Clinical Case Reports最新文献

{"title":"Anterior Chest Wall Leiomyoma in a 4-Year-Old Girl: A Rare Pediatric Case.","authors":"Rajabu Athumani Bakari, Alfred Chibwae, Gerald Mpemba, Alex Mashaka, Mohammed H Kawambwa, Amos Brighton, Georvin Marco Haule, Mathayo Shadrack, Petronilla Joseph Ngiloi, Charles Komba","doi":"10.1002/ccr3.72653","DOIUrl":"https://doi.org/10.1002/ccr3.72653","url":null,"abstract":"<p><p>Anterior chest wall leiomyoma is an exceptionally rare benign tumor in children. Complete surgical excision with appropriate chest wall reconstruction provides excellent outcomes, and histopathological confirmation including immunohistochemistry is essential to exclude malignancy.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 ","pages":"e72653"},"PeriodicalIF":0.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Less Can Be Enough: Sustained Remission of Pediatric Eosinophilic Esophagitis With Low-Frequency Dupilumab.","authors":"Giovanni Scatigna, Annarita Iadecola, Martina Piersanti, Giovanni Di Nardo, Maurizio Mennini","doi":"10.1002/ccr3.72457","DOIUrl":"https://doi.org/10.1002/ccr3.72457","url":null,"abstract":"<p><p>Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease requiring long-term therapy. Dupilumab, an interleukin-4 and interleukin-13 receptor antagonist, is approved for EoE at a weekly 300 mg dosing regimen. However, data on reduced-frequency dosing, especially in pediatric patients, remain limited. This is the case of a 12-year-old girl presented with vomiting, food impaction, and dysphagia. Endoscopy revealed longitudinal furrows and whitish exudates (EREFS 4), and histology confirmed EoE with 75 eosinophils/high-power field (HPF) and high EoEHSS grade and stage scores. Conventional therapies with proton pump inhibitors, topical fluticasone, and an elimination diet achieved only partial improvement. Dupilumab (300 mg every 2 weeks) induced complete clinical, endoscopic (EREFS 0), and histologic remission (EoEHSS grade/stage 0-1, peak < 6 eos/HPF) after 6 months. Given the remission and parental concern about prolonged therapy, the dosing interval was cautiously extended to every 3 weeks as a monitored off-label trial. Topical steroids and dietary restrictions were discontinued. The patient remained asymptomatic and in complete histologic remission for more than 2 years (as of August 2025: EREFS 0, EoEHSS 0, with a peak eosinophil count of ≤ 6 eos/HPF) without any adverse events. This case illustrates that sustained remission of pediatric EoE may be achievable with individualized, response-based dupilumab de-escalation. While promising, this off-label approach requires confirmation in prospective studies before routine implementation.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 ","pages":"e72457"},"PeriodicalIF":0.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Lower Lip Swelling due to Granulomatous Cheilitis.","authors":"Jesus Ruiz, Jacob Garner","doi":"10.1002/ccr3.72669","DOIUrl":"https://doi.org/10.1002/ccr3.72669","url":null,"abstract":"<p><p>Granulomatous cheilitis should be considered in the differential diagnosis of persistent, unexplained orofacial swelling, particularly when standard treatments fail.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 ","pages":"e72669"},"PeriodicalIF":0.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gingival Squamous Cell Carcinoma: Diagnostic Challenges and Clinical Implications.","authors":"Gitanjali Subedi, Arjun Hari Rijal, Simant Lamichhane, Pratibha Poudel, Sachita Thapa, Manoj Humagain","doi":"10.1002/ccr3.72664","DOIUrl":"https://doi.org/10.1002/ccr3.72664","url":null,"abstract":"<p><p>Oral squamous cell carcinoma (OSCC) is one of the highly invasive malignancies globally, accounting for the vast majority of all oral cancers, that is, more than 90%. Carcinomas of the gingiva represent a distinct subgroup of OSCC, constituting approximately 12% of all OSCC cases. These neoplasms might mimic the inflammatory and reactive state of the periodontium, often leading to a delay in diagnosis and hence, poorer prognosis. A case of gingival squamous cell carcinoma in a 48-year-old female patient has been reported here, in which the patient had no risk factors for the development of this neoplasm. The patient presented with a 3-month history of pain and burning sensation in the lower left back region of the jaw. Clinical examination showed a proliferative lesion extending from the marginal gingiva to the buccal vestibule adjacent to teeth 36 and 37. Given the clinical manifestations and differential diagnosis of infectious granulomatous lesions and malignant neoplasms, an excisional biopsy was performed and a diagnosis of well-differentiated squamous cell carcinoma was made. The patient was subsequently referred to the Oral and Maxillofacial Surgery Department for further treatment, which included surgical excision of the tumor with segmental mandibulectomy and selective neck dissection. The patient is still being monitored one and a half years after the treatment and does not show any signs of recurrence. Therefore, the lesion must be identified early to start treatment, stop metastases, and enhance the prognosis.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 ","pages":"e72664"},"PeriodicalIF":0.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily Remote Monitoring of Pediatric Patients With Cardiac Implantable Electronic Devices: Early Arrhythmia Detection and Timely Clinical Intervention.","authors":"Piotr Wieniawski, Jakub Zabłocki, Bożena Werner","doi":"10.1002/ccr3.72651","DOIUrl":"https://doi.org/10.1002/ccr3.72651","url":null,"abstract":"<p><p>In recent years, significant progress has been made in the management of pediatric arrhythmias through the use of cardiac implantable electronic devices (CIEDs) such as pacemakers (PMs) and implantable cardioverter-defibrillators (ICDs). Remote monitoring (RM) ideally enables rapid arrhythmia detection and shortens the time to clinical intervention. We herein present three pediatric cases from our institution to illustrate the clinical utility of RM in patients with complex cardiac conditions. In each case, RM facilitated timely recognition of arrhythmias, guided appropriate interventions, and contributed to improved patient outcomes. These experiences highlight the importance of daily RM as an integral component of care not only for children with CIEDs, offering both safety benefits and reduced hospitalization burden.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 ","pages":"e72651"},"PeriodicalIF":0.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to 'Congenital Lobar Emphysema in an Infant Presenting With Persistent Cough and Progressive Respiratory Symptoms: A Case Report'.","authors":"","doi":"10.1002/ccr3.72677","DOIUrl":"https://doi.org/10.1002/ccr3.72677","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1002/ccr3.72624.].</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 ","pages":"e72677"},"PeriodicalIF":0.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Nerves to Vessels: Unmasking Churg-Strauss Behind Polyneuropathy.","authors":"Hiba Antar, Sylvana Balhas, Zeinab El Mawla","doi":"10.1002/ccr3.72663","DOIUrl":"https://doi.org/10.1002/ccr3.72663","url":null,"abstract":"<p><p>Eosinophilic granulomatosis with polyangiitis (EGPA), formerly Churg-Strauss vasculitis, is a rare systemic autoimmune disease. Neurological involvement is a significant complication. This report details a case of EGPA with severe, progressive polyneuropathy and atypical serological findings, highlighting diagnostic challenges and the importance of early intervention. A 55-year-old male with asthma and uncontrolled diabetes presented with progressive neuropathic pain and paraplegia. He had a history of significant eosinophilia. Clinical examination revealed a rash, neurological deficits, and signs of multisystem involvement. Laboratory tests showed marked eosinophilia, elevated inflammatory markers, renal impairment, and positive ANCA. Imaging revealed cerebral ischemic changes and small vessel vasculitis. A skin biopsy confirmed leukocytoclastic vasculitis, and echocardiography showed cardiac dysfunction. The constellation of symptoms led to a diagnosis of EGPA with multisystem involvement. This case illustrates the classic triad of EGPA symptoms: asthma, hypereosinophilia, and multisystem involvement, particularly neurological. The patient's progressive neurological symptoms and positive ANCA supported the diagnosis of CNS vasculitis. The rapid onset of neurological involvement, despite the patient's age and delayed diagnosis, underscores the aggressive nature of EGPA. The multisystem involvement, including cardiac and renal systems, highlights the need for a comprehensive diagnostic and therapeutic approach. Early diagnosis and aggressive immunosuppressive therapy are crucial for preventing irreversible damage. The atypical finding of c-ANCA positivity, rather than the more common p-ANCA, presents a diagnostic challenge and warrants further investigation into specific ANCA subtypes (MPO vs. PR3). This case emphasizes the need for a high index of suspicion for EGPA in patients with unexplained neurological symptoms, especially those with asthma or hypereosinophilia, even in the presence of unusual serological markers. EGPA is a complex disease with diverse neurological and systemic manifestations. This case emphasizes the importance of early recognition and prompt treatment with corticosteroids and immunosuppressive agents to improve patient outcomes and prevent long-term sequelae. Clinicians should consider EGPA in patients with unexplained neurological symptoms, especially those with a history of asthma or hypereosinophilia.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 ","pages":"e72663"},"PeriodicalIF":0.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Management of Fetal Supraventricular Tachycardia With Flecainide in a Case Complicated by Early Hydrops Fetalis: A Case Report.","authors":"Amirabbas Faridpour, Yazdan Ghandi, Alireza Golbabaei","doi":"10.1002/ccr3.72117","DOIUrl":"https://doi.org/10.1002/ccr3.72117","url":null,"abstract":"<p><p>Fetal arrhythmia that can lead to hydrops fetalis and fetal heart failure if untreated. This case report describes the successful treatment of a fetus with SVT at 26 weeks of gestation using flecainide. A 37-year-old gravida 3, para 2 woman was diagnosed with fetal SVT during a routine ultrasound, which also revealed mild pleural effusion, pericardial effusion, and ascites, raising concerns for hydrops fetalis. A fetal echocardiogram confirmed a heart rate of 250-300 beats per minute with preserved cardiac function. The mother was started on oral flecainide at 100 mg twice daily, which was increased to 150 mg twice daily after 3 days due to persistent fetal tachycardia. Within 24 h of the dosage adjustment, the fetal heart rate normalized to 120-130 beats per minute, and the hydrops resolved by the third week of treatment. The mother delivered a healthy baby at 39 weeks, and the infant has remained free of SVT episodes to date. This case demonstrates the efficacy and safety of flecainide in treating fetal SVT, particularly in cases complicated by early hydrops.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 ","pages":"e72117"},"PeriodicalIF":0.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not Only Enteropathy: The Overlooked \"Gastric Side\" of Olmesartan.","authors":"Cecilia Lina Pugliano, Stefania Piccirelli, Denise Bianchi, Clarissa Ferrari, Cristiano Spada, Paola Cesaro","doi":"10.1002/ccr3.70845","DOIUrl":"https://doi.org/10.1002/ccr3.70845","url":null,"abstract":"<p><p>Several medications can be associated with gastrointestinal adverse effects. Olmesartan has been linked to a broad spectrum of gastrointestinal injuries. Although sprue-like enteropathy is well known, less common involvements such as gastropathy can be equally debilitating. Differential diagnosis can be challenging in individual cases, but in our patient, drug withdrawal led to complete recovery.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 ","pages":"e70845"},"PeriodicalIF":0.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Atypical Hip Pain in a Recreational Athlete: A Case Report.","authors":"Qvick Milan, Steyaert Adelheid, Watteyne Karel","doi":"10.1002/ccr3.72662","DOIUrl":"https://doi.org/10.1002/ccr3.72662","url":null,"abstract":"<p><p>Osteochondromas are the most common benign bone tumors, but pelvic involvement is rare. We present a case of an iliac osteochondroma manifesting with atypical hip pain, adding to the limited literature on pelvic osteochondromas and highlighting the diagnostic and management challenges of such cases in an athletic population. A 28-year-old male presented with progressive right greater trochanteric area pain, predominantly nocturnal and exacerbated by running and football but absent during cycling. Physical examination and ultrasound revealed no abnormalities. CT and MRI revealed a pedunculated osseous mass arising from the anterosuperior ilium with cortical and medullary continuity, consistent with osteochondroma. MRI demonstrated a thin cartilage cap (< 2 cm) and local irritation of the iliopsoas. Analgesic therapy, sacroiliac joint injection, and physiotherapy failed to provide relief. After discussion in a multidisciplinary oncology board, the patient underwent en bloc excision. Prognosis was considered favorable given the absence of aggressive imaging features. This case emphasizes that nocturnal hip pain and activity-dependent symptom modulation in a recreational athlete are atypical for the far more common musculotendinous causes of hip pain and should prompt clinicians to consider underlying osseous pathology. Further, it illustrates the importance of multimodality imaging in osteochondromas for accurate characterization and supports the role of multidisciplinary tumor boards in guiding management of rare benign bone tumors.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 ","pages":"e72662"},"PeriodicalIF":0.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}