Clinical nutrition ESPEN最新文献

{"title":"Intestinal transport of organic food compounds and drugs: A scoping review on the alterations observed in chronic kidney disease","authors":"Mara Lauriola ,&nbsp;Ward Zadora ,&nbsp;Ricard Farré ,&nbsp;Björn Meijers","doi":"10.1016/j.clnesp.2024.10.166","DOIUrl":"10.1016/j.clnesp.2024.10.166","url":null,"abstract":"<div><h3>Background and aims</h3><div>Around 850 million people worldwide are affected by chronic kidney disease (CKD). Patients with CKD often develop malnutrition and sarcopenia and changes in the pharmacokinetics of drugs. A reduced kidney function partially explains the prolonged half-life of certain drugs due to decreased renal clearance, which leads to an increased risk of adverse effects. While the intestine plays a fundamental role in this context, a systematic review of the effects of CKD on intestinal transport is lacking. We aimed to systematically summarize all the available evidence on intestinal transport of organic food components (carbohydrates/sugar, proteins/amino acids, fats, vitamins) and drugs (including drug transporters) in CKD.</div></div><div><h3>Methods</h3><div>We conducted a systematic search of all the articles published until the 1st of April 2024, on five databases i.e. Embase, PubMed, Web of Science Core Collection, Cochrane Library, and Scopus. This systematic review was registered on the Open Science Framework (OSF) (<span><span>osf.io/5e6wb</span><svg><path></path></svg></span>) and was carried out according to the PRISMA 2020 guidelines.</div></div><div><h3>Results</h3><div>From 9205 articles identified, 68 met the inclusion criteria. Absorption of organic food compounds seems to be altered, in general, and reduced for vitamins. The expression of intestinal efflux drug transporters may be altered in CKD.</div></div><div><h3>Conclusions</h3><div>Despite alterations in intestinal transport is suggested to be altered in CKD, the lack of recent studies, the paucity of human data and the heterogeneity of the methodologies used underscore the need for more research on the effect of CKD and uremia on intestinal transport.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"64 ","pages":"Pages 461-482"},"PeriodicalIF":2.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Request for clarification on the association between intradialytic eating practices and hemodialysis outcomes","authors":"Chuan-Lan Yang,&nbsp;Hung-Li Su,&nbsp;Yu-Jing Wu,&nbsp;Yu-Ting Hsieh,&nbsp;Huei-Chun Li,&nbsp;Yi-Ling Chen,&nbsp;Chih-Chung Shiao","doi":"10.1016/j.clnesp.2024.10.168","DOIUrl":"10.1016/j.clnesp.2024.10.168","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"64 ","pages":"Pages 447-448"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world experience with glucagon-like peptide 2 analogues in patients with short bowel syndrome and chronic intestinal failure: Results from an international survey in expert intestinal failure centers","authors":"Tim Vanuytsel ,&nbsp;Narisorn Lakananurak ,&nbsp;Sophie Greif ,&nbsp;Elizabeth Wall ,&nbsp;Hilary Catron ,&nbsp;Jean Herlitz ,&nbsp;Lisa Moccia ,&nbsp;Vanessa Kumpf ,&nbsp;David Mercer ,&nbsp;Mark Berner-Hansen ,&nbsp;Leah Gramlich","doi":"10.1016/j.clnesp.2024.10.161","DOIUrl":"10.1016/j.clnesp.2024.10.161","url":null,"abstract":"<div><h3>Background and aims</h3><div>Glucagon-like peptide 2 (GLP-2) analogues are the first available disease-modifying treatments for patients with intestinal failure (IF) due to short bowel syndrome (SBS). Efficacy in terms of reduction of parenteral support (PS) has been demonstrated in multiple studies and real-world reports. However, it remains unclear how many patients are eligible to receive the treatment, when treatment is started after intestinal resection, how treatment efficacy is assessed outside of clinical trials, and how the treatment is modified in case of non-response or adverse events. The aim of this study was to investigate the real-world management of patients treated with GLP-2 analogues in expert centers around the world.</div></div><div><h3>Methods</h3><div>A survey questionnaire was developed by a multidisciplinary working group consisting of 52 questions related to various aspects of multidisciplinary care of SBS-IF patients. The 17 questions related to the use of GLP-2 analogues in clinical practice were analyzed for this study. The online survey was sent to 33 participating centers in a phase 3 study of a long-acting GLP-2 analogue. Only responses from countries with access to commercially available GLP-2 analogues were included in the study. A descriptive analysis was performed for each question. Results are presented as median (interquartile range).</div></div><div><h3>Results</h3><div>The responses from the 19 expert IF centers with access to GLP-2 analogues indicated that 10 (10–20) % of patients with SBS-IF were treated with a GLP-2 analogue, which was less than the number of eligible patients (30 (25–40) %). In most centers (10 centers, 53 %), GLP-2 therapy was started 6–12 months after the last intestinal resection, with 5 centers (26 %) starting later (12–24 months). Multiple parameters were used in combination to determine the response to GLP-2 analogues of which the three most common were &gt;20 % decrease in PS (95 %), at least 1 day of PS reduction per week (84 %) and increased urinary output (68 %). In non-responders GLP-2 therapy was stopped within the first year by 67 % of the centers. Finally, strategies in case of significant adverse events include stopping the GLP-2 analogue (used by 79 % of experts), dose reduction (67 %) and temporary treatment interruption (62 %).</div></div><div><h3>Conclusion</h3><div>The results of this survey completed by expert IF centers show the real-life use of GLP-2 analogues in clinical practice. Key learning points identified include the accounting for a period of intestinal adaptation before starting GLP-2 analogues and not stopping the treatment too early in case of non-response. The best strategy in case of adverse effects should be studied further.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"64 ","pages":"Pages 496-502"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low handgrip strength as a marker of severity in the diagnostic criteria for cancer cachexia","authors":"Tatsuma Sakaguchi ,&nbsp;Keisuke Maeda ,&nbsp;Tomoko Takeuchi ,&nbsp;Yuria Ishida ,&nbsp;Ryoko Kato ,&nbsp;Junko Ueshima ,&nbsp;Akio Shimizu ,&nbsp;Ayano Nagano ,&nbsp;Koki Kawamura ,&nbsp;Koji Amano ,&nbsp;Naoharu Mori","doi":"10.1016/j.clnesp.2024.10.162","DOIUrl":"10.1016/j.clnesp.2024.10.162","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>The diagnostic criteria for cachexia, as proposed by the Asian Working Group for Cachexia (AWGC), include weight loss, a low body mass index, and additional factors such as a low handgrip strength (HGS), anorexia, or elevated CRP levels. This study aimed to evaluate the significance of low HGS as a diagnostic criterion in patients with advanced cancer.</div></div><div><h3>Methods</h3><div>This single-centre, retrospective cohort study was conducted between April 2019 and March 2023. Patients aged ≥18 years with malignant diseases were included. Patients without records on HGS were excluded. Low HGS was defined as a HGS &lt;28 kg for men and &lt;18 kg for women. The overall median survival time (MST) was analysed by univariate and multivariate analyses.</div></div><div><h3>Results</h3><div>A total of 894 patients were analysed. Cachexia was prevalent in 74 %, though only 3.4 % were diagnosed based solely on low HGS. The MST in patients with cachexia was 122 days, and in those with low HGS was 73 days. The associations between low HGS and high mortality remained significant after adjusting for AWGC criteria, modified weight loss grading system, age, gender, performance status, calf circumferenceand fluid retention. The MST varied with the number of additional factors being met: 422 days for one criterion, 92 days for two, and 55 days for all three (<em>p</em> &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>This study supports that HGS serve as important prognostic tool in patients with various cancers.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"64 ","pages":"Pages 435-440"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative nutritional status and serum insulin-like growth factor of children with cyanotic and acyanotic congenital heart disease","authors":"Maryam Aryafar ,&nbsp;Mohammad Mahdavi ,&nbsp;Hossein Shahzadi ,&nbsp;Haniyeh Golafrouz ,&nbsp;Fatemeh Gabeleh ,&nbsp;Javad Nasrollahzadeh","doi":"10.1016/j.clnesp.2024.10.163","DOIUrl":"10.1016/j.clnesp.2024.10.163","url":null,"abstract":"<div><h3>Background</h3><div>Malnutrition is common among children with congenital heart disease (CHD). We compared the anthropometric indices, serum insulin-like growth factor (IGF), and IGF acid-labile subunit (IGFALS) of children with cyanotic and acyanotic CHD before corrective surgery.</div></div><div><h3>Methods</h3><div>This 82-patient case–control study included 1- to 24-month-old CHD patients referred for corrective surgery. (41 with tetralogy of Fallot [TOF] and 41 with ventricular septal defect [VSD] or atrial septal defect [ASD]). Anthropometric indices represented as Z-scores were used to determine nutritional status. Serum IGF-1 and IGFALS levels were measured.</div></div><div><h3>Results</h3><div>The median [quartile] age of the acyanotic group was 8 [7,11] months which was lower than the cyanotic group (11 [8,14.5] months). The prevalence of underweight (weight for age Z [WAZ] &lt; −2), wasting (weight for length Z [WLZ] &lt; −2), and thinness (body mass index Z [BMIZ] &lt; −2) was significantly higher in children with acyanotic than cyanotic children with. WAZ, WLZ, and BMIZ were significantly lower in acyanotic children than cyanotic children with CHD (−2.5 ± 1.2 vs −1.0 ± 1.2, p &lt; 0.001 for WAZ, −2.5 ± 1.5 vs −0.8 ± 1.4, p &lt; 0.001 for WLZ, and −2.5 ± 1.5 vs −0.8 ± 1.4, p &lt; 0.001 for BMIZ), but length for age Z was not different between the two groups (−1.2 ± 1.0 vs −0.8 ± 1.1, p = 0.31). A comparison of preoperative serum albumin, IGF-1, and IGFALS showed no differences.</div></div><div><h3>Conclusions</h3><div>In CHD children without corrective surgery, moderate to severe underweight and wasting were more common in acyanotic CHD (VSD and ASD) than in cyanotic CHD (TOF), but the higher prevalence of malnutrition was not associated with lower IGF-1 and IGFALS levels.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"64 ","pages":"Pages 449-454"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional requirements in pregnancy and lactation","authors":"Saeedeh Talebi ,&nbsp;Hamid reza kianifar ,&nbsp;Atieh Mehdizadeh","doi":"10.1016/j.clnesp.2024.10.155","DOIUrl":"10.1016/j.clnesp.2024.10.155","url":null,"abstract":"<div><div>Optimal nutrition during pregnancy and lactation is vital for the health of the mother and fetus. Nutritional needs should begin in the preconception period, as the fetus depends on the placenta for essential nutrients required for growth and development. A balanced diet rich in nutrient-dense foods—such as whole grains, vegetables, fruits, dairy, legumes, fish, and lean meats—is essential to meet caloric needs during pregnancy. Assessment of maternal health, including dietary history and micronutrient status, is critical to identify potential risks and ensure adequate nutrition. The increased need for micronutrients must be met to prevent complications and fetal growth.</div><div>Exclusive breastfeeding is recommended for the first six months, and continued breastfeeding is recommended throughout the first year and beyond. During pregnancy and lactation, calorie intake should be increased by focusing on protein and healthy fats. The composition of breast milk is adapted during the breastfeeding period, so that it can provide the necessary nutrients for the growth of the infant. Personalized nutrition plans, developed in consultation with health care professionals, are critical to optimizing maternal and infant health outcomes. This manuscript supports the importance of comprehensive nutritional strategies during pregnancy and lactation to reduce risks and support healthy growth and development of mother and child.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"64 ","pages":"Pages 400-410"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between maternal vitamin D status during late pregnancy and acute lower respiratory tract infections and acute diarrheal disease during infancy – A cohort study","authors":"Amritha Vinod ,&nbsp;Vikneswari Karthiga ,&nbsp;Soma Venkatesh Chakraborty ,&nbsp;Soundararajan Palanisamy ,&nbsp;Setu Rathod","doi":"10.1016/j.clnesp.2024.10.157","DOIUrl":"10.1016/j.clnesp.2024.10.157","url":null,"abstract":"<div><h3>Background</h3><div>Acute lower respiratory tract infection (ALRI) and acute diarrheal disease (ADD) are the leading causes of mortality in children globally. There is emerging evidence of an association between maternal hypovitaminosis D and ALRI/ADD during infancy.</div></div><div><h3>Objective</h3><div>To determine whether maternal hypovitaminosis D (25(OH)D [&lt;20 ng/ml] during late pregnancy is associated with increased risk of ALRI/ADD in their offspring during infancy.</div></div><div><h3>Methods</h3><div>This South Indian hospital-based, ambispective cohort study included 140 mother-baby dyads with known maternal vitamin D status before delivery in late third trimester (72 mothers with hypovitaminosis D and 68 mothers with adequate vitamin D level). Babies with cord blood vitamin D deficiency were treated as per consensus guidelines and those with adequate levels were supplemented with 400 IU vitamin D daily for 1 year. All infants were followed up at 6,10,14 weeks and 6, 9, 12 months for the occurrence, frequency, and severity of ALRI (pneumonia, bronchiolitis, viral induced wheezing) and ADD.</div></div><div><h3>Results</h3><div>Overall incidence of ALRI was 0.23 per child year during infancy. Incidence of ALRI was 0.12 per child year in adequate maternal vitamin D group versus 0.32 per child year in maternal hypovitaminosis D group (p value = 0.024) and that of bronchiolitis/viral wheeze was 0.07 per child year in adequate maternal vitamin D group versus 0.21 per child year in maternal hypovitaminosis D group (p value = 0.047). Cox regression analysis with maternal hypovitaminosis D level as predictor variable, adjusted for gestational age at birth and other covariates, revealed a hazard ratio of 3.18 (95 % CI: 1.17–8.65, p = 0.023) and 3.63 (95 % CI 1.36–9.65, p = 0.010) for ALRI and ADD respectively. No increased risk for occurrence of pneumonia was observed and none had severe pneumonia.</div></div><div><h3>Conclusion</h3><div>Maternal hypovitaminosis D is associated with increased risk of ALRI and ADD in their babies during infancy. Routine screening of pregnant women at risk for hypovitaminosis D and supplementation based on 25(OH)D level may decrease the burden of ALRI, for which further studies are needed.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"64 ","pages":"Pages 411-417"},"PeriodicalIF":2.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle characteristics of lower limb in association with physical activity in candidates of total knee arthroplasty with knee osteoarthritis","authors":"Gakuto Kitamura ,&nbsp;Manabu Nankaku ,&nbsp;Takuma Yuri ,&nbsp;Takumi Kawano ,&nbsp;Shinichi Kuriyama ,&nbsp;Shinichiro Nakamura ,&nbsp;Kohei Nishitani ,&nbsp;Ryosuke Ikeguchi ,&nbsp;Shuichi Matsuda","doi":"10.1016/j.clnesp.2024.10.160","DOIUrl":"10.1016/j.clnesp.2024.10.160","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>This study aimed to clarify the association between physical activity (PA) and physical functions, including both muscle quantity and quality of ankle plantar flexor muscles in patients with knee osteoarthritis (OA).</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted with ninety-two patients with knee OA. PA, leg muscle cross-sectional area (CSA), knee strength, passive knee angle, and knee pain of the affected side were assessed. PA was assessed by the 2011 Knee Society scoring system. CSA of the quadriceps and ankle plantar flexor muscles on the affected side was measured using a computed tomography image. Based on muscle attenuation assessed with Hounsfield units (HU), the muscle quality of targeted muscle was divided into 4 groups as follows: fat tissue (−190 to −30 HU), very low-density muscle (−29 to −1 HU), low-density muscle (0 to 34 HU), and normal-density muscle (NDM, 35 to 100 HU). The CSA was obtained for each of the 4 groups. Univariate and multivariate linear regression analyses were performed to determine the factors associated with PA.</div></div><div><h3>Results</h3><div>The regression analysis revealed that higher PA was independently associated with the NDM CSA of ankle plantar flexor (β = 0.51), higher knee extension strength (β = 0.28), and milder knee pain (β = −0.29) after adjustment with age, sex, height, weight, and body mass index.</div></div><div><h3>Conclusion</h3><div>The present study suggested that NDM CSA of ankle plantar flexor in addition to knee function is one of the factors determining the PA in patients with knee OA.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"64 ","pages":"Pages 418-424"},"PeriodicalIF":2.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between phase angle and sarcopenia in patients with connective tissue diseases.","authors":"Toshiyuki Moriyama, Mizuki Tokunaga, Ryoko Hori, Akiko Hachisuka, Hideaki Itoh, Mitsuhiro Ochi, Yasuyuki Matsushima, Satoru Saeki","doi":"10.1016/j.clnesp.2024.10.159","DOIUrl":"10.1016/j.clnesp.2024.10.159","url":null,"abstract":"<p><strong>Background and aims: </strong>Early detection and management of sarcopenia in patients with connective tissue diseases (CTDs) are essential. However, the relationship between the phase angle and sarcopenia in patients with CTDs is unknown. This study investigated the association between the phase angle and sarcopenia in patients with (CTDs) and determined the optimal phase angle cutoff values for the early detection of sarcopenia.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted in 279 hospitalized patients with CTDs undergoing rehabilitation (median age 73.3 years; 80 men and 199 women). Bioimpedance analysis was used to measure the phase angle, and sarcopenia was assessed according to the Asian Working Group for Sarcopenia criteria.</p><p><strong>Results: </strong>Sarcopenia was identified in 134 patients (36 men and 98 women). Patients with sarcopenia had a significantly smaller phase angle than those without sarcopenia. Multivariate analysis revealed that phase angle was significantly associated with sarcopenia after adjusting for confounding factors in each sex. The optimal phase angle cutoff value for identifying sarcopenia was 4.6° for men and 4.3° for women, with area under the curve values of 0.795 and 0.754, respectively.</p><p><strong>Conclusion: </strong>Phase angle is a valuable marker for identifying sarcopenia in patients with CTDs. The established phase angle cutoff values of 4.6° in men and 4.3° in women can facilitate the early detection and management of sarcopenia.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"503-508"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in metabolic syndrome severity and prevalence across nine waist circumference measurements collected from smartphone digital anthropometrics","authors":"Austin J. Graybeal,&nbsp;Caleb F. Brandner,&nbsp;Abby T. Compton,&nbsp;Sydney H. Swafford,&nbsp;Ryan S. Aultman,&nbsp;Anabelle Vallecillo-Bustos,&nbsp;Jon Stavres","doi":"10.1016/j.clnesp.2024.10.158","DOIUrl":"10.1016/j.clnesp.2024.10.158","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Given the technological advances in 3D smartphone (SP) anthropometry, this technique presents a unique opportunity to improve metabolic syndrome (MetS) screening through optimal waist circumference (WC) landmarking procedures. Thus, the purpose of this study was to evaluate the associations between individual MetS risk factors and nine independent WC sites collected using tape measurement or SP anthropometrics and to determine the differences in MetS severity and prevalence when using these different WC measurement locations.</div></div><div><h3>Methods</h3><div>A total of 130 participants (F:74, M:56; age: 27.8 ± 11.1) completed this cross-sectional evaluation. Using traditional tape measurement, WC was measured at the lowest rib (WC_Rib), superior iliac crest (WC_Iliac), and between the WC_Rib and WC_Iliac (WC_Mid). Additionally, WC measurements were automated using a SP application at six sites along the torso. MetS risk factors were used to calculate MetS severity (MetS_index) and prevalence. Associations were evaluated using multiple linear regression, the effect of each WC site on MetS_index was analyzed using mixed-models ANCOVA, and differences in MetS prevalence using WC_Iliac as the current standard were determined using sensitivity, specificity, chi-squared tests, and odds ratios.</div></div><div><h3>Results</h3><div>The reference SP-WC (SP_Ref) and WC_Rib demonstrated the largest associations (all p &lt; 0.001) with HDL cholesterol (SP_Ref: −0.48; WC_Rib: −0.49), systolic (SP_Ref: 0.32; WC_Rib: 0.30) and diastolic blood pressure (SP_Ref: 0.34; WC_Rib: 0.32), and fasting blood glucose (SP_Ref: 0.38; WC_Rib: 0.37). SP_Ref and WC_Rib were the only WC without significantly different MetS_index; yet demonstrated lower MetS_index and sensitivity (SP_Ref: 77.8 %; WC_Rib: 74.1 %) relative to WC_Iliac, the conventional (or standard) WC measure.</div></div><div><h3>Conclusions</h3><div>Compared to the current standard, SP_Ref and WC_Rib protocols are more highly associated with individual MetS risk factors and produce different MetS_index and diagnoses; highlighting the need for new MetS WC protocols. Given the surge in remote/mobile healthcare, SP_Ref may be an alternative to traditional methods in this context but requires further investigation before implementation.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"64 ","pages":"Pages 390-399"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}