Clinical Journal of Gastroenterology最新文献

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Pancreatic cancer secondary to biliary tract cancer associated with pancreaticobiliary maljunction: intraductal dissemination through the common channel.
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-03-07 DOI: 10.1007/s12328-025-02108-z
Keishi Sugimachi, Takahiro Tomino, Tomonari Shimagaki, Emi Onishi, Yutaka Koga, Kenichi Taguchi, Masayuki Furukawa, Terumasa Hisano, Rie Sugimoto, Masaru Morita
{"title":"Pancreatic cancer secondary to biliary tract cancer associated with pancreaticobiliary maljunction: intraductal dissemination through the common channel.","authors":"Keishi Sugimachi, Takahiro Tomino, Tomonari Shimagaki, Emi Onishi, Yutaka Koga, Kenichi Taguchi, Masayuki Furukawa, Terumasa Hisano, Rie Sugimoto, Masaru Morita","doi":"10.1007/s12328-025-02108-z","DOIUrl":"https://doi.org/10.1007/s12328-025-02108-z","url":null,"abstract":"<p><p>Patients with pancreaticobiliary maljunction (PBM) have a high risk of biliary tract cancer (BTC). The risk of pancreatic cancer is also reported to be higher in patients with PBM compared to the general population; the underlying cause remains unclear. We report a 73-year-old man with widespread pancreatic cancer involving the entire pancreas. The patient previously underwent curative resection for gallbladder cancer and hilar cholangiocarcinoma concomitant with PBM. A total pancreatectomy was performed for the new pancreatic lesion. Histopathological examination revealed a papillary tumor predominantly composed of intraepithelial lesions that extended throughout the pancreatic duct, with skip lesions and irregular invasive foci at multiple sites within the duct. The morphological features and mucin profile were similar to those of the previous biliary lesions. Genetic analysis of the current lesion showed wild-type KRAS, GNAS, and PIK3CA genes consistent with the previous lesions, indicating that the pancreatic and biliary lesions were molecularly identical clones. Based on the clinicopathological findings and molecular analysis, we concluded that the BTC had spread intraluminally to the pancreatic duct through the common channel of the PBM, resulting in intraductal dissemination. Patients with PBM should be followed for pancreatic lesions, because of the risk of intraductal dissemination of BTC.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microsatellite-high intrahepatic cholangiocarcinoma with favorable treatment outcome using pembrolizumab.
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-03-04 DOI: 10.1007/s12328-025-02103-4
Shigeru Horiguchi, Hironari Kato, Kazuya Miyamoto, Kosaku Morimoto, Akihiro Matsumi, Hiroyuki Terasawa, Yuki Fujii, Kazuyuki Matsumoto, Takehiro Tanaka, Motoyuki Otsuka
{"title":"Microsatellite-high intrahepatic cholangiocarcinoma with favorable treatment outcome using pembrolizumab.","authors":"Shigeru Horiguchi, Hironari Kato, Kazuya Miyamoto, Kosaku Morimoto, Akihiro Matsumi, Hiroyuki Terasawa, Yuki Fujii, Kazuyuki Matsumoto, Takehiro Tanaka, Motoyuki Otsuka","doi":"10.1007/s12328-025-02103-4","DOIUrl":"https://doi.org/10.1007/s12328-025-02103-4","url":null,"abstract":"<p><p>Intrahepatic cholangiocarcinoma has a poor prognosis. In unresectable cases, the survival period is short despite combination therapy with cytotoxic anticancer agents and immune checkpoint inhibitors. The usefulness of immune checkpoint inhibitors against malignant tumors with microsatellite instability-high (MSI-H) mutations was shown in the KEYNOTE158 study; however, data for intrahepatic cholangiocarcinoma are insufficient. In the present case, a 65-year-old man with intrahepatic cholangiocarcinoma and lymph node metastasis could not be treated with a combination of gemcitabine, CDDP, and S-1. A comprehensive cancer genomic profiling (CGP) test showed MLH1 pathogenic mutation and MSI-H. When pembrolizumab was administered, the tumor shrinkage effect was rapidly observed, which was sustained even after 30 months. No pathogenic mutations were observed in the germline test, and MSI-high was considered to be due to the MLH1 pathogenic mutation occurring sporadically in somatic cells. MSI-H intrahepatic cholangiocarcinoma is extremely rare. However, because pembrolizumab is expected to be effective, CGP testing should be actively performed.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of pancreatic arteriovenous malformation diagnosed after the onset of abdominal symptoms.
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-03-03 DOI: 10.1007/s12328-025-02104-3
Katsuharu Tono, Tsutomu Nishida, Kengo Matsumoto, Masafumi Yamashita, Aya Sugimoto, Dai Nakamatsu, Masashi Yamamoto, Hiromi Tamura, Junzo Shimizu, Koji Fukui
{"title":"A case of pancreatic arteriovenous malformation diagnosed after the onset of abdominal symptoms.","authors":"Katsuharu Tono, Tsutomu Nishida, Kengo Matsumoto, Masafumi Yamashita, Aya Sugimoto, Dai Nakamatsu, Masashi Yamamoto, Hiromi Tamura, Junzo Shimizu, Koji Fukui","doi":"10.1007/s12328-025-02104-3","DOIUrl":"https://doi.org/10.1007/s12328-025-02104-3","url":null,"abstract":"<p><p>Pancreatic arteriovenous malformation (P-AVM) is an extremely rare vascular anomaly characterized by abnormal connections between arteries and veins bypassing the capillary network. Less than 200 cases have been reported worldwide, and standardized treatment guidelines have not yet been established. A 72-year-old man presented with abdominal distension, diarrhea, and appetite loss. Contrast-enhanced abdominal computed tomography revealed a 5 cm mass in the pancreatic tail with multiple feeding and draining vessels, a portosystemic shunt, and moderate ascites, suggesting a P-AVM. Endoscopic ultrasonography revealed a hypoechoic area in the pancreatic tail measuring 50 mm in diameter. Esophagogastroduodenoscopy revealed F2-type esophageal varices. Based on imaging findings and clinical history, the patient was diagnosed with P-AVM, and Osler-Weber-Rendu disease was excluded. Initial treatment with transarterial embolization was attempted, but proved insufficient due to high blood flow and multiple feeders. Surgical resection via distal pancreatectomy was subsequently performed to alleviate portal hypertension and resolve abdominal symptoms, although significant intraoperative bleeding occurred. This case highlights the diagnostic and therapeutic challenges of P-AVMs, particularly in high-flow lesions with complex vascular anatomy. Surgical resection remains the definitive treatment for symptomatic P-AVM and effectively resolves the associated complications. The insights gained from this case may contribute to the clinical management of this rare condition.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of multiple advanced colon cancers with spontaneous regression of only one lesion after biopsy: a case report and literature review. 一例多发性晚期结肠癌,活检后只有一个病灶自发消退:病例报告和文献综述。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-03-03 DOI: 10.1007/s12328-025-02106-1
Yoshiko Nakano, Gen Nishikawa, Kanako Degawa, Koki Moriyoshi, Katsutoshi Kuriyama, Yasuhiro Watanabe, Shin'ichi Miyamoto
{"title":"A case of multiple advanced colon cancers with spontaneous regression of only one lesion after biopsy: a case report and literature review.","authors":"Yoshiko Nakano, Gen Nishikawa, Kanako Degawa, Koki Moriyoshi, Katsutoshi Kuriyama, Yasuhiro Watanabe, Shin'ichi Miyamoto","doi":"10.1007/s12328-025-02106-1","DOIUrl":"https://doi.org/10.1007/s12328-025-02106-1","url":null,"abstract":"<p><p>A 90-year-old man underwent a colonoscopy due to abdominal distension, revealing half-circumferential Type 2 advanced cancers in the ascending and transverse colon. No distant metastasis was detected, and 3 months later, laparoscopic extended right hemicolectomy was performed for both lesions. Pathological examination revealed ulcers and mucus retention in the ascending colon lesion without tumor components. A small number of signet ring cell-like tumor cells were found in the regional lymph node of the ascending colon, while well-to-moderately differentiated tubular adenocarcinoma was observed on the serosal surface in the transverse colon. Tumor regression was observed in the ascending colon cancer and lymph-node metastasis. Mismatch repair (MMR) protein immunostaining was conducted on biopsy tissues from both lesions. The ascending colon lesion showed weak positivity for MLH1, positivity for MSH2 and MSH6, and negativity for PMS2, indicating MMR deficiency, whereas the transverse colon lesion showed positivity for all of them, indicating MMR-proficient tumor. This is the first case report of multiple advanced colon cancers, where only one lesion exhibited spontaneous regression after biopsy, suggesting a potential link between MMR deficiency and the spontaneous regression of colorectal cancer.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of relapsed pan-colonic ulcerative colitis accompanied with gastroduodenal lesions immediately after COVID-19.
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-03-01 DOI: 10.1007/s12328-025-02107-0
Katsuya Endo, Tomonori Satoh, Yuki Yoshino, Shiho Kondo, Yoko Kawakami, Daisuke Fukushi, Atsuko Takasu, Takayuki Kogure, Morihisa Hirota, Kennichi Satoh
{"title":"A case of relapsed pan-colonic ulcerative colitis accompanied with gastroduodenal lesions immediately after COVID-19.","authors":"Katsuya Endo, Tomonori Satoh, Yuki Yoshino, Shiho Kondo, Yoko Kawakami, Daisuke Fukushi, Atsuko Takasu, Takayuki Kogure, Morihisa Hirota, Kennichi Satoh","doi":"10.1007/s12328-025-02107-0","DOIUrl":"https://doi.org/10.1007/s12328-025-02107-0","url":null,"abstract":"<p><p>Some patients with ulcerative colitis (UC) suffer from complicated UC-associated upper gastrointestinal lesions. However, the trigger of these lesions has not been clarified. Herein, we present a 28-year-old man with relapsed pan-colonic UC accompanied by gastroduodenal lesions immediately after contracting coronavirus disease 2019 (COVID-19). In this patient, UC relapsed approximately 7 days after the COVID-19 onset, despite being in remission for 3 years. The patient also developed symptoms such as epigastric pain and nausea on day 19 of COVID-19. The endoscopic and pathologic findings of the stomach and duodenum closely resembled colorectal lesions of UC; accordingly, we diagnosed the patient with UC-associated gastroduodenal lesions. Corticosteroids were significantly effective in the colorectal and upper gastrointestinal lesions, leading to remission. This report is the first to describe UC-associated upper GI lesions that developed right after COVID-19 infection. Therefore, COVID-19 can be a possible trigger of UC-associated upper gastrointestinal lesion. Further studies are needed to understand the relationship between the onset of UC or UC-associated upper GI lesions and COVID-19.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of chronic hepatitis B complicated by systemic sarcoidosis that regressed following nucleos(t)ide analog therapy.
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-02-26 DOI: 10.1007/s12328-025-02105-2
Shigeaki Semba, Yuji Teraoka, Hiroki Kamada, Naohiro Kato, Takeshi Mizumoto, Yuzuru Tamaru, Tsuyoshi Hatakeyama, Atsushi Yamaguchi, Hirotaka Kouno, Shigeto Yoshida
{"title":"A case of chronic hepatitis B complicated by systemic sarcoidosis that regressed following nucleos(t)ide analog therapy.","authors":"Shigeaki Semba, Yuji Teraoka, Hiroki Kamada, Naohiro Kato, Takeshi Mizumoto, Yuzuru Tamaru, Tsuyoshi Hatakeyama, Atsushi Yamaguchi, Hirotaka Kouno, Shigeto Yoshida","doi":"10.1007/s12328-025-02105-2","DOIUrl":"https://doi.org/10.1007/s12328-025-02105-2","url":null,"abstract":"<p><p>Herein, we report the case of a 75-year-old woman with systemic sarcoidosis complicated by chronic hepatitis B. She presented with high fever and fatigue, with imaging studies revealing multiple tumor nodules in the liver and spleen, along with generalized lymphadenopathy, leading to her admission to our hospital for further evaluation and treatment. Blood tests revealed chronic hepatitis B, and nucleoside analog therapy with entecavir was initiated before the sarcoidosis diagnosis. A liver biopsy confirmed sarcoidosis, and treatment continued without steroid use. Significant improvement in symptoms and tumor size reduction were observed within weeks. After 6 months of treatment, positron emission tomography/computed tomography showed further regression of the liver and spleen tumors, with no symptom recurrence. Given the rarity of sarcoidosis complicated by chronic hepatitis B, this case suggests that controlling hepatitis B virus infection with nucleos(t)ide analogs might improve sarcoidosis symptoms without steroid use. The immunologic mechanisms underlying this cooccurrence remain unclear, and such cases are extremely rare. Therefore, this case may contribute to the understanding and management of sarcoidosis in patients with concurrent chronic hepatitis B.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case series of small bowel adenocarcinoma associated with Crohn's disease.
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-02-18 DOI: 10.1007/s12328-025-02102-5
Hazuki Miyazaki, Takayuki Ogino, Yuki Sekido, Takahiro Matsui, Tsuyoshi Hata, Norikatsu Miyoshi, Mamoru Uemura, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi
{"title":"Case series of small bowel adenocarcinoma associated with Crohn's disease.","authors":"Hazuki Miyazaki, Takayuki Ogino, Yuki Sekido, Takahiro Matsui, Tsuyoshi Hata, Norikatsu Miyoshi, Mamoru Uemura, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi","doi":"10.1007/s12328-025-02102-5","DOIUrl":"https://doi.org/10.1007/s12328-025-02102-5","url":null,"abstract":"<p><p>Long-standing Crohn's disease (CD) is well known to be associated with gastrointestinal malignancies. Patients with CD have a higher risk of developing small bowel adenocarcinoma (SBA) compared to healthy individuals. However, CD-associated SBA is not as common as colorectal cancer. While patients with CD often present with complicated stricture lesions in the small intestine, it is difficult to confirm all lesions by endoscopy. There is still no consensus on the surgical treatment of small bowel strictures with suspected CD-associated SBA. We report a case of small bowel high-grade dysplasia and two cases with advanced SBA. Case 1 involved a 53-year-old man whose high-grade dysplastic lesion of the small intestine was discovered incidentally postoperatively and successfully resected curatively. Case 2 was that of a 60-year-old man and Case 3 involved a 69-year-old man. Both patients had multiple small bowel stenotic lesions and were diagnosed with advanced small bowel cancer during follow-up. In conclusion, for patients with long-standing Crohn's disease who are refractory to treatment or have stenotic lesions, surgical resection should be considered as a treatment option with CD-associated SBA in consideration.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ascending colon perforation by a migrated pancreatic spontaneous dislodgment stent: a case report.
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-02-14 DOI: 10.1007/s12328-025-02101-6
Mari Okumura, Hideaki Koga, Hiroki Eguchi, Naoto Sato, Ran Utsunomiya, Yuhei Wakahara, Kazuhiro Morimoto, Kohei Sugiyama
{"title":"Ascending colon perforation by a migrated pancreatic spontaneous dislodgment stent: a case report.","authors":"Mari Okumura, Hideaki Koga, Hiroki Eguchi, Naoto Sato, Ran Utsunomiya, Yuhei Wakahara, Kazuhiro Morimoto, Kohei Sugiyama","doi":"10.1007/s12328-025-02101-6","DOIUrl":"https://doi.org/10.1007/s12328-025-02101-6","url":null,"abstract":"<p><p>Here, we report a case of a 74-year-old woman treated for acute cholecystitis. She initially underwent percutaneous transhepatic gallbladder drainage; however, cholecystitis recurred when the drain was clamped. Therefore, endoscopic transpapillary gallbladder drainage (ETGBD) was performed. Endoscopic sphincterotomy was performed, and a transpapillary gallbladder stent was placed. Additionally, a pancreatic spontaneous dislodgment stent (PSDS) was inserted to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis. Cholecystitis resolved, and the patient was discharged seven days later. Twenty-five days after ETGBD, she experienced abdominal pain, and computed tomography revealed ascending colon perforation by the migrated PSDS. She underwent laparoscopic surgery, in which the perforation was sutured, and an ileostomy was performed. The postoperative course was uneventful, and colonoscopy performed two months after surgery revealed multiple diverticula in the ascending colon. PSDS-induced gastrointestinal perforations are extremely rare. Previous case reports have suggested that perforation is caused by long-term stent retention in the gastrointestinal tract due to obstructions, such as peritonitis carcinomatosa or postoperative adhesions. We believe that in this case, the PSDS was retained because of multiple colonic diverticula. PSDS should be used with caution in patients with multiple colonic diverticula, peritonitis carcinomatosa, and postoperative adhesions.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of deep endometriosis with cyst formation as a differential diagnosis of rectal duplication cyst in the presacral space.
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-02-12 DOI: 10.1007/s12328-025-02100-7
Masato Nakano, Yoshifumi Shimada, Hikaru Ozeki, Akio Matsumoto, Mae Nakano, Shuhei Kondo, Ryosuke Goto, Nozomi Yachida, Kosuke Yoshihara, Toshifumi Wakai
{"title":"A case of deep endometriosis with cyst formation as a differential diagnosis of rectal duplication cyst in the presacral space.","authors":"Masato Nakano, Yoshifumi Shimada, Hikaru Ozeki, Akio Matsumoto, Mae Nakano, Shuhei Kondo, Ryosuke Goto, Nozomi Yachida, Kosuke Yoshihara, Toshifumi Wakai","doi":"10.1007/s12328-025-02100-7","DOIUrl":"https://doi.org/10.1007/s12328-025-02100-7","url":null,"abstract":"<p><p>Cysts occurring in the presacral space may become malignant and therefore require surgical removal. A wide variety of cystic lesions can occur in the presacral space, such as tailgut cysts, dermoid cysts, and duplication cysts. However, deep endometriosis with cyst formation in the presacral space is extremely rare. Here, we report a case of deep endometriosis that presented characteristic imaging and pathological findings and required a differential diagnosis of rectal duplication cyst. A 49-year-old female was referred with a chief complaint of lower abdominal pain. Magnetic resonance imaging (MRI) revealed a cystic lesion with a three-layered wall structure on the right side of the rectum, suggesting a rectal duplication cyst. The lesion had a maximum diameter of 8 cm and extended from the lower end of the second sacral vertebra to the levator ani muscle. The cystic lesion was removed laparoscopically, and intraoperative findings revealed no communication between the cystic lesion and the rectum. We found that the wall of the deep endometriosis with cyst formation had a histopathological three-layered structure and considered that the layered structure closely resembled the intestinal wall on MRI. Deep endometriosis should be recognized as a differential diagnosis of cystic lesions in the presacral space.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) of the rectum.
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-02-10 DOI: 10.1007/s12328-025-02099-x
Hiroyuki Fujimura, Atsushi Goto, Yuta Izumiya, Shunsuke Ito, Akiyoshi Tanaka, Hiroshi Itoh, Taro Takami
{"title":"Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) of the rectum.","authors":"Hiroyuki Fujimura, Atsushi Goto, Yuta Izumiya, Shunsuke Ito, Akiyoshi Tanaka, Hiroshi Itoh, Taro Takami","doi":"10.1007/s12328-025-02099-x","DOIUrl":"https://doi.org/10.1007/s12328-025-02099-x","url":null,"abstract":"<p><p>A 75-year-old man presented to our hospital complaining of abdominal distention. He underwent lower gastrointestinal endoscopic examination, which indicated a raised tumor of 20 mm in diameter in the sigmoid colon transition region of the rectum. Endoscopic mucosal resection was performed with the aims of treatment and diagnosis. Histopathological examination revealed a moderately differentiated adenocarcinoma with neuroendocrine carcinoma, which was classified as a mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN). The tumor had highly invaded the submucosa and positive vertical margins. Computed tomography showed no obvious lymph node metastasis or distant metastasis, so the patient underwent high-level anterior resection of the remaining lesion. The final diagnosis was MiNEN, pT3(SS), INFb, Ly1c, V0, Pn1a, pPM0, pDM0, pRM0, pN1a, and pStage IIIb (TNM Classification of Malignant Tumors, 8th Edition). The patient is recurrence free at 3 years without postoperative adjuvant therapy. We report this case with a review of the literature.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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