Clinical Journal of Gastroenterology最新文献_第10页

Spontaneous reactivation of hepatitis B virus with multiple novel mutations in an elderly patient with resolved hepatitis B virus infection. 一名乙型肝炎病毒感染已治愈的老年患者自发重新激活乙型肝炎病毒，并出现多种新型变异。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-08-01 Epub Date: 2024-05-15 DOI: 10.1007/s12328-024-01984-1

Tokio Sasaki, Keisuke Kakisaka, Akio Miyasaka, Masao Nishiya, Naoki Yanagawa, Hidekatsu Kuroda, Takayuki Matsumoto, Masaharu Takahashi, Hiroaki Okamoto

{"title":"Spontaneous reactivation of hepatitis B virus with multiple novel mutations in an elderly patient with resolved hepatitis B virus infection.","authors":"Tokio Sasaki, Keisuke Kakisaka, Akio Miyasaka, Masao Nishiya, Naoki Yanagawa, Hidekatsu Kuroda, Takayuki Matsumoto, Masaharu Takahashi, Hiroaki Okamoto","doi":"10.1007/s12328-024-01984-1","DOIUrl":"10.1007/s12328-024-01984-1","url":null,"abstract":"Spontaneous reactivation of the Hepatitis B virus (HBV) is rare in individuals with previously resolved infections. This report presents the case of a 71 year-old Japanese woman who experienced HBV reactivation without any prior immunosuppressive therapy or chemotherapy. Before the onset of liver injury, the patient was negative for hepatitis B surface antigen (HBsAg) but positive for hepatitis B surface antibody. She subsequently developed liver injury, with the reappearance of HBsAg and HBV DNA. The patient was successfully treated with tenofovir alafenamide, and prednisolone. Full-genome sequencing of HBV revealed subgenotype B1 without hepatitis B e-negative mutations in the precore and core promoter regions and 12 amino acid alterations in the pre-S1/S, P, and X genes. Notably, the S gene mutations D144A and K160N, which alter the antigenicity of HBsAg and potentially contribute to its reactivation, were identified. This case emphasizes the importance of vigilance for spontaneous reactivation of resolved HBV, highlighting the need for comprehensive genomic analysis to understand the associated virological intricacies.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colonic intussusception after endoscopic mucosal resection successfully managed by endoscopic procedure. 内镜粘膜切除术后的结肠肠套叠通过内镜手术成功治愈。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-03-20 DOI: 10.1007/s12328-024-01953-8

Keiichi Hashiguchi, Shoichiro Mine, Junya Shiota, Taro Akashi, Maiko Tabuchi, Moto Kitayama, Kayoko Matsushima, Yuko Akazawa, Naoyuki Yamaguchi, Kazuhiko Nakao

引用次数: 0

Endoscopic ultrasound-guided fine needle biopsy diagnosis of circumferentially extraluminal mucosa-associated lymphoid tissue lymphoma in the transverse colon: a case report. 内镜超声引导下细针活检诊断出横结肠周向腔外黏膜相关淋巴组织淋巴瘤：病例报告。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-04-12 DOI: 10.1007/s12328-024-01945-8

Tomoyuki Niwa, Moeka Watahiki, Toshikatsu Kosugi, Daisuke Kusama, Hiroki Tamakoshi, Masaki Takinami, Junichi Kaneko, Yurimi Takahashi, Masafumi Nishino, Takanori Yamada

{"title":"Endoscopic ultrasound-guided fine needle biopsy diagnosis of circumferentially extraluminal mucosa-associated lymphoid tissue lymphoma in the transverse colon: a case report.","authors":"Tomoyuki Niwa, Moeka Watahiki, Toshikatsu Kosugi, Daisuke Kusama, Hiroki Tamakoshi, Masaki Takinami, Junichi Kaneko, Yurimi Takahashi, Masafumi Nishino, Takanori Yamada","doi":"10.1007/s12328-024-01945-8","DOIUrl":"10.1007/s12328-024-01945-8","url":null,"abstract":"A 61-year-old man present to us with continued abdominal pain without abdominal tenderness for 1 month. Blood testing showed elevated biliary enzymes and inflammation. Contrast-enhanced computed tomography (CT) revealed thickening of the transverse colon with relatively strong enhancement but no bile duct dilatation. Colonoscopy revealed localized edema and granular mucosa in the transverse colon. Fluoroscopic endoscopy exhibited the absence of haustra. Multiple biopsies were performed, but differentiation between mild inflammation and mucosa-associated lymphoid tissue (MALT) lymphoma was inconclusive. To establish a definitive diagnosis, transgastric endoscopic ultrasound-guided fine needle biopsy of the hypoechoic mass was performed. Histopathological analysis exhibited the proliferation of small-sized lymphocytes. Fluorescence in situ hybridization revealed the characteristic API2-MALT1 translocation of MALT lymphoma. We performed liver biopsy to investigate biliary enzyme elevation. Histopathology confirmed lymphocytic infiltration within Glisson's capsule. Immunohistochemistry showed positive for CD20 and negative for CD3 and CD5, signifying the infiltration of MALT lymphoma in the liver. Based on these findings, we diagnosed MALT lymphoma, Lugano classification Stage IV. We performed bendamustine-rituximab (BR)-combined therapy. After six courses of BR-combined therapy, colonoscopy revealed improvement in the lead pipe sign and CT revealed disappearance of the mass.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-embolization syndrome-like symptoms due to shedding of necrotic material of hepatocellular carcinoma into the bile duct following transcatheter arterial chemoembolization: an instructive case. 经导管动脉化疗栓塞术后肝细胞癌坏死物质脱落至胆管引起的栓塞后综合征样症状：一个有启发意义的病例。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-03-02 DOI: 10.1007/s12328-024-01932-z

Ikuhiro Kobori, Rion Masaoka, Hiroki Maeda, Fuki Hayakawa, Yumi Kusano, Hitoshi Kino, Akiko Fujii, Koichi Soga, Yasumi Katayama, Masaya Tamano

引用次数: 0

Hereditary hemorrhagic telangiectasia with hepatic arteriovenous shunt diagnosed due to liver damage. 遗传性出血性毛细血管扩张症伴有肝动静脉分流，因肝脏受损而确诊。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-03-04 DOI: 10.1007/s12328-024-01923-0

Satoru Hagiwara, Toru Takase, Itsuki Oda, Yoriaki Komeda, Naoshi Nishida, Akihiro Yoshida, Tomoki Yamamoto, Takuya Matsubara, Masatoshi Kudo

引用次数: 0

Diffuse abdominal lymphangiomatosis without tumoral masses: a case report. 腹部弥漫性淋巴管瘤病，无肿瘤肿块：病例报告。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-03-09 DOI: 10.1007/s12328-024-01941-y

Dina Belhasan, Fahd Ghalim

引用次数: 0

A case of progressive xanthogranulomatous pancreatitis with splenic abscess. 一例伴有脾脓肿的进行性黄疽性胰腺炎。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-03-08 DOI: 10.1007/s12328-024-01930-1

Keiji Nagata, Kojiro Nakamura, Taku Iida, Junji Iwasaki, Ryo Ito, Satsuki Asai, Misa Ishihara, Toshiyuki Hata, Atsushi Itami, Takahisa Kyogoku

{"title":"A case of progressive xanthogranulomatous pancreatitis with splenic abscess.","authors":"Keiji Nagata, Kojiro Nakamura, Taku Iida, Junji Iwasaki, Ryo Ito, Satsuki Asai, Misa Ishihara, Toshiyuki Hata, Atsushi Itami, Takahisa Kyogoku","doi":"10.1007/s12328-024-01930-1","DOIUrl":"10.1007/s12328-024-01930-1","url":null,"abstract":"Xanthogranulomatous inflammation is a chronic inflammatory reaction microscopically characterized by aggregation of foamy histiocytes, fibrous tissue, and infiltration of various inflammatory cells. In contrast to xanthogranulomatous inflammation in the gallbladder or kidney, xanthogranulomatous pancreatitis is rare. We herein present a case of xanthogranulomatous pancreatitis in a patient who underwent distal pancreatectomy with splenectomy under preoperative suspicion of a pancreatic pseudocyst or pancreatic tumor. A 77-year-old woman with a 1 month history of epigastric pain, anorexia, and general fatigue was admitted to our hospital. Contrast-enhanced computed tomography revealed a cystic mass with ill-defined margins at the pancreatic tail together with a splenic abscess. Contrast-enhanced endoscopic ultrasound detected a hyperechoic cystic lesion at the tail of the pancreas with heterogeneous internal echogenicity, and part of the intra-cystic content was enhanced by the contrast agent. Endoscopic retrograde cholangiopancreatography showed a cystic lesion at the tail of the pancreas that continued into the main pancreatic duct, and the main pancreatic duct was slightly narrowed downstream of the cystic lesion. Pancreatic juice cytology revealed suspicious cells, leading to the possibility of intraductal papillary mucinous carcinoma. Distal pancreatectomy with splenectomy was performed, and the histopathological diagnosis was xanthogranulomatous pancreatitis with no malignant findings.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the complexities of megacystis-microcolon-intestinal hypoperistalsis syndrome: insights from genetic studies. 探索巨囊-微结肠-肠道蠕动减弱综合征的复杂性：基因研究的启示。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-03-09 DOI: 10.1007/s12328-024-01934-x

Prasad K V Devavarapu, Kalyan Ram Uppaluri, Vrushabh Anil Nikhade, Kalyani Palasamudram, Kavutharapu Sri Manjari

{"title":"Exploring the complexities of megacystis-microcolon-intestinal hypoperistalsis syndrome: insights from genetic studies.","authors":"Prasad K V Devavarapu, Kalyan Ram Uppaluri, Vrushabh Anil Nikhade, Kalyani Palasamudram, Kavutharapu Sri Manjari","doi":"10.1007/s12328-024-01934-x","DOIUrl":"10.1007/s12328-024-01934-x","url":null,"abstract":"Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is an uncommon genetic disorder inherited in an autosomal recessive pattern that affects the muscles that line the bladder and intestines. The most common genes associated with MMIHS mutations are ACTG2, LMOD1, MYH11, MYL9, MYLK, and PDCL3. However, the complete genetic landscape of MMIHS still needs to be fully understood. The diagnosis of MMIHS can be challenging. However, advances in prenatal and diagnostic techniques, such as ultrasound and fetal urine analysis, have improved the ability to detect the syndrome early. Targeted next-generation sequencing (NGS) and other diagnostic tests can also diagnose MMIHS. The management of MMIHS involves addressing severe intestinal dysmotility, which often necessitates total parenteral nutrition (TPN), which can lead to complications such as hepatotoxicity and nutritional deficiencies. Multivisceral and intestinal transplantation has emerged as therapeutic options, offering the potential for improved outcomes and enteral autonomy. Understanding the genetic underpinnings of MMIHS is crucial for personalized care. While the prognosis varies, timely interventions and careful monitoring enhance patient outcomes. Genetic studies have given us valuable insights into the molecular mechanisms of MMIHS. These studies have identified mutations in genes involved in the development and function of smooth muscle cells. They have also shown that MMIHS is associated with defects in the signaling pathways that control muscle contraction. Continued research in the genetics of MMIHS holds promise for unraveling the complexities of MMIHS and improving the lives of affected individuals.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140068244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of disseminated peritoneal metastases after 2-year conservative treatment for intramucosal colon carcinoma due to a perforation during endoscopic submucosal dissection. 一例因内镜黏膜下剥离术中穿孔导致的黏膜内结肠癌保守治疗 2 年后腹膜转移扩散病例。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-02-18 DOI: 10.1007/s12328-024-01925-y

Yoshikazu Nakatsugawa, Yusuke Okuyama, Akifumi Fukui, Makoto Tanaka, Yutaka Inada, Takeshi Nishimura, Hideki Fujii, Naoya Tomatsuri, Hideki Sato, Yoji Urata

{"title":"A case of disseminated peritoneal metastases after 2-year conservative treatment for intramucosal colon carcinoma due to a perforation during endoscopic submucosal dissection.","authors":"Yoshikazu Nakatsugawa, Yusuke Okuyama, Akifumi Fukui, Makoto Tanaka, Yutaka Inada, Takeshi Nishimura, Hideki Fujii, Naoya Tomatsuri, Hideki Sato, Yoji Urata","doi":"10.1007/s12328-024-01925-y","DOIUrl":"10.1007/s12328-024-01925-y","url":null,"abstract":"A 70-year-old man was admitted to our hospital for the treatment of a large granular-type laterally spreading tumor in the splenic flexure of the descending colon. The preoperative diagnosis was intramucosal colon carcinoma and endoscopic submucosal dissection was performed. During treatment, a small perforation occurred accidentally. After conservative treatment with endoscopic suturing, the patient was discharged without additional surgery. The pathological diagnosis was an intramucosal carcinoma. One year after treatment, no local recurrence was observed on endoscopy, and abdominal computed tomography showed no obvious metastasis. Two years later, fluorodeoxyglucose-positron emission tomography/computed tomography, laparoscopic findings, and histopathologic findings by experimental excision of omentum revealed several disseminated peritoneal metastases from previously treated colon carcinoma. To the best of our knowledge, this is the first report of peritoneal dissemination after a small perforation during endoscopic submucosal dissection and conservative therapy for early-stage colon carcinoma. This report suggests the possibility of tumor dissemination in patients with small perforations during endoscopic procedures. Endoscopists should be aware of these rare potential risks and perform later surveillance carefully.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139897904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Granulomatous hepatitis with Crohn's disease: a case report. 肉芽肿性肝炎合并克罗恩病：病例报告。

IF 0.8

Clinical Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-03-19 DOI: 10.1007/s12328-024-01937-8

Tatsuya Suzuki, Yuka Hayakawa, Shun Kaneko, Kento Takenaka, Keiya Watakabe, Yuko Kinowaki, Akira Takemoto, Kazuo Ohtsuka, Yasuhiro Asahina, Ryuichi Okamoto

引用次数: 0