Clinical Journal of Gastroenterology最新文献_第2页

Successful novel use of dupilumab for gastrointestinal involvement of idiopathic hypereosinophilic syndrome: case report and review of the literature. 成功使用杜匹单抗治疗特发性高ereosinophilic综合征胃肠道受累的新方法：病例报告和文献综述。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-09-11 DOI: 10.1007/s12328-024-02036-4

Clare Moffatt, Christopher Soriano, David W Dawson, Guy A Weiss

{"title":"Successful novel use of dupilumab for gastrointestinal involvement of idiopathic hypereosinophilic syndrome: case report and review of the literature.","authors":"Clare Moffatt, Christopher Soriano, David W Dawson, Guy A Weiss","doi":"10.1007/s12328-024-02036-4","DOIUrl":"10.1007/s12328-024-02036-4","url":null,"abstract":"Hypereosinophilic syndrome (HES) is characterized by blood and tissue hypereosinophilia leading to organ damage. Gastrointestinal involvement is the third most common manifestation. We present a patient with idiopathic HES with secondary eosinophilic esophagitis (EoE), gastritis, and enteritis, corticosteroids-dependent, azathioprine- and mepolizumab-refractory. The patient achieved clinical and histopathologic remission following dupilumab treatment. A 28 year-old female presented with chronic episodic nausea and emesis since childhood and initial diagnosis of primary eosinophilic gastrointestinal disease (EGID), improved with corticosteroids, refractory to azathioprine. She was found to have peripheral eosinophilia and multifactorial anemia, with iron, B12, and folate deficiencies. Esophageal, gastric, duodenal, and terminal ileum biopsies showed significant eosinophilic infiltrate. Bone marrow biopsy at age 31 confirmed HES diagnosis. By age 32, she became total parental nutrition (TPN)-dependent. She failed trials of benralizumab and mepolizumab [anti-interleukin (IL)-5 inhibitors], and cromolyn (mast-cell stabilizer). After developing new esophageal stricture, we initiated dupilumab (IL-4/13 inhibitor), recently FDA-approved for EoE. After 9 weeks, esophageal stricture, gut tissue eosinophilia, and prior intestinal ulcerations resolved. She ceased TPN and is tolerating a non-restricted diet, with complete symptom resolution. Our patient's complete remission with dupilumab shows promise for broadening its use in treating GI involvement in HES, along with primary EGIDs.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of immune checkpoint inhibitor-associated hemophagocytosis after initiation of atezolizumab plus bevacizumab therapy for advanced hepatocellular carcinoma. 一例晚期肝细胞癌患者在接受阿特珠单抗加贝伐单抗治疗后出现免疫检查点抑制剂相关性嗜血细胞增多症。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-10-03 DOI: 10.1007/s12328-024-02040-8

Hisashi Hidaka, Hirotoshi Kamata, Haruki Uojima, Shuichiro Iwasaki, Junki Iida, Takahide Nakazawa, Chika Kusano

引用次数: 0

Endoscopic ultrasound-guided fine-needle biopsy diagnosing pancreatic metastasis seven years after renal leiomyosarcoma resection: a case report. 内镜超声引导下细针活检诊断肾脏良性肉瘤切除术七年后的胰腺转移：病例报告。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-09-06 DOI: 10.1007/s12328-024-02033-7

Takuya Okamoto, Shuhei Shintani, Hiromitsu Maehira, Kosuke Hiroe, Shiori Onoda, Hidenori Kimura, Atsushi Nishida, Masaji Tani, Ryoji Kushima, Osamu Inatomi

{"title":"Endoscopic ultrasound-guided fine-needle biopsy diagnosing pancreatic metastasis seven years after renal leiomyosarcoma resection: a case report.","authors":"Takuya Okamoto, Shuhei Shintani, Hiromitsu Maehira, Kosuke Hiroe, Shiori Onoda, Hidenori Kimura, Atsushi Nishida, Masaji Tani, Ryoji Kushima, Osamu Inatomi","doi":"10.1007/s12328-024-02033-7","DOIUrl":"10.1007/s12328-024-02033-7","url":null,"abstract":"Renal leiomyosarcoma metastasis to the pancreas is exceptionally rare. Here, we present a case of metastatic recurrence in the pancreas seven years after renal leiomyosarcoma resection. A 73-year-old female with a history of renal leiomyosarcoma surgery seven years prior presented with a well-defined 40 × 30 mm pancreatic tail tumor detected by a computed tomography (CT) scan. The tumor exhibited hypo-enhancement in the arterial phase and a progressive enhancement pattern toward the equilibrium phase, similar to pancreatic cancer. Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) revealed bundles of spindle cells that matched those in the previously resected renal sample. Immunohistochemistry showed positive staining for desmin, confirming the diagnosis of pancreatic metastasis from renal leiomyosarcoma. The patient underwent a distal pancreatectomy to remove the metastatic lesion. The extended interval of seven years before the detection of metastasis underscores the challenges in monitoring and diagnosing metastatic patterns of renal leiomyosarcoma. EUS-FNB can assist in distinguishing metastatic pancreatic leiomyosarcoma from primary pancreatic cancer, thus influencing treatment decisions.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful embolization with subsequent pancreaticoduodenectomy for intraductal papillary mucinous neoplasm hemorrhage: a case report and review of literature. 导管内乳头状黏液瘤出血成功栓塞并随后进行胰十二指肠切除术：病例报告和文献综述。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-09-10 DOI: 10.1007/s12328-024-02035-5

Moe Tanemura, Akihiro Cho, Yukiko Niwa, Takeshi Ishita, Toshihiko Mouri, Toshiya Sugishita, Ryota Higuchi, Masaho Ota, Keita Yoshida, Satoshi Katagiri

{"title":"Successful embolization with subsequent pancreaticoduodenectomy for intraductal papillary mucinous neoplasm hemorrhage: a case report and review of literature.","authors":"Moe Tanemura, Akihiro Cho, Yukiko Niwa, Takeshi Ishita, Toshihiko Mouri, Toshiya Sugishita, Ryota Higuchi, Masaho Ota, Keita Yoshida, Satoshi Katagiri","doi":"10.1007/s12328-024-02035-5","DOIUrl":"10.1007/s12328-024-02035-5","url":null,"abstract":"Although various complications associated with intraductal papillary mucinous neoplasms have been reported, including acute pancreatitis, duct perforation, and fistula formation, spontaneous bleeding, especially life-threatening bleeding, is infrequent. In this case, emergency pancreatic resection might be one of the therapeutic options, which is associated with poor postoperative outcomes. An 87-year-old woman presented to our hospital with severe anemia (hemoglobin, 4.5 g/dl). Contrast-enhanced computed tomography revealed a large cystic lesion in the pancreatic head measuring 15 cm, with some solid components and an adjacent hematoma, suggestive of intra-cystic hemorrhage of the intraductal papillary mucinous neoplasm. The patient was hemodynamically unstable and had hypotension. After transcatheter arterial embolization, the patient became hemodynamically stable. Subsequently, an elective pylorus-preserving pancreaticoduodenectomy was successfully performed. Preoperative embolization was effective for subsequent elective pancreaticoduodenectomy in patients with severe intraductal papillary mucinous neoplasm bleeding.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thrombotic complications following bariatric surgery: how medical tourism poses challenges to comprehensive care in obesity medicine. 减肥手术后的血栓并发症：医疗旅游如何给肥胖症医学的综合治疗带来挑战。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-10-12 DOI: 10.1007/s12328-024-02047-1

Mandour Omer Mandour, Robert Bakewell, John Ong

引用次数: 0

Portal cavernoma cholangiopathy treated with living donor liver transplantation: a case report and review of the literature. 用活体肝移植治疗门静脉海绵状瘤胆管病：病例报告和文献综述。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI: 10.1007/s12328-024-02041-7

Takahiko Omameuda, Yukihiro Sanada, Yasunaru Sakuma, Yasuharu Onishi, Taiichi Wakiya, Yuta Hirata, Toshio Horiuchi, Kiichiro Takadera, Ryosuke Akimoto, Naohiro Sata

{"title":"Portal cavernoma cholangiopathy treated with living donor liver transplantation: a case report and review of the literature.","authors":"Takahiko Omameuda, Yukihiro Sanada, Yasunaru Sakuma, Yasuharu Onishi, Taiichi Wakiya, Yuta Hirata, Toshio Horiuchi, Kiichiro Takadera, Ryosuke Akimoto, Naohiro Sata","doi":"10.1007/s12328-024-02041-7","DOIUrl":"10.1007/s12328-024-02041-7","url":null,"abstract":"Portal cavernoma cholangiopathy (PCC) is a complex condition associated with portal hypertension, particularly in patients with extrahepatic portal vein obstruction (EHPVO). Herein, we present a case of liver failure with PCC in a 55-year-old male successfully treated with living-donor liver transplantation (LDLT). The patient had a history of gastrointestinal bleeding and recurrence of cholangitis. Imaging studies confirmed cavernous transformation and pericholedochal varices. Preoperative angiography verified hepatopetal flow in the pericholedochal varix, which facilitated successful anastomosis with the donor's portal vein during LDLT. Histological examination of the explanted liver confirmed vanishing bile duct syndrome (VBDS) and secondary bile stasis was considered to have caused liver failure. No postoperative complications were observed within 13 months of LDLT. We report the first case of VBDS in the PCC resulting from EHPVO that was successfully managed with LDLT. Careful management of similar cases should involve angiography and long-term postoperative monitoring of portal vein complications.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A small bowel adenocarcinoma harboring a DDR2 mutation in a celiac patient. 一名乳糜泻患者的小肠腺癌携带 DDR2 突变。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-08-08 DOI: 10.1007/s12328-024-02025-7

Ludovica Mollica, Erica Quaquarini, Annalisa Schiepatti, Erica Travaglino, Francesca Antoci, Alessandro Vanoli, Giovanni Arpa, Federico Biagi, Laura Deborah Locati

{"title":"A small bowel adenocarcinoma harboring a DDR2 mutation in a celiac patient.","authors":"Ludovica Mollica, Erica Quaquarini, Annalisa Schiepatti, Erica Travaglino, Francesca Antoci, Alessandro Vanoli, Giovanni Arpa, Federico Biagi, Laura Deborah Locati","doi":"10.1007/s12328-024-02025-7","DOIUrl":"10.1007/s12328-024-02025-7","url":null,"abstract":"We present the case of a 62-year-old man with a history of celiac disease and IgA deficiency, following a strict gluten-free diet that was admitted to our hospital for recurrent abdominal pain, fatigue and melena. Esophagogastroduodenoscopy and colonoscopy with biopsies were normal. A video-capsule endoscopy was performed and revealed a sub-stenosing, vegetating, and bleeding lesion in the first jejunal loop. He underwent laparotomic surgery with resection of the involved segment with loco-regional lymphadenectomy. The pathological report described a poorly differentiated adenocarcinoma of the jejunum, stage IIIA (pT3pN1). Analysis of next-generation sequencing (NGS) of DNA on the surgical sample revealed a likely pathogenetic variant in exon 15 of the DDR2 gene (c.2003G > A) and a TP53 non-frame-shift deletion (c.585_602del). Considering the risk of recurrence, he was candidate to 6 months of adjuvant chemotherapy with platinum salt and fluoropyrimidine. Thirty-eight months after the diagnosis, the patient is still disease free and in good clinical condition. This is the first described case of SBA with DDR2 mutation. Considering the limited therapeutic options beyond surgery for SBA, molecular analyses could become promising for the search for potential targetable alterations for treatments with new available drugs.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid deterioration of steatotic liver disease due to portal vein stenosis after pancreaticoduodenectomy. 胰十二指肠切除术后，门静脉狭窄导致脂肪肝迅速恶化。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-08-15 DOI: 10.1007/s12328-024-02027-5

Mineto Ohta, Rikiya Kanba, Keisuke Fukushima, Kazutomi Takahashi, Hiroyasu Nishimaki, Tatsuya Sasaki, Ai Fujita, Maika Kanno, Yuki Ogasawara, Kenji Namiki

{"title":"Rapid deterioration of steatotic liver disease due to portal vein stenosis after pancreaticoduodenectomy.","authors":"Mineto Ohta, Rikiya Kanba, Keisuke Fukushima, Kazutomi Takahashi, Hiroyasu Nishimaki, Tatsuya Sasaki, Ai Fujita, Maika Kanno, Yuki Ogasawara, Kenji Namiki","doi":"10.1007/s12328-024-02027-5","DOIUrl":"10.1007/s12328-024-02027-5","url":null,"abstract":"Steatotic liver disease after pancreatoduodenectomy occurs due to various factors, such as exocrine pancreatic insufficiency, impaired intestinal absorption, and malnutrition. The mechanism of steatogenesis differs to that of conventional steatotic liver disease associated with obesity and insulin resistance. We experienced a rare case of rapidly progressive steatotic liver disease accompanied by portal vein stenosis in the early postoperative period after subtotal stomach-preserving pancreaticoduodenectomy for distal cholangiocarcinoma. Although there was a complication due to postoperative drain infection, the patient was discharged from hospital with no nutritional problems. Two months postoperatively, the patient presented to the emergency room with dyspnea. CT showed a markedly steatotic liver, ascites, and portal vein stenosis. A portal vein stent was inserted transhepatically and the steatotic liver disease gradually improved. During the postoperative course, there were no problems indicated by nutritional markers; although the patient had diarrhea associated with postoperative pancreatic exocrine insufficiency, the symptoms were mild and improved after administration of oral pancrelipase. Before the intervention, the patient had intestinal edema, exacerbation of diarrhea, and a low serum zinc concentration, suggesting that impaired absorption caused by intestinal blood stasis and gut barrier dysfunction contributed to the development of steatotic liver disease.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of protein-losing gastroenteropathy due to Sjögren's syndrome detected by foggy vision with refractive error of the intraocular lens. 一例因视力模糊和眼内晶状体屈光不正而被发现的斯约格伦综合征引起的蛋白质丢失性肠胃病。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-09-19 DOI: 10.1007/s12328-024-02038-2

Naho Watanabe, Rena Kaneko, Monami Kishi, Ryo Yanai, Takashi Ikehara, Hidenari Nagai, Takahisa Matsuda

{"title":"A case of protein-losing gastroenteropathy due to Sjögren's syndrome detected by foggy vision with refractive error of the intraocular lens.","authors":"Naho Watanabe, Rena Kaneko, Monami Kishi, Ryo Yanai, Takashi Ikehara, Hidenari Nagai, Takahisa Matsuda","doi":"10.1007/s12328-024-02038-2","DOIUrl":"10.1007/s12328-024-02038-2","url":null,"abstract":"A woman in her forties visited an ophthalmologist for rapidly progressive foggy vision. Naked visual acuity had decreased to 0.15, and although her eyes showed no abnormalities, internal disease was suspected and albumin 2.6 g/dL was found. Protein leakage from the intestinal tract was suspected since there was no urinary protein excretion. 99mTechnetium-labeled albumin D scintigraphy showed protein leakage from the intestinal tract. A stool α1-antitrypsin clearance test showed an increase to 56.3 mL/day, leading to a diagnosis of protein-losing gastroenteropathy. Blood biochemistry revealed abnormally high levels of anti-SS-A and anti-SS-B antibodies (≥ 1200 U/mL and ≥ 1000 U/mL, respectively). A lip salivary gland biopsy revealed lymphocytic infiltrate at least 1 focus per 2 mm × 2 mm > 50 lymphocytes per conduit). The Schirmer test result was 5 mm/5 min or less, which led to the diagnosis of Sjögren's syndrome. The serum albumin level increased with intravenous administration of methylprednisolone 50 mg (1 mg/kg), and the patient is currently on oral prednisolone at a gradually decreasing dose. After administration of prednisolone, visual acuity recovered to 1.2 with recovery of albumin.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of undifferentiated pleomorphic rectal sarcoma occurring after radiation exposure. 一例辐射照射后发生的未分化多形性直肠肉瘤。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-08-09 DOI: 10.1007/s12328-024-02026-6

Makoto Eizuka, Yosuke Toya, Shun Yamada, Tomofumi Oizumi, Shunichi Yanai, Norihiko Kudara, Naoki Yanagawa, Tamotsu Sugai, Takayuki Matsumoto

引用次数: 0