Clinical Case ReportsPub Date : 2025-10-05eCollection Date: 2025-10-01DOI: 10.1002/ccr3.71177
Abdul Moiz Khan, Syed Wajihullah Shah, Qazi Muhammad Safwan, Rida Akhtar, Jibran Ikram, Muhammad Abu Bakkar
{"title":"Unveiling Myoepithelioma: A Case Report and Literature Review of an Uncommon Soft Tissue Tumor.","authors":"Abdul Moiz Khan, Syed Wajihullah Shah, Qazi Muhammad Safwan, Rida Akhtar, Jibran Ikram, Muhammad Abu Bakkar","doi":"10.1002/ccr3.71177","DOIUrl":"https://doi.org/10.1002/ccr3.71177","url":null,"abstract":"<p><p>Myoepitheliomas are rare salivary gland tumors, comprising only 1%-1.5% of all cases. We report a unique case of a 69-year-old woman with a painless, slowly enlarging right parotid mass. CT imaging showed an ill-defined, irregular, multilobulated heterogeneous lesion compressing the deep parotid lobe. Fine-needle aspiration cytology suggested a benign spindle cell tumor. The patient underwent superficial parotidectomy, and histopathology confirmed a benign myoepithelioma with spindle and epithelioid cells, along with distinctive fibro-myxoid changes. Immunohistochemistry was positive for p63 and S-100. Postoperative recovery was uneventful, and no recurrence was noted at two-year follow-up. This case highlights the importance of considering myoepithelioma in elderly patients and demonstrates distinct radiological and histological features aiding diagnosis.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":"e71177"},"PeriodicalIF":0.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2025-10-05eCollection Date: 2025-10-01DOI: 10.1002/ccr3.71084
Sara Alkari, Omar Hamadah
{"title":"Carbon Dioxide Laser as an Alternative Tool to the Conventional Scalpel in Lip Repositioning Surgery: A Case Series.","authors":"Sara Alkari, Omar Hamadah","doi":"10.1002/ccr3.71084","DOIUrl":"https://doi.org/10.1002/ccr3.71084","url":null,"abstract":"<p><p>CO<sub>2</sub> laser-assisted lip repositioning in three patients resulted in a mean 1.9 mm reduction in gingival display, no postoperative complications, full patient satisfaction, and a stable nasolabial angle. The procedure was conservative and minimally invasive, preserving the external facial profile.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":"e71084"},"PeriodicalIF":0.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Peripheral Calcifying Epithelial Odontogenic Tumor Masquerading as Pyogenic Granuloma of Oral Cavity.","authors":"Saravanan Sampoornam Pape Reddy, Delfin Lovelina Francis, Deepak Pandiar, Ruchi Harish, Manish Rathi, Ravikiran Narayana, Balaji Manohar, Shaili Pradhan","doi":"10.1002/ccr3.71137","DOIUrl":"https://doi.org/10.1002/ccr3.71137","url":null,"abstract":"<p><p>We presented a case of PCOT that initially displayed clinical and histological features similar to pyogenic granuloma. Excisional biopsy and histological examination were performed to determine the definitive diagnosis. Therefore, it is argued that the clinical and incisional biopsy findings represent only alterations in the submitted tissue, which may be deceptive, and the final diagnosis may differ following surgical excision.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":"e71137"},"PeriodicalIF":0.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2025-10-05eCollection Date: 2025-10-01DOI: 10.1002/ccr3.71159
Erica Franco, Chiara Rovera, Claudio Moretti, Pier Paolo Bassareo
{"title":"Arrhythmogenic Right Ventricular Cardiomyopathy and Cor Triatriatum Dexter: An Unreported Association.","authors":"Erica Franco, Chiara Rovera, Claudio Moretti, Pier Paolo Bassareo","doi":"10.1002/ccr3.71159","DOIUrl":"https://doi.org/10.1002/ccr3.71159","url":null,"abstract":"<p><p>We present a 74-year-old patient with a previous diagnosis of arrhythmogenic right ventricular cardiomyopathy manifesting as heart failure where a concomitant cor triatriatum dexter has accidentally been diagnosed by echocardiography. The association between arrhythmogenic right ventricular cardiomyopathy and cor triatriatum dexter has not been reported yet. The management of the patient is described.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":"e71159"},"PeriodicalIF":0.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2025-10-05eCollection Date: 2025-10-01DOI: 10.1002/ccr3.71148
Giulia Ciccarese, Serena Varesano, Gaetano Serviddio, Francesco Drago
{"title":"Parvovirus B19 Infection as a Potential Trigger for Systemic Diseases.","authors":"Giulia Ciccarese, Serena Varesano, Gaetano Serviddio, Francesco Drago","doi":"10.1002/ccr3.71148","DOIUrl":"https://doi.org/10.1002/ccr3.71148","url":null,"abstract":"<p><p>It is crucial to perform direct methods like polymerase chain reaction (PCR) beyond serology to diagnose an active viral infection that can trigger a cutaneous/systemic disease, such as fibromyalgia. Indeed, measuring the viral load in tissues, plasma, and serum are diagnostic tools that permit the follow-up of an active infection.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":"e71148"},"PeriodicalIF":0.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2025-10-05eCollection Date: 2025-10-01DOI: 10.1002/ccr3.71154
Abdulaziz Samran
{"title":"A New Minimally Invasive Technique for Anterior Resin-Bonded Fixed Dental Prostheses: A 5-Year Clinical Report.","authors":"Abdulaziz Samran","doi":"10.1002/ccr3.71154","DOIUrl":"https://doi.org/10.1002/ccr3.71154","url":null,"abstract":"<p><p>This clinical report describes the use of a new design for resin-bonded fixed dental prostheses (RBFDP) to replace a missing maxillary right central incisor. This report illustrates a conservative, functional, and esthetic RBFDP made of a metal-ceramic framework. Using RBFDP allowed for achieving acceptable esthetics with a conservative and functional result.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":"e71154"},"PeriodicalIF":0.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2025-10-05eCollection Date: 2025-10-01DOI: 10.1002/ccr3.71125
Alireza Khanahmad, Mohammad Hossein Khazaee-Nasirabadi, Naeem Nikpour, Mahmood Khosravi
{"title":"Familial Patterns in Acute Lymphoblastic Leukemia: Lessons From Three Siblings.","authors":"Alireza Khanahmad, Mohammad Hossein Khazaee-Nasirabadi, Naeem Nikpour, Mahmood Khosravi","doi":"10.1002/ccr3.71125","DOIUrl":"https://doi.org/10.1002/ccr3.71125","url":null,"abstract":"<p><p>Acute lymphoblastic leukemia is a sporadic condition and has been reported to be familial in less than 5% of cases. Here, we present the clinical, genetic, treatment, and pathologic features of three siblings with precursor B acute lymphoblastic leukemia by the order of occurrence, suggesting a potential involvement of germline mutations in the pathogenesis of the disease. Their parents denied consanguinity as well as any familial history of syndromic diseases or neoplasms. Cases 1 and 2 have experienced a relapse after achieving remission, and case 3 has been diagnosed in recent years. Recurrent cytogenetic abnormalities shared across Cases 2 and 3 raised the hypothesis that monosomy 20 may be a susceptible marker in familial B-ALL. HLAs were fully matched for Cases 2 and 3; so, Case 3 donated stem cells to his older brother (Case 2) 3 months before his own involvement. Today, these cases are in complete remission of the disease. This study supports genetic counseling and targeted germline testing in familial ALL cases and argues for cautious consideration of related donors in such cases.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":"e71125"},"PeriodicalIF":0.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Widespread Verrucous Plaques of Chromoblastomycosis: A 12-Year Diagnostic Odyssey.","authors":"Elisha Shrestha, Anupa Sharma, Manisha Gartaula, Aniket Basnet","doi":"10.1002/ccr3.71147","DOIUrl":"https://doi.org/10.1002/ccr3.71147","url":null,"abstract":"<p><p>Chromoblastomycosis is a deep fungal infection of the skin and subcutaneous tissue. This case underscores the critical importance of thorough laboratory investigations, particularly histopathology, in chronic dermatological conditions that mimic other granulomatous diseases. Misdiagnosis, such as treating chromoblastomycosis as cutaneous tuberculosis without confirmatory testing, can delay appropriate therapy and prolong morbidity.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":"e71147"},"PeriodicalIF":0.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Appendico-Ileal Knotting; Case Series in Ethiopia.","authors":"Tewodros Tadesse Tessema, Murtii Teressa Obolu, Tadesse Getachew Mulisa, Bitsue Girma Tilahun, Ermias Tadesse Woldegiorgis, Yared Assefa Beyene","doi":"10.1002/ccr3.71140","DOIUrl":"https://doi.org/10.1002/ccr3.71140","url":null,"abstract":"<p><p>Appendico-ileal knotting is an extremely rare complication of acute appendicitis, leading to obstruction when the inflammed appendiceal shaft wraps around the adjacent ileal segment and its mesentery. Diagnosis requires high clinical suspicion and urgent surgical exploration. Based on the extent of appendiceal base gangrene, en bloc ileal resection with appendectomy or right hemicolectomy is the mainstay of treatment to prevent systemic bacterial or toxin spread and contamination.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":"e71140"},"PeriodicalIF":0.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2025-10-05eCollection Date: 2025-10-01DOI: 10.1002/ccr3.70765
Kathryn Collins, Emily Cushing, Alex Ellerhorst, Christopher Selinsky
{"title":"Management of Recurrent Metastasis of Renal Cell Carcinoma to the Parotid Gland After Nephrectomy.","authors":"Kathryn Collins, Emily Cushing, Alex Ellerhorst, Christopher Selinsky","doi":"10.1002/ccr3.70765","DOIUrl":"https://doi.org/10.1002/ccr3.70765","url":null,"abstract":"<p><p>Renal cell carcinoma accounts for 90% of malignant renal tumors, with common metastases to the lungs, bones, and brain. Head and neck metastases are uncommon, and the parotid gland is an exceedingly rare site (0.5%). Recurrent metastasis to bilateral parotid glands has been reported in the literature, but recurrent metastasis to the ipsilateral gland has not. This is a case about a 69-year-old female who presented to our clinic with the chief complaint of a slowly enlarging left neck mass. She had a history of clear cell renal cell carcinoma treated with nephrectomy 15 years prior. An MRI reviewed from 2 years earlier incidentally noted a left parotid tail lesion that had not been evaluated. CT and fine needle aspiration biopsy raised concern for malignancy. The patient underwent superficial parotidectomy, which confirmed metastatic clear cell renal cell carcinoma. Surveillance imaging was recommended but not completed. Two years later, she re-presented with recurrence in the same parotid gland. A multidisciplinary tumor board recommended surgery with preservation of the facial nerve, followed by radiation and immunotherapy. This case underscores the unpredictable metastatic pattern of renal cell carcinoma and the importance of long-term surveillance even beyond recommended guidelines. Clinicians should maintain a high index of suspicion for metastatic renal cell carcinoma in patients with a history of nephrectomy presenting with a parotid mass, given the potential for late recurrence.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":"e70765"},"PeriodicalIF":0.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}