Clinical and Experimental Dermatology最新文献

Preliminary assessment of the diagnostic accuracy of cutaneous T-cell lymphoma through deep sequencing of T-cell receptor gamma gene. 通过T细胞受体γ基因深度测序初步评估皮肤T细胞淋巴瘤的诊断准确性。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-11-06 DOI: 10.1093/ced/llae413

Jin-Bon Hong, Tyng-Shiuan Hsieh, Tsen-Fang Tsai, Jau-Yu Liau, Hsien-Ching Chiu, Tung-Lung Lee, Tai-Chung Huang

{"title":"Preliminary assessment of the diagnostic accuracy of cutaneous T-cell lymphoma through deep sequencing of T-cell receptor gamma gene.","authors":"Jin-Bon Hong, Tyng-Shiuan Hsieh, Tsen-Fang Tsai, Jau-Yu Liau, Hsien-Ching Chiu, Tung-Lung Lee, Tai-Chung Huang","doi":"10.1093/ced/llae413","DOIUrl":"https://doi.org/10.1093/ced/llae413","url":null,"abstract":"Background: The diagnostic challenges in early mycosis fungoides (MF) and other cutaneous T-cell lymphomas (CTCL) persist despite advancements in molecular methods.Aim: The study aims to provide a preliminary assessment of next-generation sequencing in analyzing T-cell receptor gamma (TRG) sequences for distinguishing CTCL from benign inflammatory disorders.Methods: Skin samples from CTCL and benign inflammatory skin disorders proven clinicopathologically were assessed for TRG by NGS.Results: Our study analyzed skin samples from a total of 36 subjects, comprising 22 cases of CTCL, including 14 MF and 8 other CTCLs, alongside 14 cases of benign inflammatory skin disorders. According to the LymphoTrack criteria, monoclonality was detected in 75.0 % of the overall 24 CTCL patients. Specifically, in MF cases, 10 out of 14 were identified as monoclonality, with all four non-monoclonal cases being in the patch stage. For the other CTCL, 6 out of 8 cases displayed monoclonality. Among the overall 22 CTCL patients, 11 had multiple biopsies, with 9 displaying the same dominant clone across different sites. Among the 14 benign cases, only the case with erythrodermic psoriasis exhibited monoclonality. Our decision tree analysis suggests that a high frequency of the most abundant clone, its ratio to the third most abundant clone, and TRG V-I segment usage are effective markers aiding in diagnosing CTCL.Conclusion: Combination of the clone frequencies, and TRG V segment usage may enhance diagnosis for MF and other CTCLs, aiding in differentiating them from benign conditions. However, molecular diagnosis for patch-stage MF remains challenging.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protean Cutaneous Manifestation Caused by ABCA12 variants: Erythrokeratodermia Variabilis-like Ichthyosis and Unique Palmoplantar Keratoderma. 由 ABCA12 变体引起的蛋白皮肤病：红角化性鱼鳞病（Erythrokeratodermia Variabilis-like Ichthyosis）和独特的掌跖角化病（Unique Palmoplantar Keratoderma）。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-11-05 DOI: 10.1093/ced/llae478

Chih-Yu Chang, Min-Chia Yang, Hui-Ching Cheng, Yu-Chen Lin, John McGrath, Chao-Kai Hsu, Wei Ting Tu

引用次数: 0

Basal cell carcinoma of the neo-phallus: an emerging complication of gender reassignment surgery. 新阴茎基底细胞癌：变性手术的新并发症。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-11-05 DOI: 10.1093/ced/llae481

Alla Altayeb, Anna Nielsen-Scott, David Chandler

引用次数: 0

Anifrolumab use in refractory dermatomyositis: a case report and literature review. 在难治性皮肌炎中使用阿尼洛单抗：病例报告和文献综述。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-11-02 DOI: 10.1093/ced/llae476

Alejandro Claudio-Oliva, Myriam Viedma-Martínez, Gonzalo Gallo-Pineda, Maria Prieto-Rozados, Isabel Villegas-Romero, David Jiménez-Gallo, Mario Linares-Barrios

引用次数: 0

Zoon balanitis: not a distinct clinicopathological entity? 动物包皮龟头炎：不是一种独特的临床病理学实体？

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-11-01 DOI: 10.1093/ced/llae457

Richard E Watchorn, Claire Doyle, Georgios Kravvas, Christopher B Bunker

{"title":"Zoon balanitis: not a distinct clinicopathological entity?","authors":"Richard E Watchorn, Claire Doyle, Georgios Kravvas, Christopher B Bunker","doi":"10.1093/ced/llae457","DOIUrl":"https://doi.org/10.1093/ced/llae457","url":null,"abstract":"Zoon balanitis (ZB) was originally described in the 1950s in patients with clinical features resembling erythroplasia of Queyrat, but with histology that demonstrated a plasma cell infiltrate without evidence of dysplasia. Subsequently, ZB has been extensively reported in the literature, reflecting widespread acknowledgement as an established distinct clinicopathological entity. However, its existence as such has been questioned and there have been suggestions in the literature that ZB represents either a non-specific irritant reaction pattern, or a part of the heterogenous clinicopathological complex of male genital lichen sclerosus (MGLSc). In this study, the entire historical literature of published cases of ZB was subject to review, to determine respectively whether clinical or histological features of MGLSc had been present and been overlooked. One hundred and one papers were reviewed. Seventy-five contained images purporting to be of ZB. Images that were deemed to be of inadequate quality or to present uninformative anatomical views were excluded. The images in 66 manuscripts were amenable to scrutiny; 98.5% of these images demonstrated clinical signs of MGLSc, such as adhesions, effacement of the coronal sulcus and the frenulum, tightening of the prepuce, constrictive posthitis, etiolation of the glans, lichenoid inflammation and sclerosis. These findings strongly suggest that ZB occurs in the vast majority of cases as a manifestation of MGLSc and that its recognition as a distinct clinicopathological entity should be questioned, if not discontinued.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Sustainability in Dermatological Surgery. Part 2: Reducing Activity and Future Ecological Strategies. 皮肤外科的环境可持续性。第 2 部分：减少活动和未来生态战略。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-11-01 DOI: 10.1093/ced/llae470

Fatima Ali, Aaron Wernham, Rachel Abbott

{"title":"Environmental Sustainability in Dermatological Surgery. Part 2: Reducing Activity and Future Ecological Strategies.","authors":"Fatima Ali, Aaron Wernham, Rachel Abbott","doi":"10.1093/ced/llae470","DOIUrl":"https://doi.org/10.1093/ced/llae470","url":null,"abstract":"This two-part review addresses the pressing need for environmental sustainability in dermatological surgery, driven by the NHS's commitment to net-zero emissions. Part 2 of this review extends the discussion of sustainability in dermatological surgery by focusing on system-wide changes in service delivery and identifying future opportunities for reducing environmental impact. Building on the strategies outlined in Part 1, which explored low-carbon alternatives and operational resource optimisation, Part 2 advocates for a comprehensive shift in the skin surgery service. Key strategies include reducing overall surgical activity, advancing research and innovation, and enhancing management practices to align with sustainability goals. Reducing surgical activity mainly involves the prevention of skin cancers, in addition to optimising current patient pathways and empowering patients to take ownership of their follow-up. Outside of immediate clinical decision-making at the individual level, the review highlights the importance of managerial policy, procurement practices and supply chain factors in driving broader national and international sustainability efforts. Advancing the sustainability agenda will also require targeted research and innovation, particularly in digital health solutions using evidence-based practices. By integrating these strategies, this review aims to provide a framework for reducing the environmental footprint of dermatological surgery and advancing towards a more sustainable healthcare system.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in patient sentiment on Reddit through periods of atopic dermatitis treatment. 特应性皮炎治疗期间患者对 Reddit 的情感变化。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-10-30 DOI: 10.1093/ced/llae455

Andrew K Yang, Camille M Powers, Hannah Verma, Divija Sharma, Austin J Piontkowski, Jeremy Orloff, Benjamin Ungar, Nicholas Gulati

引用次数: 0

Comment on 'Patient-initiated follow-up for high-risk cutaneous squamous cell carcinoma: how we do it and 2 years of outcome data'. 就 "由患者发起的高危皮肤鳞状细胞癌随访：我们如何做以及两年的结果数据 "发表评论。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-10-30 DOI: 10.1093/ced/llae480

Delaney D Ding

引用次数: 0

"Sick of the Jab!": Immunization Barriers in an Immunosuppressed Dermatology Cohort. "厌倦了刺戳！"：免疫抑制性皮肤病队列中的免疫障碍。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-10-29 DOI: 10.1093/ced/llae479

Ji Fung Yong, Laoise Griffin, Michael O'Connell

引用次数: 0

Asymptomatic, slowly progressing erythematous papules with adult onset. 无症状、进展缓慢的红斑丘疹，成人发病。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-10-29 DOI: 10.1093/ced/llae475

Cristina Grechin, Sally McGrath, Odharnaith O'Brien, Marina O'Kane

引用次数: 0