Clinical nutrition ESPEN最新文献

{"title":"Association between myopia and refined carbohydrate consumption: A cross-sectional study from the Constances cohort","authors":"Claire Berticat ,&nbsp;Elisa Venturini ,&nbsp;Vincent Daien ,&nbsp;Marcel Goldberg ,&nbsp;Marie Zins ,&nbsp;Michel Raymond","doi":"10.1016/j.clnesp.2025.03.033","DOIUrl":"10.1016/j.clnesp.2025.03.033","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>The effects of refined carbohydrate consumption on the prevalence of myopia have been little studied. The aim of this study is to explore the potential link between this consumption and myopia in individuals aged 40 or under in the population-based Constances cohort, in conjunction with other known risk and confounding factors.</div></div><div><h3>Methods</h3><div>The association between the probability of myopia in at least one eye and refined carbohydrate consumption was tested for 5271 participants, aged 40 or younger, in conjunction with education level, physical activity, energy intake, age, sex, fasting blood glucose, Body Mass Index (BMI), and Mediterranean diet quality. Refined carbohydrate intake was estimated by glycemic load. Myopia was assessed by the Monoyer score. Significant sex interactions led to stratified analysis by sex.</div></div><div><h3>Results</h3><div>The risk of myopia was significantly increased for men with refined carbohydrate consumption (<strong><em>p</em></strong> = 0.012, Odd Ratio (OR) = 1.12, Confidence Interval (CI) = 1.02–1.22) but not for women (<strong><em>p</em></strong> = 0.657, OR = 1.02, CI = 0.94–1.10). Some previously identified myopia risk factors were concurrently observed: a higher level of education increased the probability of myopia in both sexes (men <strong><em>p</em></strong> &lt; 10⁻¹¹, OR = 1.36, CI = 1.24–1.49; women <strong><em>p</em></strong> = &lt; 10⁻⁴, OR = 1.19, CI = 1.09–1.28), while a higher level of physical activity might be protective in men (<strong><em>p</em></strong> = 0.08, OR = 0.93, CI = 0.85–1.01).</div></div><div><h3>Conclusion</h3><div>This research reveals how high refined carbohydrate consumption might influence myopia and confirms recent studies on its risk factors. It also highlights significant sex differences in the prevalence and factors associated with myopia, emphasizing that modifiable risk factors, crucial for public health initiatives, may vary between men and women.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"67 ","pages":"Pages 329-337"},"PeriodicalIF":2.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary intake of oxalic acid affects plasma oxalic acid concentration in patients with kidney failure","authors":"Wesley J. Visser ,&nbsp;Gideon Post Hospers ,&nbsp;Anneke M.E. van Egmond ,&nbsp;Mirjam Laging ,&nbsp;Jeroen G.H.P. Verhoeven ,&nbsp;Sara J. Baart ,&nbsp;Chris R.B. Ramakers ,&nbsp;Ingrid R.A.M. Mertens zur Borg ,&nbsp;Michel J. Vos ,&nbsp;Ido P. Kema ,&nbsp;Dennis A. Hesselink ,&nbsp;Jacqueline van de Wetering ,&nbsp;Marlies E.J. Reinders ,&nbsp;Ewout J. Hoorn ,&nbsp;David Severs ,&nbsp;Joke I. Roodnat","doi":"10.1016/j.clnesp.2025.03.030","DOIUrl":"10.1016/j.clnesp.2025.03.030","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Hyperoxaluria may cause kidney stones, kidney function decline and eventually kidney (transplant) failure. High plasma concentrations may lead to systemic oxalosis. Plasma oxalic acid concentrations increase when kidney function deteriorates. Apart from kidney function, the contribution of dietary intake on the oxalic acid plasma concentration is unknown.</div></div><div><h3>Methods</h3><div>Average and last 24 h dietary oxalic acid intake was assessed by a self-developed food frequency questionnaire. Based on frequency and portion size, the FFQ calculates daily average oxalic acid intake and last 24 h intake. Plasma oxalic acid concentration was determined immediately before kidney transplantation.</div></div><div><h3>Results</h3><div>We included 418 patients, median age 62 years (51–69), 60 % male, 66 % on dialysis, median dialysis vintage 13 months (0–27). Average oxalic acid intake was 199 mg/day (range 4–1599); in the last 24 h before transplantation it was 138 mg/day (range 0–3906). Median plasma oxalic acid concentration was 32.2 μmol/L (range 4.6–243.2), while 98.3 % of patients had concentrations above the upper normal value (7.2 μmol/L). Multivariable linear regression analysis showed that plasma oxalic acid concentration was associated with average and last 24-h intake, body mass index, dialysis vintage, age, residual diuresis, and dialysis <em>versus</em> pre-dialysis status. The associations found are clinically relevant, with the lowest and highest intakes translating to plasma oxalic acid changes of 23.5 and 49.5 μmol/L, respectively.</div></div><div><h3>Conclusion</h3><div>In nearly all patients with kidney failure plasma oxalic acid concentration was above the upper normal concentration and dietary oxalic acid intake affects plasma oxalic acid concentration.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"67 ","pages":"Pages 303-310"},"PeriodicalIF":2.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of post-hospitalization dysphagia on dependence in activities of daily living at discharge in older adults with hip fracture: A nationwide inpatient database study","authors":"Shuntaro Tamura ,&nbsp;Tomohiko Kamo ,&nbsp;Sota Kobayashi ,&nbsp;Hiroyuki Saito ,&nbsp;Tatsuya Igarashi ,&nbsp;Yoichi Kaizu ,&nbsp;Kazuhiro Miyata ,&nbsp;Hiroki Kubo ,&nbsp;Hirofumi Ogihara ,&nbsp;Ryo Momosaki","doi":"10.1016/j.clnesp.2025.03.041","DOIUrl":"10.1016/j.clnesp.2025.03.041","url":null,"abstract":"<div><h3>Background</h3><div>Older adults with hip fractures of the femur have a higher probability of developing dysphagia after surgery. Dysphagia affects older patients with hip fractures in multiple ways, thus clinicians need to understand the impact of dysphagia on the effectiveness of treatment.</div></div><div><h3>Aims</h3><div>The aim of this study is to clarify the impact of dysphagia on dependence in activities of daily living in older adults with hip fractures.</div></div><div><h3>Methods</h3><div>This retrospective observational study utilized a nationwide inpatient database, encompassing acute inpatient care from 2017 to 2022. Older adults (≥60 years) with hip fractures who underwent surgery and survived to discharge were included. Dysphagia was analyzed as a factor affecting dependence in activities of daily living at discharge using binomial logistic regression and the inverse probability of treatment weighting (IPTW) method, which was based on propensity scores.</div></div><div><h3>Results</h3><div>The analysis included 88,809 older adults with hip fractures. Binomial logistic regression analysis showed that dysphagia was significantly associated with dependence in activities of daily living, with an odds ratio of 3.24 (95 % confidence interval [CI], 2.72–3.85; p &lt; 0.01). Furthermore, sensitivity analysis confirmed these findings. After adjusting for IPTW, dysphagia remained a significant factor for dependence in activities of daily living at discharge, with an odds ratio of 2.55 (95 % CI, 2.45–2.64; p &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>In older adults with hip fractures, dysphagia negatively affects the activities of daily living at discharge. These results are useful for clinicians for understanding the significance of preventing dysphagia development.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"67 ","pages":"Pages 355-361"},"PeriodicalIF":2.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urea-to-creatinine ratio as a biomarker for clinical outcome and response to nutritional support in non-critically ill patients: A secondary analysis of a randomized controlled trial","authors":"Julian Diethelm ,&nbsp;Carla Wunderle ,&nbsp;Arthur R.H. van Zanten ,&nbsp;Pascal Tribolet ,&nbsp;Zeno Stanga ,&nbsp;Beat Mueller ,&nbsp;Philipp Schuetz","doi":"10.1016/j.clnesp.2025.03.042","DOIUrl":"10.1016/j.clnesp.2025.03.042","url":null,"abstract":"<div><h3>Background</h3><div>Assessing a patient's catabolism in clinical practice is challenging but could help guide nutritional interventions. The urea-to-creatinine ratio (UCR) reflects muscle breakdown and protein metabolism and has been associated with risk for overfeeding and adverse outcomes in the critical care setting. We validated this concept in a well-characterized population of medical ward patients from a previous nutritional trial.</div></div><div><h3>Methods</h3><div>This secondary analysis of the Effect of Early Nutritional Support on Frailty, Functional Outcomes, and Recovery of Malnourished Medical Inpatients Trial (EFFORT) examined baseline UCR and changes during follow-up in medical inpatients at risk for malnutrition. A catabolic state was defined as a high baseline UCR or an increase in UCR over 7 days. The primary endpoint was mortality at 30 days.</div></div><div><h3>Results</h3><div>We included 1595 of 2028 EFFORT patients with baseline UCR measurements and 870 who also had UCR measurements on day 7. A high baseline UCR, as well as an increase in UCR over 7 days, were associated with increased mortality (adjusted HR for 30-day mortality 2.05 (1.47–2.87) p &lt; 0.001 and 2.02 (1.34–3.06) p = 0.001). There was no difference in treatment response when stratifying patients based on baseline or follow-up UCR.</div></div><div><h3>Conclusion</h3><div>Assessment of catabolism through UCR measurement at baseline and changes during follow-up was associated with increased mortality and adverse outcomes in medical inpatients at nutritional risk. However, this stratification was not associated with response to nutritional therapy in our sample. Further studies into the dynamic changes in UCR are needed to better understand the clinical implications for medical ward patients.</div></div><div><h3>Clinical Trial Registration</h3><div><span><span>Clinicaltrials.gov</span><svg><path></path></svg></span> as NCT02517476 (registered 7 August 2015)</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"67 ","pages":"Pages 242-249"},"PeriodicalIF":2.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of health interests and knowledge among 8,799 secondary school pupils following mixed, vegetarian, and vegan diets","authors":"Derrick R. Tanous ,&nbsp;Gerhard Ruedl ,&nbsp;Clemens Drenowatz ,&nbsp;Werner Kirschner ,&nbsp;Gerold Wirnitzer ,&nbsp;Manuel Schätzer ,&nbsp;Katharina C. Wirnitzer","doi":"10.1016/j.clnesp.2025.03.043","DOIUrl":"10.1016/j.clnesp.2025.03.043","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>The accumulation of health knowledge may motivate the development of long-term healthy behavior in secondary school ages. The present investigation aimed to assess the health interests and knowledge of secondary school pupils following different types of diets.</div></div><div><h3>Methods</h3><div>The <em>From Science 2 School</em> study was developed with a cross-sectional design. Pupils of secondary school levels I and II were invited to complete an online survey with questions on the individual, physical activity, nutrition, and health. Analysis of variance (ANOVA) and chi-squared tests were used in the statistical analysis.</div></div><div><h3>Results</h3><div>A basic sample of 8845 participants completed the survey. Following data clearance, 8799 pupils (aged 15.1 years; 63.1 % girls, 36.9 % boys) were eligible for the final analysis. Pupils followed a mixed diet (n = 8164; 92.8 %) vegetarian diet (n = 493; 5.6 %), or vegan diet (n = 142; 1.6 %). Girls were more likely to consume a vegetarian (n = 429; 87 %) or vegan diet (n = 108; 76 %; p &lt; 0.01). The vegetarian and vegan subgroups were more frequently interested in health and nutrition (p &lt; 0.01) but similar for interest in physical activity and sports (p &gt; 0.05). A higher prevalence of overweight and obesity was found among the mixed diet subgroup (n = 987; 12.1 %; p &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>This is the first study to assess health interests and knowledge in school pupils following vegetarian and vegan diets. The results indicate that following a vegetarian or vegan type of diet during childhood and adolescence is associated with a higher level of health knowledge and nutritional understanding.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"67 ","pages":"Pages 311-320"},"PeriodicalIF":2.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the addition of a multicomponent additive to the human milk provided to preterm newborns with outcomes: A prospective cohort","authors":"Thayanne Gurgel de Medeiros Mendes ,&nbsp;Amanda Caroline Pereira Nunes ,&nbsp;Ana Verônica Dantas de Carvalho ,&nbsp;Juliana Dantas de Araújo Santos Camargo ,&nbsp;Márcia Marília Gomes Dantas Lopes","doi":"10.1016/j.clnesp.2025.03.032","DOIUrl":"10.1016/j.clnesp.2025.03.032","url":null,"abstract":"<div><h3>Background</h3><div>The nutritional needs of preterm newborns (PTNB) are increased and enhancing nutritional management is essential to meet them. The addition of multicomponent additive (MA) to human milk (HM) is used as a treatment strategy. The objective of the research is to analyze the association between the use of MA added to HM with nutritional and clinical outcomes in low-birth weight PTNB admitted to a neonatal intensive care unit (NICU).</div></div><div><h3>Methods</h3><div>Prospective cohort study with PTNB weighing less than 2500 g during hospitalization in the NICU, who were divided into two distinct groups based on the presence or absence of MA supplementation. We investigated outcomes related to nutritional status at discharge, length of stay, presence of metabolic bone disease of prematurity (MBDP), extrauterine growth restriction (EUGR) and encouragement of breastfeeding at discharge.</div></div><div><h3>Results</h3><div>A total of 65 PTNB were included. We found that the lower the BW, the more often the use of MA was observed (p = 0.006). At discharge, there was a decline in z- scores, in which 46 % of PTNB who used MA developed malnutrition. The length of stay was longer in the group of PTNB who used MA (p &lt; 0.001). The percentage of PTNB with MBDP who used MA (52.5 %) was higher than the percentage of those who did not use it (p = 0.006). The probability of PTNB with MBDP using MA is 2.65 times higher than those without MDBP.</div></div><div><h3>Conclusion</h3><div>The use of MA to HM did not prevent or avoid the decline in nutritional status of the PTNBs, considering that those who used it had greater difficulty gaining weight, longer hospital stays, and more MBPD diagnoses compared to the group that did not use supplementation. However, the MA was crucial as it provided essential nutritional support for those PTNB who are more susceptible to MBDP.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"67 ","pages":"Pages 338-343"},"PeriodicalIF":2.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between phase angle and hospital-associated disability in hospitalized patients in the internal medicine ward: A prospective observational study","authors":"Kei Shirakawa ,&nbsp;Moriho Mugita ,&nbsp;Masafumi Hirota ,&nbsp;Ryoji Izumoto ,&nbsp;Takashi Tanaka ,&nbsp;Toshiaki Arai ,&nbsp;Eigo Fujioka ,&nbsp;Hiromu Yabuta ,&nbsp;Tomoki Yoden ,&nbsp;Takuya Sakamoto ,&nbsp;Kenshiro Hiraga ,&nbsp;Noa Watanabe ,&nbsp;Koichiro Kataoka ,&nbsp;Shigeyoshi Tsuji","doi":"10.1016/j.clnesp.2025.03.046","DOIUrl":"10.1016/j.clnesp.2025.03.046","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the association between the phase angle (PhA) and hospital-associated disability (HAD) in older patients admitted to an internal medicine ward.</div></div><div><h3>Methods</h3><div>This was a prospective observational study in a single acute care hospital. HAD was defined as a decrease of at least five points in the Barthel index at discharge compared to pre-admission. Multiple logistic regression analysis was used to determine the association between PhA and HAD. The cut-off point for PhA was evaluated using a receiver operating characteristic curve.</div></div><div><h3>Results</h3><div>This study included 215 patients (113 males; mean age: 80.8 years). The HAD incidence rate was 27.9 %. Multiple logistic regression analysis showed that PhA was associated with HAD (odds ratio: 3.47, 95 % confidence interval: 1.95–6.18, <em>p</em> &lt; 0.001). The PhA cut-off points for predicting HAD were 3.7° for men and 3.6° for women.</div></div><div><h3>Conclusion</h3><div>PhA was associated with HAD in older patients admitted to the internal medicine ward and may be a useful indicator for predicting HAD.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"67 ","pages":"Pages 296-302"},"PeriodicalIF":2.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total, unprocessed, and processed red meat intake in relation to the risk of pancreatic cancer: A systematic review and dose–response meta-analysis of prospective cohort studies","authors":"Batoul Ghosn ,&nbsp;Mohammadreza Moradi Baniasadi ,&nbsp;Moharam Jalalzadeh ,&nbsp;Ahmad Esmaillzadeh","doi":"10.1016/j.clnesp.2025.03.021","DOIUrl":"10.1016/j.clnesp.2025.03.021","url":null,"abstract":"<div><div>Data on the association between red meat from both processed and unprocessed sources and risk of pancreatic cancer is controversial. Therefore, this study summarized current evidence on the relationship between red and processed red meat intake and pancreatic cancer risk through a meta-analysis. A systematic search was conducted on PubMed, ISI Web of Science and Scopus for prospective cohorts up to October 2024. Hazard ratio (HR) and 95 % confidence intervals (CIs) for the highest vs. the lowest category of the exposures were combined using random-effects models. Dose–response relations were explored by one-stage weighted mixed effects meta-analysis. 19 studies involving 4,291,065 participants with 13,820 pancreatic cancer cases were included. The highest intake of total red meat was positively related to risk of pancreatic cancer (Pooled HR: 1.12, 95%CIs: 1.01, 1.24; I²: 36.5 %, P_Q-test: 0.10). Such association was not significant for unprocessed (Pooled HR: 1.05, 95%CIs: 0.88, 1.24; I²: 66.6 %, P_Q-test: 0.002) and processed (Pooled HR: 1.02, 95%CIs: 0.86, 1.21; I²: 66.0 %, P_Q-test: 0.001) red meat intake. No significant association was observed between each 3 serving/wk of total, unprocessed, and processed red meat and risk of pancreatic cancer. Also, no evidence for a nonlinear association was found for all associations. This meta-analysis suggests a positive relation between the highest consumption of total red meat and pancreatic cancer. However, this relation was not substantial in terms of unprocessed and processed red meat.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"67 ","pages":"Pages 265-275"},"PeriodicalIF":2.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of human papillomavirus (HPV) status in body composition and nutritional features in patients with oropharyngeal cancer","authors":"M. Choulli ,&nbsp;F. Morey ,&nbsp;S. Tous ,&nbsp;J. Brenes ,&nbsp;X. Wang ,&nbsp;B. Quirós ,&nbsp;A.R. González-Tampán ,&nbsp;M.A. Pavón ,&nbsp;M. Gomà ,&nbsp;M. Taberna ,&nbsp;M.E. Alemany ,&nbsp;M. Oliva ,&nbsp;M. Mena ,&nbsp;L. Arribas ,&nbsp;R. Mesia","doi":"10.1016/j.clnesp.2025.03.013","DOIUrl":"10.1016/j.clnesp.2025.03.013","url":null,"abstract":"<div><h3>Background and aims</h3><div>Patients with oropharyngeal squamous cell carcinoma (OPSCC) are highly prone to malnutrition and sarcopenia due to the tumor's location and treatment-related toxicity. Human papillomavirus (HPV)-related and HPV-unrelated OPSCC represent two distinct biological entities. This study aimed to assess nutritional characteristics and body composition differences at diagnosis, as well as 3- and 6-months post- (chemo) radiation treatment, stratified by HPV status in OPSCC patients.</div></div><div><h3>Methods</h3><div>Retrospective data analysis of a prospective cohort of OPSCC patients diagnosed and treated with curative intent from 2016 to 2022 at our center. Sociodemographic, clinical, and nutritional data were retrieved from medical records from diagnosis to 6 months post-treatment. Body composition parameters were assessed by analyzing the cross-sectional area of the third lumbar vertebra (L3) using available positron emission tomography (PET) and computed tomography (CT) scans at baseline, 3- and 6-months post-treatment.</div></div><div><h3>Results</h3><div>Seventy patients were included, 33 (47.1 %) of whom had HPV-related OPSCC. HPV-related patients had higher body mass index (27.3 vs 21.9 kg/m²; p &lt; 0.001) and better baseline nutritional status (p = 0.023), but no differences in skeletal muscle index (SMI, p = 0.103) compared to HPV-unrelated patients. At 3- and 6-months post-treatment the two groups showed similar SMI and total adipose tissue index loss (p &gt; 0.05 for both). HPV status was not independently associated with body composition changes over time (p = 0.624).</div></div><div><h3>Conclusions</h3><div>Although HPV-related patients were better nourished than HPV-unrelated patients at diagnosis, by the end of treatment, both groups exhibited similar nutritional deterioration.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"67 ","pages":"Pages 417-426"},"PeriodicalIF":2.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heparin in peripherally inserted central catheters did not alter elective removal and complication rates in preterm infants","authors":"Dirk Wackernagel ,&nbsp;Vanessa Gavelli ,&nbsp;Per Nydert","doi":"10.1016/j.clnesp.2025.03.024","DOIUrl":"10.1016/j.clnesp.2025.03.024","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>In preterm and sick newborn infants, peripherally inserted central catheters (PICC) are used for the delivery of concentrated parenteral nutrition and other high risk drugs. Despite the precaution issued by the ESPGHAN 2018, heparin is used in many neonatal intensive care units (NICU) and is thought to extend PICC usability. This study aimed to examine the association of prophylactic heparin with elective PICC removal rates, with complication rates and dwell-times.</div></div><div><h3>Methods</h3><div>All PICCs placed at two different Level III NICUs during 2017, were analyzed retrospectively. Out of 168 PICCs, 36 had to be excluded, leaving 132 PICCs for analysis. Prophylactic heparin was used in 90 PICCs (heparin-group) and 42 PICCs without (control group)</div></div><div><h3>Results</h3><div>Sixty-six PICCs (73 %) vs 30 (71 %) could be removed electively in the heparin-group (adjusted Odds Ratio 95 % confidence interval (CI) 0.95 [0.31, 2.89], p &gt; 0.9). Complications occurred in 17 (19 %) and 8 (19 %) PICCs in the heparin-group and control-group, respectively. Dwell-times did not differ significantly with median 10 days (Interquartile range (IQR) 6,17) in the heparin-group and 8 days (IQR 7,12) in the control-group with an adjusted hazard ratio 0.70 (95 % CI [0.45, 1.09], p = 0.11).</div></div><div><h3>Conclusion</h3><div>In our retrospective analysis, adding heparin to admixtures infused via PICCs did not alter the odds of elective removals or complication rates. Furthermore, Dwell-times did not differ significantly between the two groups. In line with the ESPGHAN recommendations, our data can not support the use of heparin to improve PICC usability.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"67 ","pages":"Pages 200-205"},"PeriodicalIF":2.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}