Clinical Case Reports最新文献_第3页

Bedside Transcranial Doppler as a Dynamic Warning Tool for Rapidly Evolving Intracranial Hypertension in Pneumococcal Meningitis. 床边经颅多普勒作为肺炎球菌脑膜炎快速发展的颅内高压的动态预警工具。

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Clinical Case Reports Pub Date : 2026-10-13 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73733

Mahmoud Ahmed, Victoria Collins, Andrea Lavinio

引用次数: 0

Coexistence of Ebstein Anomaly and Cerebral Cavernous Malformation: A Case Report. Ebstein畸形与脑海绵状血管瘤共存1例。

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73720

Nazmin Ahmed, Mohaiminul Islam, Md Raad Kazi, Jubair Ahmed Sikder, Tajrian Sultana, Mohammad Nazrul Hossain

{"title":"Coexistence of Ebstein Anomaly and Cerebral Cavernous Malformation: A Case Report.","authors":"Nazmin Ahmed, Mohaiminul Islam, Md Raad Kazi, Jubair Ahmed Sikder, Tajrian Sultana, Mohammad Nazrul Hossain","doi":"10.1002/ccr3.73720","DOIUrl":"10.1002/ccr3.73720","url":null,"abstract":"In most patients who have Ebstein anomaly (EA), neurological symptoms are either associated with thromboembolic episodes or due to arrhythmic complications. Cerebral cavernous malformation (CCM) is a vascular anomaly made up of sinusoidally dilated blood vessels, often presenting with seizure activity or intracranial bleeding. There has never been any documented report regarding coexisting EA and CCM. Herein, we have reported a 32-year-old female with an established history of Ebstein anomaly diagnosed in 2013 who had a history of generalized tonic-clonic fits since 2020. Neuroimaging studies showed the presence of a right frontal lobe mass with typical \"popcorn-like\" appearance and hemosiderin ring on MRI, indicative of cerebral cavernous malformation. The patient declined surgery and was managed conservatively with levetiracetam. With the occurrence of further fits in 2025, neuroimaging showed similar findings but without the presence of intratumoral bleeding. Subsequently, she underwent a left frontoparietal craniotomy for GTE of the lesion with cavernoma on histopathology. The neurological status of the patient was stable during her discharge on the fourth postoperative day. This case documents a previously unreported coexistence of Ebstein anomaly and cerebral cavernous malformation in a single patient. Given the rarity of both conditions, coexistence is coincidental. This indicates the need for genetic and molecular studies to determine whether a real biological association exists.","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73720"},"PeriodicalIF":0.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large Obstructive Left Atrial Myxoma in an Adolescent Girl Presenting With Stroke. 以中风为表现的青春期女孩的大梗阻性左心房黏液瘤。

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73723

Cyndee Jocson, Alexander Dahl, Stefanie Cheang

引用次数: 0

IF 0.6

Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73708

Masoud Maboudi, Maryam Montazeri, Sara Ghandi, Moozhan Mofidi

{"title":"Cancer-Related Fever in Metastatic Prostate Cancer: A Case Report.","authors":"Masoud Maboudi, Maryam Montazeri, Sara Ghandi, Moozhan Mofidi","doi":"10.1002/ccr3.73708","DOIUrl":"https://doi.org/10.1002/ccr3.73708","url":null,"abstract":"Fever in cancer patients is often mistakenly attributed to infection, leading to unnecessary antibiotic use. Neoplastic fever, though well-documented in hematologic malignancies, is rare in solid tumors, particularly prostate cancer. This case report presents an 81-year-old male with metastatic prostate cancer, who was admitted to Razi Hospital in Qaemshahr, Mazandaran, with persistent fever, chills, and urinary symptoms following radiotherapy. Despite broad-spectrum antibiotics, the fever persisted, and extensive infectious workups yielded no identifiable source. The patient's condition was further complicated by hyponatremia, elevated inflammatory markers, and a negative initial blood culture. As the fever continued, oncological evaluation was initiated, leading to the diagnosis of neoplastic fever. Chemotherapy with docetaxel and zoledronic acid resulted in the resolution of fever, confirming the oncologic nature of the fever. This case underscores the importance of recognizing neoplastic fever in cancer patients with persistent fever of unknown origin, particularly when infectious causes have been excluded. Early oncologic intervention, rather than prolonged antibiotic therapy, can prevent unnecessary treatments and improve patient outcomes. This case highlights the need for a high index of suspicion in managing cancer patients with fever, especially in the absence of an infectious etiology.","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73708"},"PeriodicalIF":0.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep Gluteal Syndrome and Persistent Sciatica in a Patient With Unilateral Piriformis Muscle Hypertrophy: A Case Report. 单侧梨状肌肥大患者的深臀综合征和持续性坐骨神经痛1例报告。

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73730

Najoua Ghani

引用次数: 0

Intranodal Epithelioid Schwannoma in an Intraparotid Lymph Node: A Case Report and Literature Review. 腮腺内淋巴结结内上皮样神经鞘瘤1例报告及文献复习。

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73709

Maryam Vajihinejad, Kianoosh Najafi, Mohammad Hossein Ahrar, Ahmad Shamsi

引用次数: 0

A Rare Case of Chronic Lymphocytic Leukemia and Chronic Myeloid Leukemia in an Elderly Patient: A Case Report. 老年慢性淋巴细胞白血病合并慢性髓系白血病1例报告。

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73136

Mostafa Kamandi, Mohammad Mahdi Alvandi Fard

{"title":"A Rare Case of Chronic Lymphocytic Leukemia and Chronic Myeloid Leukemia in an Elderly Patient: A Case Report.","authors":"Mostafa Kamandi, Mohammad Mahdi Alvandi Fard","doi":"10.1002/ccr3.73136","DOIUrl":"https://doi.org/10.1002/ccr3.73136","url":null,"abstract":"Chronic Lymphocytic Leukemia (CLL) and Chronic Myeloid Leukemia (CML) are two distinct hematological malignancies with different pathophysiologies and clinical courses. While each is relatively common in the elderly population, their simultaneous occurrence in a single patient is exceptionally rare and poses diagnostic and therapeutic challenges. We present the case of a 79-year-old male who was evaluated for progressive fatigue, weight loss, and marked leukocytosis. Laboratory investigations, peripheral blood smear, flow cytometry, and molecular studies were utilized to establish the diagnosis. Initial findings revealed extreme leukocytosis, anemia, and elevated LDH. Peripheral smear and molecular testing confirmed CML through detection of the BCR::ABL1 fusion gene. Concurrently, flow cytometry identified a clonal B-cell population positive for CD5, CD19, and CD20, consistent with CLL. Imaging showed splenomegaly and pathologic lymphadenopathy. The patient was treated with imatinib and hydroxyurea, resulting in normalization of white blood cell count, though anemia and thrombocytopenia persisted. This case highlights a rare synchronous diagnosis of CML and CLL in an elderly patient. The comprehensive diagnostic evaluation was critical in establishing the dual pathology. The case underscores the need for heightened clinical suspicion in atypical presentations and contributes to the limited body of knowledge on coexistent myeloid and lymphoid malignancies.","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73136"},"PeriodicalIF":0.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suboptimal Response to Eculizumab in Renal-Limited Thrombotic Microangiopathy Associated With Malignant Hypertension and Monoclonal Gammopathy: A Case Report. Eculizumab治疗与恶性高血压和单克隆gamm病相关的肾限制性血栓性微血管病的次优反应：1例报告

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73712

Wenjuan Lei, Tianli Shi, Man Xu, Jun Zhou

引用次数: 0

Regenerative Endodontic Procedure in Mandibular First Molar: A Clinical Case Report. 下颌第一磨牙再生根管治疗1例临床报告。

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73610

Sorour Saeedi, Ali Hamedi, Mani Mansouri, Iman Shiezadeh

{"title":"Regenerative Endodontic Procedure in Mandibular First Molar: A Clinical Case Report.","authors":"Sorour Saeedi, Ali Hamedi, Mani Mansouri, Iman Shiezadeh","doi":"10.1002/ccr3.73610","DOIUrl":"https://doi.org/10.1002/ccr3.73610","url":null,"abstract":"Regenerative endodontic procedures (REPs) have emerged as a biologically based treatment modality for managing immature permanent teeth with necrotic pulp, offering the potential for continued root development and periapical healing. This case report describes the regenerative endodontic treatment of a necrotic, immature mandibular first molar in a 9-year-old female patient. The treatment protocol involved canal disinfection using double antibiotic paste (DAP), induction of intracanal bleeding to form a natural scaffold, and coronal sealing with mineral trioxide aggregate (MTA). A 12-month follow-up demonstrated successful resolution of the periapical lesion, continued root maturation with increased root length and wall thickness, and clinical absence of symptoms. The extraoral sinus tract also healed completely within this period. This case highlights the clinical viability of REPs in immature multirooted teeth, emphasizing the importance of appropriate case selection, careful scaffold induction, and long-term monitoring. Although short-term outcomes were favorable, extended follow-up is necessary to fully validate the durability of regenerative success.","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73610"},"PeriodicalIF":0.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Aquaporin-4-Positive Neuromyelitis Optica Spectrum Disorder: Diagnostic Challenges and Transition From B-Cell Depletion Therapy to Ravulizumab. 病例报告：水通道蛋白-4阳性视谱神经脊髓炎：诊断挑战和从b细胞耗竭治疗到Ravulizumab的过渡。

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73704

Aram Zabeti

引用次数: 0