Clinical and Experimental Dermatology最新文献

{"title":"Cutaneous toxicities in patients with metastatic uveal melanoma receiving tebentafusp: a retrospective review. The experience of a single large specialist institution.","authors":"Xingyue Maria Wang, Andrew Furness, Kara Heelan","doi":"10.1093/ced/llaf426","DOIUrl":"https://doi.org/10.1093/ced/llaf426","url":null,"abstract":"<p><p>Tebentafusp is a novel T-cell receptor-bispecific protein that targets glycoprotein 100 and CD3. It is the only approved systemic therapy for patients with unresectable or metastatic HLA-A*02:01 positive uveal melanoma. Cutaneous toxicities are common, yet there are limited studies in the literature. We conducted a retrospective observational cohort study of patients with HLA-A*02:01- positive unresectable or metastatic uveal melanoma at our tertiary referral centre, who received tebentafusp therapy from August 2021 to January 2024. Cutaneous toxicity occurred in 89% of patients, but reactions were manageable with no patients permanently discontinuing treatment. To our knowledge, we also report the first case of bullous pemphigoid associated with tebentafusp.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of cutaneous malignancy following the concomitant use of cyclosporine and narrowband UV-B phototherapy in patients with vitiligo.","authors":"Joon Jae Jeon, You Hyun Kim, Hyunsoo Son, Ju Yeong Lee, Min Chul Ha, Seung-Won Jung, Solam Lee","doi":"10.1093/ced/llaf428","DOIUrl":"https://doi.org/10.1093/ced/llaf428","url":null,"abstract":"<p><p>This nationwide population-based cohort study investigates the incidence of cutaneous malignancies associated with the concomitant treatment of cyclosporine (CsA) and narrowband UV-B phototherapy (NBUVB) in patients with vitiligo, using the Korean National Health Insurance Service database. The concomitant CsA and NBUVB therapy may not significantly increase the incidence of cutaneous malignancies. Given the chronic autoimmune nature of vitiligo and the economic burden it imposes, these findings provide novel insights into the potential safety of these combination regimens.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'Schnitzler Syndrome without Monoclonal Gammopathy: A systematic review and case presentation'.","authors":"Nicole Fagan, Niall Conlon, Katie Ridge","doi":"10.1093/ced/llaf432","DOIUrl":"https://doi.org/10.1093/ced/llaf432","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective observational study of the dermatoscopic findings of non-segmental vitiligo in different stages of evolution.","authors":"Narayanan Baskaran, Binod Khaitan, Vishal Gupta, M Ramam, Kanika Sahni","doi":"10.1093/ced/llaf431","DOIUrl":"https://doi.org/10.1093/ced/llaf431","url":null,"abstract":"<p><strong>Introduction: </strong>Dermatoscopy has rapidly gained ground as a tool to assess vitiligo activity. However, a methodical approach to assess dermatoscopy in vitiligo and evaluating its role in predicting outcome are still evolving.</p><p><strong>Objectives: </strong>To compare dermatoscopic findings of individual vitiligo lesions in different stages of evolution and to evaluate its utility to predict outcome at follow-up.</p><p><strong>Methods: </strong>A total of 171 lesions in 68 patients of non-segmental vitiligo were recruited. Lesions were classified as stable, progressive and repigmenting based on history and/or clinical photography. A total of 101 lesions in 40 patients were followed up at 3 months. The lesions were re-classified based on photographic comparison with baseline images. The dermatoscopic findings included type and distribution of pigment network, margin definition, perifollicular and perilesional pigment, leucotrichia, and eccrine opening discernibility.</p><p><strong>Results: </strong>Stable lesions showed complete absence of pigment network both at baseline (92.9%) and follow-up (80.9%). Progressive lesions showed variability both in type and distribution of pigment, ill-defined margins (57.6%), and perilesional hypopigmentation (39.7%). Micro-koebnerization, perilesional white globules, peppering of pigment at the periphery of lesion, and loss of pigment in linear pattern in the periphery were specific for progressive disease. Repigmenting lesions demonstrated perilesional (38.3%) and perifollicular hyperpigmentation (76.7%). Well-defined margins and perilesional hyperpigmentation at baseline were associated with lesions remaining stable, whereas lesions with focal/diffuse reduction of pigment and perilesional hypopigmentation and/or white globules were more likely to progress.</p><p><strong>Conclusion: </strong>Dermatoscopy is useful in determining disease activity and is of potential utility in assessing outcome of vitiligo lesions in a large proportion of cases.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toll-like receptor patterns in epidermodysplasia verruciformis associated - squamous cell carcinomas.","authors":"Cibele C A Pereira, Luis Alberto R Fróes, Lana Luiza C Silva, Maira G Saldanha, Naiura V Pereira, Walmar R P Oliveira, Mirian N Sotto","doi":"10.1093/ced/llaf429","DOIUrl":"https://doi.org/10.1093/ced/llaf429","url":null,"abstract":"<p><strong>Background: </strong>Epidermodysplasia verruciformis (EV) is a rare genetic condition characterized by viral warts and an increased risk of squamous cell carcinoma (SCC), particularly associated with specific human papillomavirus (HPV) types, notably beta-HPV variants 5 and 8. Toll-like receptors (TLRs) are crucial for immune response regulation and may contribute to cancer development in EV.</p><p><strong>Objectives: </strong>This study aimed to assess the expression levels of TLRs 3, 4, 5, and 9 in SCC samples from EV patients versus those without EV (NEV) to understand their potential roles in EV-related carcinogenesis.</p><p><strong>Methods: </strong>We examined tumour samples from 18 patients with EV alongside samples from 90 NEV participants. Techniques included tissue microarray analysis and conventional histological evaluation, with immunohistochemistry performed to detect TLR expression. Controls were included to validate the specificity of the results, and statistical analyses employed the Kruskal-Wallis test with Dunn-Bonferroni post-hoc comparisons.</p><p><strong>Results: </strong>TLRs 3, 4, 5, and 9 were detected in both patient groups, with distinct expression patterns. TLR3 levels were higher in the normal skin of EV patients, while TLR9 was more prominent in tumours. In NEV patients, TLR3 and TLR4 expression varied with tumour stages; invasive SCC showed increased TLR5 and TLR9 levels. EV samples showed significantly higher TLR4 and TLR9 expression relative to NEV samples.</p><p><strong>Conclusions: </strong>The differing TLR expression patterns indicate diverse immune mechanisms involved in EV-related carcinogenesis, suggesting that TLRs could be potential therapeutic targets, meriting further investigation into their roles in tumour growth regulation.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A long awaited diagnosis: atypical presentation of Mycobacterium marinum - a patient's perspective.","authors":"Claudine Howard-James, Kevin Molloy","doi":"10.1093/ced/llaf430","DOIUrl":"https://doi.org/10.1093/ced/llaf430","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Infection Risk Associated with Janus Kinase Inhibitors: A Pharmacovigilance Analysis Using the Food and Drug Administration's Adverse Event Reporting System Database.","authors":"Cansu Altınöz Güney, Huriye Aybüke Koç","doi":"10.1093/ced/llaf427","DOIUrl":"https://doi.org/10.1093/ced/llaf427","url":null,"abstract":"<p><strong>Background: </strong>The use of JAK inhibitors (JAKis) is growing in dermatology with approvals for atopic dermatitis, alopecia areata, plaque psoriasis, and psoriatic arthritis. This study aimed to evaluate infectious adverse events (iAEs) associated with abrocitinib, baricitinib, deucravacitinib, ritlecitinib, tofacitinib, and upadacitinib.</p><p><strong>Methods: </strong>Data were retrieved from the FDA Adverse Event Reporting System (FAERS) via the open-source AERSMine platform (version:2025-04-16; Cincinnati Children's Hospital Medical Center, USA). Reports from 2004Q1 to 2024Q2 were screened under the MedDRA System Organ Class \"Infections and Infestations\". The analysis encompassed all indications, not only dermatologic use. Disproportionality metrics including Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), and Information Component (IC) were calculated.</p><p><strong>Results: </strong>Tofacitinib had the highest number of iAE reports (n=68,669), followed by upadacitinib (n=17,822). Most reports involved females and those aged 25-65, except baricitinib, which was more frequent in ≥66. Disproportionality analysis revealed sex- and age-related differences in iAE risk, with male sex generally associated with lower risk. Pediatric patients (0-14 years) had an elevated iAE risk with abrocitinib and upadacitinib, while older adults (≥66) showed increased risk with baricitinib and tofacitinib. Commonly reported iAEs included COVID-19, herpes zoster, nasopharyngitis, influenza, urinary tract infection, pneumonia, and sinusitis. Each JAKi was associated with distinct high-signal iAEs.</p><p><strong>Conclusion: </strong>This is the most comprehensive real-world analysis of iAEs linked to oral JAKis. While infection risks varied across agents, both common and rare but serious events were identified. Findings highlight the importance of individualized monitoring and preventive strategies, and reinforce the value of post-marketing surveillance in ensuring safe JAKi use.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Hidradenitis Suppurativa and Peripheral Arterial Occlusion Disease: a propensity-score-matched cohort study.","authors":"Hui-Chin Chang, Shao-Wei Lo, Yun-Feng Li, Tsu-Man Chiu, Chao-Bin Yeh, Yi-Sheng Jhang, Shiu-Jau Chen, Shuo-Yan Gau","doi":"10.1093/ced/llaf423","DOIUrl":"https://doi.org/10.1093/ced/llaf423","url":null,"abstract":"<p><strong>Background: </strong>Considering the plausible mechanistic associations and the significant clinical implications of Hidradenitis suppurativa (HS) and peripheral arterial occlusive disease (PAOD), this study aimed to investigate the risk of incident PAOD in patients with HS.</p><p><strong>Method: </strong>A retrospective cohort study using the TriNetX research network was conducted. HS patients were matched 1:1 with non-HS controls based on demographic and clinical factors. The primary outcome was the incidence of PAOD, analyzed using hazard ratios (HRs) and Kaplan-Meier curves over a 15-year follow-up period. Sensitivity and stratification analyses were performed to validate the findings.</p><p><strong>Result: </strong>Over a 15-year follow-up, HS patients demonstrated a significantly higher risk of developing PAOD compared to matched controls (HR 1.230, 95% CI 1.164-1.300) in the crude model. This risk persisted after adjusting for possible confounders. Kaplan-Meier analysis showed a higher cumulative probability of PAOD in the HS cohort (adjusted HR 1.478, 95% CI 1.357-1.610, log-rank p-value of <0.01) over the entire follow-up period. Sensitivity analyses confirmed the robustness of these findings across various models. Stratification analyses indicated consistent PAOD risk across gender and age subgroups, with higher risks observed in males (HR 1.794, 95% CI 1.541-2.089) and patients aged ≥65 years (HR 1.769, 95% CI 1.534-2.039).</p><p><strong>Conclusion: </strong>HS is associated with an increased risk of PAOD, independent of traditional cardiovascular risk factors. These findings underscore the importance of cardiovascular risk assessment and management in patients with HS. Further research is needed to elucidate the underlying mechanisms and evaluate the impact of HS treatment on PAOD risk.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epoxy Resin Allergy: prevalence and clinical spectrum in a regional population in the Southwest of England.","authors":"Peter Phillips, Preshita Divekar","doi":"10.1093/ced/llaf424","DOIUrl":"https://doi.org/10.1093/ced/llaf424","url":null,"abstract":"<p><p>Epoxy resins, commonly in adhesives, cause occupational allergic contact dermatitis, particularly among male tradesmen. Diglycidyl ether of bisphenol A (DGEBA) is the screening agent for epoxy allergy in the British and European Baseline Series. Recent reports highlight new non-occupational sources of sensitisation in women engaged in craft hobbies. We investigated whether similar trends are emerging in our region. We retrospectively analysed our clinic's patch test data for a 13-year period (2009-2022). Of 2445 patients tested, 15 (0.6%) were sensitised to DGEBA; males 9 (1.2%), females 6 (0.4%). 8 of 10 (80%) sensitized individuals with known relevance were exposed occupationally, 3 of whom had airborne exposure. To be included in the baseline series, an allergen must patch test positive in ≥ 0.5% of consecutively tested patients. Our findings confirm that DGEBA remains a relevant allergen, supporting its continued inclusion. No cases of non-occupational sensitisation from new sources were identified.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality and readability of online resources for atopic dermatitis: a cross-sectional analysis.","authors":"Christopher Shenouda, Eric McMullen, Grace Xiong, Sana Gupta, Dea Metko, Andy Cui, Joony Hong, Shireen Dumont, Ilya Mukovozov","doi":"10.1093/ced/llaf419","DOIUrl":"https://doi.org/10.1093/ced/llaf419","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}