Clinical Case Reports最新文献_第7页

A Rare Case of Chronic Lymphocytic Leukemia and Chronic Myeloid Leukemia in an Elderly Patient: A Case Report. 老年慢性淋巴细胞白血病合并慢性髓系白血病1例报告。

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73136

Mostafa Kamandi, Mohammad Mahdi Alvandi Fard

{"title":"A Rare Case of Chronic Lymphocytic Leukemia and Chronic Myeloid Leukemia in an Elderly Patient: A Case Report.","authors":"Mostafa Kamandi, Mohammad Mahdi Alvandi Fard","doi":"10.1002/ccr3.73136","DOIUrl":"https://doi.org/10.1002/ccr3.73136","url":null,"abstract":"Chronic Lymphocytic Leukemia (CLL) and Chronic Myeloid Leukemia (CML) are two distinct hematological malignancies with different pathophysiologies and clinical courses. While each is relatively common in the elderly population, their simultaneous occurrence in a single patient is exceptionally rare and poses diagnostic and therapeutic challenges. We present the case of a 79-year-old male who was evaluated for progressive fatigue, weight loss, and marked leukocytosis. Laboratory investigations, peripheral blood smear, flow cytometry, and molecular studies were utilized to establish the diagnosis. Initial findings revealed extreme leukocytosis, anemia, and elevated LDH. Peripheral smear and molecular testing confirmed CML through detection of the BCR::ABL1 fusion gene. Concurrently, flow cytometry identified a clonal B-cell population positive for CD5, CD19, and CD20, consistent with CLL. Imaging showed splenomegaly and pathologic lymphadenopathy. The patient was treated with imatinib and hydroxyurea, resulting in normalization of white blood cell count, though anemia and thrombocytopenia persisted. This case highlights a rare synchronous diagnosis of CML and CLL in an elderly patient. The comprehensive diagnostic evaluation was critical in establishing the dual pathology. The case underscores the need for heightened clinical suspicion in atypical presentations and contributes to the limited body of knowledge on coexistent myeloid and lymphoid malignancies.","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73136"},"PeriodicalIF":0.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suboptimal Response to Eculizumab in Renal-Limited Thrombotic Microangiopathy Associated With Malignant Hypertension and Monoclonal Gammopathy: A Case Report. Eculizumab治疗与恶性高血压和单克隆gamm病相关的肾限制性血栓性微血管病的次优反应：1例报告

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73712

Wenjuan Lei, Tianli Shi, Man Xu, Jun Zhou

引用次数: 0

Regenerative Endodontic Procedure in Mandibular First Molar: A Clinical Case Report. 下颌第一磨牙再生根管治疗1例临床报告。

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73610

Sorour Saeedi, Ali Hamedi, Mani Mansouri, Iman Shiezadeh

{"title":"Regenerative Endodontic Procedure in Mandibular First Molar: A Clinical Case Report.","authors":"Sorour Saeedi, Ali Hamedi, Mani Mansouri, Iman Shiezadeh","doi":"10.1002/ccr3.73610","DOIUrl":"https://doi.org/10.1002/ccr3.73610","url":null,"abstract":"Regenerative endodontic procedures (REPs) have emerged as a biologically based treatment modality for managing immature permanent teeth with necrotic pulp, offering the potential for continued root development and periapical healing. This case report describes the regenerative endodontic treatment of a necrotic, immature mandibular first molar in a 9-year-old female patient. The treatment protocol involved canal disinfection using double antibiotic paste (DAP), induction of intracanal bleeding to form a natural scaffold, and coronal sealing with mineral trioxide aggregate (MTA). A 12-month follow-up demonstrated successful resolution of the periapical lesion, continued root maturation with increased root length and wall thickness, and clinical absence of symptoms. The extraoral sinus tract also healed completely within this period. This case highlights the clinical viability of REPs in immature multirooted teeth, emphasizing the importance of appropriate case selection, careful scaffold induction, and long-term monitoring. Although short-term outcomes were favorable, extended follow-up is necessary to fully validate the durability of regenerative success.","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73610"},"PeriodicalIF":0.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Aquaporin-4-Positive Neuromyelitis Optica Spectrum Disorder: Diagnostic Challenges and Transition From B-Cell Depletion Therapy to Ravulizumab. 病例报告：水通道蛋白-4阳性视谱神经脊髓炎：诊断挑战和从b细胞耗竭治疗到Ravulizumab的过渡。

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73704

Aram Zabeti

引用次数: 0

Root Migration After Coronectomy of a Mandibular Third Molar With the Inferior Alveolar Nerve Passing Between the Roots: A Case Report. 下颌第三磨牙冠切除术后牙根移位，下牙槽神经在牙根间穿过1例。

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73673

Vito Marquez Rocco, Andreas Thor, Abdullah A Hashim, Dominique Bellerud

{"title":"Root Migration After Coronectomy of a Mandibular Third Molar With the Inferior Alveolar Nerve Passing Between the Roots: A Case Report.","authors":"Vito Marquez Rocco, Andreas Thor, Abdullah A Hashim, Dominique Bellerud","doi":"10.1002/ccr3.73673","DOIUrl":"https://doi.org/10.1002/ccr3.73673","url":null,"abstract":"Extraction of mandibular third molars (MTMs) is one of the most common procedures in oral and maxillofacial surgery. It carries a risk of inferior alveolar nerve (IAN) injury, which may result in altered or lost sensation of the lower lip, chin, teeth, and gingiva. Coronectomy, a surgical technique in which the crown is removed while the vital roots are retained, has been proposed to reduce this risk in cases with close root-nerve proximity. We report the case of a 41-year-old female patient in whom cone beam computed tomography (CBCT) revealed the IAN coursing between the roots of an MTM. Coronectomy was performed to preserve nerve integrity. Follow-up CBCT demonstrated significant migration of the retained root complex within 6-12 months, increasing the distance from the IAN. Five years later, infection associated with the retained roots required surgical root removal. Owing to the favorable migration of the root complex, extraction was completed without IAN injury. This case illustrates that, despite the possibility of late complications requiring reintervention, coronectomy may facilitate root migration away from the nerve and allow safer delayed root removal in anatomically high-risk situations. Careful patient selection, meticulous surgical technique, and long-term radiographic follow-up are essential. Further high-quality long-term studies are needed to standardize coronectomy protocols, evaluate complications, and assess cost-effectiveness compared with conventional extraction.","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73673"},"PeriodicalIF":0.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-and-a-Half-Year Follow-Up After Sacroiliac Joint Fusion With Preexisting Ipsilateral Total Hip Arthroplasty: A Case Report. 骶髂关节融合术合并同侧全髋关节置换术3年半随访1例。

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73714

Dustin J Kress, Jason J Haselhuhn, Neill B Hatcher, Kari Odland, David W Polly

引用次数: 0

Tubal Ectopic Pregnancy With Grossly Visible Intact Embryonic Structures: A Case Image. 输卵管异位妊娠伴肉眼可见的完整胚胎结构：一例图像。

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Clinical Case Reports Pub Date : 2026-10-12 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73731

Mojgan Akbarzadeh-Jahromi, Neda Soleimani, Sahand Mohammadzadeh

引用次数: 0

Recurrent Projectile Vomiting as the Sole Presenting Feature of Coeliac Disease With Marsh-Oberhuber Grade 3C Enteropathy in a 13-Year-Old Girl: A Case Report. 复发性抛射性呕吐是13岁女孩腹腔疾病合并Marsh-Oberhuber级3C肠病的唯一表现特征：1例报告。

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Clinical Case Reports Pub Date : 2026-10-11 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73717

Rahman Syed, Ameer Afzal Khan, Mehtab Alam, Suleman Shah, Mian Gul Rahman, Mohammed Al Meqbaali, Bilal Iqbal, Mohammed Al Sinani

引用次数: 0

Acute Hemorrhagic Manifestations in a Pregnant Patient With Type 1 von Willebrand Disease: Challenges in Management of Bleeding Disorders During Gestation. 妊娠1型血管性血友病患者的急性出血表现：妊娠期出血性疾病管理的挑战

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Clinical Case Reports Pub Date : 2026-10-11 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73728

Jose Luis Rojas-Oviedo, María Fernanda Leal Walteros, Dauris Lineth Mejía Pérez, Jorge Eliecer Castellanos Corredor, Danna Geraldinne Amaya Sánchez, Ana Sofía Lancheros Ramírez

引用次数: 0

Unmasking Huntington Disease: How a Neuropsychiatric Crisis Overcame Cultural Barriers to a Delayed Diagnosis. 揭露亨廷顿病：神经精神危机如何克服文化障碍延迟诊断。

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Clinical Case Reports Pub Date : 2026-10-11 eCollection Date: 2026-10-01 DOI: 10.1002/ccr3.73726

Charles Donkor-Baah, George Harold Kitson-Mills, Stephen Annan Arthur, Irene Acquah

{"title":"Unmasking Huntington Disease: How a Neuropsychiatric Crisis Overcame Cultural Barriers to a Delayed Diagnosis.","authors":"Charles Donkor-Baah, George Harold Kitson-Mills, Stephen Annan Arthur, Irene Acquah","doi":"10.1002/ccr3.73726","DOIUrl":"https://doi.org/10.1002/ccr3.73726","url":null,"abstract":"Huntington disease is an autosomal dominant neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric dysfunction. We report the case of a 53-year-old man who presented after a suicide attempt involving pesticide ingestion, following years of worsening choreiform movements, reported cognitive decline, and severe depression. Despite a strong multigenerational family history of similar symptoms, the condition was perceived as a familial \"curse,\" leading to a prolonged reliance on traditional remedies and delayed engagement with biomedical healthcare services. Examination revealed generalized chorea, dysarthria, motor impersistence, and severe depression. Genetic analysis identified 44 CAG repeats in the huntingtin (HTT) gene, confirming the diagnosis of Huntington disease. This case underscores the influence of cultural beliefs on healthcare-seeking behavior, which can delay the diagnosis of hereditary neurological disorders until a psychiatric crisis precipitates medical evaluation and intervention.","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73726"},"PeriodicalIF":0.6,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0