Clinical Journal of Gastroenterology最新文献_第3页

Ascending colon cancer with spontaneous regression of the primary tumor despite persistent isolated regional lymph node metastasis. 升格结肠癌，原发肿瘤自发消退，尽管持续孤立的区域淋巴结转移。

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2025-08-01 Epub Date: 2025-05-14 DOI: 10.1007/s12328-025-02143-w

Yu Watahiki, Kazumasa Kawashima, Michio Onizawa, Daiki Nemoto, Takuro Matsumoto, Wataru Sakamoto, Rei Sekine, Yuko Hashimoto, Takuto Hikichi, Hiromasa Ohira

{"title":"Ascending colon cancer with spontaneous regression of the primary tumor despite persistent isolated regional lymph node metastasis.","authors":"Yu Watahiki, Kazumasa Kawashima, Michio Onizawa, Daiki Nemoto, Takuro Matsumoto, Wataru Sakamoto, Rei Sekine, Yuko Hashimoto, Takuto Hikichi, Hiromasa Ohira","doi":"10.1007/s12328-025-02143-w","DOIUrl":"10.1007/s12328-025-02143-w","url":null,"abstract":"Spontaneous regression of cancer, particularly that of colorectal cancer, is rare. We encountered a rare case of spontaneous regression of ascending colon cancer with regional lymph node metastasis. A 70-year-old woman was referred for colonoscopy after a fecal immunochemical test yielded positive results. A colonoscopy revealed a 15-mm depressed lesion that was confirmed as adenocarcinoma. Regression of the primary tumor was observed over the course of multiple endoscopic examinations. Subsequently, robot-assisted laparoscopic right hemicolectomy and D3 lymph node dissection were performed. A histopathological examination revealed complete regression of the primary tumor. However, metastasis to a regional lymph node was observed. Immunohistochemistry indicated colon cancer with high microsatellite instability, infiltration of CD4-positive T cells, and predominant infiltration of CD8-positive T cells at the primary site and metastatic lymph node. Immunological studies of the regressed primary tumor and remaining lymph node metastasis instigated a discussion regarding spontaneous regression mechanisms. This case emphasizes the necessity for vigilant clinical management of similar cases because the potential for lymph node metastasis persists even when the spontaneous regression of the primary tumor is observed.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"588-594"},"PeriodicalIF":0.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant hepatic hemangioma with internal necrosis discovered due to fever of unknown origin and treated successfully with surgical resection: a case report. 因不明原因的发热而发现的巨大肝血管瘤伴内坏死，手术切除成功治疗1例。

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2025-08-01 Epub Date: 2025-05-22 DOI: 10.1007/s12328-025-02145-8

Rei Ryozawa, Hirohito Takeuchi, Katsutoshi Sugimoto, Hiroaki Osakabe, Chie Takishita, Jun Matsubayashi, Yuichi Nagakawa, Toshitaka Nagao, Takao Itoi

{"title":"Giant hepatic hemangioma with internal necrosis discovered due to fever of unknown origin and treated successfully with surgical resection: a case report.","authors":"Rei Ryozawa, Hirohito Takeuchi, Katsutoshi Sugimoto, Hiroaki Osakabe, Chie Takishita, Jun Matsubayashi, Yuichi Nagakawa, Toshitaka Nagao, Takao Itoi","doi":"10.1007/s12328-025-02145-8","DOIUrl":"10.1007/s12328-025-02145-8","url":null,"abstract":"Hepatic hemangiomas are typically asymptomatic benign liver tumors. This report describes a case of a large hepatic hemangioma with internal bleeding and necrosis, presenting as fever of unknown origin, which was successfully treated with surgical resection. A woman in her 40s presented with persistent fever and fatigue. Imaging revealed a 13 cm mass in the posterior sector of the right hepatic lobe, with areas of high attenuation suggestive of internal bleeding. Laboratory tests revealed elevated levels of C-reactive protein, interleukin-6, and complement components (C3, C4, and CH50), along with an increased erythrocyte sedimentation rate. Symptomatic treatment with antipyretic medications failed to resolve the fever; therefore, hepatic resection was performed for diagnostic and therapeutic purposes. Post-operative recovery was uneventful, and the fever resolved completely. Pathological examination revealed cavernous hemangioma with well-defined necrotic areas. Post-operative blood tests showed normalization of the preoperatively elevated prognostic markers. Bleeding and necrosis associated with a large hemangioma appear to trigger the release of damage-associated molecular patterns, stimulating interleukin 6 production, promoting prostaglandin E2 synthesis, and ultimately leading to fever. Hepatic resection is an effective treatment for large hemangiomas in patients presenting with fever.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"706-713"},"PeriodicalIF":0.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of ulcerative colitis in a patient undergoing surgery due to exacerbation resulting in toxic megacolon after SARS-CoV-2 vaccination. 因接种SARS-CoV-2后病情加重导致中毒性巨结肠而接受手术的患者发生溃疡性结肠炎1例

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2025-08-01 Epub Date: 2025-04-28 DOI: 10.1007/s12328-025-02136-9

Ryota Ogihara, Minoru Matsuura, Takuya Ishida, Hiromu Morikubo, Tatsuya Mitsui, Daisuke Saito, Jun Miyoshi, Junji Shibahara, Eiji Sunami, Tadakazu Hisamatsu

引用次数: 0

IL-17A inhibitor-induced ulcerative colitis treated with an anti-IL-23 antibody. 抗il -23抗体治疗IL-17A抑制剂诱导的溃疡性结肠炎。

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Clinical Journal of Gastroenterology Pub Date : 2025-08-01 Epub Date: 2025-06-02 DOI: 10.1007/s12328-025-02153-8

Natsuki Ishida, Yusuke Asai, Tomohiro Takebe, Kenichi Takahashi, Kiichi Sugiura, Tomoharu Matsuura, Kazuo Kurihara, Takahiro Suzuki, Tetsuya Honda, Ken Sugimoto

{"title":"IL-17A inhibitor-induced ulcerative colitis treated with an anti-IL-23 antibody.","authors":"Natsuki Ishida, Yusuke Asai, Tomohiro Takebe, Kenichi Takahashi, Kiichi Sugiura, Tomoharu Matsuura, Kazuo Kurihara, Takahiro Suzuki, Tetsuya Honda, Ken Sugimoto","doi":"10.1007/s12328-025-02153-8","DOIUrl":"10.1007/s12328-025-02153-8","url":null,"abstract":"Interleukin-17 (IL-17) has been suggested to have a protective effect on the intestinal mucosa. The administration of an anti-IL-17 receptor monoclonal antibody has been associated with the onset of inflammatory bowel disease. We present a case of ulcerative colitis caused by secukinumab, an anti-IL-17 receptor A monoclonal antibody, that was treated with mirikizumab, a p19-directed antibody against IL-23. A man in his 20 s with psoriasis vulgaris was administered secukinumab at the dermatology department of our hospital. After the induction of secukinumab therapy, he gradually developed diarrhea, and after 4 months, bloody stools were observed. The patient was diagnosed with left-sided ulcerative colitis based on the findings of a colonoscopic examination. Secukinumab was discontinued and prednisolone was started; however, there was little improvement. His symptoms improved with the introduction of mirikizumab, and the condition is now clinically and endoscopically stable. In this case, an anti-IL-23 antibody was effective against ulcerative colitis induced by an Il-17A antibody agent. Although IL-23 exists upstream of the Th17 system, mirikizumab, an anti-IL-23 antibody preparation, has been shown to have the potential to alleviate UC.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"626-631"},"PeriodicalIF":0.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic management of pancreatic and biliary duct stenoses due to a giant pseudoaneurysm in a patient clinically suggestive of Loeys-Dietz syndrome. 胰管和胆管狭窄的内镜治疗，由于一个巨大的假性动脉瘤的患者临床提示Loeys-Dietz综合征。

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Clinical Journal of Gastroenterology Pub Date : 2025-08-01 Epub Date: 2025-05-28 DOI: 10.1007/s12328-025-02151-w

Tomohiro Tanikawa, Akihisa Akagi, Mayuko Kawada, Katsunori Ishii, Takashi Fushimi, Noriyo Urata, Mitsuhiko Suehiro, Hidenori Shiraha, Ken Haruma, Hirofumi Kawamoto

{"title":"Endoscopic management of pancreatic and biliary duct stenoses due to a giant pseudoaneurysm in a patient clinically suggestive of Loeys-Dietz syndrome.","authors":"Tomohiro Tanikawa, Akihisa Akagi, Mayuko Kawada, Katsunori Ishii, Takashi Fushimi, Noriyo Urata, Mitsuhiko Suehiro, Hidenori Shiraha, Ken Haruma, Hirofumi Kawamoto","doi":"10.1007/s12328-025-02151-w","DOIUrl":"10.1007/s12328-025-02151-w","url":null,"abstract":"Loeys-Dietz syndrome is a rare connective tissue disorder characterized by the formation of aggressive arterial aneurysms. There are a few reports of Loeys-Dietz syndrome with pseudoaneurysms causing simultaneous pancreatic and biliary stenoses. Herein, we report the case of a 42-year-old man with Loeys-Dietz syndrome who presented with acute pancreatitis and liver dysfunction caused by a giant pancreaticoduodenal artery pseudoaneurysm compressing the main pancreatic and bile ducts. To minimize the risk of pseudoaneurysm rupture during endoscopic intervention, transcatheter arterial embolization was performed, followed by endoscopic intervention. Although initial clinical improvement was observed after endoscopic stent placement, a fistula between the pancreatic duct and the thrombosed pseudoaneurysm was detected at 4 months but spontaneously closed with continued stenting. Despite persistent ductal stenosis requiring long-term stent management, the fistula had closed 1 year after the initial stent placement. To the best of our knowledge, this is the first report describing a structured treatment strategy for pancreaticobiliary obstruction caused by a Loeys-Dietz syndrome-related pseudoaneurysm. This case highlights the importance of a stepwise interventional radiology-first approach and careful follow-up for the management of complex vascular compressive syndromes.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"721-726"},"PeriodicalIF":0.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant hepatic hemangioma in a Japanese adult patient reduced by sirolimus therapy. 巨大肝血管瘤在日本成年患者西罗莫司治疗减少。

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2025-08-01 DOI: 10.1007/s12328-025-02183-2

Mio Tsuruoka, Masashi Ninomiya, Jun Inoue, Kosuke Sato, Keishi Ouchi, Kengo Watanabe, Kotaro Doi, Tomoya Sasazaki, Atsushi Masamune

{"title":"Giant hepatic hemangioma in a Japanese adult patient reduced by sirolimus therapy.","authors":"Mio Tsuruoka, Masashi Ninomiya, Jun Inoue, Kosuke Sato, Keishi Ouchi, Kengo Watanabe, Kotaro Doi, Tomoya Sasazaki, Atsushi Masamune","doi":"10.1007/s12328-025-02183-2","DOIUrl":"https://doi.org/10.1007/s12328-025-02183-2","url":null,"abstract":"Although observation is the standard management strategy for hepatic hemangiomas (HHs), surgical intervention may be indicated in cases of progressive enlargement, lesions > 50 mm, those causing compressive symptoms, or those associated with Kasabach-Merritt syndrome. Here, we report the case of a 51-year-old woman with a giant HH occupying almost the entire liver with a volume of 6572.5 mL. The patient presented with severe compressive symptoms and coagulopathy; however, surgical resection was infeasible. Because she did not develop liver failure, transplantation was not indicated, and no effective treatment options were available. Sirolimus, a mammalian target of rapamycin inhibitor, has been used to treat intractable lymphatic disorders and congenital vascular malformations; however, there have been no previous reports on its use in adult giant HHs. Moreover, sirolimus was administered, which resulted in remarkable tumor shrinkage. This suggests that sirolimus may be a valuable therapeutic option for adult patients with giant HHs in whom conventional treatments are not applicable.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pimitespib therapy for a patient with PDGFRA D842V-mutant gastrointestinal stromal tumor. 吡咪唑治疗PDGFRA d842v突变型胃肠道间质瘤1例

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2025-08-01 Epub Date: 2025-05-10 DOI: 10.1007/s12328-025-02144-9

Tatsuo Kanda, Masafumi Ishikawa, Kae Techigawara, Toshiyuki Saginoya, Koichi Hamada, Motonobu Saito, Noriyuki Uesugi, Yasushi Teranishi

{"title":"Pimitespib therapy for a patient with PDGFRA D842V-mutant gastrointestinal stromal tumor.","authors":"Tatsuo Kanda, Masafumi Ishikawa, Kae Techigawara, Toshiyuki Saginoya, Koichi Hamada, Motonobu Saito, Noriyuki Uesugi, Yasushi Teranishi","doi":"10.1007/s12328-025-02144-9","DOIUrl":"10.1007/s12328-025-02144-9","url":null,"abstract":"Gastrointestinal stromal tumors (GISTs) with platelet-derived growth factor receptor alpha (PDGFRA) mutations are resistant to tyrosine kinase inhibitors. Pimitespib, a novel heat shock protein 90 inhibitor, was recently approved as a fourth-line treatment for advanced GISTs; however, data on its efficacy against PDGFRA-mutant GISTs remain scarce. We report a case of a 67-year-old male with a gastric GIST harboring a PDGFRA exon 18 Asp842Val mutation. The patient presented with a large peritoneal metastasis at the hepatic hilum and underwent proton beam therapy, achieving 8 months of disease control. However, the tumor progressed thereafter. Regorafenib was introduced but failed immediately owing to tumor penetration. The treatment was switched to pimitespib (160 mg daily, 5 days on, 2 days off, per 21-day cycle), and the patient completed four cycles of the therapy. Post-treatment 18F-fluorodeoxyglucose (FDG)-positron emission tomography showed a significant reduction in FDG uptake by the metastatic lesion. Pimitespib therapy was eventually discontinued because of duodenal bleeding, with a time to treatment failure of 13 weeks. Although based on a single case, this report demonstrates a significant metabolic response to pimitespib in PDGFRA-mutant GIST. More cases are required to fully elucidate the efficacy of this therapy against such rare tumors.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"595-600"},"PeriodicalIF":0.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two cases of pancreatic abscess detected at autopsy after gemcitabine + nab-paclitaxel treatment for pancreatic cancer. 吉西他滨+ nab-紫杉醇治疗胰腺癌后尸检发现胰腺脓肿2例。

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2025-08-01 Epub Date: 2025-05-29 DOI: 10.1007/s12328-025-02133-y

Ryo Kodama, Masato Takemoto, Yuma Kamijo, Yukiko Yokota, Hisanobu Saegusa, Hiroyasu Ushimaru, Mutsuki Makino, Kenji Kawaguchi

引用次数: 0

Usefulness of double-balloon endoscopy-assisted injection sclerotherapy for hemorrhagic varices in the jejunum reconstructed for liver transplantation in a pediatric case. 双球囊内镜辅助下注射硬化治疗儿童肝移植重建空肠出血性静脉曲张一例。

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2025-08-01 Epub Date: 2025-05-27 DOI: 10.1007/s12328-025-02150-x

Hiroki Kajiura, Kaname Uno, Kiyoshi Kume, Tomoyuki Koike, Masahiro Saito, Yusuke Shimoyama, Masashi Ninomiya, Sota Oguro, Kei Takase, Atsushi Masamune

{"title":"Usefulness of double-balloon endoscopy-assisted injection sclerotherapy for hemorrhagic varices in the jejunum reconstructed for liver transplantation in a pediatric case.","authors":"Hiroki Kajiura, Kaname Uno, Kiyoshi Kume, Tomoyuki Koike, Masahiro Saito, Yusuke Shimoyama, Masashi Ninomiya, Sota Oguro, Kei Takase, Atsushi Masamune","doi":"10.1007/s12328-025-02150-x","DOIUrl":"10.1007/s12328-025-02150-x","url":null,"abstract":"A 10-year-old girl was admitted to our hospital for treatment of recurrent melena and severe anemia. Her treatment history comprised Kasai's portoenterostomy for biliary atresia as an infant, followed by liver transplantation and partial splenectomy for portal hypertension at 1 year old. Her medications comprised steroids, immunosuppressive agents, a β-blocker, and a potassium-competitive acid blocker. Since the age of 5 years, she had repeatedly visited a local hospital for melena, but the bleeding source had not been identified. She was referred to our hospital, and laboratory data revealed severe anemia. An enhanced computed tomography showed post-liver transplantation status, splenomegaly, and gastric varices, without extravasation. Esophagogastroduodenoscopy and colonoscopy did not identify the bleeding source. Double-balloon endoscopy (DBE) revealed variceal bleeding and serosanguinous fluid accumulated at the choledochojejunostomy site in the jejunum. After obtaining informed consent, our team and the radiologists cooperatively performed DBE-assisted endoscopic injection sclerotherapy with 75% n-butyl-2-cyanoacrylate through a 23- gage needle according to high-resolution varicerography in a hybrid emergency room. Subsequently, the patient was discharged and regularly monitored without any complications. We demonstrated the first pediatric case of successful DBE-assisted endoscopic injection for hemorrhagic jejunal varices after liver transplantation for biliary atresia and partial splenectomy.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"619-625"},"PeriodicalIF":0.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrence as a tumor deposit after endoscopic submucosal dissection of early rectal cancer. 早期直肠癌内镜下粘膜下剥离后复发为肿瘤沉积。

IF 0.9

Clinical Journal of Gastroenterology Pub Date : 2025-08-01 Epub Date: 2025-06-23 DOI: 10.1007/s12328-025-02160-9

Takaaki Yoshikawa, Momoko Iketani, Atsushi Yamauchi, Sonoka Katsuyama, Sota Nakagami, Kenshiro Hirohashi, Shujiro Yazumi

{"title":"Recurrence as a tumor deposit after endoscopic submucosal dissection of early rectal cancer.","authors":"Takaaki Yoshikawa, Momoko Iketani, Atsushi Yamauchi, Sonoka Katsuyama, Sota Nakagami, Kenshiro Hirohashi, Shujiro Yazumi","doi":"10.1007/s12328-025-02160-9","DOIUrl":"10.1007/s12328-025-02160-9","url":null,"abstract":"We found a 15 mm, 0-IIa + IIc polyp in the rectosigmoid with colonoscopy (CS), and performed endoscopic submucosal dissection (ESD) for it. The histopathologic specimen revealed that it was well-differentiated adenocarcinoma, T1b (SM2, 2000 μm), Ly0, v0, BD1, pHM0, and pVM0. Despite the non-curative resection with SM-deep invasion, the patient chose careful follow-up with contrast-enhanced computed tomography and CS. A nodule was first detected on the left side just out of the lower rectum 3 and a half years after ESD. Since it enlarged gradually, we judged that it was local recurrence in form of lymph-node metastasis and performed additional surgery 5 years after ESD. Pathological findings disclosed that the nodule was local recurrence as a tumor deposit (TD). One year after TD resection, lung metastasis was additionally founded and was resected surgically. If ESD accomplishes complete resection for T1b colorectal cancer and deep submucosal invasion is the only factor of non-curative resection, follow-up may be chosen instead of additional surgical resection. However, careful follow-up should be considered, because recurrence including TD may happen several years after ESD.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"646-652"},"PeriodicalIF":0.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0