Clinical and Experimental Dermatology最新文献

{"title":"Clinical spectrum of penile intraepithelial neoplasia in a sexual health service: a retrospective case series.","authors":"Tiffany R Phillips, Eric P F Chow, Mark I Darling","doi":"10.1093/ced/llag439","DOIUrl":"https://doi.org/10.1093/ced/llag439","url":null,"abstract":"<p><strong>Background: </strong>Penile intraepithelial neoplasia (PeIN) is an uncommon precursor to invasive penile squamous cell carcinoma (SCC). Its heterogeneous appearance may overlap with inflammatory penile dermatoses, genital warts, or infection, potentially delaying diagnosis. We aimed to characterise the clinical spectrum, inflammatory context, biopsy triggers, histopathology, management, and outcomes of histopathologically confirmed PeIN presenting to a sexual health service.</p><p><strong>Methods: </strong>We conducted a retrospective case series of patients with histopathologically confirmed low-grade or high-grade squamous intraepithelial lesions, or invasive SCC, assessed at Melbourne Sexual Health Centre, Australia, from 2018-2025. Electronic records were reviewed for demographics, immune status, circumcision status, lesion site and morphology, symptoms, coexisting inflammatory disease, biopsy indications, histopathology, treatment, recurrence, and follow-up. Data were analysed descriptively.</p><p><strong>Results: </strong>Thirteen patients aged 25-72 years were identified; four had lichen sclerosus and three had immunosuppression or immune-modifying therapy. Most were uncircumcised at diagnosis. Lesions predominantly involved the glans or inner foreskin, but also occurred on the shaft, and showed marked heterogeneity, including erythematous or white plaques, papules, warty or hyperkeratotic lesions, erosions, fissures, and ulcerated nodules. Symptoms ranged from none to pain, burning, itch, hypersensitivity, malodour, and non-healing sores. Several lesions initially appeared inflammatory or wart-like; sometimes in the setting of documented lichen sclerosus. Biopsy was generally prompted by persistence, focal hyperkeratosis or induration, ulceration or erosion, architectural change, progressive enlargement, or incomplete response to empiric therapy. Histopathology showed predominantly high-grade lesions; one patient had low-grade disease with biopsy-confirmed recurrence, and two had invasive SCC. All cases were HPV-associated by reported histopathological features and/or p16 positivity. Management was frequently multimodal and multidisciplinary, including circumcision, local or wide excision, partial penectomy, imiquimod, 5-fluorouracil, cryotherapy, and treatment of coexisting inflammation. Outcomes were generally favourable where documented, although recurrence or suspected recurrence occurred in some patients and ongoing surveillance was often required.</p><p><strong>Conclusions: </strong>PeIN presenting to sexual health services is clinically diverse and commonly embedded within an inflammatory clinical narrative. Persistent or atypical penile lesions, particularly those showing focal change or incomplete treatment response, warrant a low threshold for biopsy and coordinated dermatology-urology management.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basal cell carcinoma subtypes in Mohs surgery can differ from biopsy histology.","authors":"Alyssa Breneman, Lauren M Fahmy, Tessa M LeWitt, Anna Bowling, Ella Miller, Cheng-Shiun Leu, Faramarz H Samie","doi":"10.1093/ced/llag438","DOIUrl":"https://doi.org/10.1093/ced/llag438","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatrics and genetics.","authors":"Barry Patton, Lisa Roche, Cathal O'Connor","doi":"10.1093/ced/llag435","DOIUrl":"https://doi.org/10.1093/ced/llag435","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous Eccrine Porocarcinoma and Squamous Cell Carcinoma in Epidermodysplasia Verruciformis.","authors":"Milton Rosa, Leonor Branquinho Ruivo, Dolores López-Presa, Miguel Duarte Reis, Joana Antunes, Paulo Filipe","doi":"10.1093/ced/llag434","DOIUrl":"https://doi.org/10.1093/ced/llag434","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc supplementation does not result in a reduced serum copper in dermatology patients.","authors":"Emma Mackender, Annabel Morton, Eleanor Clarke, Alexa Rose Shipman","doi":"10.1093/ced/llag431","DOIUrl":"https://doi.org/10.1093/ced/llag431","url":null,"abstract":"<p><p>Zinc is an essential electrolyte required for normal growth and development. Zinc supplementation has also shown to improve neutrophilic dermatoses such as sterile pustular disorders, due to the reduction of phagocytic function which modulates inflammatory proteins. However, there have been case reports of zinc supplementation resulting in hypocupraemia, due to competition of the divalent metal transporter in the gastrointestinal system that absorbs both zinc and copper. There are no existing guidelines recommending monitoring serum copper whilst supplementing with zinc in dermatology practice. Serum levels of both zinc and copper were taken on a cohort of dermatology patients on zinc supplementation. Results from 23 patients found that no patients displayed low serum copper due to zinc supplementation. The duration of supplementation ranged from 3 months to 20+ years. Zinc supplementation may cause hypocupraemia, but this was not demonstrated in a dermatology cohort, suggesting that frequent monitoring of copper may be unnecessary.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pemphigoid After Immune Checkpoint Inhibitors and Other Anti-Neoplastic Medications: A Danish Nationwide Case-Control Study.","authors":"Philip Ahle Erichsen, Ida M Heerfordt, Mette Mogensen, Rasmus Huan Olsen, Henrik Horwitz","doi":"10.1093/ced/llag426","DOIUrl":"https://doi.org/10.1093/ced/llag426","url":null,"abstract":"<p><strong>Background: </strong>Immune checkpoint inhibitors have been linked to an increased risk of incident pemphigoid.</p><p><strong>Objective: </strong>To examine the association between immune checkpoint inhibitor treatment and incident pemphigoid using nationwide data in Denmark, including comparison with other anti-neoplastic medications.</p><p><strong>Methods: </strong>This was a nationwide matched case-control study in Denmark of cases with incident pemphigoid identified through Danish national registries between 2019 and 2024. Cases were matched 1:100 with population controls on age, sex and index date. Exposure was defined as at least one recorded hospital administration of an immune checkpoint inhibitor within three months before the index date. Odds ratios (ORs) with 95% CIs were estimated using conditional logistic regression. In additional analyses, we examined molecularly targeted therapy and conventional chemotherapy using the same exposure window.</p><p><strong>Results: </strong>We identified a total of 951 cases of pemphigoid and 95,100 controls. Among cases, 7 (0.74%) had been treated with an immune checkpoint inhibitor compared to 64 (0.07%, OR: 11.05, 95% CI: 5.04-24.22) of controls. In an additional analysis 5 cases (0.53%) had been treated with molecularly targeted therapy and 6 cases (0.63%) had been treated with conventional chemotherapy compared to 262 (0.28%, OR: 1.91, 95% CI: 0.79-4.65) and 250 (0.26%, OR: 2.42, 95% CI: 1.07-5.45) of controls respectively. After adjusting for these other anti-neoplastic medications, the association between immune checkpoint inhibitor exposure and pemphigoid remained statistically significant (OR: 10.41, 95% CI: 4.72-22.94).</p><p><strong>Conclusion: </strong>Immune checkpoint inhibitor treatment was associated with a substantially increased risk of incident pemphigoid in this Danish nationwide case-control study.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatopathology.","authors":"Mary-Catherine Walsh, Aoife Boyle, Helena Devenney, Trevor Markham","doi":"10.1093/ced/llag432","DOIUrl":"https://doi.org/10.1093/ced/llag432","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune Bullous Disorders Associated With Immune Checkpoint Inhibitors: A Retrospective Review of a Single Center Cohort Over the Past Decade.","authors":"Deborah Cull, Katherine Holder, Disha Chakraborty, Sydney Proffer, Anagha Bangalore-Kumar, Austin Todd, Julia Lehman, Sindhuja Sominidi Damodaran","doi":"10.1093/ced/llag427","DOIUrl":"https://doi.org/10.1093/ced/llag427","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Immune checkpoint inhibitors (ICIs) directed against PD-1, PD-L1, and CTLA-4 augment antitumor immune responses but may also induce unintended immune activation, resulting in immune-related adverse events (irAEs). Cutaneous manifestations of irAEs are among the most common, ranging from mild eruptions to severe autoimmune blistering disorders (AIBDs). Although bullous pemphigoid (BP) is the most reported ICI-related autoimmune bullous disorder (irAIBD), data on the spectrum, and management of other ICI-associated AIBDs remain limited. Understanding these reactions is crucial to managing treatment interruptions and influencing oncologic outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aims to comprehensively characterize ICI-associated irAIBDs by examining demographics, clinical presentation, disease severity, therapeutic approaches, treatment responses, clinical outcomes, and mortality.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A single-institution retrospective chart review was conducted, using a text-based database search from 2011-2023. Adult patients (≥18 years) with biopsy-confirmed AIBDs attributed to ICIs were included. Demographic, oncologic, and immunotherapy details, as well as clinical, histopathologic, and immunofluorescence characteristics of AIBDs, were reviewed. Treatment approaches, outcomes, and mortality data were analyzed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Forty-four patients with irAIBDs were identified, predominantly representing males (29, 65.9%) with a mean age of 70.4 years (range: 62-80 years). Lung carcinoma (12, 27.2%) and melanoma (9, 20.4%) were the most frequent underlying malignancies, and pembrolizumab (25, 56.8%) was the most common agent. Bullous pemphigoid (BP) accounted for most cases (36, 81.8%), followed by lichen planus pemphigoides (LPP) (6, 13.6%), with one case each of mucous membrane pemphigoid (MMP) and linear IgA bullous dermatosis (LABD). Pruritus was reported in most (42, 9%) patients, and upper (36, 81.8%), lower (32, 72.2%) extremities and the chest (34, 77.2%) were most often involved. Eosinophilic infiltration was present in most (23, 81.8%) of BP cases, and linear IgG and C3 deposition were the predominant immunofluorescence patterns in BP. Most patients received topical (34, 77.2%) and/or systemic corticosteroids (32, 72.7%), while 16 required at least temporary ICI discontinuation. Four BP (4, 9.1%) patients were treated with dupilumab. Other systemic agents used included doxycycline (22, 50%), intravenous immunoglobulin (IVIG) (5, 11.3%), rituximab (6, 13.6%), dapsone (1, 2.2%), mycophenolate mofetil (1, 2.2%), methotrexate (1, 2.2%), and colchicine (1, 2.2%). Three cases with Grade 3 severity necessitated permanent ICI discontinuation. Clinical stabilization (24, 54.5%) or remission of the irAIBD (16, 36.3%) was achieved in most cases. One death (2.2%) was attributed to sepsis in a patient with severe irAIBD.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;ICI-associated AIBDs a","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pruritic genital eruption in a young man with Crohn disease.","authors":"Shin Iinuma, Hana Yamauchi, Yasuyuki Fujita","doi":"10.1093/ced/llag428","DOIUrl":"https://doi.org/10.1093/ced/llag428","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-level adverse-event frequency may not reflect exposure-adjusted IVIG risk.","authors":"Fatih Kaplan","doi":"10.1093/ced/llag429","DOIUrl":"https://doi.org/10.1093/ced/llag429","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}