Clinical Journal of Gastroenterology最新文献_第3页

Portal vein stenting blocked the inflow tract and completely resolved bile duct varices, formed by cavernous transformation of the portal vein. 门静脉支架植入术阻断了流入道，彻底消除了由门静脉海绵状变形成的胆管静脉曲张。

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Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-08-20 DOI: 10.1007/s12328-024-02029-3

Daiyu Matsubara, Naotaka Kugiyama, Katsuya Nagaoka, Motohiro Yoshinari, Shunpei Hashigo, Keita Shimata, Yoshitaka Tamura, Toshinori Hirai, Taizo Hibi, Yasuhito Tanaka

{"title":"Portal vein stenting blocked the inflow tract and completely resolved bile duct varices, formed by cavernous transformation of the portal vein.","authors":"Daiyu Matsubara, Naotaka Kugiyama, Katsuya Nagaoka, Motohiro Yoshinari, Shunpei Hashigo, Keita Shimata, Yoshitaka Tamura, Toshinori Hirai, Taizo Hibi, Yasuhito Tanaka","doi":"10.1007/s12328-024-02029-3","DOIUrl":"10.1007/s12328-024-02029-3","url":null,"abstract":"There is no established treatment for bleeding bile duct varices (BDVs). We report the first case of portal vein (PV) stenting completely eradicating bleeding BDVs. A 70-year-old male with malignant lymphoma developed BDVs due to PV obstruction, which had caused compression and stricture of the distal bile duct. Endoscopic retrograde cholangiography was performed to evaluate the stricture and bleeding from the ruptured BDV was observed. Endoscopic hemostasis was difficult, requiring reopening of the extra-hepatic PV and reducing the blood flow to the BDVs for hemostasis. Therefore, PV stenting was performed. During the procedure, portal angiography confirmed an inflow tract to the BDVs. Therefore, covered stents were placed in the PV and adjusted to block the inflow tract to the BDVs at the distal end. After stenting, the BDVs were successfully blocked and all PV blood flowed through the stent placed in the extra-hepatic PV. Two weeks after stenting, the BDVs had disappeared completely and the bleeding has not recurred for months. We experienced a case in which PV stenting not only reopened an obstructed PV but also successfully occluded the inflow tract. This case demonstrates the potential of PV stenting for the treatment of hemorrhagic BDVs.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"1106-1110"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful novel use of dupilumab for gastrointestinal involvement of idiopathic hypereosinophilic syndrome: case report and review of the literature. 成功使用杜匹单抗治疗特发性高ereosinophilic综合征胃肠道受累的新方法：病例报告和文献综述。

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Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-09-11 DOI: 10.1007/s12328-024-02036-4

Clare Moffatt, Christopher Soriano, David W Dawson, Guy A Weiss

{"title":"Successful novel use of dupilumab for gastrointestinal involvement of idiopathic hypereosinophilic syndrome: case report and review of the literature.","authors":"Clare Moffatt, Christopher Soriano, David W Dawson, Guy A Weiss","doi":"10.1007/s12328-024-02036-4","DOIUrl":"10.1007/s12328-024-02036-4","url":null,"abstract":"Hypereosinophilic syndrome (HES) is characterized by blood and tissue hypereosinophilia leading to organ damage. Gastrointestinal involvement is the third most common manifestation. We present a patient with idiopathic HES with secondary eosinophilic esophagitis (EoE), gastritis, and enteritis, corticosteroids-dependent, azathioprine- and mepolizumab-refractory. The patient achieved clinical and histopathologic remission following dupilumab treatment. A 28 year-old female presented with chronic episodic nausea and emesis since childhood and initial diagnosis of primary eosinophilic gastrointestinal disease (EGID), improved with corticosteroids, refractory to azathioprine. She was found to have peripheral eosinophilia and multifactorial anemia, with iron, B12, and folate deficiencies. Esophageal, gastric, duodenal, and terminal ileum biopsies showed significant eosinophilic infiltrate. Bone marrow biopsy at age 31 confirmed HES diagnosis. By age 32, she became total parental nutrition (TPN)-dependent. She failed trials of benralizumab and mepolizumab [anti-interleukin (IL)-5 inhibitors], and cromolyn (mast-cell stabilizer). After developing new esophageal stricture, we initiated dupilumab (IL-4/13 inhibitor), recently FDA-approved for EoE. After 9 weeks, esophageal stricture, gut tissue eosinophilia, and prior intestinal ulcerations resolved. She ceased TPN and is tolerating a non-restricted diet, with complete symptom resolution. Our patient's complete remission with dupilumab shows promise for broadening its use in treating GI involvement in HES, along with primary EGIDs.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"1003-1008"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of immune checkpoint inhibitor-associated hemophagocytosis after initiation of atezolizumab plus bevacizumab therapy for advanced hepatocellular carcinoma. 一例晚期肝细胞癌患者在接受阿特珠单抗加贝伐单抗治疗后出现免疫检查点抑制剂相关性嗜血细胞增多症。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-10-03 DOI: 10.1007/s12328-024-02040-8

Hisashi Hidaka, Hirotoshi Kamata, Haruki Uojima, Shuichiro Iwasaki, Junki Iida, Takahide Nakazawa, Chika Kusano

引用次数: 0

Symptomatic hepatic cyst treated with endoscopic ultrasound-guided drainage and minocycline hydrochloride injection: a case report. 通过内窥镜超声引导引流和盐酸米诺环素注射治疗无症状肝囊肿：病例报告。

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Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-08-05 DOI: 10.1007/s12328-024-02028-4

Kensuke Hoshi, Naoki Okano, Yoichiro Sato, Shuntaro Iwata, Yusuke Kimura, Susumu Iwasaki, Kensuke Takuma, Yoshinori Igarashi, Takahisa Matsuda

引用次数: 0

Abscopal effect in a patient with advanced hepatocellular carcinoma upon resuming bevacizumab in combination with atezolizumab after radiotherapy. 一名晚期肝细胞癌患者在放疗后恢复贝伐珠单抗联合阿特珠单抗治疗时的失神效应。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI: 10.1007/s12328-024-02030-w

Tasuku Nakabori, Toshiki Ikawa, Kazuhiro Kozumi, Makiko Urabe, Yugo Kai, Ryoji Takada, Kenji Ikezawa, Kaori Mukai, Koji Konishi, Kazuyoshi Ohkawa

{"title":"Abscopal effect in a patient with advanced hepatocellular carcinoma upon resuming bevacizumab in combination with atezolizumab after radiotherapy.","authors":"Tasuku Nakabori, Toshiki Ikawa, Kazuhiro Kozumi, Makiko Urabe, Yugo Kai, Ryoji Takada, Kenji Ikezawa, Kaori Mukai, Koji Konishi, Kazuyoshi Ohkawa","doi":"10.1007/s12328-024-02030-w","DOIUrl":"10.1007/s12328-024-02030-w","url":null,"abstract":"Combining bevacizumab with atezolizumab enhances the antitumor effects of the treatment by activating an immune response. This combination is approved for the treatment of unresectable hepatocellular carcinoma (HCC). An abscopal effect is associated with an immune response triggered by radiation-induced immunogenic cell death, based on experimental models. Thus, combining radiotherapy and immunotherapy is expected to induce an abscopal effect. However, the clinical significance of immunotherapy in the abscopal effect remains unknown due to the rarity of clinical cases. Herein, we report a case of advanced HCC with lung and adrenal metastases. The antitumor efficacy of atezolizumab and bevacizumab (atezo/bev) was enhanced following stereotactic body radiotherapy (SBRT), although atezo/bev did not yield a sufficient therapeutic response pre-SBRT. Furthermore, an abscopal effect following SBRT was not observed during atezolizumab alone but was evoked after resuming bevacizumab in combination with atezolizumab, culminating in the patient achieving a complete response status. These findings suggest that immune activation following radiotherapy may be related to the induction of an abscopal effect in clinical practice as well as in experimental settings, and combining immunotherapy with bevacizumab post-radiotherapy could evoke an abscopal effect in a case of HCC, even though immune checkpoint inhibitor use alone may be insufficient.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"1053-1057"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful radical surgery for lymph node metastasis in a patient with hepatocellular carcinoma following atezolizumab plus bevacizumab combination therapy: a case report and literature review. 阿特珠单抗加贝伐单抗联合疗法成功为一名肝细胞癌患者实施淋巴结转移根治术：病例报告和文献综述。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-08-20 DOI: 10.1007/s12328-024-02032-8

Ken Sato, Takehiro Shimizu, Akira Watanabe, Ayako Yamazaki, Yuki Kanayama, Tatsuma Murakami, Norifumi Harimoto, Hideaki Yokoo, Ken Shirabe, Toshio Uraoka

{"title":"Successful radical surgery for lymph node metastasis in a patient with hepatocellular carcinoma following atezolizumab plus bevacizumab combination therapy: a case report and literature review.","authors":"Ken Sato, Takehiro Shimizu, Akira Watanabe, Ayako Yamazaki, Yuki Kanayama, Tatsuma Murakami, Norifumi Harimoto, Hideaki Yokoo, Ken Shirabe, Toshio Uraoka","doi":"10.1007/s12328-024-02032-8","DOIUrl":"10.1007/s12328-024-02032-8","url":null,"abstract":"A woman in her early 80 s was followed up in our hospital for chronic hepatitis C after viral eradication. We detected rapid-growing lymph node metastasis of hepatocellular carcinoma (HCC) after treatment with transcatheter arterial chemoembolization and/or radiofrequency ablation. We found that the metastasis was operable, but the size and location of the metastasis obliged the patient to receive pancreatoduodenectomy, which was too invasive. Then we initiated systemic chemotherapy to perform radical minimally invasive surgery. We treated the patient with 3 weekly cycles of atezolizumab 1200 mg plus bevacizumab 15 mg/kg. The patient tolerated the treatment well, and treatment-emergent adverse events included deterioration of hypertension and increased uric protein. After a total of 4 cycles of therapy, abdominal computed tomography findings showed that the metastasis evidently decreased, and a complete response was achieved based on the Revised Response Evaluation Criteria in Solid Tumors (RECIST) guidelines (version 1.1). Seventeen days later, the metastasis was dissected. Subsequently, we confirmed that there was no pathological metastatic lesion in the resected lymph node. Our case is the first report of successful application of the radical therapy to lymph node metastasis of HCC via combination therapy with atezolizumab/bevacizumab.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"1067-1074"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful embolization with subsequent pancreaticoduodenectomy for intraductal papillary mucinous neoplasm hemorrhage: a case report and review of literature. 导管内乳头状黏液瘤出血成功栓塞并随后进行胰十二指肠切除术：病例报告和文献综述。

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Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-09-10 DOI: 10.1007/s12328-024-02035-5

Moe Tanemura, Akihiro Cho, Yukiko Niwa, Takeshi Ishita, Toshihiko Mouri, Toshiya Sugishita, Ryota Higuchi, Masaho Ota, Keita Yoshida, Satoshi Katagiri

{"title":"Successful embolization with subsequent pancreaticoduodenectomy for intraductal papillary mucinous neoplasm hemorrhage: a case report and review of literature.","authors":"Moe Tanemura, Akihiro Cho, Yukiko Niwa, Takeshi Ishita, Toshihiko Mouri, Toshiya Sugishita, Ryota Higuchi, Masaho Ota, Keita Yoshida, Satoshi Katagiri","doi":"10.1007/s12328-024-02035-5","DOIUrl":"10.1007/s12328-024-02035-5","url":null,"abstract":"Although various complications associated with intraductal papillary mucinous neoplasms have been reported, including acute pancreatitis, duct perforation, and fistula formation, spontaneous bleeding, especially life-threatening bleeding, is infrequent. In this case, emergency pancreatic resection might be one of the therapeutic options, which is associated with poor postoperative outcomes. An 87-year-old woman presented to our hospital with severe anemia (hemoglobin, 4.5 g/dl). Contrast-enhanced computed tomography revealed a large cystic lesion in the pancreatic head measuring 15 cm, with some solid components and an adjacent hematoma, suggestive of intra-cystic hemorrhage of the intraductal papillary mucinous neoplasm. The patient was hemodynamically unstable and had hypotension. After transcatheter arterial embolization, the patient became hemodynamically stable. Subsequently, an elective pylorus-preserving pancreaticoduodenectomy was successfully performed. Preoperative embolization was effective for subsequent elective pancreaticoduodenectomy in patients with severe intraductal papillary mucinous neoplasm bleeding.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"1118-1124"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic ultrasound-guided fine-needle biopsy diagnosing pancreatic metastasis seven years after renal leiomyosarcoma resection: a case report. 内镜超声引导下细针活检诊断肾脏良性肉瘤切除术七年后的胰腺转移：病例报告。

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Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-09-06 DOI: 10.1007/s12328-024-02033-7

Takuya Okamoto, Shuhei Shintani, Hiromitsu Maehira, Kosuke Hiroe, Shiori Onoda, Hidenori Kimura, Atsushi Nishida, Masaji Tani, Ryoji Kushima, Osamu Inatomi

{"title":"Endoscopic ultrasound-guided fine-needle biopsy diagnosing pancreatic metastasis seven years after renal leiomyosarcoma resection: a case report.","authors":"Takuya Okamoto, Shuhei Shintani, Hiromitsu Maehira, Kosuke Hiroe, Shiori Onoda, Hidenori Kimura, Atsushi Nishida, Masaji Tani, Ryoji Kushima, Osamu Inatomi","doi":"10.1007/s12328-024-02033-7","DOIUrl":"10.1007/s12328-024-02033-7","url":null,"abstract":"Renal leiomyosarcoma metastasis to the pancreas is exceptionally rare. Here, we present a case of metastatic recurrence in the pancreas seven years after renal leiomyosarcoma resection. A 73-year-old female with a history of renal leiomyosarcoma surgery seven years prior presented with a well-defined 40 × 30 mm pancreatic tail tumor detected by a computed tomography (CT) scan. The tumor exhibited hypo-enhancement in the arterial phase and a progressive enhancement pattern toward the equilibrium phase, similar to pancreatic cancer. Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) revealed bundles of spindle cells that matched those in the previously resected renal sample. Immunohistochemistry showed positive staining for desmin, confirming the diagnosis of pancreatic metastasis from renal leiomyosarcoma. The patient underwent a distal pancreatectomy to remove the metastatic lesion. The extended interval of seven years before the detection of metastasis underscores the challenges in monitoring and diagnosing metastatic patterns of renal leiomyosarcoma. EUS-FNB can assist in distinguishing metastatic pancreatic leiomyosarcoma from primary pancreatic cancer, thus influencing treatment decisions.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"1111-1117"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portal cavernoma cholangiopathy treated with living donor liver transplantation: a case report and review of the literature. 用活体肝移植治疗门静脉海绵状瘤胆管病：病例报告和文献综述。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI: 10.1007/s12328-024-02041-7

Takahiko Omameuda, Yukihiro Sanada, Yasunaru Sakuma, Yasuharu Onishi, Taiichi Wakiya, Yuta Hirata, Toshio Horiuchi, Kiichiro Takadera, Ryosuke Akimoto, Naohiro Sata

{"title":"Portal cavernoma cholangiopathy treated with living donor liver transplantation: a case report and review of the literature.","authors":"Takahiko Omameuda, Yukihiro Sanada, Yasunaru Sakuma, Yasuharu Onishi, Taiichi Wakiya, Yuta Hirata, Toshio Horiuchi, Kiichiro Takadera, Ryosuke Akimoto, Naohiro Sata","doi":"10.1007/s12328-024-02041-7","DOIUrl":"10.1007/s12328-024-02041-7","url":null,"abstract":"Portal cavernoma cholangiopathy (PCC) is a complex condition associated with portal hypertension, particularly in patients with extrahepatic portal vein obstruction (EHPVO). Herein, we present a case of liver failure with PCC in a 55-year-old male successfully treated with living-donor liver transplantation (LDLT). The patient had a history of gastrointestinal bleeding and recurrence of cholangitis. Imaging studies confirmed cavernous transformation and pericholedochal varices. Preoperative angiography verified hepatopetal flow in the pericholedochal varix, which facilitated successful anastomosis with the donor's portal vein during LDLT. Histological examination of the explanted liver confirmed vanishing bile duct syndrome (VBDS) and secondary bile stasis was considered to have caused liver failure. No postoperative complications were observed within 13 months of LDLT. We report the first case of VBDS in the PCC resulting from EHPVO that was successfully managed with LDLT. Careful management of similar cases should involve angiography and long-term postoperative monitoring of portal vein complications.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"1080-1086"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thrombotic complications following bariatric surgery: how medical tourism poses challenges to comprehensive care in obesity medicine. 减肥手术后的血栓并发症：医疗旅游如何给肥胖症医学的综合治疗带来挑战。

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Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-10-12 DOI: 10.1007/s12328-024-02047-1

Mandour Omer Mandour, Robert Bakewell, John Ong

引用次数: 0