Clinical and Experimental Dermatology最新文献

{"title":"LC-OCT-controlled cryotherapy for extramammary paget's disease: a case report.","authors":"Gerardo Palmisano, Gwendoline Diet, Carmen Orte Cano, Elisa Cinotti, Linda Tognetti, Pietro Rubegni, Javiera Perez-Anker, Susana Puig, Josep Malvehy, Jean-Luc Perrot, Véronique Del Marmol, Ketty Peris, Mariano Suppa","doi":"10.1093/ced/llaf161","DOIUrl":"https://doi.org/10.1093/ced/llaf161","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of interventions for idiopathic guttate hypomelanosis.","authors":"Hima Gopinath, Rajeev Aravindakshan, Sowmya Kaimal, Siva Santosh Pentapati, Yamini Marimuthu","doi":"10.1093/ced/llaf134","DOIUrl":"https://doi.org/10.1093/ced/llaf134","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic guttate hypomelanosis is a common benign leukoderma, the incidence of which increases with age. Treatment is often sought for cosmetic reasons. However, there is a paucity of information on effective treatments for this condition.</p><p><strong>Objectives: </strong>To evaluate and compile the effects of interventions for idiopathic guttate hypomelanosis.</p><p><strong>Evidence review: </strong>MEDLINE (through PUBMED), Web of Science, and Scopus databases were searched for interventions for idiopathic guttate hypomelanosis from inception through November 2023. Reference lists were searched for additional articles. Human randomized controlled trials (RCTs), clinical studies (non-RCTs), and case series studies (n>5) of topical, light, and energy-based devices and procedural interventions for idiopathic guttate hypomelanosis. Re-pigmentation was the primary outcome. At least two reviewers were involved in article screening, selection, data extraction, and quality assessment.</p><p><strong>Results: </strong>We included 20 articles from 522 articles: 9 randomized studies and 11 quasi-experimental studies. The number of patients varied from 6 to 240, and the maximum number of lesions included was 2129. Thirteen studies used a quartile grading score to report outcomes. Half the randomized studies had a high risk of bias, and the outcome measures were heterogeneous across studies. However, the treatment modalities were well-tolerated.</p><p><strong>Conclusion: </strong>A wide range of interventions are effective in idiopathic guttate hypomelanosis. Most modalities involved some form of therapeutic wounding. However, study design and methodology limitations must be considered for each intervention. There is a paucity of large randomized controlled trials with standardized outcome measures and follow-up data on the longetivity of re-pigmentation in idiopathic guttate hypomelanosis.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C4d staining as a diagnostic marker in anti-p200 pemphigoid.","authors":"Maike M Holtsche, Nina van Beek, Enno Schmidt, Christian Rose","doi":"10.1093/ced/llaf150","DOIUrl":"https://doi.org/10.1093/ced/llaf150","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there still a role for clindamycin and rifampicin in the treatment of hidradenitis suppurativa: A review of the literature.","authors":"Hannah E Wainman, Eliza Hutchison, Niamh T McSwiney, Ayesha Shahid, Emmanuel Toni, John R Ingram","doi":"10.1093/ced/llaf160","DOIUrl":"https://doi.org/10.1093/ced/llaf160","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Dermoscopic characteristics of Exogenous ochronosis: Results of a multicenter study by the International Dermoscopy Society Task Force on \"Imaging in Skin of Color\".","authors":"Keshavamurthy Vinay, Hitaishi Mehta, Yasmeen J Bhat, Soumil Khare, Nkechi Anne Enechukwu, Payal Chauhan, Balachandra S Ankad, Kelati Awatef, Sudha Rani, Feroze Kaliyadan, Enzo Errichetti","doi":"10.1093/ced/llaf159","DOIUrl":"https://doi.org/10.1093/ced/llaf159","url":null,"abstract":"<p><strong>Introduction: </strong>Exogenous ochronosis (EO) is an acquired pigmentary disorder characterized by blue-black or gray-blue skin discoloration due to prolonged use of topical hydroquinone (HQ). This study aimed to characterize the clinico-epidemiologic and dermoscopic features of EO in Fitzpatrick skin types III-VI.</p><p><strong>Methodology: </strong>This retrospective study involved the International Dermoscopy Society Task Force on \"Imaging in Skin of Color\". Inclusion criteria included confirmed or suspected EO diagnosis in patients of skin of color, and availability of complete clinical history and high quality clinical and dermoscopic images. Cases were classified as definitive EO if histopathologically confirmed, and as probable EO based on characteristic clinical features in HQ users without histopathological confirmation.</p><p><strong>Results: </strong>The study included 29 patients (93.1% female, mean age 40.04 years). EO was classified as definitive in 41.4% and probable in 58.6% of cases. The malar region was involved in all patients. The mean duration of HQ usage was 15.96 months. Common dermoscopic features observed included obliteration of follicular openings (86.2%), pigment dots (72.4%), and brown amorphous areas (72.4%). Additional features included telangiectasias (51.7%), accentuation of the pigment network (48.3%), arciform or comma-shaped structures (44.8%), white structureless areas (44.8%), and rimming of eccrine openings (31%). Histopathological findings in 12 patients confirmed EO, with banana bodies present in all.</p><p><strong>Conclusion: </strong>Dermoscopy is a valuable non-invasive diagnostic tool in EO, with obliteration of follicular openings, brown amorphous areas and comma shaped structures being a key feature. Further research is needed to optimize dermoscopic diagnostic criteria and treatment strategies.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Ugh…how do you catch that?\" - A qualitative study of the impact of psoriasis on social interactions.","authors":"Susan M Moschogianis, Anna Chisholm, Shane McKie, Christopher E M Griffiths, Rebecca Elliott, C Elise Kleyn","doi":"10.1093/ced/llaf146","DOIUrl":"https://doi.org/10.1093/ced/llaf146","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is associated with significant psychological disability. Due to the visibility of skin lesions, patients with psoriasis commonly report experiences of stigmatisation and public rejection.</p><p><strong>Objectives: </strong>We aimed to gain insight into individuals' experiences of the extent, type and management of psoriasis-related social interactions, and the long-term impact on social functioning.</p><p><strong>Methods: </strong>Qualitative, semi-structured interviews (n=24) were used to elicit the views and experiences of psoriasis patients. Data were analysed using inductive thematic analysis.</p><p><strong>Results: </strong>Analysis produced four overarching themes: 1) 'varied experiences of psoriasis-related interactions'; 2) 'threat to sense of self' 3) 'preserving social connections' and; 4) 'wasted opportunities for positive interactions'. Psoriasis had a significant impact on social interactions. Although overtly negative reactions were rare, even supportive comments were appraised negatively by patients as an unwanted reminder of the condition. Patients' behaviours within social situations were motivated by desires to minimise further attention, preserve self-identity and protect existing social relationships. Periods of social avoidance contributed to a damaged sense of self and decreased confidence in communication skills.</p><p><strong>Conclusions: </strong>Living with psoriasis may present unique social challenges. Even when the skin is well controlled clinically, patients may struggle to re-engage socially. The damage to the sense of self and decreased confidence in communication skills suggests that psychological therapies such as Acceptance and Commitment Therapy and social skills training may be beneficial.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'A Comparison of Large Language Model Powered Search Tools Reveal Differences in Output Quality, Information Transparency, and Accessibility for Mohs Micrographic Surgery Inquiries' - Enhancing Patient Education on Mohs Surgery: The Role of LLMs and Social Media.","authors":"Aparna Potluru, Yasmin Nikookam, Jonathan Guckian","doi":"10.1093/ced/llaf156","DOIUrl":"https://doi.org/10.1093/ced/llaf156","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of rapidly progressive, ulcerating nodules and plaques.","authors":"Conor Larney, Quynh Le, Louise Photiou, Michelle Goh, Edwin Tan","doi":"10.1093/ced/llaf157","DOIUrl":"https://doi.org/10.1093/ced/llaf157","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic actinic dermatitis - a familial link?","authors":"Usamah M Afzal, Donna Parkin, Jean Ayer","doi":"10.1093/ced/llaf154","DOIUrl":"https://doi.org/10.1093/ced/llaf154","url":null,"abstract":"<p><p>Chronic actinic dermatitis (CAD) is an inflammatory, immune-mediated photodermatoses that is characterised by erythematous, pruritic, lichenified plaques affecting photo-exposed areas of the body. The pathogenesis of CAD remains unknown with many postulated theories in the literature. The predominant hypothesis suggests a delayed type IV hypersensitivity reaction caused by photosensitive skin antigens - similar in disease process to allergic contact dermatitis (ACD).1 Despite current evidence suggesting no familial inheritance we present the first reported cases of CAD affecting three members of the same family, with increasing severity in each subsequent generation (i.e., two generations), strengthening the case for potential genetic predisposition.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported outcome measures for chronic spontaneous urticaria: a strategy centred on optimising patient management.","authors":"Eustachio Nettis, Oliviero Rossi, Laura Diluvio, Silvia Ferrucci, Francesca Spinelli, Ornella Bonavita, Riccardo Asero","doi":"10.1093/ced/llaf110","DOIUrl":"https://doi.org/10.1093/ced/llaf110","url":null,"abstract":"<p><p>Chronic spontaneous urticaria (CSU) is a persistent skin condition characterised by itchy wheals, angioedema, or both, significantly impacting patients' quality of life. The absence of identifiable triggers makes diagnosis, monitoring, and management particularly challenging. Patient-reported outcomes (PROs) are direct reports from patients that offer valuable insights into their health and well-being, enhancing communication between patients and clinicians and enabling more personalised care and informed decision-making. This review provides an overview of twelve patient-reported outcome measures (PROMs) used in CSU, which assist in monitoring disease activity, symptom control, and quality of life. It also explores the potential of mobile health (mHealth) apps as a modern solution for real-time disease monitoring, addressing some of the current challenges in CSU management.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}