Clinical and Experimental Dermatology最新文献

{"title":"Comment on 'Augmenting Secondary Intention Healing in Dermatologic Surgery Through Low-Cost Interventions'.","authors":"Aparna Potluru, Richard Barlow, Aaron Wernham","doi":"10.1093/ced/llaf143","DOIUrl":"https://doi.org/10.1093/ced/llaf143","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Clarity in Dermatological Titles: An Analysis of Service Provider Title Usage in the UK\".","authors":"Amy Long, Donna Cummins","doi":"10.1093/ced/llaf142","DOIUrl":"https://doi.org/10.1093/ced/llaf142","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collection of demographic data in clinical trials - are UK Dermatology Clinical Trial Network-supported studies better than the rest?","authors":"Hannah E Wainman, Kate Clement, Rebecca Dingle, W C Gavin Fong, Gemma Whicker, Kim S Thomas","doi":"10.1093/ced/llaf141","DOIUrl":"https://doi.org/10.1093/ced/llaf141","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bipolar disorder among individuals with atopic dermatitis: a case-control study in the All of Us Research Program.","authors":"Anthony Mitchel Wride, Gloria F Chen, Ryan Fan, Audrey C Leasure, Stephen Scott Jones, Daniel F Levey, William Damsky, Jeffrey M Cohen","doi":"10.1093/ced/llae451","DOIUrl":"10.1093/ced/llae451","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) has been associated with psychiatric comorbidities.</p><p><strong>Objectives: </strong>To characterize the association between AD and bipolar disorder (BPD) with a case-control study of the National Institutes of Health All of Us Research Program.</p><p><strong>Methods: </strong>We used Systematized Nomenclature of Medicine diagnostic codes to identify cases of AD. Four age-, sex- and race/ethnicity-matched controls were found for each case using propensity score matching. After controlling for age, sex, race/ethnicity, income, smoking status and depression, the relationship between AD and BPD was evaluated using logistic regression.</p><p><strong>Results: </strong>We identified 13 431 AD cases and 53 724 matched controls. Participants with AD were more likely than controls to have BPD (7.8% vs. 4.6%, P < 0.001). After adjusting for demographics and comorbidities, we observed a significant association (odds ratio 1.49, 95% confidence interval 1.37-1.62; P < 0.001).</p><p><strong>Conclusions: </strong>Compared with individuals without AD, individuals with AD have 1.49-fold increased odds of having BPD. Further investigation is needed to gain a better understanding of this association.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"760-763"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'Sick of the jab!': immunization barriers in an immunosuppressed dermatology cohort.","authors":"Ji Fung Yong, Laoise Griffin, Michael O'Connell","doi":"10.1093/ced/llae479","DOIUrl":"10.1093/ced/llae479","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"873-874"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'Patient-initiated follow-up for high-risk cutaneous squamous cell carcinoma: how we do it and 2 years of outcome data'.","authors":"Delaney D Ding","doi":"10.1093/ced/llae480","DOIUrl":"10.1093/ced/llae480","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"871-873"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Itching for innovation: the role of aryl hydrocarbon receptor agonists as a future therapy for atopic dermatitis.","authors":"Areen Wazir, Edel A O'Toole","doi":"10.1093/ced/llae502","DOIUrl":"10.1093/ced/llae502","url":null,"abstract":"<p><p>Atopic dermatitis (AD) is a chronic, inflammatory skin condition that affects over 200 million people worldwide. Patients commonly present with dry, itchy and sore skin. The challenge in finding optimal treatment for AD stems from the heterogeneous nature of the disease and its multifaceted aetiology: skin barrier dysfunction, immune system dysregulation, genetic factors, environmental factors and alterations in skin microorganisms. Traditional treatments for AD, such as corticosteroids, calcineurin inhibitors and immunosuppressants, have several limitations, such as the reoccurrence of symptoms when discontinued, lack of targeted action and risk of adverse effects. The aim of this literature review was to explore and summarize the role of aryl hydrocarbon receptor (AHR) agonists (namely tapinarof) as potential future therapy for AD. It is hoped that AHR agonists will overcome the limitations of traditional AD therapies and exert their therapeutic value by maintaining the integrity of the skin barrier, defending against oxidative stress, modulating immune activity and inflammation and restoring a healthy skin microbiome. Tapinarof, a topical AHR agonist, is showing promising results and has recently concluded its long-term extension phase III trial (ADORING 3). For tapinarof to be integrated into the AD treatment pathway, robust research evidence must be presented on its efficacy, durability, potential remittive effect and safety across different AD subtypes in a large, diverse patient population. In addition, the cost-effectiveness of tapinarof compared with its topical counterparts needs to be considered and multidisciplinary collaboration is required between researchers, clinicians and policymakers.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"747-754"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of wide local excision and secondary intention healing in hidradenitis suppurativa: a single-centre study on quality of life and mental health outcomes.","authors":"Alessandra Michelucci, Flavia Manzo Margiotta, Giorgia Salvia, Antonella Vietina, Agata Janowska, Riccardo Morganti, Marco Romanelli, Valentina Dini","doi":"10.1093/ced/llae515","DOIUrl":"10.1093/ced/llae515","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that significantly impacts patients' quality of life and mental health. Effective management often involves both medical and surgical interventions.</p><p><strong>Objectives: </strong>To assess the effectiveness of wide local excision and secondary intention healing in improving quality of life and mental health in patients with moderate-to-severe HS.</p><p><strong>Methods: </strong>A single-centre prospective study was conducted with 40 patients with moderate-to-severe HS that had been refractory to previous treatment. Presurgical mapping of lesions was performed using ultra-high-frequency ultrasound. Patients underwent wide surgical excision followed by secondary intention healing based on HS-TIME (tissue, infection/inflammation, moisture, edges) principles. Quality of life was measured using Skindex-16, and mental health was assessed using the Hospital Anxiety and Depression Scale (HADS), with subscales for anxiety (HADS-A) and depression (HADS-D). Assessments were conducted at baseline, 4 weeks after surgery and after complete wound healing. Statistical analyses included paired t-tests and multiple linear regression to determine factors influencing outcomes.</p><p><strong>Results: </strong>Fourteen men and 26 women with a mean (SD) age of 39 (15) years participated in the study. Significant improvements were observed in Skindex-16 scores (presurgery 57.92, postsurgery 16.03) and HADS scores (HADS-A presurgery 6.13, postsurgery 2.63; HADS-D presurgery 5.50, postsurgery 3.21), indicating reduced pain, discomfort and psychological distress. Multivariate analysis revealed that improvements were associated with male sex, HS stage II disease, longer disease duration and lower body mass index.</p><p><strong>Conclusions: </strong>Wide local excision combined with secondary intention healing significantly improves quality of life and mental health in patients with HS. The findings suggest that a comprehensive approach addressing both surgical and psychological aspects can enhance patient outcomes. Future research should focus on long-term benefits and the development of standardized postoperative care protocols.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"836-840"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acne-related quality of life and mental health among adolescents: a cross-sectional analysis.","authors":"Shireen Dumont, Elsa Lorthe, Andrea Loizeau, Viviane Richard, Mayssam Nehme, Klara M Posfay-Barbe, Rémy P Barbe, Laurence Toutous Trellu, Silvia Stringhini, Idris Guessous, Roxane Dumont","doi":"10.1093/ced/llae453","DOIUrl":"10.1093/ced/llae453","url":null,"abstract":"<p><strong>Background: </strong>Acne vulgaris is one of the most common skin conditions worldwide among adolescents. Beyond its physical manifestations, acne can leave invisible psychological scars.</p><p><strong>Objectives: </strong>We aimed to examine the protective and risk factors of acne-related quality of life and its association with mental health outcomes.</p><p><strong>Methods: </strong>The analysis included data collected in 2023 from adolescents enrolled in the SEROCoV-KIDS population-based cohort. By combining the Acne Severity and Acne-Specific Quality of Life (Acne-QoL) scales, the following three groups were established: Acne-LowAQoL (adolescents with acne and low acne-related quality of life), Acne-HighAQoL and NoAcne-HighAQoL. We used multinomial and logistic regression to assess the association between health behaviours and mental health outcomes in these groups.</p><p><strong>Results: </strong>Among 335 adolescents [mean age 16.1 years (SD 1.8), 56% female sex], 65 (19.4%) reported experiencing acne while maintaining a high Acne-QoL, 26 (7.7%) reported having acne and a low Acne-QoL, and 244 (72.9%) reported having nearly no acne. Low engagement in physical activity [adjusted odds ratio (aOR) 0.30, 95% confidence interval (CI) 0.12-0.77], addictive use of social media (aOR 3.78, 95% CI 1.60-8.96), and prolonged screen time (aOR 2.99, 95% CI 1.26-7.08) were independently associated with Acne-LowAQoL. Conversely, those from the group, Acne-HighAQoL, reported higher social support (aOR 1.95, 95% CI 1.07-3.54). Adolescents with Acne-LowAQoL showed lower levels of self-esteem, resilience and increased psychological distress.</p><p><strong>Conclusions: </strong>Among adolescents with acne, physical activity and social support were positively associated with good acne-related quality of life, which translated into better mental health. In contrast, screen time and social media use notably worsened mental health. Dermatologists should incorporate these considerations into clinical practice to ensure effective patient care.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"795-803"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological characteristics and favourable prognosis of paediatric cutaneous nodular fasciitis: a case series.","authors":"Mutong Zhao, Xiaofeng Han, Li Wei, Juan Sun, Xu Li, Yuan Liang","doi":"10.1093/ced/llae517","DOIUrl":"10.1093/ced/llae517","url":null,"abstract":"<p><p>Cutaneous nodular fasciitis (cNF) is a rare, benign myofibroblastic proliferation commonly misdiagnosed as a malignancy due to its rapid growth and histological features. We reviewed 15 paediatric patients with cNF, highlighting clinical, histological and molecular characteristics. The patients' median age was 6 years, and there was a predilection for cNF in the head and neck region. Histologically, cNF showed plump spindle cells and myxoid stromal changes. USP6 rearrangement, particularly MYH9-USP6 fusion, was present in the majority of patients. Spontaneous resolution was observed in nonsurgically managed cases. Accurate diagnosis by screening for USP6 rearrangement is essential to avoid overtreatment. This study underscores the benign nature of cNF and the importance of conservative management, especially in cosmetically sensitive areas.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"850-853"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}