Clinical and Experimental Dermatology最新文献

Evaluating the Quality and Readability of Online Information on Hidradenitis Suppurativa: A Systematic Review. 评价化脓性汗腺炎在线信息的质量和可读性：一项系统综述。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-28 DOI: 10.1093/ced/llaf236

Marra Aghajani, Ericka Maye, Kate Burrell, Cindy Kok, John W Frew

{"title":"Evaluating the Quality and Readability of Online Information on Hidradenitis Suppurativa: A Systematic Review.","authors":"Marra Aghajani, Ericka Maye, Kate Burrell, Cindy Kok, John W Frew","doi":"10.1093/ced/llaf236","DOIUrl":"https://doi.org/10.1093/ced/llaf236","url":null,"abstract":"Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder associated with significant physical, psychological, and social burdens. Despite increasing recognition, diagnostic delays remain common, often prompting patients to seek information online. This systematic review evaluated the quality and readability of HS-related information across AI-generated content, search engine derived resources, and social media platforms. A comprehensive search of PubMed, Embase, Cochrane Library, and Google Scholar identified 17 studies published between 2017 and 2024 that assessed HS-related online content using validated scoring tools and/or physician evaluation. More than 50% of studies rated online HS materials as variable in quality, with 36.4% rating them as moderate. Readability assessments revealed that most resources exceeded the recommended 6th to 8th grade reading level, limiting accessibility for patients. Social media platforms, particularly TikTok and YouTube, featured highly engaging but frequently inaccurate or anecdotal content, with physician-generated materials receiving lower engagement than non-medical sources. These findings highlight the critical need for simplified, evidence-based online resources to improve health literacy and support informed decision-making in HS. The prevalence of misinformation, particularly regarding alternative treatments and pharmaceutical scepticism, underscores the urgency of enhanced patient education strategies. Future efforts should focus on AI-driven readability improvements, clinician engagement in digital education, and collaboration with social media platforms to ensure the availability of accessible, high-quality HS information.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of psoriasis and genetic predisposition with the risk of cardiometabolic diseases: a population-based cohort study. 牛皮癣和遗传易感性与心脏代谢疾病风险的关联：一项基于人群的队列研究

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-28 DOI: 10.1093/ced/llaf234

Juan Peng, Xiaoyun Xie, Yan Zhang, Danrong Jing, Guowei Zhou, Guanxiong Zhang, Xiang Chen, Zhijun Huang, Hong Liu

{"title":"Association of psoriasis and genetic predisposition with the risk of cardiometabolic diseases: a population-based cohort study.","authors":"Juan Peng, Xiaoyun Xie, Yan Zhang, Danrong Jing, Guowei Zhou, Guanxiong Zhang, Xiang Chen, Zhijun Huang, Hong Liu","doi":"10.1093/ced/llaf234","DOIUrl":"https://doi.org/10.1093/ced/llaf234","url":null,"abstract":"Background: The correlation between psoriasis with individual cardiometabolic diseases (CMDs), including coronary heart disease (CHD), stroke, hypertension, heart failure (HF), and type 2 diabetes mellitus (T2DM), have yielded conflicting results, and genetic susceptibility's role in modifying these relationships remains unexplored.Objective: To investigate the association of psoriasis with the risk of CMDs, and to assess the modified effect of genetic susceptibility on these associations.Methods: A total of 390,165 participants from the UK Biobank cohort were enrolled. Cox proportional hazards models were used to examine the association between psoriasis and the incidence of CMDs. The genetic risk score for these diseases was incorporated as tertiles to assess potential effect modification in these association. The outcome was CMDs.Results: During a median 12.0-year follow-up, a total of 23,811 incident CHD events, 6,941 HF, 82,963 hypertension, 6,902 stroke, and 16,788 T2DM were recorded. Participants with psoriasis had an increased risk of incident CHD (hazard ratio [HR] 1.11, 95% confidence interval [CI] 1.03-1.21), HF (HR 1.20, 95% CI 1.06-1.35), hypertension (HR 1.10, 95% CI 1.05-1.15), and T2DM (HR 1.22, 95% CI 1.11-1.34) compared to those without psoriasis. The adverse impact of psoriasis was pronounced among individuals with a high genetic predisposition. The elevated risk of CMDs associated with psoriasis may be partially explained by inflammation and dyslipidemia.Conclusions: Psoriasis was associated with the incidence of CMDs, particularly among individuals with higher genetic predisposition. Hence, our study emphasized the significance of preventing and managing CMDs among psoriasis patients, particularly those with high genetic risk.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of 5-Aminolevulinic Acid Photodynamic Therapy Followed by Sequential 30% Supramolecular Salicylic Acid Treatment in Moderate-to-severe Acne Vulgaris: a Prospective, Randomized, Split-face Controlled Study. 5-氨基乙酰丙酸光动力治疗后连续30%超分子水杨酸治疗中重度寻常痤疮的效果：一项前瞻性、随机、裂面对照研究

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-27 DOI: 10.1093/ced/llaf230

Yu Yan, Dixin Wang, Peiru Wang, Yun Wu, Yajing Cao, Haiyan Zhang, Linglin Zhang, Xiaojing Liu, Xiuli Wang

{"title":"Effect of 5-Aminolevulinic Acid Photodynamic Therapy Followed by Sequential 30% Supramolecular Salicylic Acid Treatment in Moderate-to-severe Acne Vulgaris: a Prospective, Randomized, Split-face Controlled Study.","authors":"Yu Yan, Dixin Wang, Peiru Wang, Yun Wu, Yajing Cao, Haiyan Zhang, Linglin Zhang, Xiaojing Liu, Xiuli Wang","doi":"10.1093/ced/llaf230","DOIUrl":"https://doi.org/10.1093/ced/llaf230","url":null,"abstract":"Background: 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) is one of the effective treatments for moderate to severe acne, but is associated with adverse effects such as erythema and requires multiple sessions. Supramolecular salicylic acid (SSA) is a type of chemical peel with good anti-inflammatory effects and mild adverse effects. Combining the two is novel for the treatment of acne vulgaris.Objective: The purpose of this study was to investigate the efficacy and safety of ALA-PDT followed by sequential 30% SSA treatment on moderate to severe acne vulgaris.Methods: A total of 19 patients with moderate-to-severe acne vulgaris were enrolled in this prospective, randomized, split-face controlled study. The patients were treated once a week for a total of two treatments and followed up until 4 weeks after the final treatment.Results: ALA-PDT followed by sequential 30% SSA treatment significantly reduces the number of lesions compared to ALA-PDT treatment, especially for comedones and papules without additional damage to the skin barrier. Despite transient mild pain reported by patients during SSA treatment, the protocol demonstrated significant attenuation of post ALA-PDT erythema and ultraviolet (UV)-induced dermal pigmentation clusters.Conclusion: ALA-PDT followed by sequential 30% SSA enhances the efficacy of ALA-PDT in moderate-to-severe acne vulgaris and attenuates adverse effects partially.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gluteofemoral erythema of pregnancy: a pregnancy-specific skin disease. 妊娠臀股红斑：一种妊娠期特有的皮肤病。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-27 DOI: 10.1093/ced/llaf158

Ying Zhang, Wenhui Wang, Chunlei Zhang, Weiwei Li

引用次数: 0

Outcomes of PASI and PASI components in two phase 3 trials of deucravacitinib in patients with moderate to severe plaque psoriasis. deucravacitinib治疗中重度斑块型银屑病的两项3期临床试验中PASI和PASI成分的结果

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-24 DOI: 10.1093/ced/llaf215

Mark Lebwohl, Melinda Gooderham, Richard B Warren, Diamant Thaçi, Peter Foley, Alice B Gottlieb, Tiago Torres, Zoran Popmihajlov, Ying-Ming Jou, Misti Linaberry, Carolin Daamen, Christopher E M Griffiths

{"title":"Outcomes of PASI and PASI components in two phase 3 trials of deucravacitinib in patients with moderate to severe plaque psoriasis.","authors":"Mark Lebwohl, Melinda Gooderham, Richard B Warren, Diamant Thaçi, Peter Foley, Alice B Gottlieb, Tiago Torres, Zoran Popmihajlov, Ying-Ming Jou, Misti Linaberry, Carolin Daamen, Christopher E M Griffiths","doi":"10.1093/ced/llaf215","DOIUrl":"https://doi.org/10.1093/ced/llaf215","url":null,"abstract":"Deucravacitinib was significantly more effective than placebo in the 52-week, phase 3 POETYK PSO-1 and PSO-2 trials. This study further evaluated deucravacitinib efficacy versus placebo in these trials based on Psoriasis Area and Severity Index (PASI) outcomes. Patients with moderate to severe plaque psoriasis received placebo or deucravacitinib 6 mg once daily. At Week 16, patients crossed over from placebo to deucravacitinib. Deucravacitinib-treated patients had greater reductions from baseline in PASI within 1 week, with higher improvements observed versus placebo at Week 16. Patients who crossed over to deucravacitinib at Week 16 achieved similar improvements at Week 52 as patients treated continuously with deucravacitinib from Day 1. Significantly higher proportions of deucravacitinib-treated patients achieved treat-to-target PASI thresholds (≤1, ≤2, ≤3, ≤4, ≤5), and significantly greater improvements were observed in each PASI component (body region [head, trunk, upper/lower extremities]; plaque characteristics [erythema, induration, desquamation]) versus placebo at Week 16.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Papillon-Lefèvre syndrome: palmoplantar keratoderma with teeth abnormalities. 乳突-左椎体综合征：掌跖角化病伴牙齿异常。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llaf080

Priyansh Gupta, Priyanka Sangwan, Vishal Thakur, Biswanath Behera

引用次数: 0

Global prevalence of mental health comorbidity in patients with acne: an analysis of trends from 1961 to 2023. 痤疮患者精神健康共病的全球患病率：1961年至2023年的趋势分析

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llae531

Yiran Chen, Suting Sun, Han Yang, Xiaoya Fei, Ying Zhang, Jiankun Song, Yi Ru, Hang Zhao, Ying Luo, Le Kuai, Yue Luo, Bin Li, Mengji Xie, Bin Fan, Xiaojie Ding

{"title":"Global prevalence of mental health comorbidity in patients with acne: an analysis of trends from 1961 to 2023.","authors":"Yiran Chen, Suting Sun, Han Yang, Xiaoya Fei, Ying Zhang, Jiankun Song, Yi Ru, Hang Zhao, Ying Luo, Le Kuai, Yue Luo, Bin Li, Mengji Xie, Bin Fan, Xiaojie Ding","doi":"10.1093/ced/llae531","DOIUrl":"10.1093/ced/llae531","url":null,"abstract":"Background: Patients with acne increasingly face mental health challenges such as anxiety, depression and suicidal thoughts. However, no global systematic analysis exists on this topic.Objectives: To examine the prevalence of mental disorders - specifically, anxiety, depression and suicidal thoughts - among patients with acne.Methods: An exhaustive search of six databases was conducted up to May 2023. Data analysis was performed using Python and Stata MP 17, including subgroup evaluations, metaregression and sensitivity analyses.Results: Forty-three studies were analysed. The findings indicate that depression, anxiety and suicidal thoughts in patients with acne are prevalent at rates of 22%, 29% and 12%, respectively. Rates of depression were highest in Asia at 42%, led by India (53%) and Saudi Arabia (51%). Anxiety was also most common in Asia, at 45%, notably in Singapore (60%) and Iran (58%). Suicidal thoughts were highest in Oceania, specifically New Zealand at 24%. The study is limited by the inclusion of only Chinese- and English-language research, potentially introducing selection bias.Conclusions: The results of this study highlight the incidence of mental health disorders coexisting with acne. This study may help to foster greater understanding and awareness among both medical professionals and patients regarding the psychological complexities tied to acne.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1083-1093"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential gene set enrichment of the epithelial-mesenchymal transition pathway in BRAF- vs. NRAS-mutated metastatic melanoma. BRAF与NRAS突变的转移性黑色素瘤上皮-间质转化途径的差异基因集富集。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llaf023

Victor J Raimundi-Santos, Tyrel R Porter

引用次数: 0

A spectrum of BAP1 expression from naevus to melanoma in a patient with BAP1 tumour predisposition syndrome. BAP1肿瘤易感综合征患者从痣到黑色素瘤的BAP1表达谱

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llaf004

Yasuaki Ogura, Takatoshi Shimauchi, Tomoko Sugiyama, Yuki Sugimura, Masahiro Nakagawa, Harumo Osawa, Risa Kojima, Moriya Iwaizumi, Tetsuya Honda

引用次数: 0

Multimodal skin imaging of a dermatofibrosarcoma protuberans using line-field confocal optical coherence tomography, ultra-high frequency ultrasound and reflectance confocal microscopy. 利用线场共聚焦光学相干断层扫描、超高频超声波和反射共聚焦显微镜对原发性皮纤维肉瘤进行多模式皮肤成像。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llae543

Lucas Boussingault, Yasaman Jazaeri, Dilara Sanak, Dana Bernardi, Anne-Laure Trépant, Elisa Cinotti, Linda Tognetti, Javiera Pérez-Anker, Jean Luc Perrot, Véronique Del Marmol, Mariano Suppa

引用次数: 0