Joshua Chacko, Raymond Haward, Newton Ashish Shah, Saravenensandeep V. Pathmanathan, Bharath Sundaramoorthy, Jyothi Halepalya Tukaram
{"title":"A Rare Case of Budd–Chiari Syndrome in a Young Female","authors":"Joshua Chacko, Raymond Haward, Newton Ashish Shah, Saravenensandeep V. Pathmanathan, Bharath Sundaramoorthy, Jyothi Halepalya Tukaram","doi":"10.1002/ccr3.70478","DOIUrl":"https://doi.org/10.1002/ccr3.70478","url":null,"abstract":"<p>Budd–Chiari syndrome is a rare disorder characterized by hepatic vein obstruction, with an incidence of 1 in 100,000. It can be diagnosed through imaging studies and initially managed with anticoagulants. Acute Budd–Chiari syndrome can be treated with thrombolysis to dissolve blood clots obstructing hepatic veins. Venous obstructions in Budd–Chiari syndrome can be fixed through angioplasty or venous stenting to restore blood flow. Liver decompression can be achieved with TIPS, and severe cases may require liver transplantation.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 5","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70478","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Managing Internal Inflammatory Root Resorption and Perforation of a Mandibular Primary Molar: A Case Report With 15 Months Follow-Up","authors":"Mana Mowji, Motahareh Khosrojerdi","doi":"10.1002/ccr3.70475","DOIUrl":"https://doi.org/10.1002/ccr3.70475","url":null,"abstract":"<p>In the present case, calcium-enriched mixture (CEM) cement demonstrated an excellent ability to impede internal inflammatory root resorption in a second primary molar with poor prognosis of a 5-year-old boy with an extremely immature apex.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 5","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70475","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Constrictive Pericarditis as a Rare Manifestation of Graft-Versus-Host Disease: A Case Report","authors":"Alireza Arzhangzadeh, Mahmood Zamirian, Ladan Nasermoadeli, Asma Mousavi, Salma Nozhat, Roozbeh Narimani Javid, Sasan Shafiei, Salar Azadnik, Shayan Shojaei","doi":"10.1002/ccr3.70479","DOIUrl":"https://doi.org/10.1002/ccr3.70479","url":null,"abstract":"<p>Graft-versus-host disease (GVHD) is a serious inflammatory complication that can arise after allogeneic transplantation, characterized by donor T-cells attacking the recipient's tissues. While cardiac complications are infrequent, they are more commonly observed in cases of chronic GVHD and may manifest as pericardial effusion, cardiac tamponade, and various arrhythmias. Additionally, chronic GVHD can result in constrictive pericarditis (CP) due to the accumulation of fluid and scarring. A 25-year-old Iranian man developed CP 14 years after undergoing allogenic stem cell transplantation. Following inadequate response to medical therapy, he underwent a pericardiectomy. Pathological examination during follow-up revealed fibrosis and mild chronic inflammation. This report aims to add another case of cardiac manifestation associated with GVHD to the current literature. The main message emphasizes the urgent need for prompt diagnosis and effective pericardiectomy, which can be life-saving. Surgical referral should always be an option, and post-operative immunomodulation is crucial.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 5","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70479","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annie Pappas, Mary Mooney, Katherine Kohnen, Joshua W. Owens, Wenying Zhang, Robert J. Hopkin, Amelle Shillington
{"title":"The phenotypic spectrum of the Cornelia de Lange-like “Alazami-Yuan syndrome”: A case report of the 7th diagnosed individual and review of the literature","authors":"Annie Pappas, Mary Mooney, Katherine Kohnen, Joshua W. Owens, Wenying Zhang, Robert J. Hopkin, Amelle Shillington","doi":"10.1002/ccr3.9208","DOIUrl":"https://doi.org/10.1002/ccr3.9208","url":null,"abstract":"<p>We present a 17-year-old female with a childhood clinical diagnosis of Cornelia de Lange Syndrome (CdLS), however later genetic testing identified compound heterozygous variants in <i>TAF6</i>, consistent with AYS. This case report adds to the phenotypic spectrum observed in AYS, and draws connections to transcriptional pathways between CdLS and AYS.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 5","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.9208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comprehensive Whole-Course Management Strategy for Recurrent Renal Cell Carcinoma: Case Report and Literature Review","authors":"PengNan Hu, Di Chen, Jun Yu, Hua Mi","doi":"10.1002/ccr3.70418","DOIUrl":"https://doi.org/10.1002/ccr3.70418","url":null,"abstract":"<p>Renal cell carcinoma, a highly recurrent and metastatic malignancy. Drawing upon a decade-long expertise in managing recurrent cases, we advocate the adoption of Programmed Death-1 (PD-1) inhibitors in conjunction with Axitinib when monotherapy with Axitinib fails to restrain tumor metastasis, thereby empowering doctors with an efficacious treatment option.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 5","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multiple Ulcers Associated With Deep Vein Thrombosis Secondary to Herpes Zoster Infection of the Lower Limb","authors":"Makoto Kondo, Koji Habe, Keiichi Yamanaka","doi":"10.1002/ccr3.70264","DOIUrl":"https://doi.org/10.1002/ccr3.70264","url":null,"abstract":"<p>Persistent limb swelling and ulceration following herpes zoster may indicate the development of deep vein thrombosis, highlighting the importance of early diagnosis and initiation of anticoagulant therapy. Pain and reduced mobility are significant contributors to thrombosis, underscoring effective pain management's critical role in the prevention of deep vein thrombosis.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 5","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnosis and Management of Cushing's Syndrome During Pregnancy: Two Cases Report and Literature Review","authors":"Jingjing Huang, Zhiyu Deng, Guohua Li, Deshui Zhao","doi":"10.1002/ccr3.70477","DOIUrl":"https://doi.org/10.1002/ccr3.70477","url":null,"abstract":"<p>Cushing's syndrome (CS) during pregnancy is a rare condition, with only a few reported cases in the literature. Diagnosis is often difficult due to physiological changes during pregnancy. Careful clinical observation during pregnancy and after delivery is necessary to initiate appropriate treatment.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 5","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70477","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fulminant Hepatic Failure Following Intentional Iron Overdose—A Case Report","authors":"Hrithik Dakssesh Putta Nagarajan, Ram Vivek Ramamoorthy, Naveen Vishwanath, Miruthula Murugan, Balakrishnan Kamaraj, Shiva Jeyaprakash Narayan Balamurugan, Shubham Kumar, Shilpa Gaidhane, Sanjit Sah, Prakasini Satapathy, Rachana Mehta, Amogh Verma","doi":"10.1002/ccr3.70476","DOIUrl":"https://doi.org/10.1002/ccr3.70476","url":null,"abstract":"<p>Intentional iron overdose in adults is a rare but formidable clinical challenge, often complicated by delayed presentation and a concealed history of ingestion. We report the case of a 21-year-old male who presented 4 days after consuming large quantities of ferrous sulfate tablets. The initial nonspecific gastrointestinal symptoms progressed to severe jaundice, encephalopathy, and coagulopathy, and the diagnosis was confounded by the patient's denial of suicidal ingestion. By the time iron toxicity was identified, the therapeutic window for early decontamination or parenteral chelation had been passed. Supportive care, including advanced extracorporeal therapies, facilitated hepatic and renal recovery. This case highlights the importance of high clinical suspicion, thorough history taking, and the potential role of salvage therapies in severe late-presenting iron poisoning.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 5","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70476","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incidental Discovery of Multiple Intracranial and Orbital Metallic Foreign Bodies: A Unique Case of Long-Term Asymptomatic Buckshot Retention","authors":"Lei Duan, Bohan Zhang, Jiaxu Liao, Xiaohua Zheng","doi":"10.1002/ccr3.70443","DOIUrl":"https://doi.org/10.1002/ccr3.70443","url":null,"abstract":"<p>Long-term retention of multiple intracranial foreign bodies without significant symptoms demonstrates the human body's remarkable adaptability. This case underscores the importance of thorough radiological examination in detecting unexpected findings, providing insights into the long-term consequences of retained projectiles.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 5","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuvraj Kaushal, Abhijeet Kaur, Pranav Goyal, Mohammed Abdul Mateen, Jobby John, Yogesh Tekuru, Hamza A. Orfali
{"title":"When Potassium Takes a Break: A Case Series of 3 Cases on Hypokalemic Periodic Paralysis","authors":"Yuvraj Kaushal, Abhijeet Kaur, Pranav Goyal, Mohammed Abdul Mateen, Jobby John, Yogesh Tekuru, Hamza A. Orfali","doi":"10.1002/ccr3.70425","DOIUrl":"https://doi.org/10.1002/ccr3.70425","url":null,"abstract":"<p>This case series highlights three SHPP cases with varied triggers, managed with potassium supplementation and targeted treatments. Early diagnosis, individualized care, and patient education proved vital in preventing recurrence and complications, emphasizing the need for clinical vigilance and tailored approaches in HPP management.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 5","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}