Clinical and Experimental Dermatology最新文献

{"title":"Reconsidering tumour boundaries: implications of peritumoral Wnt dysregulation in penile squamous cell carcinoma.","authors":"Patrick Steven Tajanlangit, Sean Michael Tajanlangit","doi":"10.1093/ced/llag201","DOIUrl":"https://doi.org/10.1093/ced/llag201","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA genotype, clinical and immunofluorescence findings of 30 patients with type VII collagen antibody positive subepidermal bullous disease.","authors":"Ruman Basra, Rosanna Naderi, Sangeetha Yogarajah, John B Mee, Olivia J Shaw, Natalie Watson, Joseph Cooney, Richard W Groves, Jane F Setterfield, Thomas J Tull","doi":"10.1093/ced/llag052","DOIUrl":"https://doi.org/10.1093/ced/llag052","url":null,"abstract":"<p><p>Epidermolysis bullosa acquisita (EBA) and mucous membrane pemphigoid are mucocutaneous blistering disorders that are associated with antibodies that target type VII collagen (anti-col7). There are relatively few studies that closely investigate the clinical phenotype and HLA genotype of patients who are anti-col7 positive. We therefore characterized all patients with anti-col7-positive subepidermal bullous disease that were treated at our centre. In total, 30 patients were identified, 29 had mechanobullous skin lesions and all had oral ulceration. The most common sites for oral lesions were the tongue, lip and palatal mucosa. Laryngeal and oesophageal lesions were seen in five and six patients, respectively. Oesophageal involvement was associated with erosions and stricture formation in the cervical or thoracic oesophagus and the majority of patients with oesophageal involvement had concomitant bullous pemphigoid180/230 antibodies and were of Black African ancestry. IgA deposition on direct immunofluorescence was associated with lower age at disease onset but did not correlate with clinical features or autoantibody profiles. Concomitant BP180/230 antibody positivity was associated with earlier disease onset and Black African ancestry. HLA genotyping was performed in 18 patients and demonstrated HLA-DQB1*03 and HLA-DQB1*06 alleles were most commonly associated with anti-col7 EBA. HLA genotype did not, however, correlate with clinical features of autoantibody profiles. Taken together, this study demonstrates that concomitant BP180/230 and anti-col7 antibodies are associated with earlier disease onset, Black African ancestry and potentially oesophageal involvement.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enlarging erythematous shoulder cystic mass in a young man.","authors":"Shu Hui Leow, Salim Murtaza Esuffali Anjarwalla, Ki Wei Tan","doi":"10.1093/ced/llag159","DOIUrl":"https://doi.org/10.1093/ced/llag159","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Early Incomplete Sections on Mohs Micrographic Surgery Margin Assessment.","authors":"William Phillips, Michael J Davis, Megan H Trager, Cristian Navarrete-Dechent, Anthony Rossi, Erica Lee, Kishwer Nehal","doi":"10.1093/ced/llag196","DOIUrl":"https://doi.org/10.1093/ced/llag196","url":null,"abstract":"<p><p>Variations exist regarding evaluation of complete circumferential and deep margin assessment between Mohs surgeon's practices including section spacing, physical placement of the first section on the slide, and acceptable tumor-free margins. The impact of early incomplete sections (EIS) on margin interpretation has not been systematically studied. Here, we evaluate how inclusion of EIS affects tumor status interpretation during Mohs Micrographic Surgery. We retrospectively analyzed 500 basal cell carcinoma (BCC) Mohs pieces with EIS and prospective evaluation of 250 serially step-sectioned BCC pieces. In the retrospective cohort, inclusion of EIS reduced interpreted positivity from 47.2% to 41.2% reclassifying 12.7% of initially positive pieces as negative. Prospectively, EIS reduced positivity from 35.6 to 27.2%. Incorporation of EIS may reduce false-positive margin interpretations in Mohs Micrographic Surgery and potentially decrease unnecessary additional stages, depending on surgeon margin thresholds and cutting depth. The clinical application is nuanced and should take into account patient and tumor factors as determined by the Mohs surgeon.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHILD Syndrome without Limb Defects in a 1-year-old: revised nomenclature and successful treatment with Topical 2% Simvastatin/2% Cholesterol.","authors":"Joseph Wyer, Celia Moss, Pratima Poudel, Samantha Ibbs","doi":"10.1093/ced/llag193","DOIUrl":"https://doi.org/10.1093/ced/llag193","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shiitake mushroom, turmeric and Ginger: A recipe for a rash.","authors":"Melissa Crous, Marion Leahy, Li Jie Heleena Yoo, Laoise Griffin","doi":"10.1093/ced/llag197","DOIUrl":"https://doi.org/10.1093/ced/llag197","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic challenge: Epidermolysis bullosa acquisita of the palms and soles.","authors":"Nicole James, Shafiah Muna Abdul Gafoor, Rasika Singh, Emma Woodcock, Helen Whitley","doi":"10.1093/ced/llag199","DOIUrl":"https://doi.org/10.1093/ced/llag199","url":null,"abstract":"<p><p>Epidermolysis bullosa acquisita (EBA) is a rare autoimmune blistering disorder that can be difficult to diagnose, especially when its presentation mimics other blistering conditions. We present the case of a 56-year-old male who developed widespread blistering on flexural surfaces, palms, soles, and target lesions, with clinical features resembling bullous pemphigoid (BP), erythema multiforme (EM), and infectious aetiologies. A skin biopsy showed subepidermal bullae with linear IgG and C3 deposition at the basement membrane, with additional focal IgM and IgA positivity, and ELISA testing confirmed the presence of anti-collagen VII antibodies, diagnosing EBA. This case emphasizes the diagnostic challenge of atypical EBA presentations that overlap with BP and EM, highlighting the need to consider EBA in the differential diagnosis of blistering disorders.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between pemphigus and subsequent malignancy: A nationwide population-based study in Taiwan.","authors":"Hsi-Ling Liu, Yi-Hsien Chen, Chi-Hsiang Chung, Tsu-Hsuan Weng, Chun-Teng Tsai, Chih-Tsung Hung, Wu-Chien Chien","doi":"10.1093/ced/llag195","DOIUrl":"https://doi.org/10.1093/ced/llag195","url":null,"abstract":"<p><strong>Background: </strong>Pemphigus is a rare autoimmune vesiculobullous disorder caused by autoantibodies targeting desmosomes. While paraneoplastic pemphigus is known to be associated with malignancy, the cancer risk in non-paraneoplastic pemphigus remains unclear, particularly in Asian populations.</p><p><strong>Objectives: </strong>This study aims to assess the risk of subsequent malignancies in pemphigus patients compared to matched controls in Taiwan.</p><p><strong>Methods: </strong>Using Taiwan's National Health Insurance Research Database, a retrospective cohort study was conducted and included 357 pemphigus patients and 1,428 matched controls from 2000 to 2015. Covariates including age and sex, were adjusted using multivariable Cox regression. Adjusted hazard ratios (HRs) were calculated after controlling for age, sex, and comorbidity. Comorbidities were assessed using the revised Charlson Comorbidity Index, with higher scores indicating greater comorbidity burden. Risks of different subsequent cancers were estimated between patients with pemphigus and the control group.</p><p><strong>Results: </strong>Overall cancer risk was not significantly elevated in the pemphigus group (aHR 1.103; p = 0.342). In the sex-stratified analysis, male patients had a higher risk of malignancy compared with female patients (aHR 1.703; p = 0.039). However, after adjusting for covariates in the multivariable Cox regression model, sex was not an independent risk factor for subsequent malignancy (aHR 1.129; p = 0.321 and aHR 1.074; p = 0.367, respectively). Lymphatic and haematopoietic malignancies were correlated with the highest risk in pemphigus patients (aHR 2.903; p < 0.001). Median follow-up durations were 6.37 years in the pemphigus cohort and 6.45 years in the control cohort, yielding an overall median follow-up duration of 6.4 years.</p><p><strong>Conclusions: </strong>Pemphigus was not associated with an overall increased risk of subsequent malignancy. Sex was not an independent risk factor; however, males exhibited a higher cancer risk compared with females. Among specific cancer types, lymphatic and haematopoietic malignancies showed the strongest association with pemphigus.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactive infectious mucocutaneous eruption triggered by rhinovirus and beta-hemolytic streptococcus co-infection.","authors":"Radhika Bali, Neil P Patel","doi":"10.1093/ced/llag194","DOIUrl":"https://doi.org/10.1093/ced/llag194","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient and clinician reported outcomes of calcipotriol/betamethasone dipropionate PAD-cream for the treatment of adult patients with scalp psoriasis under real-world conditions: results from the prospective, non-interventional, multicentre PRO-SCALP study.","authors":"Jose Luis López Estebaranz, Anthony Bewley, Andreas Pinter, Jordi Galván, Volker Koscielny","doi":"10.1093/ced/llag185","DOIUrl":"https://doi.org/10.1093/ced/llag185","url":null,"abstract":"<p><strong>Background: </strong>The novel cream formulation of calcipotriol and betamethasone dipropionate based on polyaphron dispersion technology (CAL/BDP PAD-cream), has shown promising results on psoriasis in phase 3 clinical trials. However, real-world data on scalp are limited.</p><p><strong>Objectives: </strong>To assess clinician-reported outcomes (ClinROs) and patient-reported outcomes (PROs) of CAL/BDP PAD-cream in adults with mild-to-moderate scalp psoriasis under real-world conditions in Europe.</p><p><strong>Methods: </strong>PRO-SCALP is a prospective, non-interventional, multicentre, cohort study conducted between June 2023 and October 2024 in Germany, Spain and the United Kingdom. Data were collected at baseline and Week 8 (end of study, EOS). PROs included Treatment Satisfaction Questionnaire for Medication Version 9 (TSQM-9), Scalpdex questionnaire, Worst Itch-Numerical Rating Scale (WI-NRS), sleep disturbances, Psychosocial Effects of Scalp Psoriasis Questionnaire and adherence. ClinROs included treatment satisfaction and physician global assessment of scalp (scalp-PGA) and scalp-modified Psoriasis Area and Severity Index (S-mPASI).</p><p><strong>Results: </strong>253 patients (mean age: 47.9 years; 65.2% females) had evaluable data. 59.9% of them reported high adherence (visual analogue scale score 80-100). At EOS, mean (standard deviation) global satisfaction (TSQM-9) was 76.0 (21.6) and 77.6% of patients achieved a scalp-PGA score of 0/1 (clear/almost clear). Moreover, 68.4% achieved scalp-PGA success (scores of 0/1 and ≥2-point improvement). WI-NRS, S-mPASI and Scalpdex scores improved significantly (p<0.0001) from baseline to EOS. Sleep patterns and psychosocial outcomes also improved.</p><p><strong>Conclusions: </strong>CAL/BDP PAD-cream is associated with high treatment satisfaction and improved clinical outcomes and quality of life in the real-world management of scalp psoriasis.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}