Clinical Journal of Gastroenterology最新文献_第9页

Sustained clinical and histopathological remission in a patient with eosinophilic esophagitis and type-2 comorbidities at 18 months after discontinuation of dupilumab. 一名患有嗜酸性粒细胞食管炎和 2 型合并症的患者在停用杜必鲁单抗 18 个月后，临床和组织病理学症状持续缓解。

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Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI: 10.1007/s12328-024-02011-z

Víctor González-Uribe, Carlos Patricio Acosta Rodríguez-Bueno, Zaira Selene Mojica-González, Andrea Malagón-Liceaga, Martín Roberto Basile-Alvarez

{"title":"Sustained clinical and histopathological remission in a patient with eosinophilic esophagitis and type-2 comorbidities at 18 months after discontinuation of dupilumab.","authors":"Víctor González-Uribe, Carlos Patricio Acosta Rodríguez-Bueno, Zaira Selene Mojica-González, Andrea Malagón-Liceaga, Martín Roberto Basile-Alvarez","doi":"10.1007/s12328-024-02011-z","DOIUrl":"10.1007/s12328-024-02011-z","url":null,"abstract":"Eosinophilic esophagitis (EoE) is a chronic, allergen-mediated, type-2 inflammatory disease with the potential to significantly impact an individual's quality of life. Conventional treatments often result in varied responses, prompting the need for novel therapeutic approaches. We present the case of a 19-year-old male with a medical history marked by eosinophilic esophagitis, severe atopic dermatitis (AD), asthma, and allergic rhinitis. Despite undergoing diverse topical and systemic interventions to address his AD and EoE, the patient's symptoms persisted. However, following the initiation of dupilumab therapy-a dual IL-4 and IL-13 receptor antagonist-the patient experienced a substantial reduction in his Eczema Area and Severity Index score. Notably, a marked improvement was also seen regarding his symptoms of eosinophilic esophagitis. A subsequent esophageal biopsy revealed a significant decrease in eosinophilic inflammation, consistent with established clinical and histologic remission criteria. These findings corroborate the patient's reported relief from symptoms. This case underscores the potential efficacy of dupilumab as a promising therapeutic agent in managing eosinophilic esophagitis. Dupilumab offers a dual benefit of alleviating symptoms and achieving histologic and clinical remission. This novel approach presents a noteworthy advancement in the treatment of EoE.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"803-808"},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Spontaneous reactivation of hepatitis B virus with multiple novel mutations in an elderly patient with resolved hepatitis B virus infection. 更正：一名乙型肝炎病毒感染已治愈的老年患者自发重新激活乙型肝炎病毒，并出现多种新型变异。

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Clinical Journal of Gastroenterology Pub Date : 2024-10-01 DOI: 10.1007/s12328-024-01997-w

Tokio Sasaki, Keisuke Kakisaka, Akio Miyasaka, Masao Nishiya, Naoki Yanagawa, Hidekatsu Kuroda, Takayuki Matsumoto, Masaharu Takahashi, Hiroaki Okamoto

引用次数: 0

Implantation cyst appearing more than 30 years after gastrectomy. 胃切除术后 30 多年出现的植入性囊肿。

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Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-07-16 DOI: 10.1007/s12328-024-02007-9

Taisei Iwasa, Seiji Adachi, Kana Matsuura, Masatoshi Mabuchi, Hironori Nakamura, Makoto Shimazaki, Shinji Nishiwaki, Takuji Iwashita, Haruhiko Kawase, Masahito Shimizu

引用次数: 0

Three consecutive cases of acute liver failure in young women due to acetaminophen overdose: insights into Japanese social issues and transplantation landscape. 对乙酰氨基酚过量导致年轻女性急性肝功能衰竭的三个连续病例：对日本社会问题和移植前景的启示。

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Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-07-26 DOI: 10.1007/s12328-024-02024-8

Kotaro Doi, Jun Inoue, Masashi Ninomiya, Akitoshi Sano, Mio Tsuruoka, Kosuke Sato, Masazumi Onuki, Satoko Sawahashi, Keishi Ouchi, Atsushi Masamune

{"title":"Three consecutive cases of acute liver failure in young women due to acetaminophen overdose: insights into Japanese social issues and transplantation landscape.","authors":"Kotaro Doi, Jun Inoue, Masashi Ninomiya, Akitoshi Sano, Mio Tsuruoka, Kosuke Sato, Masazumi Onuki, Satoko Sawahashi, Keishi Ouchi, Atsushi Masamune","doi":"10.1007/s12328-024-02024-8","DOIUrl":"10.1007/s12328-024-02024-8","url":null,"abstract":"Acetaminophen (APAP) is an over-the-counter (OTC) drug known worldwide for its safety and efficacy. However, in Japan, OTC drug overdose has become a prominent social problem in recent years due to stricter regulations for other drugs, especially among young people, and APAP is an increasing cause of acute liver injury due to overdose. This report describes three consecutive cases of acute liver failure in young women (22, 22 and 19 years old) due to APAP overdose in December 2023. Despite severe liver injury, indicated by high ALT levels and coagulopathy, these cases recovered without requiring liver transplantation. This report discusses three cases of acute liver failure in young Japanese women following APAP overdose, reflecting a national increase in such cases due to increased misuse of OTC drugs and societal factors. Key findings include the need for early treatment with N-acetylcysteine (NAC) and the importance of mental health assessment in the management of overdose patients. The cases underscore the need for prompt team-based care to prevent serious outcomes and highlight the complexity of liver transplantation decisions in Japan, highlighting the need for comprehensive strategies to address the escalating problem of APAP overdose.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"948-954"},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constitutional mismatch repair deficiency: a case on a commonly misinterpreted mutation in colon cancer. 体制性错配修复缺陷：结肠癌中常见的误读突变案例。

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Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-08-02 DOI: 10.1007/s12328-024-02015-9

King C, Edwards H, Thompson E, Abdelmasseh M, Cuaranta A, Pacioles A, Sanabria J

引用次数: 0

Case of severe alcoholic hepatitis following acute pancreatitis. 急性胰腺炎引发重症酒精性肝炎病例。

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Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-05-29 DOI: 10.1007/s12328-024-01988-x

Takeru Yokoyama, Takanobu Iwadare, Yuki Yamashita, Akari Momose, Hiroshi Ikeuchi, Shohei Kondo, Kenta Hashigami, Mai Iwaya, Takefumi Kimura, Takeji Umemura

引用次数: 0

Expanding the therapeutic armamentarium for advanced hepatocellular carcinoma: successful transarterial chemoembolization of peritoneal extrahepatic metastasis. 扩展晚期肝细胞癌的治疗手段：成功经腹膜肝外转移瘤的经动脉化疗栓塞术。

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Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-05-28 DOI: 10.1007/s12328-024-01990-3

Nicolò Brandi, Emanuela Giampalma, Matteo Renzulli

引用次数: 0

Ruptured pseudoaneurysm in a biliary metallic stent in a patient with pancreatic cancer: a case report. 胰腺癌患者胆道金属支架假性动脉瘤破裂：病例报告。

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Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-06-07 DOI: 10.1007/s12328-024-01991-2

Naohiro Sakamoto, Tsutomu Nishida, Yoshifumi Fujii, Dai Nakamatsu, Kengo Matsumoto, Masashi Yamamoto, Koji Fukui

{"title":"Ruptured pseudoaneurysm in a biliary metallic stent in a patient with pancreatic cancer: a case report.","authors":"Naohiro Sakamoto, Tsutomu Nishida, Yoshifumi Fujii, Dai Nakamatsu, Kengo Matsumoto, Masashi Yamamoto, Koji Fukui","doi":"10.1007/s12328-024-01991-2","DOIUrl":"10.1007/s12328-024-01991-2","url":null,"abstract":"We report a case of an 87 year-old woman who was admitted with jaundice, but had no pain or fever. Contrast-enhanced computed tomography revealed a tumor in the head of the pancreas, which caused distal malignant biliary obstruction. Initial transpupillary drainage by endoscopic retrograde cholangiopancreatography (ERCP) was difficult due to severe biliary stricture caused by the tumor, but cannulation of the pancreatic duct was successful. Pancreatic ductal adenocarcinoma was revealed through cytologic examination of pancreatic juice and the patient underwent percutaneous transhepatic biliary drainage (PTBD). 16 days after the jaundice was resolved, an uncovered Zilver® metallic stent was successfully deployed using a guidewire from the PTBD route, and the patient was discharged with palliative care due to advanced age. However, 54 days after discharge, the patient presented with black vomiting and recurrent jaundice. ERCP revealed an obstructed stent with black debris, and further evaluation revealed a ruptured pseudoaneurysm that branched off the gastroduodenal artery within the metallic biliary stent. Angiography revealed that embolization was successful. The patient recovered and was discharged without further episodes.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"955-961"},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141287858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of early-stage type 3 gastric neuroendocrine tumor in the upper body of the stomach: is endoscopic resection feasible? 一例位于胃上部的早期 3 型胃神经内分泌肿瘤：内镜切除可行吗？

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Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-06-12 DOI: 10.1007/s12328-024-01999-8

Yoichi Sakurai, Hirokazu Karaki, Yusuke Nakamura, Hiroyuki Fukuda, Tomohisa Okaya, Yoshio Oheda, Yuya Yokoyama, Futoshi Hirai, Michikazu Abe, Isamu Sugano

{"title":"A case of early-stage type 3 gastric neuroendocrine tumor in the upper body of the stomach: is endoscopic resection feasible?","authors":"Yoichi Sakurai, Hirokazu Karaki, Yusuke Nakamura, Hiroyuki Fukuda, Tomohisa Okaya, Yoshio Oheda, Yuya Yokoyama, Futoshi Hirai, Michikazu Abe, Isamu Sugano","doi":"10.1007/s12328-024-01999-8","DOIUrl":"10.1007/s12328-024-01999-8","url":null,"abstract":"Although gastric neuroendocrine tumors (NETs) are uncommon compared with gastric carcinomas, the incidence of NETs has been recently increasing. Gastric NETs are classified into three subgroups, and among these, gastrin-independent sporadic type 3 gastric NETs have a poor prognosis because of frequent lymph node or distant metastasis. We experienced a case of an early-stage type 3 gastric NET associated with lymphovascular and submucosal invasion. In a 54 year-old woman, esophagogastroduodenoscopy performed during a health screening identified an elevated lesion of the upper body of the stomach. The results of immunohistochemical analyses of endoscopic biopsy specimens obtained from the lesion were positive for chromogranin A and synaptophysin, indicating an NET. Because the patient's serum gastrin level was normal and she had no predisposing conditions for NET development, the tumor was diagnosed as a type 3 gastric NET. The patient underwent local resection of the tumor and regional lymph node dissection. The resected specimen indicated a diagnosis of type 3 gastric NET with invasion into the submucosa and lymphatic duct. This is an extremely rare case of an early-stage type 3 gastric NET. Our discussion provides insight into the pathogenesis and development of these tumors and the appropriate therapeutic strategy.","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":"814-819"},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful intrahepatic cholangiocarcinoma conversion surgery after administration of fibroblast growth factor receptor inhibitor. 使用成纤维细胞生长因子受体抑制剂后，肝内胆管癌转化手术获得成功。

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Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-07-10 DOI: 10.1007/s12328-024-02014-w

Junichi Kaneko, Ryota Kiuchi, Masaki Takinami, Ippei Ohnishi, Jun Ito, Osamu Jindo, Masafumi Nishino, Yurimi Takahashi, Takanori Yamada, Takanori Sakaguchi

引用次数: 0