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Clinical and Experimental Dermatology最新文献

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Expanding the spectrum of epidermodysplasia verruciformis: Mutations linked to primary immunodeficiency disorders.
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-04-02 DOI: 10.1093/ced/llaf155
Apoorva Sharma, Pandiarajan Vignesh, Amit Rawat, Anuradha Bishnoi, Keshavamurthy Vinay
{"title":"Expanding the spectrum of epidermodysplasia verruciformis: Mutations linked to primary immunodeficiency disorders.","authors":"Apoorva Sharma, Pandiarajan Vignesh, Amit Rawat, Anuradha Bishnoi, Keshavamurthy Vinay","doi":"10.1093/ced/llaf155","DOIUrl":"https://doi.org/10.1093/ced/llaf155","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of the menstrual cycle on exacerbations of atopic dermatitis: a systematic review.
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-04-02 DOI: 10.1093/ced/llaf153
Niamh Theresa McSwiney, Eliza Hutchison, Rosa Moran, Alexandra Phillips, Daya Sumra, Hannah Wainman
{"title":"The impact of the menstrual cycle on exacerbations of atopic dermatitis: a systematic review.","authors":"Niamh Theresa McSwiney, Eliza Hutchison, Rosa Moran, Alexandra Phillips, Daya Sumra, Hannah Wainman","doi":"10.1093/ced/llaf153","DOIUrl":"https://doi.org/10.1093/ced/llaf153","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is a chronic pruritic inflammatory skin condition. Patients often report experiencing cutaneous deterioration associated with certain points of their menstrual cycle. Despite this, the literature surrounding this topic remains sparse. This review aims to summarise and compare recent publications surrounding the association between the different stages of the menstrual cycle and exacerbations of atopic dermatitis.</p><p><strong>Methods: </strong>A literature review was conducted as per PRISMA guidelines using Ovid Medline, Embase, Cochrane Library, PubMed and Web of Science. Search terms and variations on these terms included: menstruation, eczema and atopic dermatitis. A minimum of 2 authors independently screened each abstract and reviewed the full-texts for inclusion.</p><p><strong>Results: </strong>A total of 16 studies were included. All articles consistently acknowledged premenstrual deterioration in control of atopic dermatitis, typically occurring in the week prior to menstruation.</p><p><strong>Conclusion: </strong>Our results highlight that the premenstrual exacerbation of AD is a well-recognised phenomenon, typically occurring in the week prior to menstruation. Existing studies are of a low quality and we identified minimal evidence on treatment strategies for premenstrual AD exacerbations. Further large-scale studies are needed to explore treatment options for these patients, such as hormonal therapies.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential Role of Leptin in JAK2 Inhibitor-Associated Weight Gain: A Monocentric Retrospective Study.
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-04-02 DOI: 10.1093/ced/llaf144
Luciano Ibba, Luigi Gargiulo, Matteo Bianco, Sara Di Giulio, Ruggero Cascio Ingurgio, Angela Alfano, Carlo A Vignoli, Mario Valenti, Paola Facheris, Chiara Perugini, Alessandra Narcisi, Antonio Costanzo
{"title":"Potential Role of Leptin in JAK2 Inhibitor-Associated Weight Gain: A Monocentric Retrospective Study.","authors":"Luciano Ibba, Luigi Gargiulo, Matteo Bianco, Sara Di Giulio, Ruggero Cascio Ingurgio, Angela Alfano, Carlo A Vignoli, Mario Valenti, Paola Facheris, Chiara Perugini, Alessandra Narcisi, Antonio Costanzo","doi":"10.1093/ced/llaf144","DOIUrl":"https://doi.org/10.1093/ced/llaf144","url":null,"abstract":"<p><p>Janus kinase (JAK) inhibitors are widely used for treating atopic dermatitis (AD) and alopecia areata (AA). Weight gain is an emergent adverse event associated with JAK inhibitors, particularly those acting on the JAK2 pathway. We conducted a retrospective monocentric 2-cohort study, including 226 patients, to evaluate the prevalence of weight gain in patients with AD and AA who were treated with JAK inhibitors for at least one year. We included 142 patients in the JAK1/2 cohort (receiving upadacitinib 30 mg or baricitinib 4 mg) and 84 in the JAK1 cohort (receiving upadacitinib 15 mg or abrocitinib 100 mg). The JAK1/2 cohort showed an additional weight gain throughout the study period (at week 52: β=1.84, 95% C.I. 1.45-2.23, p<0.001). In conclusion, patients receiving JAK1/2 inhibitors for AD or AA are at a greater risk of weight gain than those treated with JAK1 inhibitors, likely due to impaired leptin signaling.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pigmentary keratosis lichenoides chronica, yet another variant: A case report.
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-04-01 DOI: 10.1093/ced/llaf139
Ankan Gupta, Vartika Singh, Meera Thomas, Anju George, Himadri Himadri
{"title":"Pigmentary keratosis lichenoides chronica, yet another variant: A case report.","authors":"Ankan Gupta, Vartika Singh, Meera Thomas, Anju George, Himadri Himadri","doi":"10.1093/ced/llaf139","DOIUrl":"https://doi.org/10.1093/ced/llaf139","url":null,"abstract":"<p><p>Keratosis lichenoides chronica (KLC) is a rare, chronic dermatosis considered an autoinflammatory keratinization disorder resembling lichen planus (LP). Pigmentary LP is a common dermatosis in the skin of colour; however, pigmentary KLC has never been reported, and keratosis is a defining feature of KLC. We report an Indian-origin male with a distinctive pattern of skin lesions described for keratosis lichenoides chronica sans hyperkeratosis.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure-response of ciclosporin and methotrexate in children and young people with severe atopic dermatitis: A secondary analysis of the TREatment of severe Atopic dermatitis Trial (TREAT).
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-04-01 DOI: 10.1093/ced/llaf147
Mandy Wan, Ashley P Jones, Daniel Maskrey, Monica Arenas-Hernandez, Anna Rosala-Hallas, Paula E Beattie, Susannah Baron, Fiona Browne, Sara J Brown, Joanna E Gach, Danielle Greenblatt, Ross Hearn, Eva Hilger, Ben Esdaile, Michael J Cork, Emma Howard, Marie-Louise Lovgren, Suzannah August, Farhiya Ashoor, Paula R Williamson, Tess McPherson, Donal O'Kane, Jane Ravenscroft, Lindsay Shaw, Manish D Sinha, Catherine Spowart, Bjorn R Thomas, Tracey H Sach, Alan D Irvine, Carsten Flohr
{"title":"Exposure-response of ciclosporin and methotrexate in children and young people with severe atopic dermatitis: A secondary analysis of the TREatment of severe Atopic dermatitis Trial (TREAT).","authors":"Mandy Wan, Ashley P Jones, Daniel Maskrey, Monica Arenas-Hernandez, Anna Rosala-Hallas, Paula E Beattie, Susannah Baron, Fiona Browne, Sara J Brown, Joanna E Gach, Danielle Greenblatt, Ross Hearn, Eva Hilger, Ben Esdaile, Michael J Cork, Emma Howard, Marie-Louise Lovgren, Suzannah August, Farhiya Ashoor, Paula R Williamson, Tess McPherson, Donal O'Kane, Jane Ravenscroft, Lindsay Shaw, Manish D Sinha, Catherine Spowart, Bjorn R Thomas, Tracey H Sach, Alan D Irvine, Carsten Flohr","doi":"10.1093/ced/llaf147","DOIUrl":"https://doi.org/10.1093/ced/llaf147","url":null,"abstract":"<p><p>This is a secondary analysis of a multicentre randomised controlled trial of ciclosporin and methotrexate in children and young people (CYP) with severe atopic dermatitis (AD). Longitudinal trough ciclosporin and erythrocyte methotrexate polyglutamates (MTX-PG) concentrations were measured to evaluate their associations with treatment response and adverse events. Both ciclosporin (4 mg/kg/day) and methotrexate (0.4 mg/kg/week) led to a significant reduction in disease severity scores over the 36-week treatment period. Higher trough ciclosporin concentrations were associated with lower disease severity scores and may serve as a useful tool for therapeutic drug monitoring of ciclosporin in CYP with AD. However, in contrast to a previously published study, steady-state erythrocyte-MTX-PG concentrations showed no significant association with treatment response. Drug concentrations were comparable between patients with and without drug-related adverse events.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periungual growth on the fourth finger.
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-04-01 DOI: 10.1093/ced/llaf152
Divya Nagarajan, Alec K Gramann, Rajiv I Nijhawan
{"title":"Periungual growth on the fourth finger.","authors":"Divya Nagarajan, Alec K Gramann, Rajiv I Nijhawan","doi":"10.1093/ced/llaf152","DOIUrl":"https://doi.org/10.1093/ced/llaf152","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding immunology in dermatology: exploring a case of non-Bullous pemphigoid with absent C4 allotype.
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-04-01 DOI: 10.1093/ced/llaf148
Annabelle Lim Xiao Hui, Diane Williamson, Paul Devakar Yesudian
{"title":"Understanding immunology in dermatology: exploring a case of non-Bullous pemphigoid with absent C4 allotype.","authors":"Annabelle Lim Xiao Hui, Diane Williamson, Paul Devakar Yesudian","doi":"10.1093/ced/llaf148","DOIUrl":"https://doi.org/10.1093/ced/llaf148","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Annular Hypoesthetic Plaques in Immunosuppressed Patient.
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-04-01 DOI: 10.1093/ced/llaf149
João Nuno Barbosa Soares, David Caetano, José Carlos Cardoso, André Castro Pinho
{"title":"Annular Hypoesthetic Plaques in Immunosuppressed Patient.","authors":"João Nuno Barbosa Soares, David Caetano, José Carlos Cardoso, André Castro Pinho","doi":"10.1093/ced/llaf149","DOIUrl":"https://doi.org/10.1093/ced/llaf149","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eccrine chromhidrosis: Visualization through 405 nm sub-UV reflectance dermatoscopy and polarized dermatoscopy.
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-04-01 DOI: 10.1093/ced/llaf151
Ahmet Taha Aydemir, Bengu Nisa Akay
{"title":"Eccrine chromhidrosis: Visualization through 405 nm sub-UV reflectance dermatoscopy and polarized dermatoscopy.","authors":"Ahmet Taha Aydemir, Bengu Nisa Akay","doi":"10.1093/ced/llaf151","DOIUrl":"https://doi.org/10.1093/ced/llaf151","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Representations of skin tone and sex in dermatology by generative artificial intelligence: Comment.
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-03-29 DOI: 10.1093/ced/llaf145
Hinpetch Daungsupawong, Viroj Wiwanitkit
{"title":"Representations of skin tone and sex in dermatology by generative artificial intelligence: Comment.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1093/ced/llaf145","DOIUrl":"https://doi.org/10.1093/ced/llaf145","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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