Neonatal Spontaneous Abdominal Aortic Thrombosis Associated With Hypernatremic Dehydration and Acute Renal Failure: A Case Series

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL

Clinical Case Reports Pub Date : 2025-08-03 DOI:10.1002/ccr3.70736

Fauzia Ali Noor, Asha S. Hashi, Rohini Kalagouda Patil, Kennedy Khainga, David Galgallo, Doris Kinuthia, Diana Marangu, Fred Kambuni, Nyambura Karuiki, Naomi Gachara

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Abstract

Spontaneous abdominal aortic thrombosis in neonates due to various causes is a known entity. Hypernatremic dehydration with acute kidney injury/failure can also be one of the aetiologies. A 14- and 11-day-old term neonate born to primigravida mothers presented to two different facilities with a similar presentation of hypernatremic dehydration and acute kidney injury/failure attributed to inadequate breastfeeding causing non-catheter-related spontaneous abdominal aortic thrombosis. In both cases, initial management was supportive care, fluids and electrolyte corrections, antibiotics, and antihypertensives. Anticoagulant therapy resulted in notable improvement in renal function and general well-being of the neonates. A high index of suspicion of vascular thrombosis in neonates presenting with hypernatremic dehydration and acute renal injury/failure is key to having good clinical outcomes. Newer anticoagulant drugs like rivaroxaban can be promising in the management of neonatal aortic thrombosis.

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新生儿自发性腹主动脉血栓形成与高钠血症脱水和急性肾功能衰竭相关：一个病例系列

由于各种原因导致的新生儿自发性腹主动脉血栓形成是一个已知的实体。高钠血症性脱水伴急性肾损伤/衰竭也可能是病因之一。初产妇所生的14天和11天足月新生儿被送到两个不同的机构，表现相似的高钠血症性脱水和急性肾损伤/衰竭，原因是母乳喂养不足导致非导管相关性自发性腹主动脉血栓形成。在这两个病例中，最初的治疗是支持性护理、液体和电解质纠正、抗生素和抗高血压药物。抗凝治疗显著改善了新生儿的肾功能和总体健康状况。新生儿出现高钠血症性脱水和急性肾损伤/衰竭时，高度怀疑血管血栓形成是获得良好临床结果的关键。较新的抗凝药物如利伐沙班在治疗新生儿主动脉血栓方面很有前景。

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来源期刊

Clinical Case Reports MEDICINE, GENERAL & INTERNAL-

自引率

14.30%

发文量

1268

审稿时长

13 weeks

期刊介绍： Clinical Case Reports is different from other case report journals. Our aim is to directly improve global health and increase clinical understanding using case reports to convey important best practice information. We welcome case reports from all areas of Medicine, Nursing, Dentistry, and Veterinary Science and may include: -Any clinical case or procedure which illustrates an important best practice teaching message -Any clinical case or procedure which illustrates the appropriate use of an important clinical guideline or systematic review. As well as: -The management of novel or very uncommon diseases -A common disease presenting in an uncommon way -An uncommon disease masquerading as something more common -Cases which expand understanding of disease pathogenesis -Cases where the teaching point is based on an error -Cases which allow us to re-think established medical lore -Unreported adverse effects of interventions (drug, procedural, or other).