Andrew Mpagwuni Ziblim, Mawunyo Ntumi, Nana Kwame Baah-Adade, Samuel Ofosu Agamah, Dziwornu Kunutsor, Elizabeth Acheampong, Abdul-Wakil Wunpini Salifu, Augustine Frimpong Marfoh, Nyagse Salifu, Ernest Ofosu-Appiah
{"title":"Acute Compartment Syndrome Post-Thrombolysis for Acute Pulmonary Embolism—A Case Report","authors":"Andrew Mpagwuni Ziblim, Mawunyo Ntumi, Nana Kwame Baah-Adade, Samuel Ofosu Agamah, Dziwornu Kunutsor, Elizabeth Acheampong, Abdul-Wakil Wunpini Salifu, Augustine Frimpong Marfoh, Nyagse Salifu, Ernest Ofosu-Appiah","doi":"10.1002/ccr3.70764","DOIUrl":"https://doi.org/10.1002/ccr3.70764","url":null,"abstract":"<p>The use of thrombolysis for acute pulmonary embolism is well established. Thrombolysis poses the risk of mostly minor bleeding; however, intracranial bleeding is the most feared complication. Less recognized is the possibility of limb-threatening complications, such as acute compartment syndrome, which need a high index of suspicion, prompt evaluation, and intervention.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 8","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70764","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fauzia Ali Noor, Asha S. Hashi, Rohini Kalagouda Patil, Kennedy Khainga, David Galgallo, Doris Kinuthia, Diana Marangu, Fred Kambuni, Nyambura Karuiki, Naomi Gachara
{"title":"Neonatal Spontaneous Abdominal Aortic Thrombosis Associated With Hypernatremic Dehydration and Acute Renal Failure: A Case Series","authors":"Fauzia Ali Noor, Asha S. Hashi, Rohini Kalagouda Patil, Kennedy Khainga, David Galgallo, Doris Kinuthia, Diana Marangu, Fred Kambuni, Nyambura Karuiki, Naomi Gachara","doi":"10.1002/ccr3.70736","DOIUrl":"https://doi.org/10.1002/ccr3.70736","url":null,"abstract":"<p>Spontaneous abdominal aortic thrombosis in neonates due to various causes is a known entity. Hypernatremic dehydration with acute kidney injury/failure can also be one of the aetiologies. A 14- and 11-day-old term neonate born to primigravida mothers presented to two different facilities with a similar presentation of hypernatremic dehydration and acute kidney injury/failure attributed to inadequate breastfeeding causing non-catheter-related spontaneous abdominal aortic thrombosis. In both cases, initial management was supportive care, fluids and electrolyte corrections, antibiotics, and antihypertensives. Anticoagulant therapy resulted in notable improvement in renal function and general well-being of the neonates. A high index of suspicion of vascular thrombosis in neonates presenting with hypernatremic dehydration and acute renal injury/failure is key to having good clinical outcomes. Newer anticoagulant drugs like rivaroxaban can be promising in the management of neonatal aortic thrombosis.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 8","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful Use of Combined Fractional Laser Resurfacing for Deep Scalp Defect","authors":"Daniel Ricardo Galimberti, Gabriella Benites Andrade, Pamela Montaño Salguero, Irene Fusco","doi":"10.1002/ccr3.70677","DOIUrl":"https://doi.org/10.1002/ccr3.70677","url":null,"abstract":"<p>Among the techniques to approach scalp reconstruction, the use of combined fractional laser skin resurfacing (10,600 nm/1540 nm) is a promising therapy that results in rapid wound closure, as demonstrated in this clinical case describing a man with a deep scalp wound who was successfully treated with combined fractional laser.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 8","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70677","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hamed Hanif, Negin Safari, Reza Sharifi, Nima Ostadrahimi, Alaaeldin Ahmad
{"title":"The Role of 3D Printed Spine Model in Complex Spinal Deformity Surgery; an Experience With a Case, Technical Notes and Review of the Literature","authors":"Hamed Hanif, Negin Safari, Reza Sharifi, Nima Ostadrahimi, Alaaeldin Ahmad","doi":"10.1002/ccr3.70675","DOIUrl":"https://doi.org/10.1002/ccr3.70675","url":null,"abstract":"<p>Complex spinal deformity in adults, often from neglected congenital deformities, poses surgical challenges. Understanding the 3D anatomy is crucial. A 3D-printed spinal model aids pre-operative planning, intra-operative navigation, and education. It reduces surgery time, bleeding, and X-ray dose, while improving screw placement accuracy and navigation of intra-spinal pathologies.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 8","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70675","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Distal Abdominal Aortic Thrombus With Approximately Full Occlusion—A Case of Pre-Endovascular Care in Resource-Limited Settings","authors":"Hilary Chipongo, Abizer Sarkar, Esmail Sangey, Kishan Chudasama, Amar Swali, Shaffin Rajan","doi":"10.1002/ccr3.70759","DOIUrl":"https://doi.org/10.1002/ccr3.70759","url":null,"abstract":"<p>Up-to-date management of a distal abdominal aortic thrombus is challenging as no dedicated guideline for treating this condition exists. In our setting, it is one of the rare arterial vascular emergencies that can lead to devastating consequences and an increase in patient morbidity or mortality. For this publication, we have a case report of an elderly female of Asian descent who failed multiple attempts of conservative management with thrombolytics but benefited from an intra-arterial papaverine infusion to salvage her ischemic lower limb.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 8","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70759","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shanshan Liang, Jingjing Zeng, Peiying Zhong, Chengyao Jia, Li Zhang
{"title":"Monoclonal Gammopathies of Clinical Significance—Scleromyxedema: A Case Report and Literature Review","authors":"Shanshan Liang, Jingjing Zeng, Peiying Zhong, Chengyao Jia, Li Zhang","doi":"10.1002/ccr3.70741","DOIUrl":"https://doi.org/10.1002/ccr3.70741","url":null,"abstract":"<p>Scleromyxedema is an uncommon, chronic connective tissue disorder with an obscure etiology. It is distinguished by fibromyxoid skin lesions and elevated serum monoclonal immunoglobulin levels. The condition's rarity limits epidemiological data, making prevalence and incidence assessment difficult. Herein, we detail a clinical case of scleromyxedema, encompassing diagnosis and treatment, to augment medical understanding of this rare entity. The aim of this study is to delve into the complexities of diagnosing scleromyxedema, encompassing its diverse clinical presentations, with the goal of refining diagnostic acumen and expediting the identification process. This, in turn, mitigates the risks associated with diagnostic delays. Moreover, the imperative of instituting pertinent therapeutic measures is highlighted as a fundamental aspect of patient management, underscoring the significance of a tailored approach to treatment. Concurrently, this endeavor demands rigorous precision from clinical laboratory staff. The accurate provision of laboratory data is essential to prevent oversights and misinterpretations in diagnosing this rare condition.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 8","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70741","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristian Castillo-Rodriguez, Dina Soliman, Michel Juarez, Sherif Roman, John Abdelmalek, Zhaunn Sly, Ankush Lahoti, Victor Test
{"title":"Platypnea-Orthodeoxia Syndrome Post-Pneumonectomy: A Case of Right-To-Left Shunting and Successful PFO Closure","authors":"Cristian Castillo-Rodriguez, Dina Soliman, Michel Juarez, Sherif Roman, John Abdelmalek, Zhaunn Sly, Ankush Lahoti, Victor Test","doi":"10.1002/ccr3.70715","DOIUrl":"https://doi.org/10.1002/ccr3.70715","url":null,"abstract":"<p>Platypnea-orthodeoxia syndrome is a rare disorder characterized by dyspnea (platypnea) and arterial desaturation (orthodeoxia) in the upright position, with symptom relief upon lying down. This syndrome is commonly associated with cardiac anomalies, particularly patent foramen ovale (PFO), where increased right atrial pressure facilitates right-to-left shunting, leading to hypoxemia. Other associated conditions include cirrhosis, pericardial effusion, and pneumonectomy. We present a 32-year-old female with a history of right pneumonectomy for invasive aspergillosis who presented with worsening dyspnea and a greater than 10% drop in SpO<sub>2</sub> when seated compared to the supine position. Initial imaging demonstrated rightward displacement of thoracic structures, including the right atrium, but a transthoracic echocardiogram was negative for intracardiac shunt. Due to persistent hypoxemia, a transesophageal echocardiogram was performed, revealing a right-to-left shunt, an atrial septal aneurysm, and a prominent Eustachian valve. The patient underwent successful PFO closure, leading to the complete resolution of both dyspnea and hypoxemia. This case emphasizes the importance of comprehensive diagnostic evaluation in patients with POS, especially those with complex cardiopulmonary histories.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 8","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70715","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pacemaker Lead Infection in a Patient Undergoing Hemodialysis","authors":"Yuki Chiba, Tasuku Nagasawa","doi":"10.1002/ccr3.70751","DOIUrl":"https://doi.org/10.1002/ccr3.70751","url":null,"abstract":"<p>Pacemaker (PM)-lead infection is a significant complication in patients with pacemakers, which can lead to infective endocarditis. Although PM-lead infection is challenging to diagnose due to its diverse clinical presentations, positron emission tomography-computed tomography is a valuable tool for definitive diagnosis.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 8","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70751","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saja Abouodeh, Yasmeen Alshami, Osama Hroub, Mohammad Hroub, Ahmad G. Hammouri, Ahmad Shaltaf, Wafa Shihadeh, Nimatee Dawod
{"title":"Extremely Rare Neonatal Case With Pyloric Atresia, Heart Defects, Hypotonia, Jaundice, and Acidosis","authors":"Saja Abouodeh, Yasmeen Alshami, Osama Hroub, Mohammad Hroub, Ahmad G. Hammouri, Ahmad Shaltaf, Wafa Shihadeh, Nimatee Dawod","doi":"10.1002/ccr3.70727","DOIUrl":"https://doi.org/10.1002/ccr3.70727","url":null,"abstract":"<p>Pyloric atresia (PA) is an exceptionally rare congenital cause of gastric outlet obstruction, often associated with syndromic conditions such as epidermolysis bullosa (EB). This case highlights a diagnostically challenging presentation of *non-syndromic pyloric atresia* in a neonate, complicated by a moderate mid-muscular ventricular septal defect (VSD), metabolic acidosis, and physiologic hydronephrosis, without any cutaneous manifestations. Initial hypotonia and respiratory irregularities diverted suspicion toward neurological or septic etiologies, delaying definitive diagnosis. Imaging, including upper gastrointestinal contrast study and echocardiography, confirmed the diagnosis of complete gastric outlet obstruction due to PA and coexisting VSD. The patient underwent successful gastro-duodenostomy with resolution of symptoms and stable postoperative recovery. This case underscores the importance of maintaining a high index of suspicion for gastrointestinal obstruction in neonates with polyhydramnios and early feeding intolerance, even in the absence of classic syndromic features. Comprehensive, multidisciplinary evaluation—incorporating pediatric surgery, neonatology, and cardiology—is essential to address overlapping congenital anomalies and optimize outcomes. This report contributes to the limited literature on non-syndromic PA with multisystem involvement.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 8","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70727","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Walter Appati, Divine Aseye Yao Amenuke, Adelaide Appati, Queenster Oforiwaa Twumasi
{"title":"Pulmonary Tuberculosis Presenting as Bronchogenic Carcinoma in a Young Ghanaian Adult: A Case Report and Review of the Literature","authors":"Walter Appati, Divine Aseye Yao Amenuke, Adelaide Appati, Queenster Oforiwaa Twumasi","doi":"10.1002/ccr3.70710","DOIUrl":"https://doi.org/10.1002/ccr3.70710","url":null,"abstract":"<p>Tuberculosis is an infectious disease that primarily affects the lungs and can pose diagnostic challenges to physicians. This case report discusses a 23-year-old male who initially presented with signs suggestive of lung carcinoma. A pleural biopsy done confirmed a TB-related right pleura necrotizing granuloma that responded well to anti-TB medications.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 8","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70710","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}