Clinical Journal of Gastroenterology最新文献

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Solitary Peutz-Jeghers polyp harboring a focus of high-grade dysplasia in the colon: a case report and literature review. 结肠中藏有高级别发育不良病灶的孤立性 Peutz-Jeghers 息肉:病例报告和文献综述。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-11-13 DOI: 10.1007/s12328-024-02059-x
Takato Maeda, Tadashi Yoshizawa, Takao Oyama, Satoru Nakagawa, Yasuhisa Murai, Ryuma Machida, Nao Ishidoya, Juichi Sakamoto, Hideki Iwamura, Hirotake Sakuraba
{"title":"Solitary Peutz-Jeghers polyp harboring a focus of high-grade dysplasia in the colon: a case report and literature review.","authors":"Takato Maeda, Tadashi Yoshizawa, Takao Oyama, Satoru Nakagawa, Yasuhisa Murai, Ryuma Machida, Nao Ishidoya, Juichi Sakamoto, Hideki Iwamura, Hirotake Sakuraba","doi":"10.1007/s12328-024-02059-x","DOIUrl":"10.1007/s12328-024-02059-x","url":null,"abstract":"<p><p>A solitary Peutz-Jeghers (PJ) polyp is a rare hamartomatous lesion without an associated PJ syndrome. However, little is known regarding malignancy arising in solitary PJ polyps. Here, we report a case of a solitary colonic PJ polyp with focal dysplasia. A 45-year-old asymptomatic man underwent total colonoscopy following a positive fecal occult blood test. The patient had no history of mucocutaneous pigmentation or family history of PJ syndrome. A 20 mm erythematous pedunculated polyp was observed in the sigmoid colon. Magnified endoscopy revealed a tubular or branch-like pit pattern with localized areas of irregular pits. These findings were suggestive of colorectal adenoma with high-grade dysplasia, and endoscopic mucosal resection was performed. Histopathological examination revealed arborizing proliferation of hyperplastic epithelia with smooth muscle bundles. In addition, a small number of irregular crypts with high-grade dysplasia were observed in the hyperplastic epithelium. Based on these histological findings, we finally diagnosed the patient with a solitary colonic PJ polyp with high-grade dysplasia. The present case suggests that solitary colonic PJ polyps may harbor dysplastic changes and require pathological evaluation with en bloc resection of the polyps.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"89-94"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic ultrasound navigated application of botulinum toxin in severe esophageal motility disorder. 超声内镜下肉毒毒素在重度食管运动障碍中的应用。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-12-03 DOI: 10.1007/s12328-024-02066-y
Diana Vážanová, Martin Ďuriček, Peter Uhrík, Peter Bánovčin
{"title":"Endoscopic ultrasound navigated application of botulinum toxin in severe esophageal motility disorder.","authors":"Diana Vážanová, Martin Ďuriček, Peter Uhrík, Peter Bánovčin","doi":"10.1007/s12328-024-02066-y","DOIUrl":"10.1007/s12328-024-02066-y","url":null,"abstract":"<p><p>The use of botulinum toxin in the therapy of esophageal motility disorders is reserved for elderly and comorbid patients considered risky for endoscopic or surgical treatment. However, there is a lack of data on the treatment of motility disorders outside the Chicago classification.We present the case of a 56-year-old patient with dysphagia and non-cardial chest pain (Eckardt 8). High resolution manometry ruled out achalasia or other motility disorder, but confirmed a localized 7-cm-long spastic segment in the upper to middle third of esophagus. We considered endoscopic or surgical therapy in this location too risky, therefore we decided to apply botulinum toxin into this segment. The spasm on high resolution manometry correlated with the thickened muscularis propria layer according to the endoscopic ultrasound. We used endoscopic ultrasound for the navigation of botulinum toxin application into the muscularis propria layer. We applied 100 IU of botulinum toxin into four quadrants, 20 and 24 cm from front teeth (12.5 IU for 1 application).The therapy led to improvement of symptoms (Eckardt 3) and to restitution of propulsive peristalsis with complete elimination of spastic segment. The worsening of symptoms appeared after 2 years, with subsequent recurrence of motility disorder fulfilling criteria of type II achalasia.Presenting this case, we wanted to point at the unique use of botulinum toxin as useful treatment in selected cases of unclassified esophageal motility disorder as a bridge therapy. Moreover, endoscopic ultrasound could be used to guide precise application of botulinum toxin.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"43-47"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of malignant lymphoma of the extrahepatic bile duct diagnosed by detailed imaging examination and endoscopic ultrasound-guided fine needle aspiration. 详细影像学检查及超声内镜引导下细针穿刺诊断肝外胆管恶性淋巴瘤1例。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-11-30 DOI: 10.1007/s12328-024-02075-x
Noriaki Iijima, Shinya Nakamura, Yasutaka Ishii, Yumiko Tatsukawa, Juri Ikemoto, Sayaka Miyamoto, Kazuki Nakamura, Masaru Furukawa, Koji Arihiro, Shiro Oka
{"title":"A case of malignant lymphoma of the extrahepatic bile duct diagnosed by detailed imaging examination and endoscopic ultrasound-guided fine needle aspiration.","authors":"Noriaki Iijima, Shinya Nakamura, Yasutaka Ishii, Yumiko Tatsukawa, Juri Ikemoto, Sayaka Miyamoto, Kazuki Nakamura, Masaru Furukawa, Koji Arihiro, Shiro Oka","doi":"10.1007/s12328-024-02075-x","DOIUrl":"10.1007/s12328-024-02075-x","url":null,"abstract":"<p><p>A 70-year-old woman presented to our hospital with abdominal pain. Imaging examinations showed diffuse and extensive wall thickening at the perihilar bile duct; however, the degree of stricture was mild, and the mucosal epithelium was smooth. A transpapillary biopsy was performed considering cholangiocarcinoma and IgG4 sclerosing cholangitis as differential diagnoses; however, no pathologic diagnosis was obtained. Peroral cholangioscopy revealed a regular epithelium at the stricture, and endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of the enlarged lymph node confirmed the diagnosis of diffuse large B-cell lymphoma. Multiagent chemotherapy was administered, which led to complete remission. Because primary bile duct malignant lymphomas are rare and specific, clinical, and imaging findings are lacking, and many of those reported so far have been diagnosed by postoperative pathology. As chemotherapy is the first-line treatment for malignant lymphoma, obtaining an accurate diagnosis is crucial. Our findings support that smooth and mild biliary strictures with mainly submucosal wall thickening may be characteristic imaging findings of primary bile duct malignant lymphoma, and that peroral cholangioscopy and EUS-FNA may be helpful for an accurate diagnosis.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"176-182"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alpha-fetoprotein-producing intramucosal gastric cancer found during examination of metastatic lymph nodes. 检查转移淋巴结时发现甲胎蛋白分泌型黏膜内胃癌。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-11-19 DOI: 10.1007/s12328-024-02064-0
Tomoya Sano, Takahiro Toyokawa, Mami Yoshii, Yuichiro Miki, Tatsuro Tamura, Shigeru Lee, Kiyoshi Maeda
{"title":"Alpha-fetoprotein-producing intramucosal gastric cancer found during examination of metastatic lymph nodes.","authors":"Tomoya Sano, Takahiro Toyokawa, Mami Yoshii, Yuichiro Miki, Tatsuro Tamura, Shigeru Lee, Kiyoshi Maeda","doi":"10.1007/s12328-024-02064-0","DOIUrl":"10.1007/s12328-024-02064-0","url":null,"abstract":"<p><p>Endoscopic resection has been applied as an absolute indication for early gastric cancer showing intramucosal cancer ≤ 2 cm in diameter, differentiated-type adenocarcinoma without ulcerative findings. We describe the case of a 76-year-old man who underwent radical gastrectomy for alpha-fetoprotein-producing gastric cancer, in which the depth of invasion was clinically diagnosed as T1a after lymph node metastases were detected. Upper gastrointestinal endoscopy revealed a type 0-IIc tumor nearly 10 mm in diameter at the antrum. Computed tomography showed a 47-mm nodule along the common hepatic artery and a 22-mm nodule in the infrapyloric area. Both were pathologically confirmed as adenocarcinoma by endoscopic ultrasound-guided aspiration. No evidence of malignancy elsewhere was seen on <sup>18</sup>F-fluorodeoxyglucose positron emission tomography. Serum alpha-fetoprotein level was elevated. Postoperatively, microscopic examination revealed moderately differentiated adenocarcinoma confined to the mucosal layer without lymphovascular involvement. Immunohistochemical examination for alpha-fetoprotein revealed that the metastatic nodes were positive despite the primary tumor being negative. The patient died of exacerbation of myelodysplastic syndrome 5 years 8 months postoperatively with no recurrence. Our experience suggests the need for further studies to validate whether the indications for endoscopic resection can apply to alpha-fetoprotein-producing gastric cancer in the same manner as to conventional gastric cancer.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"57-61"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four cases of early stage poorly differentiated non-ampullary duodenal adenocarcinoma: a case report. 四例早期分化较差的非髓质十二指肠腺癌:病例报告。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-11-19 DOI: 10.1007/s12328-024-02058-y
Koyo Kido, Yohei Ikenoyama, Shoichi Yoshimizu, Manabu Takamatsu, Arisa Ueki, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yu Takahashi, Takuji Gotoda
{"title":"Four cases of early stage poorly differentiated non-ampullary duodenal adenocarcinoma: a case report.","authors":"Koyo Kido, Yohei Ikenoyama, Shoichi Yoshimizu, Manabu Takamatsu, Arisa Ueki, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yu Takahashi, Takuji Gotoda","doi":"10.1007/s12328-024-02058-y","DOIUrl":"10.1007/s12328-024-02058-y","url":null,"abstract":"<p><p>Early-stage, poorly differentiated, non-ampullary duodenal adenocarcinomas are rare, and their clinicopathological features remain unelucidated. Between September 2006 and April 2022, 205 consecutive patients underwent endoscopic or surgical resection for early-stage non-ampullary duodenal adenocarcinomas at our hospital. There were no cases of poorly differentiated adenocarcinoma among the 188 cases of mucosal carcinoma. Meanwhile, among the 17 cases of submucosal invasive carcinoma, four cases were poorly differentiated adenocarcinomas. Herein, we report four cases of these carcinomas. All four lesions were reddish in color and were located on the oral side of the papilla. The gross types were either protruded (0-I) or mixed, elevated, and depressed (0-IIa + IIc). During preoperative diagnosis, submucosal invasion was suspected in all lesions, and biopsies were performed. Based on histological analyses of biopsy specimens, a diagnosis of poorly differentiated or signet-ring cell components was made in all cases, and a pancreaticoduodenectomy was performed. The median tumor size was 6.5 (range, 5-12) mm, and all lesions were poorly differentiated adenocarcinomas with submucosal invasion and lymph node metastasis. Regarding the tumor immunophenotype, one and three cases exhibited gastric and mixed gastrointestinal phenotypes, respectively. Two patients experienced metastatic recurrence; one of them died from the primary disease.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"74-80"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autopsy diagnosis of diffuse intrahepatic cholangiocarcinoma. 尸检诊断为弥漫性肝内胆管癌。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-10-21 DOI: 10.1007/s12328-024-02052-4
Akihiro Maruyama, Takahiro Nishikawa, Asuka Nagura, Takuya Kurobe, Jun Yashika, Yuho Nimura, Leiwing Hu, Tomohiro Yamaguchi, Iori Kojima, Koji Nonogaki
{"title":"Autopsy diagnosis of diffuse intrahepatic cholangiocarcinoma.","authors":"Akihiro Maruyama, Takahiro Nishikawa, Asuka Nagura, Takuya Kurobe, Jun Yashika, Yuho Nimura, Leiwing Hu, Tomohiro Yamaguchi, Iori Kojima, Koji Nonogaki","doi":"10.1007/s12328-024-02052-4","DOIUrl":"10.1007/s12328-024-02052-4","url":null,"abstract":"<p><p>Intrahepatic cholangiocarcinoma (ICC), a severe liver cancer, makes up to 20% of all hepatic malignancies and is difficult to diagnose early due to its often asymptomatic nature. This case report documents a rare presentation of ICC with multiple diffuse nodules not previously recorded in medical literature. A 65-year-old man with no significant medical history presented with back pain, anorexia, and significant weight loss. Elevated tumor markers and enlarged lymph nodes were observed, though imaging did not reveal a primary liver mass. Diagnostic efforts, including computed tomography and positron emission tomography scans and biopsies of lymph nodes and bone marrow, suggested adenocarcinoma of unknown primary origin. A definitive diagnosis was only made post-mortem, revealing multiple diffuse nodules in the liver identified as ICC, marking a rare presentation without a primary mass. This case highlights the diagnostic challenges posed by atypical ICC manifestations, where typical imaging does not indicate a primary mass, delaying diagnosis and treatment. The findings emphasize the importance of considering ICC in differential diagnoses in cases of unknown primary adenocarcinoma with liver involvement. The discovery of ICC with diffusely infiltrative nodules underscores the necessity for comprehensive diagnostic evaluations in patients presenting with nonspecific systemic symptoms and abnormal liver findings.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"154-160"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive and ataxic adverse events following entrectinib treatment in NTRK1 fusion gene-positive intrahepatic cholangiocarcinoma: a case report. 恩替尼治疗NTRK1融合基因阳性肝内胆管癌后认知和心性失调不良事件:1例报告
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-12-07 DOI: 10.1007/s12328-024-02076-w
Kazuya Koyama, Hidetaka Iwamoto, Kenji Takahashi, Tetsuhiro Okada, Hidemasa Kawabata, Yohei Kitano, Hiroki Tanabe, Mikihiro Fujiya, Toshikatsu Okumura, Yusuke Mizukami
{"title":"Cognitive and ataxic adverse events following entrectinib treatment in NTRK1 fusion gene-positive intrahepatic cholangiocarcinoma: a case report.","authors":"Kazuya Koyama, Hidetaka Iwamoto, Kenji Takahashi, Tetsuhiro Okada, Hidemasa Kawabata, Yohei Kitano, Hiroki Tanabe, Mikihiro Fujiya, Toshikatsu Okumura, Yusuke Mizukami","doi":"10.1007/s12328-024-02076-w","DOIUrl":"10.1007/s12328-024-02076-w","url":null,"abstract":"<p><p>We report the rare case of severe cognitive disorder and ataxia caused by entrectinib in a patient with NTRK1 fusion gene-positive intrahepatic cholangiocarcinoma. The case was a 56-year-old woman after nine courses of GCS therapy. The patient experienced grade 1 muscle weakness on day 4 and grade 3, cognitive disorder on day 7 after receiving entrectinib, which led to hospitalization. The symptoms were reversible and tended to improve after withdrawal of entrectinib. It is crucial to increase awareness of TRKi-specific adverse events and their proper management.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"183-187"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of situs inversus totalis with hemosuccus pancreaticus due to intrapancreatic pseudocyst perforation of the common hepatic artery treated with a vascular stent graft. 一例因胰腺内假性囊肿导致肝总动脉穿孔而引起的全瘫伴胰腺血肿,采用血管支架移植治疗。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-10-08 DOI: 10.1007/s12328-024-02046-2
Ko Tomishima, Hironao Okubo, Daiki Abe, Shunsuke Nakamura, Takumi Okuaki, Tomonori Yamauchi, Koichi Ito, Yuka Fukuo, Takahiro Yamamoto, Hiroyuki Isayama
{"title":"A case of situs inversus totalis with hemosuccus pancreaticus due to intrapancreatic pseudocyst perforation of the common hepatic artery treated with a vascular stent graft.","authors":"Ko Tomishima, Hironao Okubo, Daiki Abe, Shunsuke Nakamura, Takumi Okuaki, Tomonori Yamauchi, Koichi Ito, Yuka Fukuo, Takahiro Yamamoto, Hiroyuki Isayama","doi":"10.1007/s12328-024-02046-2","DOIUrl":"10.1007/s12328-024-02046-2","url":null,"abstract":"<p><p>Hemosuccus pancreaticus (HP) is characterized by gastrointestinal bleeding from the papilla of Vater via the pancreatic duct. In this report, we describe a case of HP due to arterial perforation in a pancreatic pseudocyst and discuss the computed tomography (CT) findings and efficacy of stent graft placement. A 64-year-old man with a history of heavy alcohol use, situs inversus totalis, and total gastrectomy was hospitalized with hematochezia. Enhanced CT revealed a pseudoaneurysm in the common hepatic artery (CHA) with mildly high density in the main pancreatic duct. Subsequent CT revealed an enlarged cystic lesion with inflow of contrast medium. Angiography confirmed blood flow from the CHA into the pancreatic pseudocyst, and the patient was diagnosed with HP due to intrapancreatic pseudocyst perforation of the CHA pseudoaneurysm. Coil packing into the pseudocyst failed to block the blood flow, and a covered stent graft was placed into the CHA. The patient had an uneventful clinical course. The identification of a pseudoaneurysm and a high-density area in the main pancreatic duct on enhanced CT and changes in the pancreatic cyst diameter may indicate the acute phase of HP, and stent grafting is an effective treatment for intracystic arterial perforation.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"214-219"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of MSI-high pancreatic body-tail cancer successfully treated with radical resection after pembrolizumab. 一例 MSI 高的胰腺体尾癌患者在使用 Pembrolizumab 后成功接受了根治性切除术。
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-10-14 DOI: 10.1007/s12328-024-02043-5
Miki Ito, Toru Watanabe, Yoko Oga, Shigeki Matsumoto, Nana Kimura, Masakazu Nagamori, Haruyoshi Tanaka, Kazuto Shibuya, Isaku Yoshioka, Tsutomu Fujii
{"title":"A case of MSI-high pancreatic body-tail cancer successfully treated with radical resection after pembrolizumab.","authors":"Miki Ito, Toru Watanabe, Yoko Oga, Shigeki Matsumoto, Nana Kimura, Masakazu Nagamori, Haruyoshi Tanaka, Kazuto Shibuya, Isaku Yoshioka, Tsutomu Fujii","doi":"10.1007/s12328-024-02043-5","DOIUrl":"10.1007/s12328-024-02043-5","url":null,"abstract":"<p><p>A 72-year-old woman was diagnosed with unresectable pancreatic body-tail cancer (cT4N1M1, cStage IV) with para-aortic lymph node metastasis. She underwent six courses of gemcitabine + nab-paclitaxel as first-line chemotherapy, 12 courses of oxaliplatin + irinotecan + levofolinate + fluorouracil as second-line chemotherapy, and five courses of albumin-suspended irinotecan + levofolinate + fluorouracil as third-line chemotherapy. After each chemotherapy regimen, the disease was determined to be progressive. Analyses of endoscopic ultrasound-fine needle aspiration specimens and peripheral blood samples revealed microsatellite-instability (MSI)-high pancreatic cancer. The patient underwent 19 courses of pembrolizumab and achieved a partial response. She then underwent conversion surgery, including distal pancreatectomy, lymph node dissection, local gastrectomy and partial mesenteric resection of transverse colon. She is currently alive without recurrence at 18 months postoperatively. It is extremely rare for patients with unresectable and MSI-high pancreatic cancer to successfully undergo conversion surgery after pembrolizumab treatment.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"208-213"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Achievement of duodenal ulcer remission by vedolizumab in children with eosinophilic gastroenteritis. vedolizumab治疗嗜酸性胃肠炎儿童十二指肠溃疡缓解的疗效
IF 0.8
Clinical Journal of Gastroenterology Pub Date : 2025-01-20 DOI: 10.1007/s12328-025-02096-0
Riki Taniguchi, Ryusuke Nambu, Kayoko Ichimura, Masashi Yoshida, Tomoko Hara, Itaru Iwama
{"title":"Achievement of duodenal ulcer remission by vedolizumab in children with eosinophilic gastroenteritis.","authors":"Riki Taniguchi, Ryusuke Nambu, Kayoko Ichimura, Masashi Yoshida, Tomoko Hara, Itaru Iwama","doi":"10.1007/s12328-025-02096-0","DOIUrl":"https://doi.org/10.1007/s12328-025-02096-0","url":null,"abstract":"<p><p>Eosinophilic gastrointestinal disorders (EGIDs) are treated with corticosteroids and food allergen elimination. However, treatment for refractory cases is not standardized. We demonstrate the efficacy of vedolizumab, an anti-α4β7 integrin agent, in 2 children with duodenal ulcers developed by non-eosinophilic esophagitis EGIDs. In both, vedolizumab was used continuously without side effects, and long-term remission has been durable. Duodenal ulcers associated with EGIDs are increasing. Vedolizumab has potential as a treatment for even upper gastrointestinal lesions in refractory EGIDs.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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