Saleh Mohebbi, Mohammadsadegh Zabihidan, Ali Omidvari, Mehdi Abrishami
{"title":"Post-COVID-19 Maxillary Bony Sequestration: A Case Report on Mucormycosis Challenges","authors":"Saleh Mohebbi, Mohammadsadegh Zabihidan, Ali Omidvari, Mehdi Abrishami","doi":"10.1002/ccr3.71080","DOIUrl":"10.1002/ccr3.71080","url":null,"abstract":"<p>COVID-19-associated mucormycosis (CAM) is a severe opportunistic infection, typically affecting immunocompromised patients. Maxillary bony sequestration as a delayed complication in immunocompetent individuals is rare, highlighting diagnostic and therapeutic challenges. A 31-year-old male with no comorbidities presented in September 2021 with COVID-19 pneumonia (Delta variant), treated with dexamethasone and remdesivir. In October 2021, he developed right maxillary hypoesthesia and cheek swelling. Nasal endoscopy and biopsy confirmed mucormycosis, managed with liposomal amphotericin B and endoscopic debridement. In February 2023, malodor and tooth loosening prompted imaging, revealing maxillary bony sequestration due to fungal-induced vascular thrombosis and necrosis, treated with surgical resection and prosthetic reconstruction. One-month follow-up (March 2023) showed no recurrence or complications, though the short follow-up limits long-term conclusions. This case underscores maxillary bony sequestration as a rare, delayed complication of CAM, even in immunocompetent patients. Persistent symptoms like malodor or tooth mobility warrant imaging and surgical evaluation. Long-term follow-up is crucial to detect and manage such sequelae.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful Treatment of Facial Pseudolymphoma With Intravenous Rituximab: A Case Report","authors":"Elham Behrangi, Nastaran Khodakarim, Shila Amiri, Seyyedeh Tahereh Rahimi, Neda Safarzadeh, Alireza Jafarzadeh","doi":"10.1002/ccr3.71101","DOIUrl":"10.1002/ccr3.71101","url":null,"abstract":"<p>Intravenous rituximab demonstrated significant efficacy in treating a case of refractory cutaneous pseudolymphoma that failed multiple conventional therapies, including corticosteroids, hydroxychloroquine, methotrexate, and biologics. The patient, a 42-year-old man, initially developed erythematous, nodular lesions on the face following dental implant surgery, which later spread and persisted despite various immunosuppressive and anti-inflammatory treatments. Histopathological and immunohistochemical analysis confirmed B-cell pseudolymphoma. Intravenous rituximab (500 mg weekly for 4 weeks, followed by maintenance doses) led to substantial lesion regression, with no recurrence observed after 1 year of follow-up. This case underscores the therapeutic potential of rituximab for treatment-resistant pseudolymphoma and highlights the need for further research into optimal treatment protocols for this rare condition.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bertolt Brecht Kouam Nteungue, Berinyuy Nyuydzefon, Boris Arnaud Nteungue Kouomogne, Verla Vincent Siysi
{"title":"Return to Spontaneous Circulation in a Patient With Cholinergic Syndrome at the Emergency Department of Buea Regional Hospital, Cameroon","authors":"Bertolt Brecht Kouam Nteungue, Berinyuy Nyuydzefon, Boris Arnaud Nteungue Kouomogne, Verla Vincent Siysi","doi":"10.1002/ccr3.71086","DOIUrl":"10.1002/ccr3.71086","url":null,"abstract":"<p>With the increasing misuse of herbal treatment and pesticides, cases of cholinergic syndrome following herbal treatment or organophosphate poisoning have become increasingly common in our milieu. However, when advanced, mortality is high. We report the successful management of a case involving a 54-year-old African female with a known history of hypertension and people living with HIV/AIDS, who consumed a powdered concoction from a traditional herbalist with the aim of treating her hypertension. She was later found unconscious and brought to the Emergency Department. On arrival, clinical evaluation revealed an unconscious patient, gasping, with bradypnea and hypersalivation. A working diagnosis of cholinergic syndrome was made. She was intubated and treated with atropine and recovered one hour later, after which she was extubated and admitted to the intensive care unit (ICU) for supportive intensive care treatment. She was discharged 2 days after her admission to the ICU with counseling to take only medications prescribed by a medical doctor to avoid this situation in the future. Our case report shows that prompt and accurate therapy in the face of advanced organophosphate poisoning can lead to the rescue of life.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sadegh Bagherzadeh, Faramarz Roohollahi, Morteza Faghih Jouybari, Leila Bahari
{"title":"Postoperative Remote Acute Subarachnoid Hemorrhage as a Complication of Chronic Subdural Hematoma Evacuation With Burrhole: A Case Report and Literature Review","authors":"Sadegh Bagherzadeh, Faramarz Roohollahi, Morteza Faghih Jouybari, Leila Bahari","doi":"10.1002/ccr3.71076","DOIUrl":"10.1002/ccr3.71076","url":null,"abstract":"<p>Chronic subdural hematoma (CSDH) is a common neurosurgical condition. Surgical evacuation, particularly burr hole trephination, is the preferred treatment method. However, postoperative complications such as hematoma recurrence and intracerebral hemorrhage may occur. Isolated subarachnoid hemorrhage (SAH) is rare but can occur after the evacuation of a CSDH. We presented the case of an 83-year-old male who underwent the double burr hole evacuation of the left CSDH and then had SAH in the immediate postoperative CT scan. The vascular study was negative, and the patient was treated medically for SAH, resulting in a full recovery. We also found four similar reports in the literature. This is a rare complication; no vascular lesions have been identified in recorded cases. Most cases recover completely, with one fatality reported. It's generally considered a benign condition. Our recommendations include strict perioperative blood pressure management, preventing rapid or excessive drainage, and reversing anticoagulants to avoid this complication.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Vitreous Hemorrhage Possibly Attributable to Retinal Arterial Microaneurysm Following SARS-CoV-2 Vaccination","authors":"Tatsuya Sakamoto, Daisuke Nagasato, Hayato Tanaka, Tomoki Shirakami, Keigo Murata, Shunsuke Nakakura, Toshihiko Nagasawa, Yoshinori Mitamura, Hitoshi Tabuchi","doi":"10.1002/ccr3.71074","DOIUrl":"10.1002/ccr3.71074","url":null,"abstract":"<p>Vitreous hemorrhage caused by a ruptured retinal arterial microaneurysm can occur in patients with diabetic retinopathy after severe acute respiratory syndrome coronavirus 2 vaccination.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pregnancy in Takayasu Arteritis: A Case Report of Successful Pregnancy in a Large Aortic Aneurysm","authors":"Mona Yadollahi, Simin Almasi, Mehrdad Salehi, Farnoosh Larti, Mahdi Daliri, Akram Sardari","doi":"10.1002/ccr3.70974","DOIUrl":"10.1002/ccr3.70974","url":null,"abstract":"<p>A 29-year-old primigravida woman with a gestational age of 19 weeks visited in the cardio-obstetrics clinic for hypertension. Physical examination revealed auscultated systolic and diastolic murmurs in the second right intercostal space. Transthoracic echocardiography (TTE) showed severe left ventricle (LV) enlargement with mild systolic dysfunction. Severe aortic regurgitation (AR) and aneurysmal dilation of the proximal part of the ascending aorta were noted. Magnetic resonance imaging (MRI) without contrast showed a dilated aortic root and ascending aorta (64.4 mm at the right pulmonary artery level). Imaging and serologic findings were compatible with acute Takayasu arteritis. Despite the detailed discussion, the patient refused surgery. During the hospital admission, the patient remained stable with no change in the size of the ascending aorta. Cesarean section was done at 32 weeks of gestation. A boy with a body weight of 1360 g was born. 10 days after delivery, she underwent a bio-Bentall procedure. Follow-ups of the patient and her child were uneventful 12 months after delivery.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rodrigo Cabrera, Marlon Yesid Barrera Montañez, Sebastian Ramiro Gil-Quiñones, Adriana Motta Beltrán, Natalia Santiago-Tovar, Nora Contreras-Bravo, Dora Janeth Fonseca-Mendoza, Carlos Martin Restrepo, Adrien Morel
{"title":"Novel De Novo DLL4 Missense and Highly Accurate Protein Structure Prediction in Adams–Oliver Type 6 Syndrome","authors":"Rodrigo Cabrera, Marlon Yesid Barrera Montañez, Sebastian Ramiro Gil-Quiñones, Adriana Motta Beltrán, Natalia Santiago-Tovar, Nora Contreras-Bravo, Dora Janeth Fonseca-Mendoza, Carlos Martin Restrepo, Adrien Morel","doi":"10.1002/ccr3.70933","DOIUrl":"10.1002/ccr3.70933","url":null,"abstract":"<p>Adams–Oliver syndrome (AOS) is a rare disease classically described with scalp vertex aplasia cutis and terminal transverse limb defects. This syndrome is frequently misdiagnosed by taking each feature of the disease separately. A novel <i>de novo</i> missense variant in <i>DLL4</i> (c.998G>A, p.Cys333Tyr) was identified by Whole Exome Sequencing (WES), and structural analysis using AlphaFold and PremPS confirmed its pathogenicity by disrupting the NOTCH1 signaling pathway, highlighting the power of AI-driven tools in variant interpretation.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary Hydatid Cyst of Neck Misdiagnosed as Lipoma: A Rare Case Report From Nepal","authors":"Khusbu Kumari, Ishwor Thapaliya, Sumesh Singh, Susmin Karki, Simin Kunwar","doi":"10.1002/ccr3.71108","DOIUrl":"10.1002/ccr3.71108","url":null,"abstract":"<p>Hydatid disease, caused by Echinococcus tapeworm infection, presents a significant health concern, particularly in low and middle-income countries. This zoonotic disease predominantly affects the liver and lungs but can occur in various locations throughout the body. Here, we report a rare case of a 10-year-old girl with a hydatid cyst in the nape of her neck. Initially misdiagnosed as a lipoma on clinical examination, ultrasonography revealed the cystic nature of the mass, and histopathological examination done after surgery confirmed the diagnosis. This case highlights the importance of considering hydatid cysts in the differential diagnosis of neck masses among pediatric patients in endemic regions to ensure timely diagnosis and appropriate management.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Administration of Nebulized Nitroglycerin Inhalation Combined With Subarachnoid Anesthesia for Cesarean Delivery With Pulmonary Arterial Hypertension: A Case Report","authors":"Lian Xin, Chunxiao Hu, Yiling Qian, Shunmei Lu, Jingjing Xu, Zhengfeng Gu","doi":"10.1002/ccr3.70916","DOIUrl":"10.1002/ccr3.70916","url":null,"abstract":"<p>In patients with severe pulmonary hypertension, nebulized nitroglycerin inhalation combined with subarachnoid anesthesia is a safe anesthetic option for cesarean section. It maintains stable hemodynamics and, by decreasing pulmonary artery pressure, prevents right heart failure.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Unusual Presentation of Metastatic Soft Tissue Sarcoma to the Left Atrium and Pulmonary Veins: A Case Report and Comprehensive Literature Review","authors":"Abdulhamid Bagheri, Mohammad Khani, Mehrdad Jafari Fesharaki, Fariba Bayat, Taraneh Faghihi Langroudi, Behrang Kazeminejad, Amirreza Shahmohammadi, Elham Farahani","doi":"10.1002/ccr3.70991","DOIUrl":"10.1002/ccr3.70991","url":null,"abstract":"<p>Metastatic soft tissue sarcoma (STS) is a rare and aggressive malignancy arising from connective tissues. It is characterized by its ability to metastasize to distant sites, with the lungs being the most common location. Despite advances in diagnosis and treatment, the prognosis remains poor, particularly in cases with advanced metastasis. Management often involves a multidisciplinary approach, combining surgery, radiotherapy, chemotherapy, and newer targeted therapies. This report highlights an unusual case of STS metastasizing to the left atrium (LA) and pulmonary veins, which presented with complex clinical and therapeutic challenges. We report the case of a 74-year-old male with a history of synovial cell sarcoma of the left elbow, initially treated with wide resection surgery and adjuvant radiotherapy. Eight months post-treatment, bone metastasis to the ipsilateral humerus bone was detected and managed surgically. The patient later presented with sudden-onset numbness and weakness on the left side, along with sudden-onset aphasia, raising suspicion of neurologic or embolic complications. Diagnostic evaluation, including transthoracic echocardiogram (TEE) and chest computed tomography, revealed a large mass in the LA and pulmonary vein, consistent with metastatic sarcoma. Open-heart surgery was performed to resect the tumor palliatively. Adjuvant chemotherapy and radiotherapy were initiated. Follow-up demonstrated stability of the disease for up to 1 year under the treatment protocol.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}