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Rethinking Common Diagnoses: Idiopathic Multicentric Castleman Disease Presenting as TAFRO Syndrome: A Case Report. 重新思考常见诊断：特发性多中心Castleman病表现为TAFRO综合征：1例报告。
IF 0.6
Clinical Case Reports Pub Date : 2026-09-30 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73663
Divita Rohatgi, Annesha Chakraborty, Sourav Kumar, Anurag Rohatgi
{"title":"Rethinking Common Diagnoses: Idiopathic Multicentric Castleman Disease Presenting as TAFRO Syndrome: A Case Report.","authors":"Divita Rohatgi, Annesha Chakraborty, Sourav Kumar, Anurag Rohatgi","doi":"10.1002/ccr3.73663","DOIUrl":"https://doi.org/10.1002/ccr3.73663","url":null,"abstract":"<p><p>Idiopathic multicentric Castleman disease (TAFRO subtype) can mimic common differentials. High suspicion is required for chronic systemic symptoms and generalized lymphadenopathy. As fine-needle aspiration is often non-diagnostic, early excisional biopsy is important. Rituximab-based therapy represents a guideline-supported alternative when anti-IL-6 treatment is unavailable or not feasible.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73663"},"PeriodicalIF":0.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simple Epithelial Hypopharyngeal Cyst Presenting as Acute Airway Obstruction in a Three-Year-Old Child: A Case Report and Literature Review. 单纯上皮性下咽囊肿表现为急性气道阻塞1例3岁儿童：1例报告及文献复习。
IF 0.6
Clinical Case Reports Pub Date : 2026-09-30 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73666
Fathalla Noori, Sohaib Salahat, Abdelrahman Salous, Thabet M Thabet, Khaled Nazzal, Abdulhafeez Daghlas
{"title":"Simple Epithelial Hypopharyngeal Cyst Presenting as Acute Airway Obstruction in a Three-Year-Old Child: A Case Report and Literature Review.","authors":"Fathalla Noori, Sohaib Salahat, Abdelrahman Salous, Thabet M Thabet, Khaled Nazzal, Abdulhafeez Daghlas","doi":"10.1002/ccr3.73666","DOIUrl":"https://doi.org/10.1002/ccr3.73666","url":null,"abstract":"<p><p>Hypopharyngeal cysts are a rare cause of pediatric upper airway obstruction and may present acutely, even in previously asymptomatic children. Early endoscopic evaluation is essential in children with stridor and unexplained airway compromise, as prompt surgical excision can be both diagnostic and curative.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73666"},"PeriodicalIF":0.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pigmented Poroid Hidradenoma: A Case Report. 色素多孔体汗腺瘤1例报告。
IF 0.6
Clinical Case Reports Pub Date : 2026-09-29 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73645
Baraa Bustami, Noureddine Litaiem, Abdulmooti Hawilo
{"title":"Pigmented Poroid Hidradenoma: A Case Report.","authors":"Baraa Bustami, Noureddine Litaiem, Abdulmooti Hawilo","doi":"10.1002/ccr3.73645","DOIUrl":"https://doi.org/10.1002/ccr3.73645","url":null,"abstract":"<p><p>Poroid hidradenoma (PH) is an infrequently encountered benign adnexal neoplasm exhibiting eccrine differentiation. Histopathologically, PH displays a distinctive combination of hidradenoma-like architectural organization characterized by a purely intradermal localization with both solid and cystic components, and cytological attributes of poroid neoplasms, consisting predominantly of poroid and cuticular cells. In the present report, we document a case of pigmented PH arising on the thigh of a 44-year-old male patient and discuss its characteristics and clinical course.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73645"},"PeriodicalIF":0.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giant Posterior Fossa Tuberculoma Mimicking Atypical Teratoid/Rhabdoid Tumor in a Child: Illustrative Case. 儿童巨大后窝结核瘤模拟非典型畸胎瘤/横纹肌样瘤：说明性病例。
IF 0.6
Clinical Case Reports Pub Date : 2026-09-29 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73631
Aamir Hussain Hela, Romana Makhdoomi, Nayil Khursheed, Nazmin Ahmed, Shazieya Akhter, Syed Sabina, Vishal Chavda, Mohsin Fayaz
{"title":"Giant Posterior Fossa Tuberculoma Mimicking Atypical Teratoid/Rhabdoid Tumor in a Child: Illustrative Case.","authors":"Aamir Hussain Hela, Romana Makhdoomi, Nayil Khursheed, Nazmin Ahmed, Shazieya Akhter, Syed Sabina, Vishal Chavda, Mohsin Fayaz","doi":"10.1002/ccr3.73631","DOIUrl":"https://doi.org/10.1002/ccr3.73631","url":null,"abstract":"<p><p>Intracranial tuberculomas are rare manifestations of extrapulmonary tuberculosis that can closely mimic malignant posterior fossa tumors in children, particularly in tuberculosis-endemic regions. The radiological and clinical overlap with aggressive neoplasms such as atypical teratoid/rhabdoid tumor (AT/RT) poses a significant diagnostic challenge. A 5-year-old immunocompetent boy presented with progressive headache and irritability. Magnetic resonance imaging (MRI) of the brain revealed a large (45 × 38 mm) lesion in the cerebellar vermis and left hemisphere with mass effect on the fourth ventricle and brainstem, causing obstructive hydrocephalus. A ventriculoperitoneal (VPMP) shunt was placed for hydrocephalus management. Subsequently, left suboccipital craniectomy with tumor decompression was performed. Intraoperative crush biopsy was initially reported as atypical rhabdoid tumor. However, final histopathological examination revealed extensive granulomatous inflammation with epithelioid cell granuloma, Langhans-type giant cells, and macrophages. Immunohistochemistry showed CD68 positivity (confirming macrophagic nature), EMA negativity (ruling out meningothelial tumor), and vimentin positivity in fibrotic tissue. Acid-fast bacilli (AFB) staining was positive. The final impression was chronic granulomatous pathology consistent with tuberculosis. This case underscores the importance of maintaining a high index of suspicion for CNS tuberculoma in the differential diagnosis of posterior fossa space-occupying lesions in children, particularly in endemic regions. Intraoperative crush biopsy may be misleading, and definitive histopathological examination with special stains is essential to avoid misdiagnosis and inappropriate treatment. Early confirmation of tuberculosis can dramatically alter management from aggressive oncological therapy to curative antitubercular treatment.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73631"},"PeriodicalIF":0.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosome Therapy for Androgenetic Alopecia in a Patient With Incomplete Response to Minoxidil and Finasteride: A Case Report. 生物体治疗雄激素性脱发患者对米诺地尔和非那雄胺不完全反应：一例报告。
IF 0.6
Clinical Case Reports Pub Date : 2026-09-29 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73656
Mohammed Almashali
{"title":"Biosome Therapy for Androgenetic Alopecia in a Patient With Incomplete Response to Minoxidil and Finasteride: A Case Report.","authors":"Mohammed Almashali","doi":"10.1002/ccr3.73656","DOIUrl":"https://doi.org/10.1002/ccr3.73656","url":null,"abstract":"<p><p>A 25-year-old man with androgenetic alopecia showed limited response to long-term minoxidil and finasteride. Three monthly Biosome treatment sessions were associated with progressive clinical improvement in apparent hair coverage on serial follow-up photographs, without treatment-related adverse events during the 3-month observation period. This case provides a hypothesis-generating clinical observation supporting further investigation of Biosome-based therapy using standardized and objective outcome measures.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73656"},"PeriodicalIF":0.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traction-Induced Avulsion of an Iliocaval Venous Branch During Multilevel OLIF for Degenerative Scoliosis: Case Report. 在多节段OLIF治疗退行性脊柱侧凸时，牵引引起的髂腔静脉分支撕脱：1例报告。
IF 0.6
Clinical Case Reports Pub Date : 2026-09-29 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73011
Tetsuro Ohba, Nobuki Tanaka, Kotaro Oda, Hayato Takei, Kai Mizukami, Go Goto, Hirotaka Haro
{"title":"Traction-Induced Avulsion of an Iliocaval Venous Branch During Multilevel OLIF for Degenerative Scoliosis: Case Report.","authors":"Tetsuro Ohba, Nobuki Tanaka, Kotaro Oda, Hayato Takei, Kai Mizukami, Go Goto, Hirotaka Haro","doi":"10.1002/ccr3.73011","DOIUrl":"10.1002/ccr3.73011","url":null,"abstract":"<p><p>Adult degenerative scoliosis can be effectively treated with lateral or oblique lumbar interbody fusion (LLIF/OLIF), but vascular injury remains a rare and potentially catastrophic complication. We report the case of a 78-year-old woman with long-standing degenerative scoliosis who underwent multilevel OLIF from L2 to L5. During trial cage placement at L2-3, massive venous hemorrhage occurred, with an estimated blood loss of approximately 3750 mL. Intraoperative angiography showed no arterial extravasation, suggesting a venous source. The wound was packed, and the patient was stabilized with aggressive resuscitation. Reexploration 3 days later, performed with a vascular surgeon, identified an avulsed iliocaval venous branch at the anterior aspect of the L2 vertebral body. Hemostasis was achieved using a fibrin sealant patch and sustained compression. After recovery, staged posterior fixation was completed without further complication. The patient recovered without neurologic deficit and maintained satisfactory alignment at follow-up. This case highlights a rare indirect vascular injury mechanism during deformity correction, likely caused by traction on a stiff iliocaval venous branch during multilevel distraction. Careful preoperative vascular assessment, gradual disc-space distraction, readiness for staged management, and early vascular surgery involvement are essential to improve safety in complex OLIF procedures.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73011"},"PeriodicalIF":0.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed Uptake on 123I-IMP SPECT as a Diagnostic Clue in Cranial Vault Lymphoma in a 25-Year-Old Man: A Case Report. 123I-IMP SPECT延迟摄取作为25岁男性颅穹窿淋巴瘤的诊断线索：1例报告。
IF 0.6
Clinical Case Reports Pub Date : 2026-09-29 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73628
Yuki Sakaeyama, Yutaka Fuchinoue, Mitsuyoshi Abe, Shuhei Kubota, Ryo Matsuzaki, Sayaka Terazono, Nobuo Sugo
{"title":"Delayed Uptake on <sup>123</sup>I-IMP SPECT as a Diagnostic Clue in Cranial Vault Lymphoma in a 25-Year-Old Man: A Case Report.","authors":"Yuki Sakaeyama, Yutaka Fuchinoue, Mitsuyoshi Abe, Shuhei Kubota, Ryo Matsuzaki, Sayaka Terazono, Nobuo Sugo","doi":"10.1002/ccr3.73628","DOIUrl":"https://doi.org/10.1002/ccr3.73628","url":null,"abstract":"<p><p>Lymphoma involving the cranial vault is an extremely rare condition that is often difficult to diagnose preoperatively because its imaging findings mimic those of other skull tumors. We report a case of diffuse large B-cell lymphoma of the cranial vault in a 25-year-old man presenting with a rapidly enlarging frontal mass. Magnetic resonance imaging demonstrated marked diffusion-weighted hyperintensity, and <sup>123</sup>I-IMP SPECT showed increased tracer uptake with further accumulation on delayed images. These findings raised suspicion of malignant lymphoma before surgery. Histopathological examination confirmed diffuse large B-cell lymphoma. This case suggests that <sup>123</sup>I-IMP SPECT may provide useful adjunctive information for raising suspicion of lymphoma among cranial vault tumors and may contribute to improved preoperative diagnosis.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73628"},"PeriodicalIF":0.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suspected C5 Nerve Root Injury Temporally Associated With Stellate Ganglion Block for Refractory Insomnia: A Case Report. 疑为C5神经根损伤伴星状神经节阻滞治疗顽固性失眠1例。
IF 0.6
Clinical Case Reports Pub Date : 2026-09-29 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73603
Xiaochen Ji, Zhiqiang Niu, Yabo Wang
{"title":"Suspected C5 Nerve Root Injury Temporally Associated With Stellate Ganglion Block for Refractory Insomnia: A Case Report.","authors":"Xiaochen Ji, Zhiqiang Niu, Yabo Wang","doi":"10.1002/ccr3.73603","DOIUrl":"10.1002/ccr3.73603","url":null,"abstract":"<p><p>Suspected C5 nerve root injury temporally associated with stellate ganglion block is uncommon, and causality may be uncertain. Immediate radiating shoulder pain, lateral upper-arm numbness, and deltoid weakness require prompt cessation, neurological assessment, electrophysiological confirmation, neurotrophic treatment, and rehabilitation. Careful needle visualization and transparent reporting of diagnostic uncertainty are essential.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73603"},"PeriodicalIF":0.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual Hemodynamic Presentation of Pediatric Kikuchi-Fujimoto Disease: Persistent Sinus Bradycardia and Vasopressor-Dependent Hypotension. 小儿菊chi- fujimoto病的异常血流动力学表现：持续性窦性心动过缓和血管加压剂依赖性低血压。
IF 0.6
Clinical Case Reports Pub Date : 2026-09-29 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73654
Abdulla Alfraij, Fatma Mothafar, Wasmi Alfadhli, Ali Ashkanani, Lujain A Kamal, Esmail Redha, Abdulrahman Aldaithan
{"title":"Unusual Hemodynamic Presentation of Pediatric Kikuchi-Fujimoto Disease: Persistent Sinus Bradycardia and Vasopressor-Dependent Hypotension.","authors":"Abdulla Alfraij, Fatma Mothafar, Wasmi Alfadhli, Ali Ashkanani, Lujain A Kamal, Esmail Redha, Abdulrahman Aldaithan","doi":"10.1002/ccr3.73654","DOIUrl":"https://doi.org/10.1002/ccr3.73654","url":null,"abstract":"<p><p>Kikuchi-Fujimoto disease rarely presents with vasopressor-dependent hypotension requiring pediatric intensive care despite preserved cardiac function. This case highlights the importance of early excisional lymph node biopsy for timely diagnosis and appropriate management of children with unexplained hemodynamic instability and necrotizing cervical lymphadenopathy.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73654"},"PeriodicalIF":0.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm (MiNEN) of the Gallbladder. A Case Report From a Low-Resource Setting. 胆囊混合神经内分泌-非神经内分泌肿瘤（MiNEN）。低资源环境下的案例报告。
IF 0.6
Clinical Case Reports Pub Date : 2026-09-29 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73652
Muhammad Farhan, Muhammad Imran, Beenish Sabir, Khalil Ahmad, Farheen Khan, Shahid Hussain, Zohaib Ahmed, Muhammad Asim, Iqra Mehmood, Rahmat Gul Omarzai
{"title":"Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm (MiNEN) of the Gallbladder. A Case Report From a Low-Resource Setting.","authors":"Muhammad Farhan, Muhammad Imran, Beenish Sabir, Khalil Ahmad, Farheen Khan, Shahid Hussain, Zohaib Ahmed, Muhammad Asim, Iqra Mehmood, Rahmat Gul Omarzai","doi":"10.1002/ccr3.73652","DOIUrl":"https://doi.org/10.1002/ccr3.73652","url":null,"abstract":"<p><p>Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) of the gallbladder are exceedingly rare entities. We report a case of a 35-year-old female with a palpable right hypochondrial mass. Imaging demonstrated a large polypoid gallbladder lesion with periportal lymphadenopathy. The patient underwent open cholecystectomy with lymphadenectomy. Histopathology and immunohistochemistry revealed a MiNEN. At 12-month follow-up, she remained free of recurrence without any adjuvant chemotherapy.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73652"},"PeriodicalIF":0.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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