因接种SARS-CoV-2后病情加重导致中毒性巨结肠而接受手术的患者发生溃疡性结肠炎1例

IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY

Clinical Journal of Gastroenterology Pub Date : 2025-04-28 DOI:10.1007/s12328-025-02136-9

Ryota Ogihara, Minoru Matsuura, Takuya Ishida, Hiromu Morikubo, Tatsuya Mitsui, Daisuke Saito, Jun Miyoshi, Junji Shibahara, Eiji Sunami, Tadakazu Hisamatsu

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引用次数: 0

摘要

我们在此报告一例长期临床缓解的静止性溃疡性结肠炎（UC）患者，在接受严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）疫苗接种后病情迅速恶化，因中毒性巨结肠导致结肠切除术。患者接受了第五剂Spikevax （mRNA-1273）疫苗，6天后出现了严重的UC发作。手术标本的病理结果与严重活动性UC合并巨细胞病毒感染一致。由于mRNA疫苗同时刺激体液和细胞免疫原性，因此值得注意的是，它们可能是UC复发的触发因素。

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A case of ulcerative colitis in a patient undergoing surgery due to exacerbation resulting in toxic megacolon after SARS-CoV-2 vaccination.

We herein report a case involving a patient with quiescent ulcerative colitis (UC) in long-term clinical remission whose condition rapidly worsened after receiving a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, leading to colectomy due to toxic megacolon. The patient received the fifth dose of the Spikevax (mRNA-1273) vaccine and experienced a severe flare-up of UC 6 days later. Pathologic findings of the surgical specimens were consistent with severe active UC concomitant with cytomegalovirus infection. Because mRNA vaccines stimulate both humoral and cellular immunogenicity, it is important to note that they can be a triggering factor for the relapse of UC.

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来源期刊

Clinical Journal of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

2.00

自引率

0.00%

发文量

182

期刊介绍： The journal publishes Case Reports and Clinical Reviews on all aspects of the digestive tract, liver, biliary tract, and pancreas. Critical Case Reports that show originality or have educational implications for diagnosis and treatment are especially encouraged for submission. Personal reviews of clinical gastroenterology are also welcomed. The journal aims for quick publication of such critical Case Reports and Clinical Reviews.