Clinical Journal of Gastroenterology最新文献_第4页

A small bowel adenocarcinoma harboring a DDR2 mutation in a celiac patient. 一名乳糜泻患者的小肠腺癌携带 DDR2 突变。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-08-08 DOI: 10.1007/s12328-024-02025-7

Ludovica Mollica, Erica Quaquarini, Annalisa Schiepatti, Erica Travaglino, Francesca Antoci, Alessandro Vanoli, Giovanni Arpa, Federico Biagi, Laura Deborah Locati

{"title":"A small bowel adenocarcinoma harboring a DDR2 mutation in a celiac patient.","authors":"Ludovica Mollica, Erica Quaquarini, Annalisa Schiepatti, Erica Travaglino, Francesca Antoci, Alessandro Vanoli, Giovanni Arpa, Federico Biagi, Laura Deborah Locati","doi":"10.1007/s12328-024-02025-7","DOIUrl":"10.1007/s12328-024-02025-7","url":null,"abstract":"We present the case of a 62-year-old man with a history of celiac disease and IgA deficiency, following a strict gluten-free diet that was admitted to our hospital for recurrent abdominal pain, fatigue and melena. Esophagogastroduodenoscopy and colonoscopy with biopsies were normal. A video-capsule endoscopy was performed and revealed a sub-stenosing, vegetating, and bleeding lesion in the first jejunal loop. He underwent laparotomic surgery with resection of the involved segment with loco-regional lymphadenectomy. The pathological report described a poorly differentiated adenocarcinoma of the jejunum, stage IIIA (pT3pN1). Analysis of next-generation sequencing (NGS) of DNA on the surgical sample revealed a likely pathogenetic variant in exon 15 of the DDR2 gene (c.2003G > A) and a TP53 non-frame-shift deletion (c.585_602del). Considering the risk of recurrence, he was candidate to 6 months of adjuvant chemotherapy with platinum salt and fluoropyrimidine. Thirty-eight months after the diagnosis, the patient is still disease free and in good clinical condition. This is the first described case of SBA with DDR2 mutation. Considering the limited therapeutic options beyond surgery for SBA, molecular analyses could become promising for the search for potential targetable alterations for treatments with new available drugs.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"1026-1032"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid deterioration of steatotic liver disease due to portal vein stenosis after pancreaticoduodenectomy. 胰十二指肠切除术后，门静脉狭窄导致脂肪肝迅速恶化。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-08-15 DOI: 10.1007/s12328-024-02027-5

Mineto Ohta, Rikiya Kanba, Keisuke Fukushima, Kazutomi Takahashi, Hiroyasu Nishimaki, Tatsuya Sasaki, Ai Fujita, Maika Kanno, Yuki Ogasawara, Kenji Namiki

{"title":"Rapid deterioration of steatotic liver disease due to portal vein stenosis after pancreaticoduodenectomy.","authors":"Mineto Ohta, Rikiya Kanba, Keisuke Fukushima, Kazutomi Takahashi, Hiroyasu Nishimaki, Tatsuya Sasaki, Ai Fujita, Maika Kanno, Yuki Ogasawara, Kenji Namiki","doi":"10.1007/s12328-024-02027-5","DOIUrl":"10.1007/s12328-024-02027-5","url":null,"abstract":"Steatotic liver disease after pancreatoduodenectomy occurs due to various factors, such as exocrine pancreatic insufficiency, impaired intestinal absorption, and malnutrition. The mechanism of steatogenesis differs to that of conventional steatotic liver disease associated with obesity and insulin resistance. We experienced a rare case of rapidly progressive steatotic liver disease accompanied by portal vein stenosis in the early postoperative period after subtotal stomach-preserving pancreaticoduodenectomy for distal cholangiocarcinoma. Although there was a complication due to postoperative drain infection, the patient was discharged from hospital with no nutritional problems. Two months postoperatively, the patient presented to the emergency room with dyspnea. CT showed a markedly steatotic liver, ascites, and portal vein stenosis. A portal vein stent was inserted transhepatically and the steatotic liver disease gradually improved. During the postoperative course, there were no problems indicated by nutritional markers; although the patient had diarrhea associated with postoperative pancreatic exocrine insufficiency, the symptoms were mild and improved after administration of oral pancrelipase. Before the intervention, the patient had intestinal edema, exacerbation of diarrhea, and a low serum zinc concentration, suggesting that impaired absorption caused by intestinal blood stasis and gut barrier dysfunction contributed to the development of steatotic liver disease.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"1093-1099"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of protein-losing gastroenteropathy due to Sjögren's syndrome detected by foggy vision with refractive error of the intraocular lens. 一例因视力模糊和眼内晶状体屈光不正而被发现的斯约格伦综合征引起的蛋白质丢失性肠胃病。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-09-19 DOI: 10.1007/s12328-024-02038-2

Naho Watanabe, Rena Kaneko, Monami Kishi, Ryo Yanai, Takashi Ikehara, Hidenari Nagai, Takahisa Matsuda

{"title":"A case of protein-losing gastroenteropathy due to Sjögren's syndrome detected by foggy vision with refractive error of the intraocular lens.","authors":"Naho Watanabe, Rena Kaneko, Monami Kishi, Ryo Yanai, Takashi Ikehara, Hidenari Nagai, Takahisa Matsuda","doi":"10.1007/s12328-024-02038-2","DOIUrl":"10.1007/s12328-024-02038-2","url":null,"abstract":"A woman in her forties visited an ophthalmologist for rapidly progressive foggy vision. Naked visual acuity had decreased to 0.15, and although her eyes showed no abnormalities, internal disease was suspected and albumin 2.6 g/dL was found. Protein leakage from the intestinal tract was suspected since there was no urinary protein excretion. 99mTechnetium-labeled albumin D scintigraphy showed protein leakage from the intestinal tract. A stool α1-antitrypsin clearance test showed an increase to 56.3 mL/day, leading to a diagnosis of protein-losing gastroenteropathy. Blood biochemistry revealed abnormally high levels of anti-SS-A and anti-SS-B antibodies (≥ 1200 U/mL and ≥ 1000 U/mL, respectively). A lip salivary gland biopsy revealed lymphocytic infiltrate at least 1 focus per 2 mm × 2 mm > 50 lymphocytes per conduit). The Schirmer test result was 5 mm/5 min or less, which led to the diagnosis of Sjögren's syndrome. The serum albumin level increased with intravenous administration of methylprednisolone 50 mg (1 mg/kg), and the patient is currently on oral prednisolone at a gradually decreasing dose. After administration of prednisolone, visual acuity recovered to 1.2 with recovery of albumin.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"1039-1046"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of undifferentiated pleomorphic rectal sarcoma occurring after radiation exposure. 一例辐射照射后发生的未分化多形性直肠肉瘤。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-08-09 DOI: 10.1007/s12328-024-02026-6

Makoto Eizuka, Yosuke Toya, Shun Yamada, Tomofumi Oizumi, Shunichi Yanai, Norihiko Kudara, Naoki Yanagawa, Tamotsu Sugai, Takayuki Matsumoto

引用次数: 0

A case of malignant lymphoma of the extrahepatic bile duct diagnosed by detailed imaging examination and endoscopic ultrasound-guided fine needle aspiration.

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-11-30 DOI: 10.1007/s12328-024-02075-x

Noriaki Iijima, Shinya Nakamura, Yasutaka Ishii, Yumiko Tatsukawa, Juri Ikemoto, Sayaka Miyamoto, Kazuki Nakamura, Masaru Furukawa, Koji Arihiro, Shiro Oka

{"title":"A case of malignant lymphoma of the extrahepatic bile duct diagnosed by detailed imaging examination and endoscopic ultrasound-guided fine needle aspiration.","authors":"Noriaki Iijima, Shinya Nakamura, Yasutaka Ishii, Yumiko Tatsukawa, Juri Ikemoto, Sayaka Miyamoto, Kazuki Nakamura, Masaru Furukawa, Koji Arihiro, Shiro Oka","doi":"10.1007/s12328-024-02075-x","DOIUrl":"https://doi.org/10.1007/s12328-024-02075-x","url":null,"abstract":"A 70-year-old woman presented to our hospital with abdominal pain. Imaging examinations showed diffuse and extensive wall thickening at the perihilar bile duct; however, the degree of stricture was mild, and the mucosal epithelium was smooth. A transpapillary biopsy was performed considering cholangiocarcinoma and IgG4 sclerosing cholangitis as differential diagnoses; however, no pathologic diagnosis was obtained. Peroral cholangioscopy revealed a regular epithelium at the stricture, and endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of the enlarged lymph node confirmed the diagnosis of diffuse large B-cell lymphoma. Multiagent chemotherapy was administered, which led to complete remission. Because primary bile duct malignant lymphomas are rare and specific, clinical, and imaging findings are lacking, and many of those reported so far have been diagnosed by postoperative pathology. As chemotherapy is the first-line treatment for malignant lymphoma, obtaining an accurate diagnosis is crucial. Our findings support that smooth and mild biliary strictures with mainly submucosal wall thickening may be characteristic imaging findings of primary bile duct malignant lymphoma, and that peroral cholangioscopy and EUS-FNA may be helpful for an accurate diagnosis.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic groove cancer with large cystic lesion.

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-11-29 DOI: 10.1007/s12328-024-02071-1

Daisuke Tomita, Masaru Matsumura, Kentoku Fujisawa, Satoshi Okubo, Junichi Shindoh, Tetsuo Tamura, Tsunao Imamura, Yasuro Miura, Yutaka Takazawa, Masaji Hashimoto

{"title":"Pancreatic groove cancer with large cystic lesion.","authors":"Daisuke Tomita, Masaru Matsumura, Kentoku Fujisawa, Satoshi Okubo, Junichi Shindoh, Tetsuo Tamura, Tsunao Imamura, Yasuro Miura, Yutaka Takazawa, Masaji Hashimoto","doi":"10.1007/s12328-024-02071-1","DOIUrl":"https://doi.org/10.1007/s12328-024-02071-1","url":null,"abstract":"Groove pancreatic cancer is a malignant tumor that originates from the groove between the pancreas, duodenum, and bile duct. Groove pancreatic cancer shares similarities with groove pancreatitis in terms of clinical symptoms and imaging findings, which often makes it difficult to distinguish between the two diseases. We describe the case of a patient with a cystic lesion associated with groove pancreatic cancer. A 54-year-old male patient presented with sudden vomiting, hematemesis, and persistent epigastric pain. Enhanced computed tomography revealed a hypoenhanced, ill-defined lesion extending from the pancreatic head to the duodenum, with a large duodenal cystic formation. Despite various diagnostic efforts, a definitive diagnosis of malignancy before surgery remained elusive. Intraoperative findings revealed that the tumor was resectable. Subtotal stomach-preserving pancreaticoduodenectomy with portal vein resection and right hemicolectomy were performed. The resected specimen revealed groove pancreatic adenocarcinoma invading the duodenum and ascending colon. A large cyst was observed within the duodenal wall, the interior of which was lined with cancer cells. Despite postoperative chemotherapy, the patient succumbed to the disease 17 months after resection. This case emphasizes that when a groove area lesion with a huge paraduodenal cyst is observed, the possibility of groove pancreatic cancer should be considered.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rectal 5-aminosalicylic acid induced pancreatitis in a patient with newly diagnosed ulcerative colitis.

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-11-29 DOI: 10.1007/s12328-024-02063-1

Carl Cosgrave, Irene Lu, Jack Shembrey, Neel Heerasing

引用次数: 0

Obstructive jaundice caused by an abdominal tuberculous mass lesion. 腹部结核性肿块病变引起的阻塞性黄疸。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-11-28 DOI: 10.1007/s12328-024-02070-2

Wilson Jing Peng Liu, Michael Yulong Wu, Matthew Zaborowski, Eugene Ng

{"title":"Obstructive jaundice caused by an abdominal tuberculous mass lesion.","authors":"Wilson Jing Peng Liu, Michael Yulong Wu, Matthew Zaborowski, Eugene Ng","doi":"10.1007/s12328-024-02070-2","DOIUrl":"https://doi.org/10.1007/s12328-024-02070-2","url":null,"abstract":"Tuberculosis is a global epidemic infection that typically presents with symptoms affecting the respiratory system. Abdominal tuberculosis is an uncommon manifestation, occurring in only 5% of tuberculosis cases globally and can present with a broad range of vague symptoms that mimic other biliary and pancreatic pathologies. We report a case of a 36-year-old woman presenting with jaundice and biliary obstruction secondary to abdominal tuberculosis. Computed tomography and magnetic resonance cholangiopancreatography revealed a loculated retroperitoneal mass abutting the pancreatic head and duodenum with associated common bile duct dilatation. Endoscopic ultrasound demonstrated an ulcerated mass in the duodenum which was biopsied. Necrotising granulomas were identified on histology and the biopsied tissue was positive on tuberculosis polymerase chain reaction testing. Thus, extrapulmonary abdominal tuberculosis was diagnosed. The patient was commenced on a 6-month course of rifampicin, isoniazid, pyrazinamide and ethambutol treatment and demonstrated complete response to medical therapy. Abdominal tuberculosis can be difficult to diagnose but should remain an important differential to be considered for patients with previous travel or residence in endemic areas presenting with gastrointestinal symptoms. Prompt diagnosis and treatment can prevent unnecessary procedures, complications and death in patients with biliary obstruction caused by abdominal tuberculosis.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of pancreatic fistula with disruption of the inferior branch of the pancreatic duct caused by a pancreatic stent after endoscopic papillectomy. 一例内镜乳头切除术后胰腺支架导致胰管下支中断的胰腺瘘。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-11-22 DOI: 10.1007/s12328-024-02067-x

Yoshihisa Takada, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Kota Uetsuki, Hiroki Kawashima

{"title":"A case of pancreatic fistula with disruption of the inferior branch of the pancreatic duct caused by a pancreatic stent after endoscopic papillectomy.","authors":"Yoshihisa Takada, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Kota Uetsuki, Hiroki Kawashima","doi":"10.1007/s12328-024-02067-x","DOIUrl":"https://doi.org/10.1007/s12328-024-02067-x","url":null,"abstract":"A 73-year-old man underwent upper gastrointestinal endoscopy for abdominal pain, which revealed an ampullary adenoma with no obvious extension into the bile or pancreatic ducts. Endoscopic papillectomy (EP) was performed and a 5-Fr 5-cm stent was placed in the pancreatic duct. The patient developed acute pancreatitis on postoperative day (POD) 1 and contrast-enhanced computed tomography performed on POD 2 revealed that the proximal end of the stent had migrated into the retroperitoneum, forming a pancreatic fistula. Stent removal and endoscopic nasopancreatic drainage were performed and the pancreatitis rapidly improved. The tumor was completely resected and after approximately three years of follow-up, no tumor recurrence or acute pancreatitis was observed.Retrospectively, the inferior branch of the pancreatic duct was prominent on pancreatography at the time of EP and the proximal end of the stent had dislocated into the inferior branch. The stent subsequently moved proximally, which could have caused pancreatitis and pancreatic fistula. The morphology of the pancreatic duct should be carefully monitored during stenting. Selecting a stent that matches each patient's specific pancreatic duct morphology may help physicians minimize the risk of adverse outcomes.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of gastric granular cell tumor successfully treated by laparoscopic and endoscopic cooperative surgery. 一例通过腹腔镜和内镜合作手术成功治疗的胃颗粒细胞瘤。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-11-22 DOI: 10.1007/s12328-024-02065-z

Kyoko Arahata, Sakiko Takarabe, Kenji Nakamura, Yasue Fujikawa, Tadashi Katayama, Keisuke Ojiro, Hiroshi Kishikawa, Aya Sasaki, Hirotoshi Hasegawa, Jiro Nishida

{"title":"A case of gastric granular cell tumor successfully treated by laparoscopic and endoscopic cooperative surgery.","authors":"Kyoko Arahata, Sakiko Takarabe, Kenji Nakamura, Yasue Fujikawa, Tadashi Katayama, Keisuke Ojiro, Hiroshi Kishikawa, Aya Sasaki, Hirotoshi Hasegawa, Jiro Nishida","doi":"10.1007/s12328-024-02065-z","DOIUrl":"https://doi.org/10.1007/s12328-024-02065-z","url":null,"abstract":"We describe a case of gastric granular cell tumor (GCT) treated with laparoscopic and endoscopic cooperative surgery (LECS). A 30-year-old male was referred to our hospital for the investigation of a subepithelial lesion (SEL). Contrast-enhanced computed tomography and esophagogastroduodenoscopy revealed a 15 mm SEL within the posterior wall of the gastric body. Endoscopic ultrasound revealed a well-demarcated, homogenous, hypoechoic lesion in the submucosa, suggesting partial invasion into the muscularis propria. Biopsy using the bite-on-bite technique showed a gastric GCT diagnosis. The patient underwent LECS, and pathological findings confirmed a benign gastric GCT without muscularis propria invasion, lymphovascular invasion, or lymph node metastasis. The patient remained recurrence-free after 24 months.Despite unresolved issues such as setting the resection margins; indications for resection, and accurate preoperative diagnosis of the invasion depth, including muscularis propria invasion, LECS may be useful for gastric GCT in the form of SEL, especially for lesions that cannot be ruled out to invade the muscularis propria invasion.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0