Clinical Case Reports最新文献

{"title":"Prevalence of Rare Diseases in Consanguineous Marriages: A Case of Ullrich Muscular Dystrophy in a Resource-Limited Setting.","authors":"Kanza Farhan, Muhammad Burhan Tariq, Amna Farhan, Erma Khalid, Suhaira Hafeez Syed, Mohammed Hammad Jaber Amin","doi":"10.1002/ccr3.73658","DOIUrl":"10.1002/ccr3.73658","url":null,"abstract":"<p><p>In regions with high consanguinity, rare recessive disorders like Ullrich congenital muscular dystrophy (UCMD) may present at birth with hypotonia and respiratory distress. To enhance quality of life and prevent recurrence in future pregnancies, early recognition, genetic counseling, and care from a multidisciplinary team of specialists are essential.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73658"},"PeriodicalIF":0.6,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Pancreatitis Presenting With ST-Segment Elevation and Marked Troponin Elevation: A Diagnostic Dilemma in a Resource-Limited Setting-A Case Report.","authors":"Selamawit Kassahun Aweke, Natnael Mathewos Assale, Anteneh Girma Mengistu, Nathanael Elias Temesgen, Eden Fanta Amajo, Saron Yohannes Tsegaye, Merahi Kefyalew Merahi","doi":"10.1002/ccr3.73716","DOIUrl":"https://doi.org/10.1002/ccr3.73716","url":null,"abstract":"<p><p>Acute pancreatitis can present with ST-segment elevation and marked troponin elevation, mimicking acute coronary syndrome. In resource-limited settings where coronary angiography, cardiac magnetic resonance imaging, and serial high-sensitivity troponin testing are unavailable, distinguishing acute myocardial injury associated with pancreatitis from Type 1 myocardial infarction can be challenging.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73716"},"PeriodicalIF":0.6,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Clinical and Radiographic Outcomes of Large Periapical Lesions Managed by Non-Surgical and Surgical Endodontic Treatment: A Case Series.","authors":"Mohsen Aminsobhani, Maryam Babaahmadi, Razieh Amiri, Maryam Habibzadeh, Nazanin Kamali","doi":"10.1002/ccr3.73727","DOIUrl":"https://doi.org/10.1002/ccr3.73727","url":null,"abstract":"<p><p>The management of large periapical lesions is challenging, as lesion size alone does not predict treatment outcome or mandate surgery. This case series presents three large periapical lesions with 4- to 12-year follow-up, illustrating different therapeutic pathways. Two cases (mandibular canine/premolar and maxillary lateral incisor) resolved with non-surgical treatment, achieving radiographic healing at 12-year and 5-year follow-ups, respectively; the lesion in Case 1 persisted at 2 years but resolved by 12 years. The third case (maxillary lateral incisor with sinus tract and swelling) failed non-surgical retreatment, requiring periradicular surgery with MTA, resulting in complete healing at 4 years. All cases achieved Periapical Index scores of 2. This series demonstrates that non-surgical management remains first-line, but persistent symptoms, sinus tracts, or lack of radiographic improvement at 1 year should prompt surgery. Long-term follow-up is essential to distinguish delayed healing from true failure.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73727"},"PeriodicalIF":0.6,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing A Stepwise Anatomic Framework for Urogenital Reconstruction Derived From Orofacial Plastic Surgery Principles: A Case Report.","authors":"Lynn Damitz, Mohammadamin Parsaei, Denniz Zolnoun","doi":"10.1002/ccr3.73696","DOIUrl":"https://doi.org/10.1002/ccr3.73696","url":null,"abstract":"<p><p>We present a novel labial reconstruction technique in a 48-year-old woman with extensive bilateral labial defects caused by steatocystoma multiplex. An anatomy-guided, stepwise approach integrating scalp and orofacial reconstructive principles enabled successful restoration using a rhomboid mucocutaneous flap, minimizing tissue tension while preserving neurovascular continuity, function, and aesthetics.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73696"},"PeriodicalIF":0.6,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Previously Unrecognized Tracheobronchopathia Osteochondroplastica Diagnosed Following Unexpected Difficult Tracheal Intubation During Robotic Surgery: A Case Report and Literature Overview\".","authors":"","doi":"10.1002/ccr3.73702","DOIUrl":"https://doi.org/10.1002/ccr3.73702","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1002/ccr3.73504.].</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73702"},"PeriodicalIF":0.6,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External Iliac Arteriovenous Fistula Caused by Stab Wound.","authors":"Takayuki Kai, Ryusuke Katsuki, Dai Oishi, Takayuki Irahara, Masanobu Tsuda, Eizo Watanabe","doi":"10.1002/ccr3.73691","DOIUrl":"https://doi.org/10.1002/ccr3.73691","url":null,"abstract":"<p><p>Major abdominal arteriovenous fistula (AVF), including external iliac vessels, is a rare condition. If untreated long term, AVFs may cause venous hypertension and heart failure. We report the case of a 47-year-old man who stabbed his left lower abdomen. His vital signs were stable. Computed tomography revealed hemoperitoneum and a left external iliac AVF. Prior to laparotomy, endovascular repair of AVF was performed. Subsequent laparotomy was performed, and omental injury and a small bowel injury were repaired. Exploration of the retroperitoneal hematoma showed no bleeding from the external iliac vessels. The patient was discharged on day 6. In the management of retroperitoneal hematoma after penetrating trauma, laparotomy has been recommended. Among hemodynamically stable patients with stab wounds and traumatic external iliac AVF, endovascular intervention may be considered prior to laparotomy. Further investigations are required to reveal the long-term safety and durability of a covered stent for traumatic AVFs.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73691"},"PeriodicalIF":0.6,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated Blastomycosis With Pulmonary, Cutaneous, and Splenic Involvement in a Construction Worker: A Case Report.","authors":"Toan N Vu, Nilay Kumar","doi":"10.1002/ccr3.73710","DOIUrl":"https://doi.org/10.1002/ccr3.73710","url":null,"abstract":"<p><p>Blastomycosis is a systemic fungal infection that is caused by <i>Blastomyces dermatitidis</i> or <i>Blastomyces gilchristii</i>. Although the lungs are the primary site of infection, blastomycosis can disseminate to the skin, bones, genitourinary system, and, rarely, visceral organs such as the spleen. Occupational exposure to soil and decaying matter, particularly in construction workers, increases the risk of blastomycosis infection. A 40-year-old male presented with a progressively enlarging right facial lesion, which initially appeared as a small papule. The lesion had gradually increased in size and pain over several months and failed to respond to antibiotics. Notable symptoms include generalized fatigue, low mood, intermittent morning headaches, confusion, poor appetite with weight loss, intermittent night sweats, and joint pain. The diagnostic workup included imaging findings of an exophytic skin lesion arising from the right cheek, pulmonary micronodules and consolidation, and splenic changes. Serum <i>Blastomyces</i> antigen testing was positive, fungal culture of tissue from the facial lesion grew <i>Blastomyces dermatitidis</i>, and histopathologic examination demonstrated granulomatous inflammation with broad-based budding yeast within the dermis, supporting the diagnosis of disseminated blastomycosis. Liposomal amphotericin B induction therapy was initiated, and the facial lesion improved. The patient was discharged home with a transition to oral itraconazole. This report presents a case of disseminated blastomycosis involving the lungs, skin, and spleen in an immunocompetent individual. High index of suspicion and recognition of cutaneous lesions in the context of occupational and environmental risk factors for blastomycosis enable early diagnosis and treatment.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73710"},"PeriodicalIF":0.6,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proximal Tracheal Mucoepidermoid Carcinoma Complicated by Early Anastomotic Stenosis-A Case Report.","authors":"Shivanjali Pandya, Gani Nuredini, Jahangir Ahmed, Khalid Ghufoor","doi":"10.1002/ccr3.73721","DOIUrl":"https://doi.org/10.1002/ccr3.73721","url":null,"abstract":"<p><p>Proximal tracheal mucoepidermoid carcinoma may remain occult despite prolonged upper-airway symptoms and normal flexible nasoendoscopy. Stridor following tracheal resection should prompt assessment of the anastomosis, as early postoperative stenosis caused by A-frame deformity and granulation tissue may be successfully managed with combined laser therapy, balloon dilatation, and intralesional corticosteroid injection.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73721"},"PeriodicalIF":0.6,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burkitt Lymphoma Presenting as Renal Failure: Learning From Diagnostic Pitfalls in Pediatrics.","authors":"Anne Boldt, Khanh Mai, Adriana Dhawan, Lucie M Turcotte, Robin Williams, Aarti Kamat","doi":"10.1002/ccr3.73725","DOIUrl":"https://doi.org/10.1002/ccr3.73725","url":null,"abstract":"<p><p>This case highlights that pediatric Burkitt lymphoma may present without classic systemic manifestations, instead presenting as acute renal failure secondary to peritoneal lymphomatosis. Prompt recognition of rapid progression, hyperuricemia, and obstructive uropathy, especially with initially normal blood counts, is essential to minimize diagnostic delay and prevent increased morbidity and mortality.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73725"},"PeriodicalIF":0.6,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suspected Mesenteric Malperfusion in Acute Type A Aortic Dissection During Pregnancy: A Case Report and Review of Reperfusion-First Strategies.","authors":"Tam Le, Steven Chok, Khuram Khan","doi":"10.1002/ccr3.73703","DOIUrl":"https://doi.org/10.1002/ccr3.73703","url":null,"abstract":"<p><p>Aortic dissection during pregnancy is rare but potentially catastrophic. Acute Type A aortic dissection generally requires urgent surgical repair. When visceral malperfusion is present, however, the optimal sequence of interventions may be complex, particularly when pregnancy and recent cesarean delivery increase operative risk. Endovascular reperfusion followed by delayed aortic repair has been proposed in selected patients, although evidence supporting this strategy in pregnancy remains limited. A 37-year-old woman at 31 weeks' gestation presented with chest and back pain. Initial CT pulmonary angiography (CTPA) performed for suspected pulmonary embolism excluded pulmonary embolism but demonstrated marked aortic root dilatation measuring 6.7 × 5.4 cm. Before definitive aortic imaging could be obtained, she developed acute respiratory deterioration and fetal distress, prompting emergency cesarean delivery under general anesthesia. Postoperatively, transthoracic echocardiography demonstrated severe aortic root and ascending aortic dilatation, severe aortic regurgitation, reduced left ventricular ejection fraction, and a dissection flap consistent with Type A aortic dissection. Because of concern for catastrophic hemorrhage associated with cardiopulmonary bypass and hypothermic circulatory arrest shortly after cesarean delivery, definitive aortic repair was deferred for approximately 24 h while the patient underwent medical optimization. During this interval, she developed progressive metabolic acidosis and worsening renal function, raising clinical concern for visceral malperfusion. Dedicated abdominal vascular imaging was not obtained, and therefore the presence, distribution, and mechanism of mesenteric malperfusion could not be anatomically confirmed before surgery. At subsequent operative exploration, extensive small- and large-bowel necrosis and markedly hypoperfused adnexal tissue were identified, precluding definitive aortic repair. The patient subsequently died after transition to comfort-focused care. In an analysis from the International Registry of Acute Aortic Dissection, mesenteric malperfusion was associated with higher in-hospital mortality than dissection without malperfusion. This case highlights the diagnostic and management challenges of acute Type A aortic dissection during pregnancy. In a pregnant patient presenting with chest or back pain and marked aortic root dilatation on PE-protocol imaging, acute aortic syndrome should prompt urgent evaluation of the entire aorta. Progressive metabolic acidosis, renal dysfunction, or unexplained clinical deterioration should raise concern for visceral ischemia. Although reperfusion-first strategies have been described in selected patients with aortic dissection and mesenteric malperfusion, their applicability in pregnancy remains uncertain and depends on defined vascular anatomy and the mechanism of malperfusion.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73703"},"PeriodicalIF":0.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}