Clinical and Translational Allergy最新文献

{"title":"Cost-of-illness analysis of chronic urticaria clinical management in five countries of Latin America","authors":"Jorge Sánchez,&nbsp;Leidy Álvarez,&nbsp;José Ignacio Larco,&nbsp;Luis Ensina,&nbsp;Guillermo Guidos-Fogelbach,&nbsp;Cesar A. Reyes-López,&nbsp;German D. Ramon,&nbsp;Karla Robles-Velasco,&nbsp;Ivan Cherrez-Ojeda","doi":"10.1002/clt2.70016","DOIUrl":"10.1002/clt2.70016","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Chronic spontaneous urticaria (CSU) is a disease with a high impact on the quality of life of patients. There are some evaluations of the economic cost of the disease in developed countries, but there is little information about the economic cost of the disease in developing countries. Our aim was to assess the economic diagnostic and therapeutic expenses of CSU in five Latin American (LA) countries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A noninterventional multicenter cross-sectional study was conducted in five LA countries: Brazil, Colombia, Ecuador, Mexico, and Peru. To determine the frequency of medical interventions as well as clinical and sociodemographic characteristics of CSU patients, questionnaires were administered to patients, primary care physicians, allergists, and dermatologists. In each country, diagnostics and therapeutic expenses were calculated by reviewing medical records, health insurance, and interviews. The main outcome was the yearly economic burden from the healthcare insurance perspective in each country.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>According to the projected costs, Brazil had the highest urticaria cost per patient/year (7009.4 USD), followed by Mexico (3695.1 USD), Ecuador (3132.8 USD), Peru (2693.9 USD), and Colombia (2392.8 USD); the cost and the frequency of use of omalizumab and antihistamines explain the total cost differences between countries. Interventions such as medical visits and exams had similar costs between countries and represented less than 10% of total urticaria cost analysis in the five countries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The cost of the CSU in LA varies widely based on the health insurance coverage, the cost of the therapies, and the frequency of therapies used. Strengthening national health systems, as well as following the recommendations of international guidelines, seems to reduce the cost of CSU and improve the quality of patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a common approach for managing food allergy and serious allergic reactions (anaphylaxis) at school. GA2LEN and EFA consensus statement","authors":"Antoine Deschildre,&nbsp;Montserrat Alvaro-Lozano,&nbsp;Antonella Muraro,&nbsp;Marcia Podesta,&nbsp;Debra de Silva,&nbsp;Mattia Giovannini,&nbsp;Simona Barni,&nbsp;Timothy E. Dribin,&nbsp;Mónica Sandoval-Ruballos,&nbsp;Aikaterini Anagnostou,&nbsp;Alessandro Fiocchi,&nbsp;Alice Toniolo,&nbsp;Andrew Bird,&nbsp;Angel Sánchez Sanz,&nbsp;Anna Asarnoj,&nbsp;Anna Nowak-Wegrzyn,&nbsp;Berber Vlieg-Boerstra,&nbsp;Brian P. Vickery,&nbsp;Carina Venter,&nbsp;Caroline Nilsson,&nbsp;Cecilia Parente,&nbsp;Céline Demoulin,&nbsp;David M. Fleischer,&nbsp;Diola Bijlhout,&nbsp;Edward F. Knol,&nbsp;Eleanor Garrow,&nbsp;Emma E. Cook,&nbsp;Fallon Schultz,&nbsp;Francesca Lazzarotto,&nbsp;Francesca Mori,&nbsp;Gary Wong,&nbsp;Gideon Lack,&nbsp;Graham Roberts,&nbsp;Gustavo Andres Marino,&nbsp;H. N. G. Oude Elberink,&nbsp;Helen A. Brough,&nbsp;Hugh A. Sampson,&nbsp;Jay Lieberman,&nbsp;Jennifer Gerdts,&nbsp;Jing Zhao,&nbsp;Josefine Gradman,&nbsp;Julia E. M. Upton,&nbsp;Julie Wang,&nbsp;Kati Palosuo,&nbsp;Kirsi M. Järvinen,&nbsp;Kirsten Beyer,&nbsp;Kunling Shen,&nbsp;Laura Polloni,&nbsp;Lianne Mandelbaum,&nbsp;Luciana Kase Tanno,&nbsp;Lucy A. Bilaver,&nbsp;Marcus S. Shaker,&nbsp;Margitta Worm,&nbsp;Maria Said,&nbsp;Mary Kelly,&nbsp;Mary Jane Marchisotto,&nbsp;Michael Makris,&nbsp;Mikaela Odemyr,&nbsp;Montserrat Fernandez-Rivas,&nbsp;Motohiro Ebisawa,&nbsp;Nandinee Patel,&nbsp;Pablo Rodríguez del Río,&nbsp;Pakit Vichyanond,&nbsp;Paul Turner,&nbsp;Pete Smith,&nbsp;Pilar Morón Gaspar,&nbsp;R. Sharon Chinthrajah,&nbsp;Rima Rachid,&nbsp;Roberta Bonaguro,&nbsp;Ruchi Gupta,&nbsp;Sabine Schnadt,&nbsp;Sakura Sato,&nbsp;Stefania Arasi,&nbsp;Stephanie Leonard,&nbsp;Sung Poblete,&nbsp;Susanne Halken,&nbsp;Thuy-My Le,&nbsp;Guillaume Pouessel,&nbsp;Tracey Dunn,&nbsp;Victoria Cardona,&nbsp;Torsten Zuberbier","doi":"10.1002/clt2.70013","DOIUrl":"https://doi.org/10.1002/clt2.70013","url":null,"abstract":"<p>GA²LEN and EFA propose minimum specifications for all industrialised countries/regions to work towards to support students with food allergies in educational settings. We reviewed research and legislation and gained feedback from over 100 patient and professional groups. We built shared expectations around: 1. training all school staff about what food allergy is, the symptoms of allergic reactions, what to do in an emergency, and when and how to use and store devices that laypeople can use to administer adrenaline (epinephrine). 2. preventing allergic reactions by using clear labelling on school menus and prepacked and non-prepacked foods and regular cleaning where students eat. 3. preparing for serious allergic reactions, with written emergency action plans for every student with food allergies, legislation allowing schools to store adrenaline for anyone who needs it in an emergency (not just those prescribed it), and training and legal safeguards for staff administering adrenaline. 4. including affected students by discussing food allergy in the curriculum, raising awareness among all students and caregivers and reviewing school processes regularly. It is time for national and international action at the policy level. Patient groups, education networks and professional societies all play a role in campaigning for shared next steps.</p>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients with detectable KIT p.D816V in peripheral blood are at high risk for adverse systemic events during venom immunotherapy and treatment failure","authors":"Ajda Demšar Luzar,&nbsp;Jakob Otorepec,&nbsp;Mitja Košnik,&nbsp;Peter Kopač,&nbsp;Julij Šelb,&nbsp;Peter Korošec,&nbsp;Matija Rijavec","doi":"10.1002/clt2.70019","DOIUrl":"https://doi.org/10.1002/clt2.70019","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Recent studies have highlighted the importance of routine screening for the somatic missense <i>KIT</i> p.D816V variant in peripheral blood leukocytes (PBL), and its association with severe sting anaphylaxis. Our study aimed to evaluate the clinical relevance of <i>KIT</i> p.D816V detected in PBL on systemic adverse events (SAEs) and the efficacy of venom immunotherapy (VIT).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 839 patients receiving VIT. The <i>KIT</i> p.D816V variant was assayed with a highly sensitive, allele-specific, quantitative PCR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p><i>KIT</i> p.D816V was detected in the PBL of 125 (15%) of 839 VIT patients. The majority (70%, 88/125) of these individuals had normal BST levels. Notably, half of the <i>KIT</i>-positive patients receiving honeybee venom immunotherapy had SAEs during treatment (48%, 18/37; <i>p</i> = 0.0136), and the <i>KIT</i> p.D816V allele burden was higher than 0.01% in the majority of those patients (61%, 11/18). Furthermore, a significant difference was observed between <i>KIT</i>-positive and <i>KIT</i>-negative patients treated with VIT in the past and who experienced a recurrent reaction to a sting after treatment termination (VIT failure). <i>KIT</i>-positive patients with VIT failure had a higher allele burden than those with successful VIT (80% vs. 40% with a <i>KIT</i> p.D816V higher than 0.01%; <i>p</i> = 0.0019). <i>KIT</i> p.D816V was a predictor of SAEs during honeybee VIT (univariate; OR = 2.43, <i>p</i> = 0.012/multivariate; OR = 2.26, <i>p</i> = 0.033) and a strong predictor of VIT failure in patients treated with wasp venom (univariate; OR = 4.1, <i>p</i> = 0.002/multivariate; OR = 3.54, <i>p</i> = 0.008).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our study revealed the high clinical relevance of <i>KIT</i> p.D816V detected in PBL. <i>KIT</i> p.D816V was a significant predictor of SAEs during honeybee VIT and a significant predictor of VIT failure after completing wasp VIT.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unique effect of aspirin on local 15-oxo-eicosatetraenoic acid synthesis in asthma patients with aspirin hypersensitivity","authors":"Piotr Szatkowski,&nbsp;Anna Gielicz,&nbsp;Adam Stępień,&nbsp;Patryk Hartwich,&nbsp;Radosław Kacorzyk,&nbsp;Hanna Plutecka,&nbsp;Adam Ćmiel,&nbsp;Gabriela Trąd-Wójcik,&nbsp;Marek Sanak,&nbsp;Lucyna Mastalerz","doi":"10.1002/clt2.70004","DOIUrl":"10.1002/clt2.70004","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Nonsteroidal anti-inflammatory drugs–exacerbated respiratory disease (NSAIDs-ERD) is characterized by altered arachidonic acid (AA) metabolism. Aspirin hypersensitivity is diagnosed using aspirin challenge, while induced sputum is collected to perform cell counts and to identify local biomarkers in induced sputum supernatant (ISS). This study aimed to assess the levels of a newly identified eicosanoid, 15-oxo-eicosatetraenoic acid (15-oxo-ETE), in ISS at baseline and during aspirin-induced bronchospasm in patients with NSAIDs-ERD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Oral aspirin challenge was performed in 27 patients with NSAIDs-ERD and in 17 patients with aspirin-tolerant asthma (ATA) serving as controls. Sputum was collected before and after aspirin challenge to determine eosinophil, neutrophil, macrophage, and lymphocyte counts as well as the concentration of AA metabolites via 15-lipoxygenase-1 (15-LOX-1) and 5-LOX pathways in ISS. Chromatography–tandem mass spectrometry was used to measure ISS levels of 15-oxo-ETE, 15-hydroxyeicosatetranoic acid (15-HETE), and leukotriene E₄ (LTE₄).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At baseline, ISS levels of 15-oxo-ETE were higher in NSAIDs-ERD than in ATA (<i>p</i> = 0.04). In contrast, baseline 15-HETE levels in ISS were lower in patients with NSAIDs-ERD (<i>p</i> = 0.03). After aspirin challenge, 15-oxo-ETE levels decreased only in patients with NSAIDs-ERD (<i>p</i> = 0.001) who developed bronchospasm. In both study groups, there was a reduction in sputum macrophage count after aspirin challenge (<i>p</i> = 0.03 and <i>p</i> = 0.02, respectively) irrespective of bronchospasm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patients with NSAIDs-ERD are characterized by higher baseline 15-oxo-ETE levels in ISS than patients with ATA. Aspirin-induced bronchospasm inhibited the local generation of 15-oxo-ETE.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 12","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of eosinophil counts in mediating the association between asthma and colon cancer","authors":"Zhi-Qing Zhan,&nbsp;Ze-Min Huang,&nbsp;Zhi-Xin Xie,&nbsp;Hao-Bin Zhou,&nbsp;Yu-Hua Luo,&nbsp;Pei-Zhen Chen,&nbsp;Tian-Ye Luo,&nbsp;Baoqing Sun,&nbsp;Zhangkai J. Cheng","doi":"10.1002/clt2.70012","DOIUrl":"10.1002/clt2.70012","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Epidemiological findings regarding the association between asthma and the risk of colon cancer (CC) are inconsistent. The causality and potential molecular mechanisms underlying asthma, eosinophil count, and CC remain unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed Mendelian randomization (MR) analysis to investigate the causality between asthma and CC and attempted to demonstrate that asthma indirectly affects CC mediated by eosinophil count through mediation analysis. Sensitivity analyses and multivariable MR were performed to test the robustness of our findings. Multiple bioinformatics tools were applied to further investigate the underlying mechanisms related to eosinophils that contribute to the pathogenesis of both asthma and CC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MR with mediation analyses suggested that eosinophil count may play a role in the mechanism through which asthma reduces the risk of CC. Our bioinformatic analyses identified PPP1R14A as a potential therapeutic target and an eosinophil-associated biomarker for CC patients. Higher expression of PPP1R14A may be associated with a poorer prognosis in CC patients. Additionally, the lysosome pathway emerges as a shared eosinophil-related pathway in both asthma and CC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Eosinophils may contribute to a lower risk of CC in patients with asthma. PPP1R14A is a potential therapeutic target and biomarker for CC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 12","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifetime asthma incidence is related to age at onset and allergies in western Sweden","authors":"Reshed Abohalaka,&nbsp;Selin Ercan,&nbsp;Lauri Lehtimäki,&nbsp;Linda Ekerljung,&nbsp;Helena Backman,&nbsp;Fatma Zehra Uslu,&nbsp;Saliha Selin Ozuygur Ermis,&nbsp;Madeleine Rådinger,&nbsp;Bright I. Nwaru,&nbsp;Hannu Kankaanranta","doi":"10.1002/clt2.70015","DOIUrl":"10.1002/clt2.70015","url":null,"abstract":"<p>Although asthma is more frequently diagnosed in childhood, a substantial proportion of cases manifests in adulthood. Nonetheless, few studies have comprehensively examined asthma incidence across different ages, genders, and asthma phenotypes. We conducted a retrospective evaluation of asthma incidence from birth to late adulthood, stratified by age, gender, and the presence or absence of allergies. Our analysis indicates that a significant number of asthma cases emerged in adulthood, particularly among middle-aged women, with adult-onset asthma surpassing childhood-onset asthma after the age of 35 years. Additionally, allergic asthma was more common in younger than older individuals but decreases with age, ultimately leading to a higher proportion of non-allergic asthma in older than younger individuals. These findings underscore the predominance of adult-onset asthma among females and confirm the majority of allergic asthma in children, which declines with age. Additionally, increasing age is associated with increased incidence of non-allergic asthma. Asthma heterogeneity should be considered in both clinical management and research.</p>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 12","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"M2 macrophage derived HMOX1 defines chronic rhinosinusitis with nasal polyps","authors":"Enhao Wang,&nbsp;Yanghe Hao,&nbsp;Jing Song,&nbsp;Jing Yuan,&nbsp;Yu Hong,&nbsp;Ying Li,&nbsp;Yang Wang,&nbsp;Chengshuo Wang,&nbsp;Ming Wang,&nbsp;Luo Zhang","doi":"10.1002/clt2.70014","DOIUrl":"10.1002/clt2.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Molecular signatures of chronic rhinosinusitis with nasal polyps (CRSwNP) related to macrophages remain unclear. This study aimed to develop a macrophage-associated diagnostic signature for CRSwNP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Transcriptome data from 54 patients with CRSwNP and 37 healthy controls across GSE136825, GSE36830, and GSE72713 were used to identify differentially expressed genes (DEGs) between two groups. Gene Set Enrichment Analysis and Weighted Gene Co-Expression Network Analysis pinpointed crucial pathways and gene clusters. A diagnostic model was created from these analyses and receiver operating characteristic curve (ROC), and further validated in our transcriptome data from 29 samples. Immune cell infiltration analysis was performed and linked those diagnostic genes to macrophages and verified by single-cell RNA sequencing data. Immunofluorescence co-staining of CD163 and HMOX1 was performed in nasal tissues. Mouse bone marrow-derived macrophage (BMDMs) cultures were used in functional experiments. Correlations between the expression of HMOX1 and eotaxin genes were investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>DEGs of CRSwNP versus control group were enriched in the INTERLEUKIN_4_AND_13_SIGNALING pathways. A four-gene diagnostic model (HMOX1, ALOX5, F13A1 and ITGB2) was developed and demonstrated high diagnostic precision with an area under ROC curve of 0.980 for training dataset and 0.895 for test dataset. M2 macrophage presence and HMOX1 expression significantly correlated with CRSwNP (<i>p</i> &lt; 0.001). Single-cell RNA sequencing data underscored the altered cellular composition in CRSwNP, with HMOX1 notably expressed in M2 macrophages. Immunofluorescence staining highlighted the increased infiltration of CD163+ M2 macrophages in nasal mucosa samples of eosinophilic CRSwNP, which correlated with HMOX1 protein levels (<i>p</i> &lt; 0.05). The HMOX1 inhibitor zinc protoporphyrin reduced the ratio of CD163 + HMOX1 + M2 macrophages in mouse BMDM cultures (<i>p</i> &lt; 0.05). HMOX1 expression showed a strong positive correlation with the expression of eotaxin genes (CCL11, CCL24, and CCL26; <i>p</i> &lt; 0.05 respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>M2 macrophage-derived HMOX1 can be used as an innovative diagnostic signature for CRSwNP, which might be a potential regulator of eosinophilic inflammation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 12","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10 practical priorities to prevent and manage serious allergic reactions: GA2LEN ANACare and EFA Anaphylaxis Manifesto","authors":"Antonella Muraro,&nbsp;Debra de Silva,&nbsp;Marcia Podesta,&nbsp;Aikaterini Anagnostou,&nbsp;Victoria Cardona,&nbsp;Susanne Halken,&nbsp;Pete Smith,&nbsp;Luciana Kase Tanno,&nbsp;Paul Turner,&nbsp;Margitta Worm,&nbsp;Montserrat Alvaro-Lozano,&nbsp;Stefania Arasi,&nbsp;Anna Asarnoj,&nbsp;Simona Barni,&nbsp;Kirsten Beyer,&nbsp;Lucy A. Bilaver,&nbsp;Andrew Bird,&nbsp;Roberta Bonaguro,&nbsp;Helen A. Brough,&nbsp;R. Sharon Chinthrajah,&nbsp;Emma E. Cook,&nbsp;Céline Demoulin,&nbsp;Antoine Deschildre,&nbsp;Timothy E. Dribin,&nbsp;Motohiro Ebisawa,&nbsp;Montserrat Fernandez-Rivas,&nbsp;Alessandro Fiocchi,&nbsp;David M. Fleischer,&nbsp;Eleanor Garrow,&nbsp;Jennifer Gerdts,&nbsp;Mattia Giovannini,&nbsp;Kirsi M. Järvinen,&nbsp;Mary Kelly,&nbsp;Edward F. Knol,&nbsp;Gideon Lack,&nbsp;Francesca Lazzarotto,&nbsp;Thuy-My Le,&nbsp;Stephanie Leonard,&nbsp;Jay Lieberman,&nbsp;Michael Makris,&nbsp;Lianne Mandelbaum,&nbsp;Mary Jane Marchisotto,&nbsp;Gustavo Andres Marino,&nbsp;Francesca Mori,&nbsp;Caroline Nilsson,&nbsp;Anna Nowak-Wegrzyn,&nbsp;Mikaela Odemyr,&nbsp;H. N. G. Oude Elberink,&nbsp;Kati Palosuo,&nbsp;Nandinee Patel,&nbsp;Jennifer Pier,&nbsp;Sung Poblete,&nbsp;Rima Rachid,&nbsp;Pablo Rodríguez del Río,&nbsp;Maria Said,&nbsp;Hugh A. Sampson,&nbsp;Angel Sánchez Sanz,&nbsp;Sabine Schnadt,&nbsp;Fallon Schultz,&nbsp;Alice Toniolo,&nbsp;Julia E. M. Upton,&nbsp;Carina Venter,&nbsp;Brian P. Vickery,&nbsp;Berber Vlieg-Boerstra,&nbsp;Julie Wang,&nbsp;Graham Roberts,&nbsp;Torsten Zuberbier,&nbsp;GA2LEN ANACare Centres and EFA","doi":"10.1002/clt2.70009","DOIUrl":"10.1002/clt2.70009","url":null,"abstract":"<p>This Anaphylaxis Manifesto calls on communities to prioritise 10 practical actions to improve the lives of people at risk of serious allergic reactions. The Global Allergy and Asthma European Network and the European Federation of Allergy and Airways Diseases Patients' Associations (EFA) compiled patient-centric priorities. We used qualitative consensus methods, research evidence and feedback from over 200 patient groups, stakeholder organisations and healthcare professionals. We encourage healthcare, education and food organisations to collaborate with people at risk of serious allergic reactions to tackle safety, anxiety and financial burdens for individuals and societies. Key priorities for prevention include awareness-raising campaigns for the public and professionals, school and workplace initiatives and mandatory precautionary allergen labels on food. Priorities for improving immediate and long-term management include educating healthcare professionals, patients and schools about when and how to use adrenaline, funding two approved adrenaline devices for everyone at risk, and facilitating access to allergy specialists. Integrated care pathways should include clinical and non-clinical management options such as individualised risk assessment and quality of life assessment, self-management plans, dietetic and psychosocial support and peer support. Organisations around the world are committing to work together towards these priorities.</p>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 12","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity predicts mortality stronger in adult-onset asthma than in age- and sex-matched controls","authors":"Helena Backman,&nbsp;Caroline Stridsman,&nbsp;Anne Lindberg,&nbsp;Eva Rönmark,&nbsp;Linnea Hedman","doi":"10.1002/clt2.70011","DOIUrl":"https://doi.org/10.1002/clt2.70011","url":null,"abstract":"&lt;p&gt;To the Editor,&lt;/p&gt;&lt;p&gt;Several studies have shown that being obese is associated with an increased risk of developing asthma, especially adult-onset asthma, as well as more severe asthma symptoms.&lt;span&gt;&lt;sup&gt;1, 2&lt;/sup&gt;&lt;/span&gt; Obesity can affect the respiratory system in several ways. Excess body fat can mechanically lead to a decrease in lung volume, which can make breathing more difficult. Obesity is also associated with a state of chronic low-grade inflammation,&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; which can contribute to the development of asthma and exacerbate asthma symptoms.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; In addition, obesity can lead to changes in the structure and function of the airways that make them more susceptible to inflammation and cause obstruction.&lt;span&gt;&lt;sup&gt;1, 4&lt;/sup&gt;&lt;/span&gt; Obesity associates with mortality both in the general population and among adults with asthma,&lt;span&gt;&lt;sup&gt;1, 3, 5&lt;/sup&gt;&lt;/span&gt; but most studies in adults are done by stratifying population-samples by presence and absence of asthma and thus with often slightly different age and more women in those with asthma.&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; Less is known about whether the obesity-mortality association is stronger in adult-onset asthma than in adults without asthma when taking age and sex into account.&lt;/p&gt;&lt;p&gt;In this hypothesis-generating study, we aimed to explore the association between obesity and mortality in patients with adult-onset asthma compared to age- and sex-matched controls.&lt;/p&gt;&lt;p&gt;During 1995–1999, 309 adults (19–61 years, 65% women) with newly onset asthma were identified in primary care and referred to the Obstructive Lung Disease in Northern Sweden (OLIN) Studies where a diagnosis of asthma and bronchial variability was confirmed.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; &lt;i&gt;N&lt;/i&gt; = 309 sex- and age-matched controls without asthma were also included. Body mass index (BMI, kg/m&lt;sup&gt;2&lt;/sup&gt;) at baseline was categorized into normal weight (BMI 20–24.9), underweight (BMI &lt; 20), overweight (BMI 25–29.9) and obesity (BMI ≥ 30). Based on the unique Swedish personal identity numbers, mortality data was linked until November 2023. Person-years were calculated as the number of years from baseline examination to death or November 2023, whichever occurred first. Means were compared across groups using &lt;i&gt;T&lt;/i&gt;-test or ANOVA, while the Chi-squared test was used to compare proportions, as appropriate. Statistical significance was set at &lt;i&gt;p&lt;/i&gt; &lt; 0.05. Cox proportional hazards regression was used to calculate hazard ratios (HR) for BMI categories (normal weight as reference) adjusted for smoking habits, age and sex, separately among cases and controls.&lt;/p&gt;&lt;p&gt;The mean age at baseline was 37 years, and there were 48% non-smokers, 31% former smokers, and 21% current smokers among the cases, compared to 53%, 22% and 25% in controls. There were more individuals with obesity in cases versus in controls (16% vs. 9%, &lt;i&gt;p&lt;/i&gt; &lt; 0.001) (Figure 1A,B). The cumulative mortality was &lt;i&gt;n&lt;/i&gt; = 27 (9%) i","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 12","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the reliability of the FricTest® 4.0 for diagnosing symptomatic dermographism","authors":"Annika Gutsche,&nbsp;Martin Metz,&nbsp;Melba Munoz,&nbsp;Kit Wong,&nbsp;Ted Omachi,&nbsp;Rui Zhao,&nbsp;Marcus Maurer,&nbsp;Vasiliki Zampeli,&nbsp;Markus Magerl","doi":"10.1002/clt2.70005","DOIUrl":"10.1002/clt2.70005","url":null,"abstract":"&lt;p&gt;To the Editor,&lt;/p&gt;&lt;p&gt;Symptomatic dermographism (SD), a common subtype of chronic inducible urticaria (CIndU), involves transient, strip-shaped wheals that itch and burn when the skin is stroked or scratched.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; SD affects ≥0.5% of the population,&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; yet despite its high frequency and marked impact on quality of life, diagnostic tools and treatment options are limited.&lt;span&gt;&lt;sup&gt;1, 3&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Diagnosis is based on the patient's medical history and provocation testing.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Historically, provocation testing used a smooth, blunt object to stroke the skin, but variations in individuals' disease presentation highlighted the need for validated, reproducible tools.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; The FricTest®4.0&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; is a hand-held, flat plastic comb-like tool with four smooth pins (3.0–4.5 mm long) firmly stroked along the skin. The resulting wheals determine the critical friction threshold (CFT), the shortest pin length/minimum pressure that elicits a positive wheal response.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;This study aimed to assess the reliability (reproducibility and repeatability) of FricTest inter-rater agreement (results from two different raters on the same patient at the same visit) and intra-rater agreement (results from the same rater on the same patient 7–14 days apart). Reliable results are important for monitoring treatment effects, helping patients understand triggers, and improving management. We assume that each patient's left and right forearms are the same, that visits are the same, and that previous provocation did not affect the reaction of subsequent tests.&lt;/p&gt;&lt;p&gt;This single-center study was conducted at the Urticaria Center of Reference and Excellence&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; at the Charité Hospital, Berlin, Germany. Adults had SD for &gt;6 weeks, had active SD at enrollment, and gave written informed consent. The study followed the Declaration of Helsinki principles, and the Berlin Charité Ethics Committee approved the protocol.&lt;/p&gt;&lt;p&gt;The primary endpoint, inter-rater agreement, was the intraclass correlation coefficient (ICC) between the CFT assessments of two raters within the same patient. The CFT scale is 0–4 (0 = no response, 4 = maximum response). ICCs plus upper and lower 95% confidence intervals (CI) were calculated using a mixed-effects linear model methodology.&lt;span&gt;&lt;sup&gt;7&lt;/sup&gt;&lt;/span&gt; Rater A and B agreement was quantified using weighted kappa across four categories: left forearm, right forearm, Visit 1, and Visit 2. An ICC&lt;0.4 indicated poor reliability, and 0.6–0.8 indicated substantial reliability.&lt;/p&gt;&lt;p&gt;Two raters randomized to the order of assessments (Forearm 1 [right], Forearm 2 [left]) administered and recorded all FricTest results. At Visit 1, Rater A applied the FricTest to Forearm 1, covered the arm, and left the room. Rater B then applied the FricTest to Forearm 2, covered the arm, and left the room. Ten minutes af","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 11","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}