Clinical Journal of Gastroenterology最新文献_第4页

Case series of small bowel adenocarcinoma associated with Crohn's disease. 与克罗恩病相关的小肠腺癌病例系列

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-04-01 Epub Date: 2025-02-18 DOI: 10.1007/s12328-025-02102-5

Hazuki Miyazaki, Takayuki Ogino, Yuki Sekido, Takahiro Matsui, Tsuyoshi Hata, Norikatsu Miyoshi, Mamoru Uemura, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi

{"title":"Case series of small bowel adenocarcinoma associated with Crohn's disease.","authors":"Hazuki Miyazaki, Takayuki Ogino, Yuki Sekido, Takahiro Matsui, Tsuyoshi Hata, Norikatsu Miyoshi, Mamoru Uemura, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi","doi":"10.1007/s12328-025-02102-5","DOIUrl":"10.1007/s12328-025-02102-5","url":null,"abstract":"Long-standing Crohn's disease (CD) is well known to be associated with gastrointestinal malignancies. Patients with CD have a higher risk of developing small bowel adenocarcinoma (SBA) compared to healthy individuals. However, CD-associated SBA is not as common as colorectal cancer. While patients with CD often present with complicated stricture lesions in the small intestine, it is difficult to confirm all lesions by endoscopy. There is still no consensus on the surgical treatment of small bowel strictures with suspected CD-associated SBA. We report a case of small bowel high-grade dysplasia and two cases with advanced SBA. Case 1 involved a 53-year-old man whose high-grade dysplastic lesion of the small intestine was discovered incidentally postoperatively and successfully resected curatively. Case 2 was that of a 60-year-old man and Case 3 involved a 69-year-old man. Both patients had multiple small bowel stenotic lesions and were diagnosed with advanced small bowel cancer during follow-up. In conclusion, for patients with long-standing Crohn's disease who are refractory to treatment or have stenotic lesions, surgical resection should be considered as a treatment option with CD-associated SBA in consideration.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"293-301"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) of the rectum. 直肠混合神经内分泌-非神经内分泌肿瘤（MiNEN）。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-04-01 Epub Date: 2025-02-10 DOI: 10.1007/s12328-025-02099-x

Hiroyuki Fujimura, Atsushi Goto, Yuta Izumiya, Shunsuke Ito, Akiyoshi Tanaka, Hiroshi Itoh, Taro Takami

引用次数: 0

Enhanced activity of autoimmune gastritis following Helicobacter pylori eradication therapy. 幽门螺杆菌根除治疗后自身免疫性胃炎活性增强。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-04-01 Epub Date: 2025-01-13 DOI: 10.1007/s12328-024-02092-w

Takashi Ihara, Ryoji Kushima, Ken Haruma

引用次数: 0

Familial Mediterranean fever with sigmoid colon stricture. 家族性地中海热伴乙状结肠狭窄。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-04-01 Epub Date: 2025-01-10 DOI: 10.1007/s12328-025-02095-1

Yuki Yamamoto, Akira Madarame, Masakatsu Fukuzawa, Tadashi Ichimiya, Yoshiya Yamauchi, Sakiko Naito, Takashi Morise, Yasuyuki Kagawa, Takahiro Muramastu, Takao Itoi

引用次数: 0

A case of pancreatic ductal adenocarcinoma growing within the pancreatic duct mimicking an intraductal tubulopapillary neoplasm. 胰管腺癌生长于胰管内，与导管内管状乳头状肿瘤相似。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-04-01 Epub Date: 2025-02-05 DOI: 10.1007/s12328-025-02098-y

Ryosuke Sato, Kazuyuki Matsumoto, Mayu Uka, Kosei Takagi, Kenji Nishida, Takehiro Tanaka, Yuki Fujii, Koichiro Tsutsumi, Shigeru Horiguchi, Motoyuki Otsuka

{"title":"A case of pancreatic ductal adenocarcinoma growing within the pancreatic duct mimicking an intraductal tubulopapillary neoplasm.","authors":"Ryosuke Sato, Kazuyuki Matsumoto, Mayu Uka, Kosei Takagi, Kenji Nishida, Takehiro Tanaka, Yuki Fujii, Koichiro Tsutsumi, Shigeru Horiguchi, Motoyuki Otsuka","doi":"10.1007/s12328-025-02098-y","DOIUrl":"10.1007/s12328-025-02098-y","url":null,"abstract":"We herein report a case of pancreatic ductal adenocarcinoma (PDAC) that developed within the pancreatic duct and was initially diagnosed as an intraductal tubulopapillary neoplasm (ITPN). A 76-year-old man presented with weight loss and main pancreatic duct dilation. The imaging studies revealed a 30-mm hypovascular tumor within the main duct of the pancreatic head. An endoscopic examination with a biopsy revealed high-grade atypical epithelial cells with immunostaining patterns suggestive of ITPN. Following robot-assisted pancreaticoduodenectomy, postoperative pathology revealed conflicting features: nodular/cribriform infiltrations typical of ITPN and non-lobular replacement with scattered infiltrations characteristic of PDAC. A comprehensive genomic profiling test detected KRAS and TP53 mutations, leading to the final diagnosis of PDAC (fT3N1aM0, stage IIB). The patient received adjuvant S-1 chemotherapy and remained recurrence-free for 15 months post-surgery. This case highlights the diagnostic challenges of differentiating intraductal pancreatic tumors and demonstrates the utility of integrating genetic testing with conventional diagnostic modalities for an accurate diagnosis and appropriate treatment selection.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"376-382"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Torsion of the wandering spleen with intestinal obstruction. 游离脾扭转伴肠梗阻。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-04-01 Epub Date: 2024-12-12 DOI: 10.1007/s12328-024-02082-y

Nobuhiro Hosoi, Makoto Sohda, Keigo Hara, Hideyuki Saito, Akihiko Sano, Makoto Sakai, Hiroomi Ogawa, Ken Shirabe, Hiroshi Saeki

{"title":"Torsion of the wandering spleen with intestinal obstruction.","authors":"Nobuhiro Hosoi, Makoto Sohda, Keigo Hara, Hideyuki Saito, Akihiko Sano, Makoto Sakai, Hiroomi Ogawa, Ken Shirabe, Hiroshi Saeki","doi":"10.1007/s12328-024-02082-y","DOIUrl":"10.1007/s12328-024-02082-y","url":null,"abstract":"Wandering spleen is a relatively rare condition and may be complicated by intestinal obstruction or abnormal intestinal rotation. Herein, we report a case where these three conditions appeared concomitantly. An 18-year-old woman with an intellectual disability was admitted to the hospital because of vomiting and fever. The patient's abdomen was distended. Computed tomography revealed a dilated small intestine, a swollen spleen located in the lower abdomen, as well as twisting and swirling of the splenic artery and vein. The patient was diagnosed with torsion of the wandering spleen and emergency surgery was performed. The vascular pedicle was found to be rotated 900° clockwise, and a markedly enlarged spleen was observed in the lower abdomen. When the splenic torsion was released, the pulsation of the splenic artery was well palpated, suggesting that the spleen could be preserved. Additionally, the sigmoid colon to the cecum was not fixed to the retroperitoneum. Dilatation of the small intestine was observed, but there were no findings of intestinal tract necrosis. Splenic torsion is part of the differential diagnosis for acute abdomen. Familiarity with embryology and anatomy is necessary to select the appropriate surgical technique.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"389-392"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microsatellite-high intrahepatic cholangiocarcinoma with favorable treatment outcome using pembrolizumab. 微卫星高肝内胆管癌，使用派姆单抗治疗效果良好。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-04-01 Epub Date: 2025-03-04 DOI: 10.1007/s12328-025-02103-4

Shigeru Horiguchi, Hironari Kato, Kazuya Miyamoto, Kosaku Morimoto, Akihiro Matsumi, Hiroyuki Terasawa, Yuki Fujii, Kazuyuki Matsumoto, Takehiro Tanaka, Motoyuki Otsuka

{"title":"Microsatellite-high intrahepatic cholangiocarcinoma with favorable treatment outcome using pembrolizumab.","authors":"Shigeru Horiguchi, Hironari Kato, Kazuya Miyamoto, Kosaku Morimoto, Akihiro Matsumi, Hiroyuki Terasawa, Yuki Fujii, Kazuyuki Matsumoto, Takehiro Tanaka, Motoyuki Otsuka","doi":"10.1007/s12328-025-02103-4","DOIUrl":"10.1007/s12328-025-02103-4","url":null,"abstract":"Intrahepatic cholangiocarcinoma has a poor prognosis. In unresectable cases, the survival period is short despite combination therapy with cytotoxic anticancer agents and immune checkpoint inhibitors. The usefulness of immune checkpoint inhibitors against malignant tumors with microsatellite instability-high (MSI-H) mutations was shown in the KEYNOTE158 study; however, data for intrahepatic cholangiocarcinoma are insufficient. In the present case, a 65-year-old man with intrahepatic cholangiocarcinoma and lymph node metastasis could not be treated with a combination of gemcitabine, CDDP, and S-1. A comprehensive cancer genomic profiling (CGP) test showed MLH1 pathogenic mutation and MSI-H. When pembrolizumab was administered, the tumor shrinkage effect was rapidly observed, which was sustained even after 30 months. No pathogenic mutations were observed in the germline test, and MSI-high was considered to be due to the MLH1 pathogenic mutation occurring sporadically in somatic cells. MSI-H intrahepatic cholangiocarcinoma is extremely rare. However, because pembrolizumab is expected to be effective, CGP testing should be actively performed.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"363-368"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed neuroendocrine-non-neuroendocrine neoplasm of the colon treated with laparoscopic resection and adjuvant chemotherapy: a case report. 腹腔镜切除辅助化疗治疗结肠混合性神经内分泌-非神经内分泌肿瘤1例。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-04-01 Epub Date: 2025-01-12 DOI: 10.1007/s12328-024-02089-5

Yuya Tanaka, Masayuki Takagi, Toshihiro Nakayama, Shuhei Kawada, Reika Matsushita, Tsunehisa Matsushita, Takahiro Ozaki, Shimpei Takagi, Sota Komai, Yasuhiro Sumi

{"title":"Mixed neuroendocrine-non-neuroendocrine neoplasm of the colon treated with laparoscopic resection and adjuvant chemotherapy: a case report.","authors":"Yuya Tanaka, Masayuki Takagi, Toshihiro Nakayama, Shuhei Kawada, Reika Matsushita, Tsunehisa Matsushita, Takahiro Ozaki, Shimpei Takagi, Sota Komai, Yasuhiro Sumi","doi":"10.1007/s12328-024-02089-5","DOIUrl":"10.1007/s12328-024-02089-5","url":null,"abstract":"Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) of the colon is rare with a poor prognosis. Since the first description of a mixed neoplasm 100 years ago, the nomenclature has evolved, most recently with the 2022 World Health Organization (WHO) classification system. We describe our experience of a case of locoregionally advanced MiNEN of the descending colon treated with curative laparoscopic resection and adjuvant chemotherapy. The patient is a 72 year old woman who presented with haematochezia. Initial clinical diagnosis was poorly differentiated adenocarcinoma of the descending colon, cT2N0M0, cStage I. Laparoscopic partial colectomy of the descending colon with D3 lymph node dissection and intracorporeal overlap anastomosis was performed. The pathological diagnosis however, returned mixed adenocarcinoma-neuroendocrine carcinoma (MANEC) of the descending colon, pT4aN1bM0, pStage IIIB, a subgroup of MiNEN: 70% was neuroendocrine carcinoma (NEC), whilst poorly differentiated mucinous carcinoma constituted 30% of the tumour. She completed 4 courses of irinotecan plus cisplatin (IP) adjuvant chemotherapy and is currently recurrence-free at postoperative year 2. The clinical course of MiNEN depends on the biology of the two components, both of which must be pathologically characterised. Even quantitatively discrete components should be carefully subtyped as their prognostic relevance is undetermined.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"314-323"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ascending colon perforation by a migrated pancreatic spontaneous dislodgment stent: a case report. 胰腺自发移位支架移位致升结肠穿孔1例。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-04-01 Epub Date: 2025-02-14 DOI: 10.1007/s12328-025-02101-6

Mari Okumura, Hideaki Koga, Hiroki Eguchi, Naoto Sato, Ran Utsunomiya, Yuhei Wakahara, Kazuhiro Morimoto, Kohei Sugiyama

{"title":"Ascending colon perforation by a migrated pancreatic spontaneous dislodgment stent: a case report.","authors":"Mari Okumura, Hideaki Koga, Hiroki Eguchi, Naoto Sato, Ran Utsunomiya, Yuhei Wakahara, Kazuhiro Morimoto, Kohei Sugiyama","doi":"10.1007/s12328-025-02101-6","DOIUrl":"10.1007/s12328-025-02101-6","url":null,"abstract":"Here, we report a case of a 74-year-old woman treated for acute cholecystitis. She initially underwent percutaneous transhepatic gallbladder drainage; however, cholecystitis recurred when the drain was clamped. Therefore, endoscopic transpapillary gallbladder drainage (ETGBD) was performed. Endoscopic sphincterotomy was performed, and a transpapillary gallbladder stent was placed. Additionally, a pancreatic spontaneous dislodgment stent (PSDS) was inserted to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis. Cholecystitis resolved, and the patient was discharged seven days later. Twenty-five days after ETGBD, she experienced abdominal pain, and computed tomography revealed ascending colon perforation by the migrated PSDS. She underwent laparoscopic surgery, in which the perforation was sutured, and an ileostomy was performed. The postoperative course was uneventful, and colonoscopy performed two months after surgery revealed multiple diverticula in the ascending colon. PSDS-induced gastrointestinal perforations are extremely rare. Previous case reports have suggested that perforation is caused by long-term stent retention in the gastrointestinal tract due to obstructions, such as peritonitis carcinomatosa or postoperative adhesions. We believe that in this case, the PSDS was retained because of multiple colonic diverticula. PSDS should be used with caution in patients with multiple colonic diverticula, peritonitis carcinomatosa, and postoperative adhesions.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"383-388"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Localized light chain amyloidosis of the stomach that regressed after eradication of Helicobacter pylori over 15 years of follow-up: a case report and new hypothesis. 15年随访根除幽门螺杆菌后恢复的胃局部轻链淀粉样变一例报告及新假设

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2025-04-01 Epub Date: 2025-01-11 DOI: 10.1007/s12328-025-02097-z

Yukihiro Shirota, Yoshimichi Ueda, Katsuaki Sato, Takayoshi Koura, Yasuhito Takeda, Yuji Hodo, Tokio Wakabayashi

{"title":"Localized light chain amyloidosis of the stomach that regressed after eradication of Helicobacter pylori over 15 years of follow-up: a case report and new hypothesis.","authors":"Yukihiro Shirota, Yoshimichi Ueda, Katsuaki Sato, Takayoshi Koura, Yasuhito Takeda, Yuji Hodo, Tokio Wakabayashi","doi":"10.1007/s12328-025-02097-z","DOIUrl":"10.1007/s12328-025-02097-z","url":null,"abstract":"Localized light chain amyloidosis is considered to be a plasmacytic B-cell lymphoproliferative disorder caused by antigenic induction. A hypothesis has been proposed that antigen-induced local plasmacytic B cells produce amyloidogenic proteins that are processed into amyloid fibrils in giant cells leading to amyloid fibril deposition. However, the inciting antigen exposure or immune response that signals plasmacytic B-cell infiltration, activation, and selection, is unknown. A case of localized light chain amyloidosis of the stomach that gradually regressed endoscopically after Helicobacter pylori eradication is presented. Histologically, plasmacytes decreased markedly and macrophages disappeared after eradication, and they are thought to play important roles in amyloid formation. There have been no reports of localized gastric amyloidosis in which the lesion regressed and few reports showing the relationship between localized gastric amyloidosis and Helicobacter pylori infection that evaluated the changes after eradication. Given the review of the latest findings about localized light chain amyloidosis, in addition to circumstantial evidence from the clinical course of this case, we would like to propose a bold new hypothesis that Helicobacter pylori could be one of the antigens inducing localized light chain amyloidosis of the stomach.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"269-277"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0