Clinical and Experimental Dermatology最新文献_第2页

Differential gene set enrichment of the epithelial-mesenchymal transition pathway in BRAF- vs. NRAS-mutated metastatic melanoma. BRAF与NRAS突变的转移性黑色素瘤上皮-间质转化途径的差异基因集富集。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llaf023

Victor J Raimundi-Santos, Tyrel R Porter

引用次数: 0

A spectrum of BAP1 expression from naevus to melanoma in a patient with BAP1 tumour predisposition syndrome. BAP1肿瘤易感综合征患者从痣到黑色素瘤的BAP1表达谱

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llaf004

Yasuaki Ogura, Takatoshi Shimauchi, Tomoko Sugiyama, Yuki Sugimura, Masahiro Nakagawa, Harumo Osawa, Risa Kojima, Moriya Iwaizumi, Tetsuya Honda

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Multimodal skin imaging of a dermatofibrosarcoma protuberans using line-field confocal optical coherence tomography, ultra-high frequency ultrasound and reflectance confocal microscopy. 利用线场共聚焦光学相干断层扫描、超高频超声波和反射共聚焦显微镜对原发性皮纤维肉瘤进行多模式皮肤成像。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llae543

Lucas Boussingault, Yasaman Jazaeri, Dilara Sanak, Dana Bernardi, Anne-Laure Trépant, Elisa Cinotti, Linda Tognetti, Javiera Pérez-Anker, Jean Luc Perrot, Véronique Del Marmol, Mariano Suppa

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A rapidly enlarging axillary nodule. 迅速增大的腋窝结节。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llae556

Maeve Herlihy, Shane Brennan, Sinead Field

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Severe verrucous erythema elevatum diutinum responding to a combined therapy with low-dose dapsone and prednisone. 低剂量氨苯砜和强的松联合治疗对严重的尿丘隆起性疣状红斑的疗效。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llaf036

Héloïse Jourdain, Justine Lavaud, Aurélie Charissoux, Philippe Bernard

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Dietary measures as an adjunctive therapy in alopecia areata: a scoping review. 饮食措施作为斑秃的辅助治疗：一项范围综述。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llaf047

Samantha Bestavros, Ryan S Huang, Eric P McMullen, Dea Metko, Cathryn Sibbald, Jeffrey Donovan

引用次数: 0

General dermatology and dermatology in primary healthcare. 普通皮肤科和初级卫生保健中的皮肤科。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llaf043

James Gaston, Anthony Moussa, John C Su, Benjamin S Daniel

引用次数: 0

High socioeconomic status is significantly associated with psoriasis: results from a cross-sectional, population-based study of 129 855 patients. 高社会经济地位与银屑病密切相关：对 129855 名患者进行的横断面人群研究结果。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llae286

Or Dagan, Yochai Schonmann, Eran Shavit, Arnon D Cohen, Yuliya Valdman-Grinshpoun, Tali Czarnowicki

{"title":"High socioeconomic status is significantly associated with psoriasis: results from a cross-sectional, population-based study of 129 855 patients.","authors":"Or Dagan, Yochai Schonmann, Eran Shavit, Arnon D Cohen, Yuliya Valdman-Grinshpoun, Tali Czarnowicki","doi":"10.1093/ced/llae286","DOIUrl":"10.1093/ced/llae286","url":null,"abstract":"Background: While the contribution of environmental factors (including smoking, overweight and stress) to psoriasis has been validated, data mining for the association between socioeconomic status (SES) and psoriasis prevalence has yielded contradictory observations.Objectives: To evaluate the association between psoriasis prevalence and SES.Methods: This was a nationwide population-based cross-sectional retrospective study that included all patients insured by 'Clalit' Health Services (N = 4 604 994). Univariable and multivariable logistic regression analyses were conducted to explore the association between psoriasis and SES while controlling for potential sociodemographic and clinical confounders.Results: The study population included 129 855 patients with psoriasis and 4 475 139 individuals without psoriasis. Higher SES was associated with an increased prevalence of psoriasis; in a fully adjusted model, Clalit members within the highest SES were 1.43-fold more likely to have psoriasis [95% confidence interval (CI) 1.39-1.48, P < 0.001], and those in the medium SES group were 1.2-fold more likely to have psoriasis compared with those in the lowest SES group (95% CI 1.18-1.26, P < 0.001; P for linear trend < 0.001).Conclusions: Positive correlation was found between SES and psoriasis prevalence. Further investigation is warranted to elucidate the factors accounting for this observation.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1138-1145"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of Japanese spotted fever with purpura fulminans. 一例伴有紫癜的日本斑疹热。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llae497

Sayaka Suzuki, Ryota Hayashi, Momo Sato, Mai Higuchi, Yukino Kase, Shingo Takei, Mahoko Oginezawa, Toru Kawai, Naoto Kanno, Hideyuki Ogata, Satoshi Shibata, Yuuki Banba, Riichiro Abe

引用次数: 0

Improved quality of life in patients treated with lebrikizumab monotherapy is mediated by improvements in itch and sleep: results from two phase III trials in patients with moderate-to-severe atopic dermatitis. lebrikizumab单药治疗患者的生活质量改善是通过改善瘙痒和睡眠来调节的：来自中重度特应性皮炎患者的两项3期试验的结果。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-05-23 DOI: 10.1093/ced/llae541

Gil Yosipovitch, Marjolein de Bruin-Weller, Marni Wiseman, Jesper Elberling, Jan Gutermuth, Evangeline Pierce, Sonia Montmayeur, Fan Emily Yang, Yuxin Ding, Laia Bardolet, Sarah Chisolm

{"title":"Improved quality of life in patients treated with lebrikizumab monotherapy is mediated by improvements in itch and sleep: results from two phase III trials in patients with moderate-to-severe atopic dermatitis.","authors":"Gil Yosipovitch, Marjolein de Bruin-Weller, Marni Wiseman, Jesper Elberling, Jan Gutermuth, Evangeline Pierce, Sonia Montmayeur, Fan Emily Yang, Yuxin Ding, Laia Bardolet, Sarah Chisolm","doi":"10.1093/ced/llae541","DOIUrl":"10.1093/ced/llae541","url":null,"abstract":"Pruritus is a hallmark symptom of atopic dermatitis (AD) and is known to worsen patients' health-related quality of life. Lebrikizumab is a high-affinity monoclonal antibody that binds interleukin-13, a key cytokine implicated in AD. This study includes data from two phase III randomized controlled trials that assessed the efficacy and safety of lebrikizumab in patients with moderate-to-severe AD, ADvocate1 (NCT04146363) and ADvocate2 (NCT04178967). We report a post hoc analysis to quantify the effect of lebrikizumab vs. placebo on the Dermatology Life Quality Index (DLQI) mediated indirectly through its effect on patient-reported outcomes, specifically itch and the interference of itch on sleep. Approximately two-thirds of the improvement at week 16 in DLQI experienced by patients treated with lebrikizumab vs. patients treated with placebo was mediated by improvements in itch and the interference of itch on sleep.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1188-1192"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0