Clinical and Translational Allergy最新文献

{"title":"A Real-World Cross-Sectional Study on Suspected Mast Cell Activation Syndrome: Multiple Heterogeneous Symptoms Identified","authors":"Annika Gutsche,&nbsp;Thomas Buttgereit,&nbsp;Rüdiger Buchkremer,&nbsp;Jens Panse,&nbsp;Nina Kreddig,&nbsp;Olga Ptock,&nbsp;Stephanie Roll,&nbsp;Weronika Grabowska,&nbsp;Felix Aulenbacher,&nbsp;Martin Metz,&nbsp;Polina Pyatilova,&nbsp;Pascale Salameh,&nbsp;Manuel P. Pereira,&nbsp;Frank Siebenhaar","doi":"10.1002/clt2.70184","DOIUrl":"10.1002/clt2.70184","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A variety of clinical signs and symptoms have been described in patients suspected of having mast cell activation syndrome (MCAS), however, symptom patterns and linked organ systems were not yet described.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional online survey included adults with physician-diagnosed self-assessed or suspected MCAS between June and September 2021. Symptoms were collected as free-text responses, and coded using the Medical Dictionary for Regulatory Activities (MedDRA). These data were then analyzed using an unsupervised machine learning approach to identify distinct participant clusters. Patient-reported outcome measures (PROMs), including the PHQ-2, GAD-7, and SF-36, were used to assess mental health symptoms and health-related quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 592 patients (mean age 45 years, 90% female) reported 400 symptoms in 58 categories. The hierarchical clustering algorithm failed to identify distinct patient clusters. We identified 256 (43%) patients with signs and symptoms aligning with the diagnostic criteria for MCAS including the most prevalent symptoms. Overall, patients infrequently reported mast cell-mediated skin symptoms, such as pruritus (13%), wheals (9%), flushing (7%), or angioedema (1%). We identified patients with comorbid signs of depression (39%), general anxiety (34%), and impaired quality of life (28%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patients with suspicion of MCAS exhibit highly heterogeneous symptoms, whereas almost 50% report symptoms corresponding to the first diagnostic criterion for MCAS. Because over a third of the patients were tested positive for other diseases, we recommend considering common and more treatable diagnoses when evaluating patients with suspected MCAS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"16 7","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum and Nasal Lavage Fluid Eosinophil-Derived Neurotoxin Levels in Clinically Defined Asthma Phenotypes","authors":"Saliha Selin Özuygur Ermis,&nbsp;Carina Malmhäll,&nbsp;Magnus P. Borres,&nbsp;Robert Movérare,&nbsp;Daniil Lisik,&nbsp;Reshed Abohalaka,&nbsp;Selin Ercan,&nbsp;Susanne Schmeisser,&nbsp;Rani Basna,&nbsp;Roxana Mincheva,&nbsp;Göran Wennergren,&nbsp;Jan Lötvall,&nbsp;Linda Ekerljung,&nbsp;Madeleine Rådinger,&nbsp;Hannu Kankaanranta,&nbsp;Bright I. Nwaru","doi":"10.1002/clt2.70183","DOIUrl":"10.1002/clt2.70183","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>As a surrogate for eosinophilic activation, eosinophil-derived neurotoxin (EDN) is a potential clinical biomarker. However, EDN levels and discriminatory ability in different asthma phenotypes are unknown. We quantified serum and nasal lavage fluid (NLF) EDN levels and assessed the potential to differentiate clinically defined asthma phenotypes in an adult-representative sample.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 1499 serum and 386 NLF samples from individuals with current asthma obtained from the West Sweden Asthma Study were analyzed for EDN. Eosinophilic asthma was defined as blood eosinophil count of ≥ 300 cells/mm³, T2-high asthma was defined as blood eosinophil count of ≥ 300 cells/mm³ or fractional exhaled nitric oxide (FeNO) levels of ≥ 25 ppb. Other asthma phenotypes were defined based on presence of atopy, chronic rhinosinusitis (CRS), nasal polyposis, and obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Subjects with eosinophilic asthma had higher serum and NLF EDN levels than those with non-eosinophilic asthma. In ROC analyses, serum EDN provided excellent discrimination between eosinophilic and non-eosinophilic asthma (area under curve [AUC] = 0.84, 95% CI = 0.82–0.86); the corresponding AUC for NLF EDN was 0.67 (95% CI = 0.62–0.73). Serum and NLF EDN were higher in atopic asthma, T2-high asthma, and asthma with nasal polyposis compared to their counterparts, but not in asthma with CRS. The highest absolute values of serum and NLF EDN were observed in the high eosinophil + FeNO group, followed by the high-eosinophil-only and high-FeNO-only groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Both serum and NLF EDN were higher in those with eosinophilic compared to non-eosinophilic asthma. However, only serum EDN appears to distinguish eosinophilic asthma in ROC analyses.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"16 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergen Immunotherapy for the Treatment of Eosinophilic Esophagitis. An EAACI Task Force Systematic Review","authors":"Martina Votto,&nbsp;Georgios Rentzos,&nbsp;Darío Antolin-Amerigo,&nbsp;Barbara Rymarczyk,&nbsp;George N. Konstantinou,&nbsp;Adam T. Fox,&nbsp;Antonella Cianferoni,&nbsp;Arzu Bakirtas,&nbsp;Carlo Maria Rossi,&nbsp;Marina Tsoumani,&nbsp;Enrico Heffler,&nbsp;Ingrid Terreehorst,&nbsp;Evangelia C. Apostolidou,&nbsp;Maria Beatrice Biló,&nbsp;Oliver Pfaar,&nbsp;Alfredo J. Lucendo,&nbsp;Georgios K. Nikolopoulos,&nbsp;Constantinos Pitsios","doi":"10.1002/clt2.70176","DOIUrl":"10.1002/clt2.70176","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Multiple routes of allergen immunotherapy (AIT) are approved for several IgE-mediated allergic diseases; however, the use of AIT in eosinophilic esophagitis (EoE) remains controversial and is supported by limited evidence. This review, conducted within the frame of an EAACI Task Force, aims to systematically evaluate the use of AIT as a potential treatment for EoE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The protocol was registered and prepared in accordance with PRISMA guidelines. The literature search was conducted across three online databases (PubMed, Embase, and Scopus) and included studies published through January 31^st, 2025. Risk of Bias was assessed for each eligible study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Four articles met the inclusion criteria. Three articles evaluated EPIT for milk-induced EoE in pediatric patients, all from the SMILEE (Study of Efficacy and Safety of Viaskin Milk for milk-induced EoE) trial and its extensions. These included a randomized, placebo-controlled trial, its open-label extension, and a pilot immunological study. The SMILEE trial found no statistically significant difference in tissue eosinophilia between the active (EPIT) and control (placebo) arms in the intention-to-treat population, while 47% of treated EoE patients tolerated milk without recurrence of esophageal eosinophilia. This finding was further supported by a subsequent open-label study with a 2-year follow-up. In the third publication, the researchers found that EPIT was associated with decreased Th2-related transcripts and increased regulatory T-cell-associated transcripts. Only one eligible study evaluated the use of SCIT for treating EoE. It was a retrospective case-control study reporting that SCIT had a neutral effect and yielded inconclusive findings regarding the course of EoE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There is insufficient high-quality evidence to support the effectiveness of alternative routes of AIT for the treatment of EoE, either as an add-on or a standalone treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"16 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Patterns of Allergen Sensitisation in the General Population: The LEAD Study","authors":"Charmaine J. M. Lim,&nbsp;Abdelrahman Omar,&nbsp;Severin Pötscher,&nbsp;Marie-Kathrin Breyer,&nbsp;Frits M. E. Franssen,&nbsp;Emiel F. M. Wouters,&nbsp;Robab Breyer-Kohansal","doi":"10.1002/clt2.70181","DOIUrl":"https://doi.org/10.1002/clt2.70181","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Allergic sensitisation is traditionally viewed as a stable trait despite studies suggesting that it may vary across life-course. This study aims to provide longitudinal evidence of allergic sensitisation and its associated factors in the general population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Aeroallergen sensitisation was assessed in the Austrian population-based cohort using repeated skin prick testing (SPT) across 3 visits (mean visit interval, 4.25 ± 0.33 years). Longitudinal sensitisation patterns were characterised as stable nonsensitised, stable sensitised, new-onset, resolution or fluctuating. We examined demographic, metabolic, behavioural, environmental and immunological factors across age strata (&lt; 18, 18 ≤ 40, 40 ≤ and ≥ 60 years).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 5046 individuals with follow-up and valid SPT in all 3 visits, 54.4% remained stably nonsensitised and 30.6% stably sensitised, 5.6% experienced resolution, 4.8% new onset and 4.6% fluctuating sensitisation. New onset expectedly predominated in &lt; 18 years, fluctuation in 18 ≤ 60 years and resolution in ≥ 60 years, indicating that sensitisation is modifiable and time-varying. Stable sensitisation was strongly associated with parental allergy and blood eosinophils while cumulative smoking modestly reduced its likelihood. Fluctuation was linked to adiposity (in adults ≥ 40 years old) and environmental exposures. Aeroallergen-specific analysis showed new-onset sensitisation was driven by outdoor allergens (ragweed, tree pollens and pets) whereas fluctuation was driven by seasonal pollens.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although predominantly stable, allergic sensitisation is dynamic and exhibits substantial temporal variation. Resolution and fluctuation occur across all ages and new sensitisation can emerge well into adulthood. These findings challenge the traditional view of fixed sensitisation and suggest it reflects a modifiable phenotype shaped by age and environmental and lifestyle exposures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"16 6","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148237818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unique Sensitization Patterns to Allergen Components in a Crustacean-Allergic Australian Cohort","authors":"Elecia Johnston,&nbsp;Sahel Heidari,&nbsp;Shaymaviswanathan Karnaneedi,&nbsp;Diamond Hira,&nbsp;Sandip Kamath,&nbsp;Andreas Ludwig Lopata","doi":"10.1002/clt2.70120","DOIUrl":"10.1002/clt2.70120","url":null,"abstract":"&lt;p&gt;Crustacean allergy affects 1%–3% of the global population, with shrimp being a common trigger. Tropomyosin (TM) is reported to be the primary allergen in up to 80% of cases, but other allergens such as arginine kinase (AK), myosin light chain (MLC), and haemocyanin may also contribute to allergic reactions. Despite the widespread prevalence of crustacean allergies, the diagnostic accuracy of whole extracts versus single components remains underexplored in Oceania [&lt;span&gt;1-4&lt;/span&gt;]. This is particularly important given the variety of crustacean species, including crabs and lobsters, each containing allergens that may differ in sequence homology and in their relative abundance across species.&lt;/p&gt;&lt;p&gt;This study reports allergic sensitisation patterns in 54 individuals with confirmed crustacean allergy (Supporting Information S1: Table S1), who exhibited clinical symptoms and tested positive in skin prick tests (SPT) and/or ImmunoCAP assays (Table 1). Specific IgE sensitisation was assessed using the ALEX2 multiplex IgE test (Macro Array Diagnostics), which includes four crustacean whole extracts: shrimp mix (&lt;i&gt;Litopenaeus setiferus&lt;/i&gt;, &lt;i&gt;Farfantepenaeus aztecus&lt;/i&gt;, &lt;i&gt;Farfantepenaeus duorarum&lt;/i&gt;), &lt;i&gt;Pandalus borealis&lt;/i&gt; (Pan b), &lt;i&gt;Chionoecetes&lt;/i&gt; spp. (Chi spp.), and &lt;i&gt;Homarus gammarus&lt;/i&gt; (Hom g), along with five single allergen components: Pen m 1, Pen m 2, Pen m 3, Pen m 4, and Cra c 6. Subjects testing negative to all crustacean allergens on the array were further analysed using immunoblotting against &lt;i&gt;Penaeus monodon&lt;/i&gt; extract and purified haemocyanin, a shrimp species widely consumed in Australia and globally. Details of the protocol are provided in the Supplementary Methods.&lt;/p&gt;&lt;p&gt;The subjects displayed a wide array of IgE binding patterns, highlighting the complex nature of sensitization within this population. TM sensitisation was demonstrated in 40.7% of the cohort, followed by troponin C (TnC) (26%), AK (22%), sarcoplasmic calcium-binding protein (SCP) (13%), and MLC (4%) (Table 1; Supporting Information S1: Figure S1A). Notably, 45% did not show any binding to TM, which is generally considered to be the major allergen in crustacean allergy. Among these TM-negative subjects, 53.1% were instead sensitised to other allergens. Importantly, while 20% of the cohort were sensitised to multiple allergens, the majority (52%) were monosensitized to one of the five allergens tested, with the highest binding observed for TnC, followed by AK, SCP, and MLC (Table 1, Supporting Information S1: Figure S1B). Similar high reactivity to TnC was also observed in other studies from tropical regions in Hong Kong and Thailand [&lt;span&gt;5&lt;/span&gt;]. IgE levels against &lt;i&gt;P. monodon&lt;/i&gt; TM (Pen m 1) showed strong correlations with TMs from &lt;i&gt;Anisakis simplex&lt;/i&gt; (Ani s 3), &lt;i&gt;Dermatophagoides pteronyssinus&lt;/i&gt; (Der p 10), &lt;i&gt;Blomia tropicalis&lt;/i&gt; (Blo t 10), and &lt;i&gt;Periplaneta americana&lt;/i&gt; (Per a 7), with &lt;i&gt;R&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; values ranging from 0.","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"16 6","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Tape Stripping: A Non-Invasive Approach Linking Epidermal Changes and Systemic Inflammation in Atopic Dermatitis","authors":"Ziyuan Tian,&nbsp;Ke Xue,&nbsp;Yong Cui","doi":"10.1002/clt2.70179","DOIUrl":"10.1002/clt2.70179","url":null,"abstract":"<p>Atopic dermatitis (AD) is a complex chronic inflammatory skin disease driven by skin barrier dysfunction, immune dysregulation, and microbial imbalance. Traditional sampling methods, such as biopsies and blood collection, have provided valuable pathophysiological insights. However, their invasiveness, associated discomfort, and limitations for repeated sampling have constrained a dynamic understanding of disease progression and treatment responses. In recent years, skin tape stripping (STS) has emerged as a minimally invasive or even non-invasive technique that addresses these limitations. STS enables the collection of corneocytes and upper granular layer cells from the epidermis, and when combined with high-throughput multi-omics technologies, such as RNA sequencing, proteomics, lipidomics, and metatranscriptomics, it provides a powerful platform to dissect the molecular mechanisms of AD, identify novel biomarkers, and facilitate stratification in precision medicine approaches.</p>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"16 6","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of Mixed Inflammatory Environment in Nasal Secretions of Diffuse Type 2 Chronic Rhinosinusitis With Nasal Polyps Under Dupilumab","authors":"Fabio S. Ryser,&nbsp;Tina Mauthe,&nbsp;Catrin Brühlmann,&nbsp;Michael B. Soyka,&nbsp;Urs C. Steiner","doi":"10.1002/clt2.70180","DOIUrl":"10.1002/clt2.70180","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In Western countries, Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is predominantly associated with a type 2 inflammatory endotype. While nasal secretion analysis shows promise for disease endotyping, current biomarkers remain limited for accurate stratification, disease monitoring, and prediction of treatment response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to investigate the inflammatory patterns in nasal secretions of patients with type 2 Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) undergoing treatment with dupilumab, an anti-IL4Rα antibody. A second objective was to evaluate markers for therapy response and monitoring.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Nasal secretions and blood samples were collected at four time points from 23 patients with histological type 2 CRSwNP undergoing dupilumab treatment and compared with 10 healthy controls. Samples were analysed using proximity extension assay method by Olink.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Proteomic analysis of nasal secretions revealed 50 differentially expressed proteins in type 2 CRSwNP compared to healthy controls. Nasal secretions of most patients revealed a mixed inflammatory endotype. Under dupilumab treatment, cytokines of all different endotypes decreased. The cytokines with the highest mean change (MCP-4, CCL23, GDNF and CCL11) showed good associations with clinical variables and were effective predictors of dupilumab response and disease control.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The inflammatory environment of the nasal mucosa in histological type 2 CRSwNP is most often characterized by a mixed type 1, 2, and 3 inflammatory endotype. Targeting type 2 inflammation with dupilumab reduces inflammation markers of all three types of inflammation. GDNF has emerged as a valuable marker for stratifying therapy and monitoring success in type 2 CRSwNP under dupilumab treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"16 6","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programmed Cell Death in Chronic Rhinosinusitis","authors":"Xingchen Liu,&nbsp;Junying Hu,&nbsp;Weigang Gan,&nbsp;Qi Wu,&nbsp;Bing Zhong,&nbsp;Feng Liu","doi":"10.1002/clt2.70175","DOIUrl":"10.1002/clt2.70175","url":null,"abstract":"<p>Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological mechanisms underlying CRS. Studies suggest that these PCD pathways not only influence the disease's progression but may also serve as novel therapeutic targets. Thus, gaining a thorough understanding of how PCD contributes to CRS is crucial for elucidating its pathogenesis and developing new treatment strategies. This article aims to investigate the mechanisms of PCD in CRS, examining its effects on disease progression and potential implications for treatment. We will begin by discussing the background of CRS and its underlying processes, followed by an exploration of the roles played by various types of PCD in CRS, and conclude with a discussion on future research directions and their practical applications.</p>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"16 6","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of PEN-FAST and CEPH-FAST for Cephalosporin Allergy Delabeling.","authors":"Deniz Göcebe, Hannah Nürnberg, Alexander Enk, Elham Khatamzas, Knut Schäkel","doi":"10.1002/clt2.70178","DOIUrl":"10.1002/clt2.70178","url":null,"abstract":"<p><strong>Background: </strong>Unverified antibiotic allergy labels lead to suboptimal antimicrobial prescribing and increased antibiotic resistance. Cephalosporins are among the most frequently administered antibiotics and cephalosporin allergy labels increasingly limit optimal therapy. Clinical decision rules that enable delabeling of low-risk patients by non-allergists are emerging as important tools. The PEN-FAST score is a validated rule for identifying low-risk penicillin allergy labels suitable for direct drug challenge. CEPH-FAST is a recently proposed adaptation for cephalosporin allergy. We evaluated the diagnostic performance of PEN-FAST and CEPH-FAST for cephalosporin allergy.</p><p><strong>Methods: </strong>In this single-center retrospective cohort study, 100 adults with reported cephalosporin allergy labels underwent allergy assessment including skin testing and drug provocation testing at a tertiary allergy clinic in Heidelberg, Germany. Logistic regression was used to identify predictors of confirmed allergy. Diagnostic performance of PEN-FAST and CEPH-FAST scores was assessed using sensitivity, specificity, predictive values, and area under the receiver operating curve (AU-ROC).</p><p><strong>Results: </strong>Cephalosporin allergy was confirmed in 48 of 100 patients. PEN-FAST categorized 20 patients at low risk, of whom one had a positive skin test (NPV 95.0%, sensitivity 97.9%, AU-ROC 0.769). CEPH-FAST classified 42 patients low-risk, but 12 had confirmed allergies (NPV 71.4%, sensitivity 75.0%, AU-ROC 0.667). Higher PEN-FAST and CEPH-FAST scores were significantly associated with confirmed allergy.</p><p><strong>Conclusion: </strong>PEN-FAST demonstrated high sensitivity and negative predictive value for identifying low-risk cephalosporin allergy and may support safe delabeling strategies. In contrast, CEPH-FAST showed reduced diagnostic performance in this cohort, highlighting the need for further validation before routine clinical implementation.</p>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"16 6","pages":"e70178"},"PeriodicalIF":4.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13239963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"16 6","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148096166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}