Beyond safety: Reassessing autonomy, infection risk, and long-term value of multi-chamber parenteral nutrition in cancer care.

We commend Goetze et al. for evaluating multi-chamber parenteral nutrition (PN) in solid tumor patients requiring home PN. Their study demonstrates improved patient autonomy and fewer PN-related adverse events, yet several limitations remain. First, the premature termination reduces statistical power, especially for infection outcomes. Second, autonomy was defined inclusively, counting family support as self-administration, which may overestimate practical independence. Third, the economic implications of higher upfront costs versus potential savings from fewer nursing visits and complications remain unclear. Finally, survival benefits were not demonstrated, underscoring the need to assess quality of life and patient-reported outcomes. Future trials should integrate cost-effectiveness and long-term endpoints to guide wider adoption.