Clinical Case ReportsPub Date : 2026-10-14eCollection Date: 2026-10-01DOI: 10.1002/ccr3.73699
Maryam Othman Alarfaj, Bashayr Saleh Alsuwailem, Meataz Khaled Aljeezan, Baker Saud Alhlibi, Mubarak Maher Bu Haya, Abdulatif Adel Alnaaim, Muneera O AlTaweel
{"title":"Abdominal Pain as the First Presentation of Severe Heart Failure With Reduced Ejection Fraction and Left Ventricular Thrombus in a Young Asymptomatic Patient: A Diagnostic Interception.","authors":"Maryam Othman Alarfaj, Bashayr Saleh Alsuwailem, Meataz Khaled Aljeezan, Baker Saud Alhlibi, Mubarak Maher Bu Haya, Abdulatif Adel Alnaaim, Muneera O AlTaweel","doi":"10.1002/ccr3.73699","DOIUrl":"10.1002/ccr3.73699","url":null,"abstract":"<p><p>A young, physically active patient with no cardiac symptoms presented with abdominal pain and was found, through incidental findings of elevated BNP, cardiomegaly, and new ECG changes, to have severe HFrEF with a left ventricular apical thrombus. Early cardiac evaluation changed management and led to complete thrombus resolution.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73699"},"PeriodicalIF":0.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2026-10-14eCollection Date: 2026-10-01DOI: 10.1002/ccr3.73706
Anna Dowling, Erin Moxey, Meghan Keenan, Ji Su Hong
{"title":"A Preschooler With Severe Social Anxiety and Selective Mutism Versus Autism Spectrum Disorder.","authors":"Anna Dowling, Erin Moxey, Meghan Keenan, Ji Su Hong","doi":"10.1002/ccr3.73706","DOIUrl":"10.1002/ccr3.73706","url":null,"abstract":"<p><p>Selective mutism (SM) and severe social anxiety can mimic autism spectrum disorder (ASD) when assessment relies heavily on observations in unfamiliar contexts. Multidisciplinary assessments comparing social interaction and communication across familiar and unfamiliar contexts may help prevent misdiagnosis. While autism-like behaviors are restricted to anxiety-provoking contexts in SM and severe social anxiety, ASD is characterized by pervasive social deficits across relationships and settings.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73706"},"PeriodicalIF":0.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2026-10-14eCollection Date: 2026-10-01DOI: 10.1002/ccr3.73556
Muhammad Rizwan Ali, Muhammad Jawad Saleem, Ali Shahid, Muhammad Suliman Sajid, Muhammad Haris, Shayan Asmat, Noor Ul Subah Afzal, Mohammad Al Diab Al Azzawi
{"title":"Contiguous Lumbar Bilateral Pars Defects at L3 and L4 (With Intact L5): Treated With Pedicle Screw Fixation and Interbody Fusion: A Case Report With Literature Review.","authors":"Muhammad Rizwan Ali, Muhammad Jawad Saleem, Ali Shahid, Muhammad Suliman Sajid, Muhammad Haris, Shayan Asmat, Noor Ul Subah Afzal, Mohammad Al Diab Al Azzawi","doi":"10.1002/ccr3.73556","DOIUrl":"https://doi.org/10.1002/ccr3.73556","url":null,"abstract":"<p><p>A 42-year-old woman had chronic L4 pars defect with Grade 2 spondylolisthesis and acute L3 pars fractures after trauma, causing back pain, sensory, and motor deficits. She underwent L3-L5 pedicle screw fixation with interbody fusion. Postoperatively, she showed rapid pain relief, neurological improvement, and stable spinal alignment on follow-up.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73556"},"PeriodicalIF":0.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2026-10-13eCollection Date: 2026-10-01DOI: 10.1002/ccr3.73733
Mahmoud Ahmed, Victoria Collins, Andrea Lavinio
{"title":"Bedside Transcranial Doppler as a Dynamic Warning Tool for Rapidly Evolving Intracranial Hypertension in Pneumococcal Meningitis.","authors":"Mahmoud Ahmed, Victoria Collins, Andrea Lavinio","doi":"10.1002/ccr3.73733","DOIUrl":"https://doi.org/10.1002/ccr3.73733","url":null,"abstract":"<p><p>In severe bacterial meningitis, an initially non-critical or technically unreliable lumbar puncture opening pressure should not reassure when hydrocephalus and coma persist. Bedside transcranial Doppler cannot measure intracranial pressure, but bilateral near-absent diastolic flow may provide an urgent warning signal prompting repeat assessment and cerebrospinal fluid diversion.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73733"},"PeriodicalIF":0.6,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2026-10-12eCollection Date: 2026-10-01DOI: 10.1002/ccr3.73720
Nazmin Ahmed, Mohaiminul Islam, Md Raad Kazi, Jubair Ahmed Sikder, Tajrian Sultana, Mohammad Nazrul Hossain
{"title":"Coexistence of Ebstein Anomaly and Cerebral Cavernous Malformation: A Case Report.","authors":"Nazmin Ahmed, Mohaiminul Islam, Md Raad Kazi, Jubair Ahmed Sikder, Tajrian Sultana, Mohammad Nazrul Hossain","doi":"10.1002/ccr3.73720","DOIUrl":"10.1002/ccr3.73720","url":null,"abstract":"<p><p>In most patients who have Ebstein anomaly (EA), neurological symptoms are either associated with thromboembolic episodes or due to arrhythmic complications. Cerebral cavernous malformation (CCM) is a vascular anomaly made up of sinusoidally dilated blood vessels, often presenting with seizure activity or intracranial bleeding. There has never been any documented report regarding coexisting EA and CCM. Herein, we have reported a 32-year-old female with an established history of Ebstein anomaly diagnosed in 2013 who had a history of generalized tonic-clonic fits since 2020. Neuroimaging studies showed the presence of a right frontal lobe mass with typical \"popcorn-like\" appearance and hemosiderin ring on MRI, indicative of cerebral cavernous malformation. The patient declined surgery and was managed conservatively with levetiracetam. With the occurrence of further fits in 2025, neuroimaging showed similar findings but without the presence of intratumoral bleeding. Subsequently, she underwent a left frontoparietal craniotomy for GTE of the lesion with cavernoma on histopathology. The neurological status of the patient was stable during her discharge on the fourth postoperative day. This case documents a previously unreported coexistence of Ebstein anomaly and cerebral cavernous malformation in a single patient. Given the rarity of both conditions, coexistence is coincidental. This indicates the need for genetic and molecular studies to determine whether a real biological association exists.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73720"},"PeriodicalIF":0.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2026-10-12eCollection Date: 2026-10-01DOI: 10.1002/ccr3.73723
Cyndee Jocson, Alexander Dahl, Stefanie Cheang
{"title":"Large Obstructive Left Atrial Myxoma in an Adolescent Girl Presenting With Stroke.","authors":"Cyndee Jocson, Alexander Dahl, Stefanie Cheang","doi":"10.1002/ccr3.73723","DOIUrl":"https://doi.org/10.1002/ccr3.73723","url":null,"abstract":"<p><p>Pediatric cardiac myxomas are rare but may present with embolic stroke and rapidly progress to life-threatening hemodynamic obstruction. Ischemic stroke with a suspected embolic source in children should prompt echocardiographic evaluation. Early recognition and urgent surgical management are critical to prevent obstruction, embolization, and death.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73723"},"PeriodicalIF":0.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2026-10-12eCollection Date: 2026-10-01DOI: 10.1002/ccr3.73708
Masoud Maboudi, Maryam Montazeri, Sara Ghandi, Moozhan Mofidi
{"title":"Cancer-Related Fever in Metastatic Prostate Cancer: A Case Report.","authors":"Masoud Maboudi, Maryam Montazeri, Sara Ghandi, Moozhan Mofidi","doi":"10.1002/ccr3.73708","DOIUrl":"https://doi.org/10.1002/ccr3.73708","url":null,"abstract":"<p><p>Fever in cancer patients is often mistakenly attributed to infection, leading to unnecessary antibiotic use. Neoplastic fever, though well-documented in hematologic malignancies, is rare in solid tumors, particularly prostate cancer. This case report presents an 81-year-old male with metastatic prostate cancer, who was admitted to Razi Hospital in Qaemshahr, Mazandaran, with persistent fever, chills, and urinary symptoms following radiotherapy. Despite broad-spectrum antibiotics, the fever persisted, and extensive infectious workups yielded no identifiable source. The patient's condition was further complicated by hyponatremia, elevated inflammatory markers, and a negative initial blood culture. As the fever continued, oncological evaluation was initiated, leading to the diagnosis of neoplastic fever. Chemotherapy with docetaxel and zoledronic acid resulted in the resolution of fever, confirming the oncologic nature of the fever. This case underscores the importance of recognizing neoplastic fever in cancer patients with persistent fever of unknown origin, particularly when infectious causes have been excluded. Early oncologic intervention, rather than prolonged antibiotic therapy, can prevent unnecessary treatments and improve patient outcomes. This case highlights the need for a high index of suspicion in managing cancer patients with fever, especially in the absence of an infectious etiology.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73708"},"PeriodicalIF":0.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2026-10-12eCollection Date: 2026-10-01DOI: 10.1002/ccr3.73730
Najoua Ghani
{"title":"Deep Gluteal Syndrome and Persistent Sciatica in a Patient With Unilateral Piriformis Muscle Hypertrophy: A Case Report.","authors":"Najoua Ghani","doi":"10.1002/ccr3.73730","DOIUrl":"10.1002/ccr3.73730","url":null,"abstract":"<p><p>A man of 47 had 6 months of left sciatica without root compression on lumbar imaging. Pelvic CT showed isolated left piriformis hypertrophy, 700 versus 450 mm<sup>2</sup>. Guided betamethasone injection relieved him within 48 h, sustained at 6 months. Asymmetry and response support, but do not prove, sciatic nerve entrapment.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73730"},"PeriodicalIF":0.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2026-10-12eCollection Date: 2026-10-01DOI: 10.1002/ccr3.73709
Maryam Vajihinejad, Kianoosh Najafi, Mohammad Hossein Ahrar, Ahmad Shamsi
{"title":"Intranodal Epithelioid Schwannoma in an Intraparotid Lymph Node: A Case Report and Literature Review.","authors":"Maryam Vajihinejad, Kianoosh Najafi, Mohammad Hossein Ahrar, Ahmad Shamsi","doi":"10.1002/ccr3.73709","DOIUrl":"10.1002/ccr3.73709","url":null,"abstract":"<p><p>An epithelioid schwannoma arising within an intraparotid lymph node is a rare benign lesion that may mimic metastatic melanoma, metastatic carcinoma, or a primary salivary gland neoplasm. Recognizing the intranodal architecture and integrating morphology with an appropriate immunohistochemical panel are essential to avoid misclassification and unnecessary aggressive oncological management.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73709"},"PeriodicalIF":0.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Case ReportsPub Date : 2026-10-12eCollection Date: 2026-10-01DOI: 10.1002/ccr3.73136
Mostafa Kamandi, Mohammad Mahdi Alvandi Fard
{"title":"A Rare Case of Chronic Lymphocytic Leukemia and Chronic Myeloid Leukemia in an Elderly Patient: A Case Report.","authors":"Mostafa Kamandi, Mohammad Mahdi Alvandi Fard","doi":"10.1002/ccr3.73136","DOIUrl":"https://doi.org/10.1002/ccr3.73136","url":null,"abstract":"<p><p>Chronic Lymphocytic Leukemia (CLL) and Chronic Myeloid Leukemia (CML) are two distinct hematological malignancies with different pathophysiologies and clinical courses. While each is relatively common in the elderly population, their simultaneous occurrence in a single patient is exceptionally rare and poses diagnostic and therapeutic challenges. We present the case of a 79-year-old male who was evaluated for progressive fatigue, weight loss, and marked leukocytosis. Laboratory investigations, peripheral blood smear, flow cytometry, and molecular studies were utilized to establish the diagnosis. Initial findings revealed extreme leukocytosis, anemia, and elevated LDH. Peripheral smear and molecular testing confirmed CML through detection of the <i>BCR::ABL1</i> fusion gene. Concurrently, flow cytometry identified a clonal B-cell population positive for CD5, CD19, and CD20, consistent with CLL. Imaging showed splenomegaly and pathologic lymphadenopathy. The patient was treated with imatinib and hydroxyurea, resulting in normalization of white blood cell count, though anemia and thrombocytopenia persisted. This case highlights a rare synchronous diagnosis of CML and CLL in an elderly patient. The comprehensive diagnostic evaluation was critical in establishing the dual pathology. The case underscores the need for heightened clinical suspicion in atypical presentations and contributes to the limited body of knowledge on coexistent myeloid and lymphoid malignancies.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"14 10","pages":"e73136"},"PeriodicalIF":0.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}