SBA with DDR2 mutation. Considering the limited therapeutic options beyond surgery for SBA, molecular analyses could become promising for the search for potential targetable alterations for treatments with new available drugs.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"1026-1032"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid deterioration of steatotic liver disease due to portal vein stenosis after pancreaticoduodenectomy. 胰十二指肠切除术后，门静脉狭窄导致脂肪肝迅速恶化。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-08-15 DOI: 10.1007/s12328-024-02027-5

Mineto Ohta, Rikiya Kanba, Keisuke Fukushima, Kazutomi Takahashi, Hiroyasu Nishimaki, Tatsuya Sasaki, Ai Fujita, Maika Kanno, Yuki Ogasawara, Kenji Namiki

{"title":"Rapid deterioration of steatotic liver disease due to portal vein stenosis after pancreaticoduodenectomy.","authors":"Mineto Ohta, Rikiya Kanba, Keisuke Fukushima, Kazutomi Takahashi, Hiroyasu Nishimaki, Tatsuya Sasaki, Ai Fujita, Maika Kanno, Yuki Ogasawara, Kenji Namiki","doi":"10.1007/s12328-024-02027-5","DOIUrl":"10.1007/s12328-024-02027-5","url":null,"abstract":"Steatotic liver disease after pancreatoduodenectomy occurs due to various factors, such as exocrine pancreatic insufficiency, impaired intestinal absorption, and malnutrition. The mechanism of steatogenesis differs to that of conventional steatotic liver disease associated with obesity and insulin resistance. We experienced a rare case of rapidly progressive steatotic liver disease accompanied by portal vein stenosis in the early postoperative period after subtotal stomach-preserving pancreaticoduodenectomy for distal cholangiocarcinoma. Although there was a complication due to postoperative drain infection, the patient was discharged from hospital with no nutritional problems. Two months postoperatively, the patient presented to the emergency room with dyspnea. CT showed a markedly steatotic liver, ascites, and portal vein stenosis. A portal vein stent was inserted transhepatically and the steatotic liver disease gradually improved. During the postoperative course, there were no problems indicated by nutritional markers; although the patient had diarrhea associated with postoperative pancreatic exocrine insufficiency, the symptoms were mild and improved after administration of oral pancrelipase. Before the intervention, the patient had intestinal edema, exacerbation of diarrhea, and a low serum zinc concentration, suggesting that impaired absorption caused by intestinal blood stasis and gut barrier dysfunction contributed to the development of steatotic liver disease.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"1093-1099"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of protein-losing gastroenteropathy due to Sjögren's syndrome detected by foggy vision with refractive error of the intraocular lens. 一例因视力模糊和眼内晶状体屈光不正而被发现的斯约格伦综合征引起的蛋白质丢失性肠胃病。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-09-19 DOI: 10.1007/s12328-024-02038-2

Naho Watanabe, Rena Kaneko, Monami Kishi, Ryo Yanai, Takashi Ikehara, Hidenari Nagai, Takahisa Matsuda

{"title":"A case of protein-losing gastroenteropathy due to Sjögren's syndrome detected by foggy vision with refractive error of the intraocular lens.","authors":"Naho Watanabe, Rena Kaneko, Monami Kishi, Ryo Yanai, Takashi Ikehara, Hidenari Nagai, Takahisa Matsuda","doi":"10.1007/s12328-024-02038-2","DOIUrl":"10.1007/s12328-024-02038-2","url":null,"abstract":"A woman in her forties visited an ophthalmologist for rapidly progressive foggy vision. Naked visual acuity had decreased to 0.15, and although her eyes showed no abnormalities, internal disease was suspected and albumin 2.6 g/dL was found. Protein leakage from the intestinal tract was suspected since there was no urinary protein excretion. 99mTechnetium-labeled albumin D scintigraphy showed protein leakage from the intestinal tract. A stool α1-antitrypsin clearance test showed an increase to 56.3 mL/day, leading to a diagnosis of protein-losing gastroenteropathy. Blood biochemistry revealed abnormally high levels of anti-SS-A and anti-SS-B antibodies (≥ 1200 U/mL and ≥ 1000 U/mL, respectively). A lip salivary gland biopsy revealed lymphocytic infiltrate at least 1 focus per 2 mm × 2 mm > 50 lymphocytes per conduit). The Schirmer test result was 5 mm/5 min or less, which led to the diagnosis of Sjögren's syndrome. The serum albumin level increased with intravenous administration of methylprednisolone 50 mg (1 mg/kg), and the patient is currently on oral prednisolone at a gradually decreasing dose. After administration of prednisolone, visual acuity recovered to 1.2 with recovery of albumin.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"1039-1046"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of undifferentiated pleomorphic rectal sarcoma occurring after radiation exposure. 一例辐射照射后发生的未分化多形性直肠肉瘤。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-08-09 DOI: 10.1007/s12328-024-02026-6

Makoto Eizuka, Yosuke Toya, Shun Yamada, Tomofumi Oizumi, Shunichi Yanai, Norihiko Kudara, Naoki Yanagawa, Tamotsu Sugai, Takayuki Matsumoto

引用次数: 0

BRAF-mutant mismatch repair deficient invasive colon cancer regressing to sessile serrated lesion. BRAF突变错配修复缺陷浸润性结肠癌向无柄锯齿状病变发展。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-07-13 DOI: 10.1007/s12328-024-02006-w

Kenshi Matsuno, Hideaki Miyamoto, Miki Shimoda, Ryosuke Gushima, Katsuya Nagaoka, Mayuko Ohuchi, Yuji Miyamoto, Kohei Ohkura, Yoshiki Mikami, Yasuhito Tanaka

{"title":"BRAF-mutant mismatch repair deficient invasive colon cancer regressing to sessile serrated lesion.","authors":"Kenshi Matsuno, Hideaki Miyamoto, Miki Shimoda, Ryosuke Gushima, Katsuya Nagaoka, Mayuko Ohuchi, Yuji Miyamoto, Kohei Ohkura, Yoshiki Mikami, Yasuhito Tanaka","doi":"10.1007/s12328-024-02006-w","DOIUrl":"10.1007/s12328-024-02006-w","url":null,"abstract":"A 69-year-old female was presented with a history of sigmoid colon cancer, uterine cancer, and intrahepatic carcinomas. After computed tomography revealed a disseminated nodule located in the peritoneum, colonoscopy demonstrated a rather flat-to-slightly elevated lesion with a depressed area located in the ascending colon. The flat component showed color similar to its surrounding area, and the depressed area showed redness and an expanded appearance. We obtained a biopsy specimen from the depressed area, and microscopic examination revealed well-differentiated adenocarcinoma, which was immunohistochemically positive for BRAF V600E-mutated and PMS2 proteins, and showed loss of MSH2 and MSH6 protein expressions. These findings suggested the lesion to have transformed from a sessile serrated lesion (SSL) to mismatch repair (MMR) deficient colon cancer. The patient underwent surgical removal of the nodule, which interpreted as metastasis of intrahepatic cholangiocarcinoma histopathologically. After postoperative chemotherapy, the follow-up colonoscopy revealed only the flat portion of the lesion without depressed area. Consequently, we performed an endoscopic resection, and microscopic examination confirmed the existence of BRAF V600E-mutated protein-positive and MMR protein-retained SSL without residual carcinoma. This is the first report of BRAF-mutant and MMR-deficient colon cancer, in association with SSL, showing regression.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"904-909"},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of pancreatic body cancer with disappearance of the dilated pancreatic duct on the tail side during preoperative treatment. 一例在术前治疗期间尾侧扩张的胰管消失的胰体癌。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-06-23 DOI: 10.1007/s12328-024-02005-x

Yusuke Okamura, Ken Fukumitsu, Tatsuya Okishio, Yuri Kanaya, Yasuhiro Saito, Ryo Kudo, Michina Morioka, Shinsuke Shibuya, Toshihide Yamaoka, Dai Manaka

{"title":"A case of pancreatic body cancer with disappearance of the dilated pancreatic duct on the tail side during preoperative treatment.","authors":"Yusuke Okamura, Ken Fukumitsu, Tatsuya Okishio, Yuri Kanaya, Yasuhiro Saito, Ryo Kudo, Michina Morioka, Shinsuke Shibuya, Toshihide Yamaoka, Dai Manaka","doi":"10.1007/s12328-024-02005-x","DOIUrl":"10.1007/s12328-024-02005-x","url":null,"abstract":"This is a case of a 67-year-old woman diagnosed with a 35-mm pancreatic body cancer with a chief complaint of epigastric discomfort. Computed tomography demonstrated invasion of the common hepatic artery, portal vein, and stomach, and chemotherapy was initiated for locally advanced pancreatic cancer. After 9 months of chemotherapy, the tumor remained stable on imaging, and the tumor markers were within the normal range. After additional chemoradiotherapy, the patient underwent a conversion surgery, a pancreaticoduodenectomy. Magnetic resonance cholangiopancreatography (MRCP) at the time of diagnosis demonstrated main pancreatic duct (MPD) dilatation on the tail side of the tumor; however, most of the MPD signal disappeared on MRCP after chemotherapy. Surgical findings failed to identify MPD on the first pancreatic resection plane, and additional resection was conducted; however, no MPD was found. As a pancreatic duct anastomosis was not available, pancreatic reconstruction was selected for pancreaticogastric anastomosis using the invagination method. Pathologically, the pancreatic tissue on the tail side of the tumor was replaced by fibrotic tissue, and MPD could not be identified. To the best of our knowledge, this is the first case report of the disappearance of a dilated pancreatic duct on the tail side accompanied by exocrine tissue loss during preoperative treatment for pancreatic cancer.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"989-993"},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatico-renal fistula associated with pancreatic cysts caused by type 1 autoimmune pancreatitis. 1型自身免疫性胰腺炎引起的胰腺囊肿伴发的胰肾瘘。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-06-26 DOI: 10.1007/s12328-024-02008-8

Kensuke Takuma, Ai Fujimoto, Naoki Okano, Akihide Hayashi, Kensuke Hoshi, Yoichiro Sato, Yusuke Kimura, Yoshinori Igarashi, Kensuke Sakamoto, Takahisa Matsuda

引用次数: 0

Diaphragmatic and pericardial reconstruction using a Gore-Tex^® patch in a patient with an invasive liver malignancy. 使用 Gore-Tex® 补丁为一名侵袭性肝脏恶性肿瘤患者重建膈肌和心包。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-07-23 DOI: 10.1007/s12328-024-02017-7

Yusuke Matsune, Takeshi Aoki, Yoshihiko Tashiro

{"title":"Diaphragmatic and pericardial reconstruction using a Gore-Tex® patch in a patient with an invasive liver malignancy.","authors":"Yusuke Matsune, Takeshi Aoki, Yoshihiko Tashiro","doi":"10.1007/s12328-024-02017-7","DOIUrl":"10.1007/s12328-024-02017-7","url":null,"abstract":"The Gore-Tex® polytetrafluoroethylene patch is one of the most used prostheses for diaphragm, vessel, and pericardial reconstruction. It is strong, flexible, and relatively inexpensive and can be fitted to match the size of the resected area. In addition, it can be used to reconstruct the pericardium and diaphragm following resection to treat diffuse malignant pleural mesothelioma or repair large hiatal hernias. However, the use of polytetrafluoroethylene for hepatocellular carcinoma with diaphragmatic and pericardial invasion has not yet been reported. We report the case of a 72-year-old man with hepatocellular carcinoma with diaphragmatic and pericardial invasion. Subsequently, laparotomic liver subsegmentectomy of segment 3 and resection of the diaphragm and pericardium were performed. The defects were successfully reconstructed using the polytetrafluoroethylene patch, without postoperative complications. This is the first report describing a case of invasive liver malignancy that required simultaneous diaphragmatic and pericardial reconstruction using a polytetrafluoroethylene patch, indicating that the polytetrafluoroethylene patch could effectively and directly treat invasive liver malignancies.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"943-947"},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relapsing sclerosing mesenteritis with multiple strictures of the small intestine. 复发性硬化性肠系膜炎伴多发性小肠狭窄。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-05-29 DOI: 10.1007/s12328-024-01989-w

Masashi Ohno, Atsushi Nishida, Takayuki Imai, Eri Tanaka, Kenichiro Takahashi, Toru Miyake, Masaji Tani, Ryoji Kushima, Osamu Inatomi

引用次数: 0