直肠混合神经内分泌-非神经内分泌肿瘤(MiNEN)。

IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY
Clinical Journal of Gastroenterology Pub Date : 2025-04-01 Epub Date: 2025-02-10 DOI:10.1007/s12328-025-02099-x
Hiroyuki Fujimura, Atsushi Goto, Yuta Izumiya, Shunsuke Ito, Akiyoshi Tanaka, Hiroshi Itoh, Taro Takami
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引用次数: 0

摘要

一名75岁男性到我院就诊,主诉腹胀。经下消化道内镜检查,发现直肠乙状结肠过渡区有一个直径20mm的凸起肿瘤。内镜下粘膜切除术,目的是治疗和诊断。组织病理学检查显示为中分化腺癌合并神经内分泌癌,分类为神经内分泌-非神经内分泌混合肿瘤(MiNEN)。肿瘤高度侵袭粘膜下层和垂直阳性边缘。计算机断层扫描未见明显淋巴结转移及远处转移,故对剩余病灶行高位前切除术。最终诊断为MiNEN、pT3(SS)、INFb、Ly1c、V0、Pn1a、pPM0、pDM0、pRM0、Pn1a、pStage IIIb (TNM Classification of Malignant Tumors,第八版)。患者术后3年无复发,无需辅助治疗。我们在回顾文献的同时报告这个病例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) of the rectum.

A 75-year-old man presented to our hospital complaining of abdominal distention. He underwent lower gastrointestinal endoscopic examination, which indicated a raised tumor of 20 mm in diameter in the sigmoid colon transition region of the rectum. Endoscopic mucosal resection was performed with the aims of treatment and diagnosis. Histopathological examination revealed a moderately differentiated adenocarcinoma with neuroendocrine carcinoma, which was classified as a mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN). The tumor had highly invaded the submucosa and positive vertical margins. Computed tomography showed no obvious lymph node metastasis or distant metastasis, so the patient underwent high-level anterior resection of the remaining lesion. The final diagnosis was MiNEN, pT3(SS), INFb, Ly1c, V0, Pn1a, pPM0, pDM0, pRM0, pN1a, and pStage IIIb (TNM Classification of Malignant Tumors, 8th Edition). The patient is recurrence free at 3 years without postoperative adjuvant therapy. We report this case with a review of the literature.

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来源期刊
Clinical Journal of Gastroenterology
Clinical Journal of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
2.00
自引率
0.00%
发文量
182
期刊介绍: The journal publishes Case Reports and Clinical Reviews on all aspects of the digestive tract, liver, biliary tract, and pancreas. Critical Case Reports that show originality or have educational implications for diagnosis and treatment are especially encouraged for submission. Personal reviews of clinical gastroenterology are also welcomed. The journal aims for quick publication of such critical Case Reports and Clinical Reviews.
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