Clinical Case Reports最新文献

{"title":"Painful Left Bundle Branch Block Syndrome Treated With Conduction System Pacing. A Report of Two Cases","authors":"Catalin Pestrea,&nbsp;Constantin Guzgan,&nbsp;Ecaterina Cicala,&nbsp;Radu Vatasescu","doi":"10.1002/ccr3.70639","DOIUrl":"https://doi.org/10.1002/ccr3.70639","url":null,"abstract":"<p>Painful left bundle branch block (LBBB) syndrome is a rare condition characterized by chest pain associated with the development of LBBB in the absence of myocardial ischemia. Although the mechanism of this entity is not fully understood, the occurrence of retrosternal chest pain is considered to be the consequence of ventricular dyssynchrony induced by LBBB. We present two cases of patients with non-ischemic cardiomyopathy and chest pain associated with intermittent LBBB morphology. In the context of a reduced left ventricular ejection fraction, a wide QRS complex, and echocardiographic evidence of intraventricular dyssynchrony, successful conduction system pacing (CSP) (His bundle and left bundle branch area pacing, respectively) was performed to correct the LBBB completely. During the procedure, the diagnosis of painful LBBB syndrome was confirmed with clear, reproducible proof that the onset of chest pain was simultaneous with the occurrence of LBBB on the electrocardiogram, both spontaneously and during rapid atrial pacing, and remitted with spontaneous or with correction of the LBBB. The evolution of the patients was favorable, with the six-month follow-up showing complete remission of symptoms and recovery of LV function.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 7","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70639","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wild Honey Intoxication: A Case Series From Nepal","authors":"Rukma Raj Kafle,&nbsp;Rakshya Arun Kandel,&nbsp;Sabin Chaulagain,&nbsp;Angela Basnet,&nbsp;Shiva Kumar Ojha,&nbsp;Alok Atreya","doi":"10.1002/ccr3.70628","DOIUrl":"https://doi.org/10.1002/ccr3.70628","url":null,"abstract":"<p>Wild honey poisoning can cause serious cardiovascular complications, including bradycardia and hypotension, even with small amounts (1–2 teaspoons) consumed. Symptoms typically emerge within 30–45 min of ingestion. Early intervention with IV fluids and atropine is effective in most cases, but severe cases may require vasopressors, particularly when presentation is delayed.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 7","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Severe Septicemia With Chromobacterium violaceum in Bangladesh","authors":"Tuhin Sadique,&nbsp;Asif Reza Khan,&nbsp;Dilruba Ahmed,&nbsp;Fazlul Kabir,&nbsp;Anup Chowdhury,&nbsp;Nazrul Islam,&nbsp;Farhana Halim,&nbsp;Nasrin Akter,&nbsp;Shoeb Bin Islam","doi":"10.1002/ccr3.70603","DOIUrl":"https://doi.org/10.1002/ccr3.70603","url":null,"abstract":"<p><i>Chromobacterium violaceum</i> is a rare but potentially fatal pathogen found in tropical and subtropical regions. Infections with <i>C. violaceum</i> have rarely been reported in humans, with an exceptionally high mortality rate, particularly when linked to septicemia. We report the case of a 45-year-old female farmer from Bangladesh who developed severe septicemia following an insect bite and subsequent self-drainage of an abscess. Blood cultures identified <i>C. violaceum</i>. The patient was treated empirically with intravenous ciprofloxacin and ceftriaxone, leading to full recovery despite resistance to ceftriaxone. Successful management of <i>C. violaceum</i> infections requires early diagnosis and prompt antimicrobial therapy. The intrinsic resistance mechanism of this organism, including the blaCVI gene associated with Carbapenem resistance, necessitates careful antibiotic selection. The literature review highlights successful cases, depending largely on timely intervention. This case highlights the need for careful antibiotic selection based on clinical response and sensitivity patterns. Moreover, increasing awareness among healthcare professionals, particularly in tropical and subtropical regions, is vital for early detection and successful treatment of this rare, life-threatening infection.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 7","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of Oral Syphilis Before and After Management","authors":"Abdulhameed Alsarraf,&nbsp;Aisha Almudahkah,&nbsp;Sarah Alabdalrazaq,&nbsp;Qutaibah Alfadalah","doi":"10.1002/ccr3.70620","DOIUrl":"https://doi.org/10.1002/ccr3.70620","url":null,"abstract":"<p>Syphilis is a sexually transmitted infection caused by the spirochete bacterium <i>Treponema pallidum</i>, presenting with oral manifestations at various stages of the disease, including primary, secondary, and tertiary phases. Oral manifestations tend to be misdiagnosed as other lesions; therefore, the diagnosis and treatment may be delayed. This case reports the diagnosis and treatment of a 27-year-old female patient who presented to the Oral Medicine clinic with oral syphilis, emphasizing the clinical presentation before and after treatment.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 7","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70620","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catastrophic Neurological Collapse Following Push-Up Exercise: A Rare Case of Spontaneous Hematomyelia Causing Acute Paraplegia in a Healthy Young Adult","authors":"Yegzeru Belete,&nbsp;Abera Kuma,&nbsp;Amanuel Anegagregn,&nbsp;Abdulkerim Girma","doi":"10.1002/ccr3.70633","DOIUrl":"https://doi.org/10.1002/ccr3.70633","url":null,"abstract":"<p>Spontaneous hematomyelia, or non-traumatic intramedullary spinal cord hemorrhage, is a rare and potentially devastating neurological condition. Unlike hematomyelia resulting from overt trauma, spontaneous cases occur in the absence of significant injury and present substantial diagnostic and therapeutic challenges. Etiologies are diverse and include spinal cord neoplasms, coagulopathies, anticoagulant use, spinal arteriovenous malformations (AVMs), radiation-induced vasculopathy, minor mechanical insults, and systemic inflammatory conditions such as COVID-19. Given its rarity and the high risk of permanent neurological impairment, timely recognition is essential. We report the case of a previously healthy 19-year-old male who developed sudden-onset lower limb weakness and back pain following a session of push-up exercises. Within 3 h, he progressed to complete paraplegia. Initial treatment at a local primary hospital was unsuccessful, and he was referred to Hawassa University Comprehensive Specialized Hospital on the fourth day of illness. Magnetic resonance imaging (MRI) of the spine revealed an intramedullary spinal cord hemorrhage consistent with spontaneous hematomyelia. Based on imaging features and clinical context, a presumptive diagnosis of juvenile spinal AVM was made; however, digital subtraction angiography (DSA) was not feasible due to financial and infrastructural constraints. The patient received conservative management, including supportive care and physiotherapy. Unfortunately, no neurological recovery was observed at nine-month follow-up. This case underscores the need to consider spontaneous hematomyelia in the differential diagnosis of acute flaccid paraplegia, especially in young, previously healthy individuals without trauma or anticoagulant exposure. It also raises awareness of physical exertion, such as upper-body resistance exercise, as a potential trigger for spinal AVM rupture. Moreover, the case highlights the significant impact of limited diagnostic and therapeutic resources in low-income settings, which may hinder timely intervention and worsen neurological outcomes.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 7","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70633","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryoballoon Ablation of Atrial Fibrillation Through a Permanent Inferior Vena Cava Filter","authors":"Ippei Saito,&nbsp;Yuichiro Sagawa,&nbsp;Atsuhito Oda,&nbsp;Hirofumi Arai,&nbsp;Kazuya Murata,&nbsp;Manabu Kurabayashi,&nbsp;Kaoru Okishige,&nbsp;Tetsuo Sasano,&nbsp;Yasuteru Yamauchi","doi":"10.1002/ccr3.70622","DOIUrl":"https://doi.org/10.1002/ccr3.70622","url":null,"abstract":"<p>Ablation using a cryoballoon can minimize the number of sheaths passing through a permanent inferior vena cava filter (pIVCF). Cryoballoon ablation with only a few sheaths can be safely and efficiently performed via the usual femoral vein approach in patients with atrial fibrillation and pIVCF.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 7","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70622","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertrophic Cardiomyopathy in a Fetus: A Rare Presentation Case Report","authors":"Alireza Golbabaei,&nbsp;Elham sadat Alavi Moghaddam,&nbsp;Mahsa Naemi,&nbsp;Hooman Mohammad Talebi","doi":"10.1002/ccr3.70599","DOIUrl":"https://doi.org/10.1002/ccr3.70599","url":null,"abstract":"<p>A 34-year-old pregnant woman at 23 weeks of gestation was referred for fetal cardiomegaly, later diagnosed as fetal hypertrophic cardiomyopathy with left ventricular outflow tract obstruction. The neonate, delivered vaginally at 39 weeks, was treated with propranolol and has shown favorable progress under regular follow-up.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 7","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Takotsubo Cardiomyopathy With Variable Patterns and Psychiatric Comorbidities: A Case Report and Comprehensive Literature Review","authors":"Hamza AlKowatli,&nbsp;Oubada Alkowatli,&nbsp;Ahmad Karzoun,&nbsp;Bisher Sawaf,&nbsp;Mhd Baraa Habib,&nbsp;Nahush Bansal,&nbsp;Muhammad Faiz,&nbsp;Robert Subbiondo","doi":"10.1002/ccr3.70635","DOIUrl":"https://doi.org/10.1002/ccr3.70635","url":null,"abstract":"<p>Takotsubo cardiomyopathy (TTC) is a transient stress-induced cardiac syndrome that can mimic acute coronary syndrome but typically lacks obstructive coronary disease. We report a case of a 50-year-old woman with complex psychiatric comorbidities who developed classical apical TTC following acute emotional distress—distinct from a prior reverse TTC episode during medical illness. Her condition stabilized with supportive care, anticoagulation, and psychiatric management. This case illustrates the phenotypic variability of TTC, the role of emotional stress in recurrence, and the importance of integrated multidisciplinary care.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 7","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70635","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Abrupt Withdrawal of Benzodiazepines a Risk Factor for Neuroleptic Malignant Syndrome? A Case Report With Single-Dose Haloperidol","authors":"Behnam Abbasi,&nbsp;Forouzan Elyasi,&nbsp;Masoud Aliyali","doi":"10.1002/ccr3.70632","DOIUrl":"https://doi.org/10.1002/ccr3.70632","url":null,"abstract":"<p>Neuroleptic malignant syndrome (NMS) is a rare but life-threatening reaction associated with the use of dopamine-modulating agents, which presents with symptoms like high fever, muscle rigidity, and autonomic instability. It is known that both the use of dopamine receptor antagonists and the sudden withdrawal of dopamine receptor agonists can trigger NMS. Benzodiazepine withdrawal can create a GABA-deficient state, linked to catatonia and possibly predisposing individuals to NMS. The case was a 53-year-old male patient with a history of high-dose benzodiazepine dependency, who developed NMS after the abrupt withdrawal of alprazolam and the single-dose intramuscular (IM) haloperidol. He presented with the symptoms of stupor, generalized rigidity, and fever, requiring admission to the Respiratory Care Unit. His medical history included long-term use of clonazepam, alprazolam, and methadone maintenance therapy (MMT). The laboratory findings also demonstrated elevated creatine phosphokinase (CPK) levels, peaking at 7896 IU/L. The treatments with bromocriptine and lorazepam further led to gradual improvement, and the patient was discharged after 11 days following the resolution of NMS symptoms. This case highlights the potential role of benzodiazepine withdrawal as a risk factor for NMS, especially when combined with antipsychotic medication like haloperidol. The shared mechanisms between the pathophysiology of NMS and benzodiazepine withdrawal suggest that the abrupt cessation of GABAergic agents may lower dopaminergic activity, contributing to the onset of NMS. Clinicians must be accordingly cautious in distinguishing benzodiazepine withdrawal from other causes of delirium and then option for appropriate treatment approaches to mitigate risks.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 7","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70632","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Varicella Pneumonia in an Adult With Robust Immune Status: A Case Report","authors":"Sunil Bhatta,&nbsp;Sukriti Pandit,&nbsp;Pratik Chaudhary","doi":"10.1002/ccr3.70630","DOIUrl":"https://doi.org/10.1002/ccr3.70630","url":null,"abstract":"<p>Primary varicella-zoster virus (VZV) infection is infrequent in adults, but it causes more than 10 to 20 times the morbidity and mortality seen in healthy children and pneumonia being the most prevalent consequence. Early recognition and aggressive management of primary varicella pneumonia with antiviral therapy and supportive care is essential to prevent severe complications such as acute respiratory distress syndrome (ARDS).</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 7","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70630","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}