Clinical nutrition ESPEN最新文献

{"title":"Intensified dietetic care during and up to three months after hospital admission in older patients at risk of malnutrition, a randomised controlled trial.","authors":"Carliene van Dronkelaar, Hinke Kruizenga, Moritz Eggelbusch, Peter J M Weijs, Michael Tieland","doi":"10.1016/j.clnesp.2024.12.008","DOIUrl":"10.1016/j.clnesp.2024.12.008","url":null,"abstract":"<p><strong>Background: </strong>Inadequate protein intake is associated with poor physical functioning and suboptimal recovery in hospitalised older adults. Despite standard dietetic care, dietary protein intakes falls well below the recommended levels. To address this problem, we developed an intensified trans-sectorial dietetic intervention that targets hospitalised older adults. This study aims to evaluate its impact on physical functioning and dietary protein intake during and post hospitalisation.</p><p><strong>Methods: </strong>This multicentre individually randomised controlled trial was conducted in five hospitals from January 2021 until December 2022. Hospitalised older adults, aged ≥55 years and at risk of malnutrition were randomised to receive regular care (CON) or intensive dietetic intervention (INT). The intervention consisted of personalized, intensive care, including trans-sectorial guidance by trained dietitians, increased consultations, and supportive materials focused on protein intake. Additionally, the intervention emphasized engagement in dietary behaviour and physical activity during hospitalisation and continued for three months post-discharge. The primary outcome was change in physical functioning measured by the Short Physical Performance Battery (SPPB) from admission to three months post-discharge, analysed with linear mixed models for repeated measures. Secondary outcomes included protein intake, body composition, muscle strength, physical activity, activities of daily living, fear of falling, pain, fatigue, appetite and quality of life.</p><p><strong>Results: </strong>A total of 76 hospitalised older adults were included in the study of which 38 were in CON and 38 received INT. The overall drop-out was 30 % (CON 26 %; INT 34 %). The participants had a median age 73 y (Inter Quartile Range: 62-78 y) with 50 % females. Overall, Physical functioning improved from 6 points (IQR: 1-9 points) at baseline to 9 points (IQR: 7-11) at three months post-discharge (p < 0.0001). Likewise, protein intake increased from 0.8 g/kg bodyweight (IQR: 0.6-1.0) to 1.0 g/kg bodyweight (IQR: 0.8-1.2) (p < 0.0001). There were no significant differences between intervention and control group. All secondary outcomes improved over time, except for fear of falling, leg extension strength, and body composition, with no significant differences between intervention and control group.</p><p><strong>Conclusions: </strong>Hospitalised older patients improved their physical functioning and protein intake after three months post-discharge, although the majority not to recommended levels. No effects of the intensive dietetic treatment could be detected due to low intervention adherence and a small sample size. Future research should be conducted with an intervention consisting of a strong combination of nutritional support and exercise with a successful implementation and a flexible study design catered to the needs of the older patient.</p><p><strong>Tr","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"315-323"},"PeriodicalIF":2.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exclusion diet and fasting practices in patients with inflammatory bowel disease: Impact on nutritional status.","authors":"Didier Quilliot, Olivier Bonsack, Meliha Mahmutovic, Laurent Peyrin-Biroulet, Benedicte Caron","doi":"10.1016/j.clnesp.2024.12.010","DOIUrl":"10.1016/j.clnesp.2024.12.010","url":null,"abstract":"<p><strong>Background: </strong>Undernutrition is purportedly highly prevalent in inflammatory bowel diseases (IBD). While several risk factors have been identified, the impact of widespread eating behaviors such as food exclusions and therapeutic fasting practices has not been evaluated. There are limited data on the prevalence of undernutrition diagnosed according to internationally recognized criteria in this population.</p><p><strong>Objectives: </strong>To estimate the prevalence of undernutrition assessed with the Global Leadership Initiative on Undernutrition (GLIM) criteria and to analyze factors associated with the characteristics of the disease and factors related to undernutrition.</p><p><strong>Methods: </strong>Patients attending our IBD nutrition clinic were screened between November 2021 and April 2022. The complete avoidance of a food category was defined as total exclusion while avoidance most of the time was defined as partial exclusion. Undernutrition was diagnosed according to GLIM criteria. Weight history, past maximal involuntary weight loss and minimal body mass index since diagnosis of IBD were also collected.</p><p><strong>Results: </strong>A total of 434 patients with IBD were included. Undernutrition was observed in 25.8 % of the whole population at inclusion (15 % with moderate undernutrition and 10.8 % with severe undernutrition). Mean involuntary maximal weight loss since illness onset was -14.5 % ± 11.0. Previous undernutrition since IBD diagnosis was reported in 81.1 % of the population, 63.6 % for severe and 17.5 % for moderate undernutrition. In multivariate analysis, undernutrition at inclusion was independently associated with total exclusion of at least one food category (OR = 1.11 95 % CI, 1.01-1.22; p = 0.031) as well as active disease (OR = 1.16 95 % CI, 1.05-1.27; p = 0.002), and negatively with the duration of IBD (OR = 0.88 95 % CI, 0.78-0.99, p = 0.031). Exclusion diet was also the main variable significantly associated with episodes of undernutrition in the past (OR = 1.11 95 % CI, 1.01-1.22; p = 0.035) as well as previous surgery (OR = 1.11 95 % CI, 1.00-1.23; p = 0.048). In these analyses, fasting practices were not independently associated with a risk of undernutrition.</p><p><strong>Conclusion: </strong>Total exclusion of at least one food category was one of the main factors associated with undernutrition independently of disease activity and duration, both at the time of inclusion and in the past, and should be avoided, whereas fasting practices were not associated with a risk of undernutrition.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"375-381"},"PeriodicalIF":2.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High vs low protein intake in chronic critical illness: A systematic review and meta-analysis.","authors":"Sílvia Castro, A Tomé, C Granja, A Macedo, A Binnie","doi":"10.1016/j.clnesp.2024.12.003","DOIUrl":"10.1016/j.clnesp.2024.12.003","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background & aims: &lt;/strong&gt;Patients with persistent organ dysfunction after the first week of intensive care unit (ICU) admission are considered to have chronic critical illness (CCI). Acquired muscle weakness is a common feature of CCI that is accompanied by loss of muscle mass and electromyographic features of myopathy. Optimizing protein intake may help prevent acquired muscle weakness and/or promote muscle recovery, however, the optimal level of protein intake in CCI is uncertain and there is a lack of consensus in published nutritional guidelines. This systematic review focuses on the impact of high versus low protein intake as part of a nutritional strategy for patients with CCI.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The terms \"protein intake\" and \"critically ill\" were systematically searched in PUBMED, CENTRAL (Cochrane Central Register of Controlled Trials), and WEB OF SCIENCE on 06/01/2023. We included studies that (1) enrolled critically ill adults (aged 18 years or over) who were in the ICU for more than 7 days and that compared (2) protein intake above and below 1.3 gr/kg administered by any route (enteral and/or parenteral), (3) had an intervention period that occurred primarily after the first 7 days of critical illness and (4) reported clinical outcomes including length of ICU and hospital stay, duration of invasive mechanical ventilation (IMV), mortality, ICU acquired infections, muscle mass and physical function. Studies pertaining to elective surgery, those with intervention periods shorter than 7 days or occurring primarily within the first 7 days of critical illness, those measuring only laboratory parameters as outcomes, and safety and feasibility studies were excluded.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Four studies were included (N = 1730) in the meta-analysis and systematic review. Higher (&gt;1.3 g/kg/d) versus lower protein intake was associated with a decrease in early mortality (defined as ICU or 28-day mortality) hazard ratio (HR) 0.42 (95 % confidence interval (CI): 0.26-0.70, P &lt; 0.001), but had no impact on late mortality (defined as the latest mortality timepoint in each study): HR 0.93 (95 % CI 0.76-1.15, P = 0.51). There was no significant difference between intervention and control groups with respect to duration of IMV, duration of ICU or hospital stay, muscle mass, or the incidence of ICU-acquired infections. One study reported improvements in physical function at 3 and 6 months in the intervention group.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;After the first week of critical illness, increasing protein intake to &gt;1.3 g/kg/d may improve early mortality but not late mortality or other clinical outcomes. The small number of relevant studies and the heterogeneity of outcomes assessed, weaken these conclusions. Further studies are warranted to discern whether higher protein intake is beneficial in chronic critical illness. PROSPERO registration number: CRD42023403554; PROSPERO registration name: \"The effect of higher","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"249-255"},"PeriodicalIF":2.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ultra-processed food consumption during pregnancy on maternal and child health outcomes: A comprehensive narrative review of the past five years.","authors":"Maria Morales-Suarez-Varela, Oscar Andrés Rocha-Velasco","doi":"10.1016/j.clnesp.2024.12.006","DOIUrl":"10.1016/j.clnesp.2024.12.006","url":null,"abstract":"<p><strong>Background & aims: </strong>Ultra-processed foods (UPF) are increasingly prevalent in modern diets and are associated with negative health outcomes such as chronic diseases due to their high processing and low nutrient density. Despite the potential impact of UPF intake during pregnancy on maternal and child health, studies in this area are limited. Therefore, this narrative comprehensive review aimed to identify associations between UPF consumption, categorized by the NOVA system, during pregnancy and maternal and child health outcomes over the past five years (2019-2024).</p><p><strong>Methods: </strong>Following PRISMA-ScR criteria (2018), MedLine/PubMed, Scopus, and Embase databases were searched for articles on maternal and child health outcomes associated with UPF consumption categorized by the NOVA system during pregnancy, out of 767 studies identified, 22 were eligible.</p><p><strong>Results: </strong>Overall, high UPF consumption during pregnancy was positively associated with various adverse maternal-child outcomes, including gestational diabetes mellitus, gestational weight gain, poor glycemic control, negative nutrition biomarkers, inflammatory markers, and hypertensive disorders during pregnancy. It also negatively impacted child growth and development, and was associated with adiposity gain, potential adverse mental disorders, indicators of poor nutrition, and poor overall diet quality.</p><p><strong>Conclusions: </strong>Despite the limited data, high consumption of UPF during pregnancy adversely affected the health outcomes of both mothers and children, impacting nutrition indicators and diet quality. Further studies on this topic are needed. Promoting healthy eating habits among pregnant women is crucial for achieving optimal health outcomes.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"288-304"},"PeriodicalIF":2.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjusting total daily energy intake is crucial for evaluating the impact of macronutrient ratios on mortality risk.","authors":"Huei-Fang Wang, Yu-Hsuan Han, Pei-Fang Yin, Gulele Dulivuwan, Yuan-Tung Chang, Chih-Chung Shiao","doi":"10.1016/j.clnesp.2024.12.007","DOIUrl":"10.1016/j.clnesp.2024.12.007","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"256-257"},"PeriodicalIF":2.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between muscle mass, visceral adiposity, and histologic tumor stromal features in colon cancer.","authors":"Cor Ravensbergen, Robert van Kooten, Stijn Crobach, Hein Putter, Willem Grootjans, Ana Navas Cañete, Koen Peeters, Rob Tollenaar, Wilma Mesker","doi":"10.1016/j.clnesp.2024.12.012","DOIUrl":"10.1016/j.clnesp.2024.12.012","url":null,"abstract":"<p><strong>Background & aims: </strong>Sarcopenia and obesity are indicators for poor outcomes in colon cancer. Additionally, aggressive histopathologic tumor stromal features, such as a low tumor-stroma ratio (TSR) and low tumor-infiltrating lymphocytes (TILs) predict survival and treatment response. As their relationship remains underexplored, we studied the association between skeletal muscle mass, visceral adipose tissue (VAT), TSR, and TILs in patients with colon cancer.</p><p><strong>Methods: </strong>We studied 194 stage II/III colon carcinoma patients who underwent elective surgery. Preoperative computed tomography (CT) scans classified patients into four groups based on skeletal muscle index (normal/low) and visceral adipose tissue index (normal/high). Tumor tissues were assessed for TSR and TILs, and five-year disease recurrence and relative hazard were evaluated.</p><p><strong>Results: </strong>Among the patients, 56 (28.9 %) were classified as Normal Muscle, Normal VAT, 26 (13.4 %) as Normal Muscle, High VAT, 75 (38.7 %) as Low Muscle, Normal VAT, and 37 (19.1 %) as Low Muscle, High VAT. Patients with low skeletal muscle mass were more often male (62.5 % vs. 39 %, P = 0.005). Stroma-high tumors were less common in Low Muscle, Normal VAT patients (24 %) compared to Normal Muscle, High VAT (50 %), Low Muscle, High VAT (48.6 %), and Normal Muscle, Normal VAT (41.1 %) patients (P = 0.020). Tumors with low TILs were similarly distributed across groups (P = 0.679). Low Muscle, Normal VAT patients had a lower recurrence hazard compared to both Low Muscle, High VAT (hazard ratio [HR] 0.34, 95 % CI 0.12-0.98, P = 0.048) and Normal Muscle, Normal VAT (HR 0.31, 95 % CI 0.11-0.87, P = 0.027) patients.</p><p><strong>Conclusions: </strong>Low Muscle, Normal VAT colon cancer patients exhibited fewer aggressive tumor features and a lower recurrence risk compared to Low Muscle, High VAT patients. These findings highlight the importance of body composition in tumor biology and prognosis.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"282-287"},"PeriodicalIF":2.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between vitamin C and breast cancer, prostate cancer and colorectal cancer: A systematic review and meta-analysis.","authors":"Maedeh Arshadi, Nima Ghazal, Fatemeh Ghavidel, Zahra Beygi, Zohal Nasiri, Pardis Zarepour, Sedigheh Abdollahi, Hosein Azizi, Farzad Khodamoradi","doi":"10.1016/j.clnesp.2024.12.001","DOIUrl":"10.1016/j.clnesp.2024.12.001","url":null,"abstract":"<p><strong>Background: </strong>For a comprehensive evaluation and due to the inconsistent results of previous studies, we performed this meta-analysis with the aim of vitamin C effect on breast cancer and prostate cancer and colorectal cancer.</p><p><strong>Methods: </strong>PubMed, Scopus and Web of Science were searched to identify studies on the association between vitamin C and breast cancer, prostate cancer and colorectal cancer through September 11, 2023. The pooled RR and the 95 % confidence intervals were used to measure the association between vitamin C and breast cancer, prostate cancer and colorectal cancer by assuming a random effects meta-analytic model. Newcastle-Ottawa scale was used for quality appraisal.</p><p><strong>Results: </strong>A total of 69 studies were included. The pooled RR for the association between vitamin C (dietary) and breast cancer in the cohort study was 0.99 [95 % CI: 0.95, 1.03], but the pooled RR in the case-control study was 0.72 [95 % CI: 0.60, 0.85]. No association was found between vitamin E (supplemental, total intake) and breast cancer in studies. The pooled RR for the association between vitamin C (dietary) and prostate cancer was 0.88 [95 % CI: 0.77, 1.00], which represents a decrease in prostate cancer. No association was found between vitamin C (supplemental) and prostate cancer in studies. The pooled RR for the association between vitamin C (dietary) and colorectal cancer was 0.55 [95 % CI: 0.42, 0.73], which represents a decrease in colorectal cancer.</p><p><strong>Conclusion: </strong>Our analysis shows an inverse significant relationship between vitamin C (dietary) and breast cancer in the case-control study. Also between vitamin C (dietary) and prostate cancer and colorectal cancer in studies, which represents a decrease in cancers.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"400-407"},"PeriodicalIF":2.9,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early postnatal effects of maternal obesity on breast milk composition and breastfeeding outcomes.","authors":"Carolina Dumke de Siqueira, Leandro Borges, Tamara Dal Mora, Najla Adel Saleh, Elizabeth Soethe Alves, Sandro Wopereis, Beatriz Garcia Mendes, Ana Carolina Rabello de Moraes, Elaine Hatanaka, Fabíola Branco Filippin-Monteiro","doi":"10.1016/j.clnesp.2024.11.036","DOIUrl":"10.1016/j.clnesp.2024.11.036","url":null,"abstract":"<p><strong>Background & aims: </strong>Breastfeeding can be challenging in mothers with overweight or obesity-related chronic low-grade inflammation, resulting in negative consequences for the newborn. The pre-gestational body mass index is negatively associated with lactogenesis II, the onset of colostrum secretion. Herein, we evaluated mothers' inflammation, metabolic status, and components of breast milk after birth to associate these factors with their nutritional and breastfeeding status.</p><p><strong>Methods: </strong>The study included volunteer mothers, categorized based on their nutritional status and anthropometric parameters, who gave birth in a tertiary maternity hospital. Serum and breast milk samples were collected 24 and 48 h after birth to determine inflammatory biomarkers (SAA, leptin, CRP, IL-1β, TNF-α, IL-8, IL-6, MCP-1, IL-10, and IFN-γ), reproductive hormones (prolactin and progesterone), as well as the breast milk composition (total protein, fatty acid, percentage of fat and Kcal). Furthermore, we conducted a six-month follow-up to assess breastfeeding outcomes. Interestingly, the composition of breast milk did not vary in the different situations analyzed, indicating the stability of the breast milk's composition in meeting infant needs, regardless of age, nutritional status, and type of birth.</p><p><strong>Results: </strong>Our findings revealed a higher concentration of pro-inflammatory biomarkers (SAA, CRP, TNF-α, IL-8, and IFN-γ) than anti-inflammatory, IL-10, in breast milk. Our study showed that mothers who were overweight after pregnancy had a newborn with a higher birth weight compared to healthy post-pregnancy weight. Our study elucidates the intricate dynamics between maternal weight, inflammation, and breastfeeding outcomes.</p><p><strong>Conclusions: </strong>While maternal overweight or obesity-related inflammation may pose challenges to lactogenesis II and influence newborn birth weight, breast milk remains a stable and reliable source of essential nutrients for infant nourishment. However, the presence of pro-inflammatory biomarkers in breast milk warrants further investigation into its potential implications for infant health.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"365-374"},"PeriodicalIF":2.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly branched cyclic dextrin supplementation and resistance training: A randomized double-blinded crossover trial examining mechanical, metabolic, and perceptual responses.","authors":"María Dolores Morenas-Aguilar, Sergio Miras-Moreno, Sara Chacón-Ventura, Juan J Martín-Olmedo, Magdalena Cwiklinska, Pablo Jiménez-Martínez, Carlos Alix-Fages, Danica Janicijevic, Amador García-Ramos","doi":"10.1016/j.clnesp.2024.12.002","DOIUrl":"10.1016/j.clnesp.2024.12.002","url":null,"abstract":"<p><strong>Background & aims: </strong>The aim of this study was to investigate the potential ergogenic effects of intra-session supplementation of highly branched cyclic dextrin (HBCD) on mechanical (number of repetitions completed and repetition velocity), metabolic (lactate concentration), and perceptual (gastrointestinal complaints and ratings of perceived exertion [RPE]) responses to resistance training.</p><p><strong>Methods: </strong>This study used a randomized, double-blinded, placebo-controlled crossover study design. Thirty physically active individuals (15 men and 15 women) completed two experimental sessions that only differed in the supplement condition (placebo or HBCD). In each experimental session, subjects were prescribed five sets of eight repetitions with the 12-repetition maximum load during the bench press, bench pull, and squat exercises. During the sessions, participants consumed a total of 750 mL of the beverage, which either contained diluted 45 g of cyclic dextrin (HBCD condition) or only 2.5 g of the calorie-free excipients (placebo condition). The supplement (placebo or HBCD) was ingested during the inter-set rest periods (50 mL before each set).</p><p><strong>Results: </strong>The main findings indicated that intra-session HBCD supplementation (i) was well-tolerated without causing gastrointestinal complaints, (ii) led to improved repetition velocity during RT in men but not in women, (iii) tended to generate comparable or higher lactate values, and (iv) did not significantly influence the perception of fatigue.</p><p><strong>Conclusions: </strong>These results suggest that HBCD can be considered an ergogenic supplement, particularly for enhancing mechanical performance in men, without noticeably affecting the perception of fatigue or discomfort.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"305-314"},"PeriodicalIF":2.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of probiotics regimens for Helicobacter pylori eradication: A systematic review, pairwise, and network meta-analysis of randomized controlled trials.","authors":"Mohammad Tanashat, Mohamed Abuelazm, Mohamed Abouzid, Yazan A Al-Ajlouni, Alaa Ramadan, Sumaya Alsalah, Abdulrahman Sharaf, Dina Ayman, Hesham Elharti, Sara Zhana, Obieda Altobaishat, Basel Abdelazeem, Fouad Jaber","doi":"10.1016/j.clnesp.2024.11.016","DOIUrl":"10.1016/j.clnesp.2024.11.016","url":null,"abstract":"<p><strong>Background: </strong>Helicobacter pylori (H. pylori) infection increases the risks of chronic gastritis, peptic ulcer diseases, and the incidence of gastric cancer. However, antibiotic resistance and adverse effects led to the emergence of alternative treatments such as probiotics supplementation. This systematic review and network meta-analysis aims to assess the efficacy and safety of incorporating probiotics into the various eradication regimens for H. pylori.</p><p><strong>Methods: </strong>We searched PubMed, Embase, Scopus, Cochrane, and Web of Science from inception to May 2023, for randomized controlled trials (RCTs) comparing standard therapy (triple or quadrable therapy). for H. pylori with or without probiotic supplementation. Dichotomous data was reported using an odds ratio (OR) for intention-to-treat (ITT) and risk ratios (RR) for side effects with a 95 % confidence interval (CI).</p><p><strong>Results: </strong>We included 91 RCTs involving 13,680 patients. Adding probiotics to standard treatment was associated with a higher H. pylori eradication rate in the ITT analysis (78.75 % vs 62.43 %, OR = 1.62, 95 % CI: 1.41 to 1.87, P < 0.0001), and per-protocol (PP) analysis (80.33 % vs 72.63 %, OR = 1.60, 95 % CI: 1.34 to 1.91, P < 0.0001). Meanwhile, dyspepsia, gastric ulcer, and peptic ulcer were comparable in both groups. The probiotics group was associated with significantly fewer side effects including, abdominal pain (RR = 0.68, 95 % CI: 0.54 to 0.86), bad taste (RR = 0.64, 95 % CI: 0.53 to 0.78), diarrhea (RR = 0.49, 95 % CI: 0.40 to 0.61), epigastric pain/bloating (RR = 0.76, 95 % CI: 0.65 to 0.88), headache/dizziness (RR = 0.46, 95 % CI: 0.29 to 0.74), (RR = 0.65, 95 % CI: 0.55 to 0.77), or nausea/vomiting (RR = 0.69, 95 % CI: 0.56 to 0.83). The network meta-analysis showed that, compared to the placebo, Bifidobacterium longum had the highest efficacy in eradicating H. pylori (ITT: 81.06 % vs 64.88 %, PP: 88 % vs 75.71 %) (OR = 2.52, 95 % CI: 1.18 to 5.49).</p><p><strong>Conclusion: </strong>Adding probiotics to standard H. pylori therapy not only increased the rate of eradication but also reduced some of the adverse reactions throughout therapy, particularly nausea, vomiting, diarrhea, abdominal pain, epigastric pain/bloating, and taste issues.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"424-444"},"PeriodicalIF":2.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}