Clinical Case Reports最新文献

{"title":"Technical Note and Short Review: A Challenging Case of a Premature Newborn Presenting With ICH, IVH, Ventriculitis, and Hydrocephalus","authors":"Hannes Egermann,&nbsp;Christian Knorr,&nbsp;Basheer Al-Shameri,&nbsp;Adolf Müller,&nbsp;Markus Denzinger,&nbsp;Stephan Lackermair","doi":"10.1002/ccr3.70990","DOIUrl":"https://doi.org/10.1002/ccr3.70990","url":null,"abstract":"<p>Premature infants are at a heightened risk of intracerebral or intraventricular hemorrhages (IVH), which often lead to posthaemorrhagic hydrocephalus and necessitate the placement of a ventriculoperitoneal (VP) shunt. Here, we present a case involving suspected ICH, which led to multiloculated hydrocephalus, recurrent ventriculitis, and meningitis. This case study highlights the complexities of managing infections and the importance of endoscopic surgery in restoring CSF flow. It also sheds light on the long-term developmental outlook when treating premature infants with multilocular hydrocephalus.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70990","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Beriberi and Wernicke's Encephalopathy Presented as Chronic Dysphagia and Weight Loss","authors":"Bobbi Lee Roth,&nbsp;Yen-Yi Peng","doi":"10.1002/ccr3.71082","DOIUrl":"https://doi.org/10.1002/ccr3.71082","url":null,"abstract":"<p>Chronic dysphagia and weight loss can be presenting signs of gastrointestinal beriberi and Wernicke's encephalopathy.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.71082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coexistence of Localized and Systemic Juvenile Scleroderma: A Case Report and Review of Literature","authors":"Aye Miremarati,&nbsp;Kosar Babaeian Roshani,&nbsp;Manijeh Tabrizi,&nbsp;Fatemeh Tahghighi Sharabian,&nbsp;Seyyedeh Azade Hoseini Nouri","doi":"10.1002/ccr3.71078","DOIUrl":"https://doi.org/10.1002/ccr3.71078","url":null,"abstract":"<p>Juvenile scleroderma (JS) is a rare chronic connective tissue disorder characterized by progressive fibrosis of the skin and soft tissues with/without internal organ involvements. Scleroderma manifests itself in both systemic (SSc) and localized (LS) forms. This case report aimed to present an Iranian girl with coexistence of SSc and LS treated by Tocilizumab. A 12-year-old girl was referred to the rheumatology clinic with the chief complaint of asymmetrical facial appearance starting from two years ago and coexisting with restricted phalangeal motion for the last 6 months. In the physical examination, she had left hemi-facial atrophy as well as stiffness, swelling, redness, shiny appearance of the skin of hands and feet, and phalangeal joints restriction. Diagnostic assessments, including relevant consultations and laboratory tests, showed nothing important except for slightly elevated erythrocyte sedimentation rate (ESR), C reactive protein (CRP), and antinuclear antibody (ANA) titer of 1/80. At first, the therapeutic intervention consisted of methotrexate, Cellcept, and low dose prednisolone. Because of the unsatisfactory response, pulse dose of methylprednisolone was added. Due to incomplete therapeutic response, intravenous (IV) Tocilizumab was administered for at least 6 months, which resulted in significant improvement, notably in facial morphea. This case report emphasized the importance of accurate and early diagnosis and tailored therapeutic interventions in JS. In patients with LS, attention should be paid to rule out the overlap of systemic and localized types to prevent treatment delay. The presence of Raynaud's phenomenon, telangiectasia, or ANA positivity in a patient with LS should alert the physician to consider the possible coexistence of SSc and LS. Pulse dose of methylprednisolone is the mainstay of treatment in LS. Considering the risk of renal crisis, corticosteroids might be administered cautiously in SSc with frequent monitoring of electrolytes and renal function. Notably, Tocilizumab can be used as a pivotal therapeutic option in managing refractory morphea.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.71078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Recognition of Infantile Systemic Hyalinosis in a Palestinian Infant: A Case Report","authors":"Lilyan Jarrar,&nbsp;Sara Mutan,&nbsp;Lana Malhis,&nbsp;Ahmad Mashni,&nbsp;Afnan Ajlone,&nbsp;Mahdi Zaid,&nbsp;Sara Abuaisha","doi":"10.1002/ccr3.71126","DOIUrl":"https://doi.org/10.1002/ccr3.71126","url":null,"abstract":"<p>Infantile systemic hyalinosis should be suspected in infants with contractures, skin changes, and diarrhea in consanguineous families. Early recognition allows timely genetic testing, supportive care, and counseling, improving family outcomes despite poor prognosis.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.71126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant Gastric Trichobezoar: A Case Report of an Adolescent Girl","authors":"Sehrish Irshad,&nbsp;Shahzeen Irshad,&nbsp;Maryam Irshad,&nbsp;Mahnoor Fatima,&nbsp;Zulqarnain Ali","doi":"10.1002/ccr3.71116","DOIUrl":"https://doi.org/10.1002/ccr3.71116","url":null,"abstract":"<p>A rare case of gastric trichobezoar associated with trichotillomania and trichophagia emphasizes the need for careful psychiatric evaluation and early imaging of such patients to ensure timely surgical intervention to prevent severe complications.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.71116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of ProGlide Knot Entrapment by the Inguinal Ligament Resulting in Hemostasis Failure","authors":"Kotaro Mukasa,&nbsp;Yasunori Yakita,&nbsp;Ryosuke Marushima,&nbsp;Shinichiro Abe,&nbsp;Soichi Asano","doi":"10.1002/ccr3.71139","DOIUrl":"https://doi.org/10.1002/ccr3.71139","url":null,"abstract":"<p>Entrapment of ProGlide sutures by the inguinal ligament can result in closure failure. Confirming puncture site location under fluoroscopy and careful dissection may help prevent this complication.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.71139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validamycin Ingestion: A Rare Case of Poisoning With a Surprisingly Benign Outcome – Our Experience in a Resource-Limited Emergency Setting","authors":"Anish Luitel,&nbsp;Sweekar Dahal,&nbsp;Kabita Yadav,&nbsp;Bodhraj Budhathoki,&nbsp;Chandan Chaudary,&nbsp;Rasmita Poudel","doi":"10.1002/ccr3.70951","DOIUrl":"https://doi.org/10.1002/ccr3.70951","url":null,"abstract":"<p>Validamycin ingestion is a rare encounter in emergency settings. There is no specific antidote, with management being largely symptomatic. Overzealous treatment and referral to higher centers are not necessary, as consumption of even large doses of Validamycin is non-toxic to humans; rather, addressing the intention behind ingestion is more important.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70951","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurizing the Cause of Stillbirth Reviewed Under Maternal and Perinatal Death Surveillance and Response System Through Minimally Invasive Tissue Sampling: A Case Report","authors":"Nuwadatta Subedi,&nbsp;Junu Shrestha,&nbsp;Sabita Paudel,&nbsp;Sunita Ranabhat,&nbsp;Dela Singh","doi":"10.1002/ccr3.70979","DOIUrl":"https://doi.org/10.1002/ccr3.70979","url":null,"abstract":"<p>Stillbirth is a public health challenge to low- and middle-income countries, and the rate of stillbirths in Nepal is 15.7 per 1000 births. Stillbirths are reviewed under the maternal and perinatal death surveillance and response (MPDSR) system in Nepal, where the causes of deaths and preventive strategies should be identified, but there are constraints in identifying accurate causes of stillbirths. The existing MPDSR system lacks a depth review of perinatal deaths, just relying on the clinical and demographic information; thus, the accurate causes are left unidentified on several occasions. We incorporated minimally invasive tissue sampling (MITS) in a case of stillbirth reviewed under MPDSR as a part of a pilot project for the first time in Nepal in the MPDSR system. Histopathology of lung tissue samples identified meconium aspiration, and the placental examination identified maternal vascular malperfusion, which was a sequel of preeclampsia. Based on the placental and lung tissue findings, the main fetal cause was identified as intrauterine hypoxia. Along with the clinical information, MITS and placental examination are useful to establish accurate causes of stillbirth, reviewed under the MPDSR system, and to develop targeted strategies for the prevention of future deaths.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70979","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Approach to Myasthenia Gravis With Thymoma: A Case Report Highlighting Management of Myasthenic Crisis and Post-Crisis Care","authors":"Sakib Abrar,&nbsp;Shah Tanvir Ahmed,&nbsp;Ibrahim Khalil,&nbsp;Md. Imran Hossain","doi":"10.1002/ccr3.71063","DOIUrl":"https://doi.org/10.1002/ccr3.71063","url":null,"abstract":"<p>Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disorder that leads to muscle weakness and rapid fatigue, often exacerbated by thymoma, a tumor of the thymus gland. This case report presents the clinical management of a 40-year-old female with MG complicated by thymoma, who presented with a severe myasthenic crisis. The patient required intensive care, including respiratory support, plasmapheresis, and immunosuppressive therapy. Initial evaluations confirmed the diagnosis of MG through the detection of high levels of anti-acetylcholine receptor antibodies, and a CT scan revealed a thymic mass, indicative of thymoma. The management strategy included acetylcholinesterase inhibitors, immunosuppressive agents, and supportive therapies to stabilize the patient. The patient responded positively to plasmapheresis, which significantly improved her condition. Follow-up CT imaging confirmed the presence of thymoma, reinforcing the need for further investigation into surgical interventions such as thymectomy. The report also emphasizes the critical role of a multidisciplinary approach in managing MG with thymoma, underscoring the importance of early diagnosis and timely intervention to prevent recurrent crises. Additionally, it discusses the evolving role of thymectomy in MG patients with thymoma and the potential of newer treatments, such as complement inhibitors, for refractory cases. This case highlights the complexities of managing MG complicated by thymoma and stresses the importance of ongoing research into therapeutic strategies. Early diagnosis, effective management, and continuous monitoring remain essential to optimizing outcomes for patients with these complex conditions.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.71063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Vital Decoronation of a Maxillary Central Incisor: A Case Report With 18 Months Follow-Up","authors":"Maryam Enteghad,&nbsp;Zahra Lotf Haghpanah","doi":"10.1002/ccr3.70913","DOIUrl":"https://doi.org/10.1002/ccr3.70913","url":null,"abstract":"<p>In the present case, decoronation and root submergence of a necrotic maxillary central incisor were performed for a 13-year-old girl. The root canal was filled with mineral trioxide aggregate (MTA), which was covered with resin-modified glass ionomer. Apexification with MTA was performed for her other maxillary central incisor, and the edentulous region was restored using a fiber-reinforced composite bridge. Long-term follow-up indicated that decoronation might be a viable option to maintain the alveolar bone.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.70913","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}