Clinical and Experimental Dermatology最新文献

{"title":"Scabies severity score: the key to predicting and preventing treatment failures?","authors":"Iria Neri, Martina Mussi, Silvia Robuffo, Alessandra Gelmetti, Marco Morante, Bianca Maria Piraccini, Marco Adriano Chessa, Corrado Zengarini","doi":"10.1093/ced/llaf107","DOIUrl":"10.1093/ced/llaf107","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1446-1447"},"PeriodicalIF":3.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the neural basis of rosacea: altered brain activity and its links with social anxiety.","authors":"Deyu Song, Ping Jiang, Yingying Tang, Wei Hua, Lei Luo, Chenyang Zhao, Xu Liu, Mingfeng Lai, Wenxin Bao, Lu Zhang, Xian Jiang, Qiyong Gong","doi":"10.1093/ced/llaf291","DOIUrl":"https://doi.org/10.1093/ced/llaf291","url":null,"abstract":"<p><strong>Bcakground: </strong>Rosacea is a chronic dermatological condition primarily affecting the face, known for its links to the central nervous system and significant social impact. However, the specific neurological underpinnings remain largely unexplored.</p><p><strong>Objective: </strong>To investigate the brain activity changes of rosacea and their links with clinical symptoms and psychosocial measurements.</p><p><strong>Methods: </strong>This cross-sectional study included 32 treatment-naïve female patients with rosacea and 29 age- and gender-matched healthy controls. Neuroimaging, clinical, and psychosocial assessments were conducted. Resting-state functional magnetic resonance imaging (rs-fMRI) data were analyzed for amplitude of low-frequency fluctuations (ALFF). We examined associations between ALFF and clinical symptoms and psychosocial measures.</p><p><strong>Results: </strong>Increased ALFF was observed in the prefrontal cortex (PFC) of patients with rosacea, particularly in the right superior frontal gyrus (SFG) and left orbital middle frontal gyrus (ORBmid) (voxel level P < 0.001, cluster level P < 0.05). The right SFG's ALFF values were positively correlated with erythema scores (r = 0.395; P < 0.05). Meanwhile, activity in the left ORBmid correlated significantly with Social Avoidance and Distress Scale (SADS) (r = 0.528; P < 0.01) and Social Appearance Anxiety Scale (SAAS) (r = 0.535, P < 0.01) scores. Mediation analysis showed that appearance anxiety mediates the association between left ORBmid's ALFF values and social avoidance (indirect effect = 0.217, 95% CI, (0.022, 0.440); P < 0.05).</p><p><strong>Conclusions: </strong>This study offers novel insights into rosacea's neuropathology, linking PFC activity with physical and psychosocial symptoms. The findings underscore the potential of targeting neuro-psycho-social aspects in comprehensive rosacea management.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab for atopic dermatitis in patients with malignancies: a case report and literature review on efficacy, safety and potential mechanisms.","authors":"Jiayang Li, Guan Jiang","doi":"10.1093/ced/llaf117","DOIUrl":"10.1093/ced/llaf117","url":null,"abstract":"<p><p>Atopic dermatitis (AD) is a persistent inflammatory skin disease marked by intense rash and itching. Traditional treatments for moderate-to-severe AD, such as methotrexate, often cause significant side-effects. Dupilumab, a biologic therapy that inhibits the interleukin (IL)-4 and IL-13 cytokines, presents a safer alternative. A comprehensive literature review corroborates the safety and effectiveness of dupilumab in patients with AD with cancer. However, the current evidence is limited, necessitating further research. Dupilumab's targeted mechanism, acting on IL-4 and IL-13, may also positively influence the tumour microenvironment, potentially boosting antitumour responses. Future studies should focus on assessing the long-term safety, efficacy and economic viability of dupilumab across larger and more diverse populations to better understand its dual role in managing both cancer and AD.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1315-1321"},"PeriodicalIF":3.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical relevance of thiopurine methyltransferase genotype testing for azathioprine in dermatology.","authors":"Sivaranjini Ramassamy, Laxmisha Chandrashekar, Jayanthi Mathaiyan, Medha Rajappa, Reka Devanathan, Sujeevan Selvarathinam, Alladi Charanraj Goud","doi":"10.1093/ced/llaf070","DOIUrl":"10.1093/ced/llaf070","url":null,"abstract":"<p><strong>Background: </strong>Polymorphisms in thiopurine methyltransferase (TPMT) are a predominant cause of azathioprine-induced leucopenia in Western countries. The exact role of these polymorphisms in the Indian population with dermatological disorders is uncertain.</p><p><strong>Objectives: </strong>To evaluate the frequency of genetic polymorphism of TPMT and its impact on the safety of azathioprine in dermatological disorders.</p><p><strong>Methods: </strong>We included consecutive patients on azathioprine who were initiated for dermatological disorders from South India. Three TPMT polymorphisms (c.238G>C, c.460G>A and c.719A>G) were assessed. The proportions of adverse events to azathioprine, especially myelosuppression, were compared between those with the wildtype genotype and those with TPMT polymorphisms.</p><p><strong>Results: </strong>Of the 123 patients (61 male and 62 female, mean age 46 years), 65% had an autoimmune blistering disorder. Adverse events to azathioprine were noted in 25 (20.3%), of whom 16 (13.0%) had myelosuppression and 4 (3.2%) each had hepatotoxicity and gastrointestinal intolerance. TPMT polymorphisms were detected in 13 (10.6%), of whom 5 had experienced adverse events. The polymorphisms could explain 25% (4 of 16) of the cases of leucopenia. The odds of developing leucopenia in patients with TPMT polymorphism were not significant (odds ratio 3.63, 95% confidence interval 0.96-13.6; P = 0.06).</p><p><strong>Conclusions: </strong>The tested TPMT polymorphisms could not predict the adverse events of azathioprine, particularly the haematological toxicity, in dermatological use among the South Indian population.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1337-1342"},"PeriodicalIF":3.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrophic rash on the trunk.","authors":"Siyue Kan, Lianjuan Yang, Qing Cai","doi":"10.1093/ced/llaf079","DOIUrl":"10.1093/ced/llaf079","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1473-1475"},"PeriodicalIF":3.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of vismodegib in basosquamous carcinoma: insights from a retrospective study including 18 patients.","authors":"Athina-Ioanna Daponte, Aimilios Lallas, Elisabeth Lazaridou, Leonidas Pavlidis, Athanasios Papas, Aikaterini Kyriakou, Zoe Apalla","doi":"10.1093/ced/llaf132","DOIUrl":"10.1093/ced/llaf132","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1455-1457"},"PeriodicalIF":3.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic malignant cylindroma arising on a background of digenic inheritance of BRCA2 and CYLD pathogenic variants targeted with PARP inhibition.","authors":"William Fostier, Akhtar Husain, Shirin Namini, Bipin Mathew, Georgie Holt, Yasin Memari, Helen Davies, Gene C C Koh, Serena Nik-Zainal, Neil Rajan","doi":"10.1093/ced/llaf064","DOIUrl":"10.1093/ced/llaf064","url":null,"abstract":"<p><strong>Background: </strong>CYLD cutaneous syndrome (CCS) is caused by germline heterozygous pathogenic variants in CYLD and results in the progressive formation of cylindromas, spiradenomas or trichoepitheliomas. Malignant cylindroma is a rare skin adnexal tumour occurring in CCS, which can metastasize with lethal outcomes and has limited genomic characterization. BRCA2 loss in CCS is not described and may modulate the cutaneous cancer risk of CCS.</p><p><strong>Objectives: </strong>To establish whether BRCA deficiency drives metastatic malignant cylindroma and to report the phenotype of three siblings with digenic inheritance of CYLD and BRCA2 pathogenic variants (PVs), one of whom developed metastatic cylindroma at 28 years old.</p><p><strong>Methods: </strong>A kindred study reporting seven members of a family with CCS was conducted in a tertiary hospital setting within the United Kingdom from April 2021 to February 2023. Clinical phenotype, pathological, radiological and genetic findings and treatment data were -collected. Whole-genome sequencing of the primary malignant cylindroma occurring in one patient was performed to identify targetable driver mutations and signatures.</p><p><strong>Results: </strong>Malignant cylindroma arose in one (proband) of the two male siblings with digenic inheritance of BRCA2 (c.5158insT) and CYLD (c.2689-2A>G) pathogenic variants. A further female sibling with digenic inheritance of the same BRCA2 and CYLD PVs developed early breast cancer. Whole-genome sequencing of the primary malignant cylindroma in the affected patient showed loss of heterozygosity of both BRCA2 and CYLD. Bioinformatic analysis confirmed homologous repair deficiency (HRD). These data supported the use of the PARP [poly(ADP-ribose) polymerase] inhibitor rucaparib to target HRD in a non-canonical BRCA-deficient skin cancer.</p><p><strong>Conclusions: </strong>Digenic inheritance of pathogenic variants in cancer-predisposing genes should prompt clinicians to be vigilant for atypical malignant presentations. We demonstrate that rapid whole-genome sequencing can inform the treatment of metastatic malignant cylindroma and identify novel systemic therapies.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1322-1329"},"PeriodicalIF":3.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment of prurigo nodularis with upadacitinib.","authors":"Gianluca Avallone, Andrea Bombelli, Davide Termini, Alessandra Chiei-Gallo, Paolo Calzari, Francesca Barei, Angelo V Marzano, Silvia M Ferrucci","doi":"10.1093/ced/llae329","DOIUrl":"10.1093/ced/llae329","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1424-1426"},"PeriodicalIF":3.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatrics and Genetics.","authors":"Grace X Li, Deshan F Sebaratnam","doi":"10.1093/ced/llaf008","DOIUrl":"10.1093/ced/llaf008","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1462-1463"},"PeriodicalIF":3.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simplifying nasal reconstruction after Mohs surgery: an algorithm based on review of over 400 cases.","authors":"Alyssa Breneman, Megan H Trager, Anna Bowling, Emily R Gordon, Karlyn Pollack, Faramarz H Samie","doi":"10.1093/ced/llaf054","DOIUrl":"10.1093/ced/llaf054","url":null,"abstract":"<p><p>The literature is lacking on reconstruction techniques for post-Mohs nasal defects with particular emphasis on the unique properties of underlying skin. We aimed to develop an algorithm to simplify the approach to post-Mohs reconstruction of the nose based on defect size, location and cutaneous features of the surrounding skin. A retrospective review of 404 patients who underwent post-Mohs nasal reconstruction by a single Mohs surgeon between 2018 and 2024 was conducted. Defects were divided into small, medium and large sizes. Locations were categorized into three zones based on cutaneous characteristics. The frequency of reconstructive techniques based on defect size and location was analysed. Trends towards specific repairs based on the cutaneous location and size of Mohs defects were used to develop an algorithm for reconstructive decision making. This algorithm was based on zones defined by cutaneous characteristics. It may serve as an initial guide for surgeons planning reconstruction of nasal defects.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1395-1398"},"PeriodicalIF":3.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}