Christian Damien Tchuisseu Ngapjang, Christian Fotso, Ronald Gobina, Philippe Albert Lingo, Quincy-Jones Shumbang Tchumukong, Bertold Brecht Kouam, Marc Effila, Emelinda Berinyuy Nyuydzefon, Verla Vincent Siysi
{"title":"Generalized Tetanus Associated With Malaria and Probable Meningitis in a 4-Year-Old Patient: A Case Report in Limbe Regional Hospital, Cameroon","authors":"Christian Damien Tchuisseu Ngapjang, Christian Fotso, Ronald Gobina, Philippe Albert Lingo, Quincy-Jones Shumbang Tchumukong, Bertold Brecht Kouam, Marc Effila, Emelinda Berinyuy Nyuydzefon, Verla Vincent Siysi","doi":"10.1002/ccr3.71043","DOIUrl":"10.1002/ccr3.71043","url":null,"abstract":"<p>Tetanus is a life-threatening disease preventable by immunization through vaccines. In resource-limited settings, its association with other acute infections should be managed cautiously. A 4-year-old unvaccinated male was referred from a nearby hospital for better management of severe malaria and probable enteric fever, after presenting there with febrile seizures, neck stiffness, and vomiting. Shortly after admission, he developed trismus, recurrent generalized paroxysmal muscle spasms, and opisthotonos. Given the clinical features and lack of antitetanic immunization, a diagnosis of tetanus and cerebral malaria was established, with probable bacterial meningitis as a relevant differential. Owing to the caregiver's financial constraints, no specific investigations were carried out. The patient was admitted to the intensive care unit (ICU) and empirically treated for all three likely diagnoses, with anti-tetanus toxoid, antibiotics, and antimalarial. Despite limited supportive care, the patient's condition considerably improved within the first 48 h in the ICU, and he spent 5 additional days in the hospital before being discharged.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bilateral Peripheral Facial Nerve Neuropathy as the Presenting Feature of Primary Sjögren Syndrome: A Case Report","authors":"Ryosuke Hanaoka","doi":"10.1002/ccr3.70940","DOIUrl":"10.1002/ccr3.70940","url":null,"abstract":"<p>Bilateral facial nerve paralysis can be the presenting feature of primary Sjögren syndrome. Minor salivary gland biopsy and anti-SS-A antibody testing are essential for diagnosis when sicca symptoms are mild, as this rare manifestation may be underdiagnosed without histopathological investigation.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shitashma Bohara, Susmin Karki, Bikas Thapa, Niharika Khanal, Bikal Ghimire, Sandeep Bohara, Amit Pradhanang, Mohan R. Sharma
{"title":"Long Segment Spinal Epidural Abscess With Acute Intestinal Obstruction: A Case Report and Literature Review","authors":"Shitashma Bohara, Susmin Karki, Bikas Thapa, Niharika Khanal, Bikal Ghimire, Sandeep Bohara, Amit Pradhanang, Mohan R. Sharma","doi":"10.1002/ccr3.71058","DOIUrl":"10.1002/ccr3.71058","url":null,"abstract":"<p>Spinal epidural abscess (SEA) is a life-threatening condition that often presents with non-specific symptoms, resulting in a delay in diagnosis and treatment. Rarely, it can co-exist with acute abdominal conditions, which can further complicate the diagnosis and management. Delay in diagnosis and the presence of comorbidities may result in unfavorable outcomes. We present a case of a 55-year-old male diagnosed with a spinal epidural abscess presenting as low back pain, fever, and paraparesis. This case report aims to investigate the clinical presentation, diagnostic challenges, and treatment approaches for spinal epidural abscesses in low and middle-income countries.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Junichi Yoshizawa, Satoshi Sugiyama, Koji Kubota, Ataru Nakayama
{"title":"Curative Resection Following Conservative Treatment for Perforated Early Gastric Cancer: A Case Report","authors":"Junichi Yoshizawa, Satoshi Sugiyama, Koji Kubota, Ataru Nakayama","doi":"10.1002/ccr3.70997","DOIUrl":"10.1002/ccr3.70997","url":null,"abstract":"<p>This report relates to a rare case of curative resection in gastric perforation due to early gastric cancer performed after conservative treatment. Conservation treatment/omentum patch could be more effective for perforated gastric cancer, and subsequent radical gastrectomy would result in a safer and more highly curative surgery.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Congenital Sliding Hiatal Hernia in a 5-Week-Old Ex-Preterm Infant With Recurrent Gastroesophageal Reflux Amid the COVID-19 Pandemic","authors":"Chariya Chap, Vissotsak Bin, Sakviseth Bin","doi":"10.1002/ccr3.71070","DOIUrl":"10.1002/ccr3.71070","url":null,"abstract":"<p>Despite the increasing prevalence of airborne infections such as COVID-19, congenital hiatal hernia should be suspected in preterm infants presenting with respiratory symptoms and recurrent reflux. Barium swallow is helpful in ruling out pneumonia. Antenatal diagnosis is a key to early recognition and timely interventions.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simultaneous Acute Appendicitis and Isolated Common Iliac Artery Aneurysm: A Case Report","authors":"Meghdad Ghasemi Gorji, Fardin Karbakhsh Ravari, Ali Rafiei, Aisa Iranmanesh, Maral Ebrahimi Alamdari","doi":"10.1002/ccr3.71050","DOIUrl":"10.1002/ccr3.71050","url":null,"abstract":"<p>This case report presents the rare simultaneous occurrence of acute appendicitis and a large right common iliac artery aneurysm in a 69-year-old male with a history of diabetes and hypertension. The patient presented with right lower quadrant abdominal pain and a pulsatile mass. Diagnostic imaging via computed tomography angiography revealed a 95 × 75 mm fusiform aneurysm and radiologic signs of acute appendicitis. Given the high risk of aneurysmal rupture and the presence of symptomatic appendicitis, a combined open surgical approach was undertaken. This involved aneurysm repair with a Dacron graft and standard appendectomy. Histopathology confirmed acute suppurative appendicitis and atherosclerotic changes in the aneurysm wall. The patient recovered well postoperatively, with imaging confirming graft patency and no residual inflammation. This case highlights the importance of comprehensive imaging and a multidisciplinary surgical strategy when managing concurrent intra-abdominal vascular and gastrointestinal emergencies.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dyala Sayed Ahmad, Rim Nasser, Moatasem Hussein Al-janabi, Fouz Hassan
{"title":"Buschke–Fischer–Brauer Keratoderma: A Case Report of a Rare Skin Disorder","authors":"Dyala Sayed Ahmad, Rim Nasser, Moatasem Hussein Al-janabi, Fouz Hassan","doi":"10.1002/ccr3.71021","DOIUrl":"10.1002/ccr3.71021","url":null,"abstract":"<p>Buschke–Fischer–Brauer keratoderma is a rare autosomal dominant disorder presenting as hyperkeratotic lesions on the palms and soles. Diagnosis requires clinical and histopathological evaluation. Management is symptomatic with keratolytics like salicylic acid and urea. Early recognition and ongoing care improve the quality of life for patients with this chronic condition.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Tamoxifen on Endometrial Thickness in Women With Thin Endometrium Following Estrogen Therapy During Frozen–Thawed Embryo Transfer","authors":"Masoumeh Zaree, Bahia Namavar Jahromi, Mohammad Ebrahim Parsanezhad, Zahra Mosallanezhad, Seyedeh-Sara Hashemi, Fatemeh YaghoobiGorgi, Alireza Salehi","doi":"10.1002/ccr3.71036","DOIUrl":"10.1002/ccr3.71036","url":null,"abstract":"<p>Endometrial thickness (ET) is an important parameter of determining endometrial receptivity for in vitro fertilization (IVF) with frozen–thawed embryo transfer (FET). ET is influenced by various intrinsic and extrinsic factors, such as hormonal fluctuations, age-related changes, underlying medical conditions, and metabolic factors. However, there are few published studies examining the effect of tamoxifen on endometrial development during IVF. The aim of this study was to evaluate the impact of tamoxifen on endometrial growth in patients undergoing IVF-FET who experienced a thin endometrium during their previous transfer cycle while undergoing estrogen therapy. This pilot study was conducted at Hazrate Zeinab Hospital, affiliated to Shiraz University of Medical Sciences in Shiraz, Iran, between 2019 and 2021. The study involved three infertile females aged 31–40 years who were referred to our center for IVF-FET. We recorded the patients' demographic and medical characteristics, the type of infertility, and the cause and duration of infertility. ET was measured using ultrasonography before the treatment began. Patients were then administered tamoxifen at a dosage of 20 mg per day, starting on the second day of their menstrual cycle for a duration of 5 days. On the seventh day of menstruation, a follow-up transvaginal ultrasonography was performed to assess the ET and evaluate the trilinear pattern. In our study of three patients with a history of inadequate response to high-dose estrogen, the endometrium improved in two patients and thickened by up to 7 mm, indicating a positive effect of tamoxifen on improving endometrial thickness.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rare Presentation of Pityriasis Lichenoides et Varioliformis Acuta: A Case of Mucosal and Face Involvement in a 15-Year-Old Male","authors":"Sandesh Shah, Joshana Shrestha, Smriti Piya","doi":"10.1002/ccr3.71010","DOIUrl":"https://doi.org/10.1002/ccr3.71010","url":null,"abstract":"<p>Pityriasis lichenoides et varioliformis acuta (PLEVA) is a rare inflammatory skin disorder, and mucosal involvement is exceptionally uncommon. We present a 15-year-old male who developed PLEVA with facial and mucosal involvement, preceded by fever. Dermoscopy revealed dotted and linear vessels with micaceous scales. Histopathology showed focal parakeratosis, epidermal exocytosis of neutrophils and lymphocytes, and dense inflammatory infiltrates extending into the subcutaneous tissue. The patient responded well to doxycycline, achieving complete resolution, though varioliform scarring and hyperpigmentation remained. This case underscores the rarity of mucosal involvement in PLEVA and highlights the importance of early recognition and treatment to minimize long-term cutaneous damage.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.71010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}