Clinical and Experimental Dermatology最新文献

{"title":"Epidemiology of atopic dermatitis: a global worldwide study.","authors":"Charbel Skayem, Marie Aleth Richard, Marketa Saint Aroman, Stéphanie Merhand, Yaron Ben Hayoun, Catherine Baissac, Bruno Halioua, Charles Taieb, Delphine Staumont-Sallé","doi":"10.1093/ced/llaf233","DOIUrl":"10.1093/ced/llaf233","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"2054-2056"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do we recognize a difficult squamous cell carcinoma? A retrospective analysis of clinically and dermoscopically misdiagnosed tumours.","authors":"Katarzyna Korecka, Paweł Pietkiewicz, Bengü Nisa Akay, Iulia Badiu, Enzo Errichetti, Konstantinos Liopyris, Caterina Longo, Ashfaq Marghoob, Cristian Navarrete-Dechent, John Paoli, Verce Todorovska, Aimilios Lallas","doi":"10.1093/ced/llaf255","DOIUrl":"10.1093/ced/llaf255","url":null,"abstract":"<p><strong>Background: </strong>In people with lighter skin phototypes, squamous cell carcinoma (SCC) is typically nonpigmented and must be distinguished from other nonpigmented tumours. Although the dermoscopic features of SCC are well-known, some SCCs are challenging to recognize even with dermoscopy.</p><p><strong>Objectives: </strong>To investigate the clinical and dermoscopic features responsible for an inaccurate clinical diagnosis of invasive SCC and potential clues that could help in the recognition of this tumour.</p><p><strong>Methods: </strong>We retrospectively screened our institutional database for clinically misdiagnosed SCCs over a 10-year time period (2013-2023). We then presented 10 expert dermoscopists with a series of clinical and dermoscopic images of misdiagnosed invasive SCCs and sought their opinion.</p><p><strong>Results: </strong>In total, 73 SCCs from 73 patients (55 men and 18 women) aged 37-97 years (mean 78.8) were included. Most tumours were located on the cheek (21%), followed by the forehead (16%), nose (12%) and scalp (12%). Thirty-seven SCCs were misdiagnosed as basal cell carcinoma, 15 as actinic keratosis, 10 as irritated seborrhoeic keratosis, 7 as Bowen disease, 2 as viral warts and 2 as cutaneous horn. White scales and keratin were voted by the experts as the main features (n = 34/73) that might have helped in the accurate clinical diagnosis of the included SCCs.</p><p><strong>Conclusions: </strong>The dermoscopic characteristics of invasive SCC might overlap with other types of tumours. In challenging tumours, the presence of white scales and keratin might guide the accurate recognition of invasive SCC.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"2016-2021"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the neural basis of rosacea: altered brain activity and its links with social anxiety.","authors":"Deyu Song, Ping Jiang, Yingying Tang, Wei Hua, Lei Luo, Chenyang Zhao, Xu Liu, Mingfeng Lai, Wenxin Bao, Lu Zhang, Xian Jiang, Qiyong Gong","doi":"10.1093/ced/llaf291","DOIUrl":"10.1093/ced/llaf291","url":null,"abstract":"<p><strong>Background: </strong>Rosacea is a chronic dermatological condition primarily affecting the face, known for its links to the central nervous system and its significant social impact. However, the specific neurological underpinnings remain largely unexplored.</p><p><strong>Objectives: </strong>To investigate the brain activity changes in patients with rosacea and their links with clinical symptoms and psychosocial measurements.</p><p><strong>Methods: </strong>This cross-sectional study included 32 treatment-naive female patients with rosacea and 29 age- and sex-matched healthy control participants. Neuroimaging, and clinical and psychosocial assessments were conducted. Resting-state functional magnetic resonance imaging (rs-fMRI) data were analysed for amplitude of low-frequency fluctuations (ALFFs). We examined associations between ALFFs and clinical symptoms and psychosocial measures.</p><p><strong>Results: </strong>Increased ALFF was observed in the prefrontal cortex (PFC) of patients with rosacea, particularly in the right superior frontal gyrus (SFG) and left orbital middle frontal gyrus (ORBmid) (voxel level P < 0.001, cluster level P < 0.05). The ALFF values of the right SFG were positively correlated with erythema scores (r = 0.395; P = 0.03). Meanwhile, activity in the left ORBmid correlated significantly with Social Avoidance and Distress Scale (r = 0.528; P = 0.002) and Social Appearance Anxiety Scale (r = 0.535, P = 0.002) scores. Mediation analysis showed that appearance anxiety mediates the association between the ALFF values of the left ORBmid and social avoidance (indirect effect = 0.217, 95% confidence interval 0.022-0.440; P < 0.05).</p><p><strong>Conclusions: </strong>This study offers novel insights into rosacea's neuropathology, linking PFC activity with physical and psychosocial symptoms. The findings underscore the potential of targeting neuropsychosocial aspects in comprehensive rosacea management.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"2022-2029"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients with atopic dermatitis on YouTube: a cross-sectional analysis.","authors":"Dea Metko, Eric McMullen, Parsa Abdi, Nwaneri Uchechi, Shanti Mehta, Deyang Li, Ilya Mukovozov","doi":"10.1093/ced/llaf109","DOIUrl":"10.1093/ced/llaf109","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"2049-2050"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mimicker of melanoma on sun-exposed sites.","authors":"Paula Finnegan, Clara Lightner, James Clover, Cynthia Heffron, Catherine Quinlan","doi":"10.1093/ced/llaf199","DOIUrl":"10.1093/ced/llaf199","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"2085-2088"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating changes in baseline characteristics and drug-utilization pattern in patients with moderate-to-severe psoriasis: findings from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR) cohort.","authors":"Oras A Alabas, Ian Evans, Kathleen Mcelhone, Zenas Z N Yiu, Nick J Reynolds, Philip Laws, Anthony Bewley, Catherine H Smith, Mark Lunt, Christopher E M Griffiths, Richard B Warren","doi":"10.1093/ced/llaf224","DOIUrl":"10.1093/ced/llaf224","url":null,"abstract":"<p><strong>Background: </strong>Since the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR) was established in 2007, numerous biologic therapies have been introduced for the better management of psoriasis.</p><p><strong>Objectives: </strong>To describe baseline demographics, disease characteristics and real-world biologic utilization in patients entering BADBIR over time.</p><p><strong>Methods: </strong>Patients with moderate-to-severe psoriasis registered in BADBIR between 2007 and 2024 were included. Percentages were used to describe categorical variables and the median with interquartile range (IQR) for continuous variables. The year of enrolment was divided into Early (2007-2014) and Late (2015-2024) periods.</p><p><strong>Results: </strong>As of April 2024, there were 21 407 registrations in BADBIR. Compared with the Early period, more minority ethnic groups [1374/11 383 (12.1%) vs. 868/10 024 (8.7%)] were enrolled in the Late period. Shorter disease duration [median years, 18 (IQR 10-28) vs. 20 (11-29)], lower severity measured using Psoriasis Area and Severity Index [median 11 (IQR 6-16) vs. 14 (IQR 10-19)] and fewer patients with comorbidities [6298/11 383 (55.3%) vs. 5905/10 024 (58.9%)] were reported in the Late vs. the Early period. There were 6236 (29.1%) patients in the conventional cohort and 15 171 (70.9%) in the biologic cohort from 2007 to 2024 (total N = 21 407). Out of 15 171 individuals in the biologic cohort, 8299 (54.7%), 3227 (21.3%) and 1170 (7.7%) switched to second, third and fourth lines of therapy, respectively. In 15 171 individuals (2007-2024), adalimumab was the most frequently prescribed first-line therapy, followed by ustekinumab and etanercept [6576 (43.4%), 3349 (22.1%) and 1750 (11.5%), respectively]. Despite the significant drop in utilization over time, adalimumab remained the most frequent first-line biologic in the Late period 3092/8716 (35.5%), followed by ustekinumab 2087/8716 (23.9%) and secukinumab 1445/8716 (16.6%). However, utilization of biologics in the subsequent lines of therapies has changed over time in newer biologics, with mainly guselkumab and risankizumab becoming the most frequent in recent years.</p><p><strong>Conclusions: </strong>Patients registered in the Late period have less severe psoriasis, shorter disease duration and fewer comorbidities than those enrolled in the Early period. The most frequent biologics at enrolment were adalimumab and ustekinumab; however, this has changed with the introduction of new and more effective biologics. BADBIR is a rich data source providing information on the management of psoriasis.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1995-2006"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum raftlin and 8-isoprostaglandin F2α as potential biomarkers in seborrhoeic dermatitis: a case-control study.","authors":"Mehmet Enes Güner, Ergül Belge Kurutaş, Perihan Öztürk","doi":"10.1093/ced/llaf243","DOIUrl":"10.1093/ced/llaf243","url":null,"abstract":"<p><strong>Background: </strong>Seborrhoeic dermatitis (SD) is a chronic inflammatory skin disorder associated with Malassezia species, immune dysregulation and potential oxidative stress. While previous studies have explored general inflammatory and oxidative mechanisms, specific biomarkers such as raftlin and 8-isoprostaglandin F2α (8-iso-PGF2α) have not yet been investigated in SD.</p><p><strong>Objectives: </strong>To evaluate serum raftlin and 8-iso-PGF2α levels in patients with SD and to determine their relationship with disease severity.</p><p><strong>Methods: </strong>This cross-sectional study included 50 patients with SD and 50 age- and sex-matched healthy controls. Disease severity was assessed using the Seborrheic Dermatitis Area and Severity Index. Serum raftlin and 8-iso-PGF2α levels were measured via the enzyme-linked immunosorbent assay. Statistical analyses included independent-samples t-tests, Spearman correlation and receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Both raftlin and 8-iso-PGF2α levels were significantly higher in patients with SD than in controls (P < 0.001 for both). ROC analysis showed strong discriminatory performance for raftlin (area under the curve 0.987; cutoff 9.30 ng mL-1, 92% sensitivity, 100% specificity) and perfect accuracy for 8-iso-PGF2α (area under the curve 1.000; cutoff 27.9 pg mL-1, 100% sensitivity and specificity). No significant correlation was found between biomarker levels and disease severity.</p><p><strong>Conclusions: </strong>This study demonstrated that serum raftlin and 8-iso-PGF2α levels are significantly elevated in patients with seborrhoeic dermatitis compared with healthy controls. ROC curve analysis indicated strong discriminatory capacity, particularly for 8-iso-PGF2α, which achieved perfect sensitivity and specificity in this cohort. While these biomarkers are not specific to SD and reflect broader inflammatory and oxidative mechanisms, their strong discriminatory ability supports their potential role as adjunctive diagnostic indicators in clinical or research settings. Further validation in larger, multicentre cohorts is warranted to assess their utility across diverse populations and comorbid conditions.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1989-1994"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finasteride use and suicide attempts through self-poisoning: a case-control study.","authors":"Ida M Heerfordt, Annika Magdalena Rhomberg-Kauert, Kim Peder Dalhoff, Morten Tulstrup, Henrik Horwitz","doi":"10.1093/ced/llaf268","DOIUrl":"10.1093/ced/llaf268","url":null,"abstract":"<p><p>This study investigated the potential link between finasteride, commonly used for hair loss, and suicide attempts via self-poisoning. It was -motivated by concerns over unanticipated psychological side-effects like suicidality identified in post-trial adverse event reports. We used data from multiple Danish health registries to assess male patients reported for suicidal intent poisoning. Each case was matched with 10 controls based on age, sex and residential municipality. We collected data on finasteride prescriptions up to 1 year before the index date, which was the date of the suicide attempt for cases and the inclusion date for controls. The study included 3366 cases and 33 660 controls. Adjustments were made for diagnosed bipolar disorder and schizophrenia, as well as occupational status. The analysis showed no link between finasteride use and suicide attempt risk, with an unadjusted odds ratio of 1.03 (95% confidence interval 0.56-1.88) and an adjusted odds ratio of 0.88 (95% confidence interval 0.45-1.71).</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"2037-2039"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Itchy bruising in a 5-year-old girl.","authors":"Xi Tan, Zhouwei Wu","doi":"10.1093/ced/llaf237","DOIUrl":"10.1093/ced/llaf237","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"2093-2095"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"True malignant transformation in a proliferating trichilemmal tumour.","authors":"Saerrah Murryam, Sian Hughes, Eduardo Calonje, Christopher Bunker","doi":"10.1093/ced/llaf247","DOIUrl":"10.1093/ced/llaf247","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"2060-2061"},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}