{"title":"Enteropathogenic Escherichia coli (EPEC) Causes Chronic Diarrhea and Hyponatremia in an Adult","authors":"Saisai Chen, Colin Feuille","doi":"10.1002/ccr3.70288","DOIUrl":"https://doi.org/10.1002/ccr3.70288","url":null,"abstract":"<p>Enteropathogenic <i>Escherichia coli</i> (EPEC) is frequently identified on gastrointestinal pathogen multiplex polymerase chain reaction testing. However, it is unclear whether EPEC causes diarrhea in adults. We describe the case of a 48-year-old man living in the United States who presented with 6 weeks of large-volume watery diarrhea and significant hyponatremia refractory to hypertonic saline and fluid restriction, who was found to have EPEC. Ciprofloxacin was initiated, resulting in the resolution of both diarrhea and hyponatremia. This case demonstrates that EPEC can be pathogenic in adults and can be associated with significant hyponatremia.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70288","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sana Muhammad Hussain, Anum Khan, Zahra Anas, Zarlish Khan, Amanullah Abbasi, Md Ariful Haque
{"title":"Unmasking the Duo: Wilson's Disease in the Context of Lupus and Existing Hepatitis E Coinfection","authors":"Sana Muhammad Hussain, Anum Khan, Zahra Anas, Zarlish Khan, Amanullah Abbasi, Md Ariful Haque","doi":"10.1002/ccr3.70368","DOIUrl":"https://doi.org/10.1002/ccr3.70368","url":null,"abstract":"<p>We report the case of a 19-year-old woman who presented with a plethora of overlapping symptoms with complex etiology, and the final diagnosis was concurrent Wilson's disease in the background of Systemic Lupus Erythematosus and Hepatitis E infection, all of which affect similar organs and lead to a presentation with jaundice, fever, neuropsychiatric symptoms, and personality changes. In this unique case, before the manifestation o of symptoms specifically related to Wilson's disease such as bizarre behavior and initial mutism, followed by irrelevant speech, the SLE symptoms were present such as oral ulcers, alopecia, and arthralgia affecting the small joints of hands and feet along with palpitations and shortness of breath. The key clinical message is the need for thorough diagnostic evaluation, as WD can be masked or mistaken for autoimmune conditions, such as SLE. The early identification and treatment of both conditions are crucial for preventing disease progression and improving patient outcomes.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70368","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bassem Al Hariri, Obada Adel Alsakaji, Abdelkarim Mohamed, Muad Abdi Hassan
{"title":"Kounis Syndrome Type 2 due to Ingestion of a Fish Meal: A Case Report","authors":"Bassem Al Hariri, Obada Adel Alsakaji, Abdelkarim Mohamed, Muad Abdi Hassan","doi":"10.1002/ccr3.70209","DOIUrl":"https://doi.org/10.1002/ccr3.70209","url":null,"abstract":"<p>Kounis syndrome is a type of acute coronary syndrome that occurs when a chemical mediator produced by mast cell activation leads to coronary artery vasospasm. This can happen due to anaphylaxis, anaphylactoid reactions, allergies, or hypersensitivities. There are three variants of Kounis syndrome, including vasospastic allergic angina, an atheromatous disease with plaque eruption, and stent thrombosis. In this case, the patient developed type 2 Kounis syndrome after consuming a fish meal, which caused him to present with a non-ST elevation myocardial infarction (NSTEMI) at our hospital.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Twin Acardiac: Case Reported From Ethiopia","authors":"Ebisa Erena muleta, Girma Geta, Awel Temema Dube, Kasu Hailu Seifu","doi":"10.1002/ccr3.70379","DOIUrl":"https://doi.org/10.1002/ccr3.70379","url":null,"abstract":"<p>Acardiac twinning is a rare congenital anomaly in monozygotic twin pregnancies, caused by abnormal placental vascular anastomosis. We present a case of monochorionic twinning: Twin A was a heterogeneous mass with no head or cardiac activity, while Twin B was well formed. Twin B passed away 1 week after birth.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Draining Large Pericardial Effusion in a Pulmonary Hypertension Patient: Between a Rock and a Hard Place","authors":"Azhar Farooqui, Mohamed Alama, Ibrahim Antoun","doi":"10.1002/ccr3.70370","DOIUrl":"https://doi.org/10.1002/ccr3.70370","url":null,"abstract":"<p>Managing pericardial effusion in autoimmune diseases like systemic lupus erythematosus becomes particularly challenging when accompanied by pulmonary hypertension (PH). The risk of acute right ventricular overload and hemodynamic collapse makes pericardial drainage a high-stakes decision. This case highlights the necessity of a multidisciplinary, individualized approach in high-risk patients. It also underscores the effectiveness of immunosuppressive therapy (e.g., mycophenolate mofetil) and pulmonary vasodilators (e.g., Ambrisentan, Tadalafil) in achieving gradual resolution. Close collaboration with PH specialists is essential for safely navigating these complex cases.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70370","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. C. Bhumika, Shrijana Shrestha, Firoz Anjum, Shreya Thapa, Rahul Shrestha
{"title":"Lupus Disguised as Chorea: Uncommon Presentation of a Common Disease","authors":"G. C. Bhumika, Shrijana Shrestha, Firoz Anjum, Shreya Thapa, Rahul Shrestha","doi":"10.1002/ccr3.70376","DOIUrl":"https://doi.org/10.1002/ccr3.70376","url":null,"abstract":"<p>This case report presents a preadolescent female with a rare presentation of lupus as isolated chorea. An investigation to find out the cause of unexplained cytopenia with raised inflammatory markers ultimately led to the diagnosis of neuropsychiatric lupus with antiphospholipid antibodies. Lupus should always be included in the differential for chorea in children.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmad S. Matarneh, Sundus Sardar, Abdel-rauof Akkari, Pankhuri Mohan, Naman Trivedi, Gurwant Kaur, Nasrollah Ghahramani
{"title":"Conservative Management of Thrombotic Microangiopathy in a Renal Transplant Recipient: The Importance of Early Recognition","authors":"Ahmad S. Matarneh, Sundus Sardar, Abdel-rauof Akkari, Pankhuri Mohan, Naman Trivedi, Gurwant Kaur, Nasrollah Ghahramani","doi":"10.1002/ccr3.70351","DOIUrl":"https://doi.org/10.1002/ccr3.70351","url":null,"abstract":"<p>Thrombotic microangiopathy (TMA) is a rare but severe complication in renal transplant recipients, often linked to tacrolimus. Early recognition and intervention, such as stopping the drug, are crucial to preventing graft loss. This case highlights the importance of prompt diagnosis and vigilance for subtle signs to ensure effective management.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70351","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Man With Two Pacemakers: The Mystery of the Electrocardiogram","authors":"Yingchun Hu, Xiaoyu Chen, Hui Huang, Weiming Luo, Yisheng Zhou, Xingkao Chen, Guoping Liu, Hanping Zhang","doi":"10.1002/ccr3.70338","DOIUrl":"https://doi.org/10.1002/ccr3.70338","url":null,"abstract":"<p>Our findings reported a confusing but interesting clinical practice. In our study, three spike signals are observed during stable pacing periods, with fixed spikes occurring during the AV delay at 180 ms intervals, excluding other operation types such as CRT and His bundle pacing.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John Lugata, Laetitia Makower, Ashley Rapheal, Ibrahim Salum, Tecla Lyamuya, Raziya Gaffur, Patricia Swai, Elizabeth Skinner, Nasra Batchu, Eusebious Maro, Alex Mremi, Bariki Mchome
{"title":"Unusual Presentation of Recurrent Vaginal Leiomyoma in Pregnancy: A Rare Case Report and Review of Current Literature","authors":"John Lugata, Laetitia Makower, Ashley Rapheal, Ibrahim Salum, Tecla Lyamuya, Raziya Gaffur, Patricia Swai, Elizabeth Skinner, Nasra Batchu, Eusebious Maro, Alex Mremi, Bariki Mchome","doi":"10.1002/ccr3.70344","DOIUrl":"https://doi.org/10.1002/ccr3.70344","url":null,"abstract":"<p>Uterine leiomyomas, commonly known as fibroids, are the most prevalent pelvic tumors in females, affecting 20%–30% of women of reproductive age. These fibroids can lead to significant symptoms and morbidity. Vaginal fibroids are rare as primary vaginal tumors; approximately 300 cases have been documented in medical literature to date. Notably, there have been no reports of vaginal leiomyomas in Sub-Saharan Africa. A 28-year-old woman presented to our specialty hospital in Northern Tanzania at 30 weeks and 1 day of gestation with a vaginal mass that had been present since conception. She had a history of a vaginal mass that was excised in 2019 at a regional hospital. Magnetic resonance imaging revealed a soft tissue mass with a necrotic component, variable areas of restriction, and extra pelvic extension. The mass compressed the urinary bladder and vagina, as well as displacing the uterus upward and the rectum to the right side. The mass measured 21.7 × 13.5 × 9.0 cm. Due to premature rupture of membranes and fetal distress, she underwent an emergency cesarean section, and both mother and baby recovered well post-operatively. Three months later, she returned for excision of the vaginal mass, and the final histological report indicated a vaginal leiomyoma.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70344","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Langerhans Cell Histiocytosis With a Neck Mass as the First Symptom","authors":"Yuxin Xie, Xiaoming Kang, Xianlin Liu, Zhigan Wang, Qiancheng Jing","doi":"10.1002/ccr3.70365","DOIUrl":"https://doi.org/10.1002/ccr3.70365","url":null,"abstract":"<p>A 60-year-old female was found to have a mass in the neck and nasopharyngeal protrusion. These manifestations were highly prone to being misdiagnosed as cervical lymph node metastasis of nasopharyngeal carcinoma. The pathological examination confirmed LCH, a cell-proliferative disease. Misdiagnosis should be avoided in clinical diagnosis.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}