Clinical and Experimental Dermatology最新文献

{"title":"Generalized pustular psoriasis treated with additional biologics after spesolimab: A case series from Japan.","authors":"Chiaki Sasaki, Kazuki Yatsuzuka, Nobushige Kohri, Satosi Yoshida, Katsuihiko Nishihara, Jun Muto, Ken Shiraishi, Yasuhiro Fujisawa","doi":"10.1093/ced/llaf457","DOIUrl":"https://doi.org/10.1093/ced/llaf457","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Standard: Targeted Reapplication in Palmoplantar Scabies of Infants.","authors":"Martina Mussi, Corrado Zengarini, Gionathan Orioni, Marco Adriano Chessa, Alessandra Gelmetti, Riccardo Balestri, Michelangelo La Placa, Bianca Maria Piraccini, Iria Neri","doi":"10.1093/ced/llaf456","DOIUrl":"https://doi.org/10.1093/ced/llaf456","url":null,"abstract":"<p><p>Infantile scabies can be challenging to treat, particularly due to behavioural and anatomical factors that reduce the efficacy of topical therapies. In this small prospective cohort study there were 22 neonates and infants (11 in either intervention group) with persistent palmar-plantar scabies. Patients were treated exclusively with permethrin 5% cream. All patients initially failed the standard regimen consisting of one full-body application, followed by a second application after 7 days. Eleven infants received an intensified regimen with three additional nights of targeted application to the hands and feet, while eleven continued with the standard regimen only. Complete resolution was observed in all 11 (100%) of cases in the intervention group, compared with none (0%) in the control group. Frequent infant behaviours, including spontaneous kicking, leg movements, and habitual fist clenching, likely reduced drug contact time on palms and soles. These findings indicate that standard topical regimens may be insufficient in this population and that targeted reapplication, combined with caregiver education, can optimize treatment outcomes in infants.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatoscopic features of labial melanotic macules in diverse skin types.","authors":"Mehmet Fatih Atak, Banu Farabi, Cliff Rosendahl, Harald Kittler, Bengü Nisa Akay","doi":"10.1093/ced/llaf452","DOIUrl":"https://doi.org/10.1093/ced/llaf452","url":null,"abstract":"<p><strong>Background: </strong>Labial melanotic macules (LaMMs) are benign pigmented lesions that typically present as solitary patches on the lower lip. While their dermatoscopic features have been previously described, limited data exists on how these features vary across different skin types.</p><p><strong>Objectives: </strong>To investigate the dermatoscopic differences of LaMMs in individuals with darker skin phototypes and compare them with lighter skin phototype LaMMs and mucosal melanomas.</p><p><strong>Methods: </strong>This retrospective study analyzes 64 LaMMs located at the mucocutaneous junction or on the mucous membrane, collected from 49 patients and four mucosal melanomas across three tertiary dermatology centers in Turkiye, Austria, and Australia between January 1, 2020, and December 31, 2022. Two investigators reviewed clinical and dermatoscopic images independently, followed by a consensus evaluation to determine the presence of dermatoscopic criteria. Lesions that were clinically equivocal and not confirmed by histopathology were excluded.</p><p><strong>Results: </strong>Multiple LaMMs were observed in 30.6% of the patients, and the majority of LaMMs (91.8%) were located on the lower lip. Overall, 53.1% of lesions exhibited asymmetry, 54.7% showed more than one dermatoscopic pattern, and 68.8% demonstrated multiple colors. No significant differences were noted between darker (n=30, 61.2%) and lighter (n=19, 38,8%) patients with LaMMs regarding age, sex, lesion location, or the presence of multiple lesions. LaMMs in darker skin were more likely to be asymmetrical and displayed multiple dermatoscopic patterns. White structureless areas and gray dots/clods were more frequently observed in darker skin type. All labial melanomas exhibited asymmetry, as well as multiple patterns and colors on dermatoscopic examination. There was no significant difference in the rates of asymmetry, multiple patterns, or multiple colors compared to LaMMs included in the study.</p><p><strong>Conclusions: </strong>LaMMs in dark skin types more commonly present with asymmetry, multiple dermatoscopic patterns, and gray color.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatrics and genetics.","authors":"Meghana Reddy, Arun Somasundaram, Arun Philips Arulnathan, Laxmisha Chandrashekar","doi":"10.1093/ced/llaf451","DOIUrl":"https://doi.org/10.1093/ced/llaf451","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VARIANT_P: a 14-years multicentric follow-up study of atypical pemphigus variants in Italy.","authors":"Lavinia Quintarelli, Irene Bonanni, Elena Biancamaria Mariotti, Laura Atzori, Clara De Simone, Camilla Vassallo, Giovanni Di Zenzo, Stefano Caccavale, Emanuele Cozzani, Gianpiero Girolomoni, Angelo Valerio Marzano, Andrea Conti, Pamela Vezzoli, Giovanni Damiani, Vito Di Lernia, Riccardo Balestri, Roberto Maglie, Alberto Corrà, Alessandro Magnatta, Marta Elettra Donati, Valentina Ruffo di Calabria, Alice Verdelli, Alessio Coi, Emiliano Antiga, Marzia Caproni","doi":"10.1093/ced/llaf438","DOIUrl":"https://doi.org/10.1093/ced/llaf438","url":null,"abstract":"<p><strong>Background: </strong>The clinical, epidemiological, and immunopathological profile of atypical forms of pemphigus, remains only partially known.</p><p><strong>Objectives: </strong>To define the clinical, epidemiological and immunological characteristics, therapies and outcome of atypical pemphigus variants.</p><p><strong>Methods: </strong>A 14-year multicenter retrospective observational study (VARIANT_P) on atypical variants of pemphigus across Italy. We collect demographic, immunopathological, and clinical data, as well as information on comorbidities and prescribed treatments.</p><p><strong>Results: </strong>We enrolled 61 patients (Sex Ratio=1.77; 13 PNP, 26 PIgA, 22 PH). Median age at diagnosis and onset were 71.1 and 70.6 (PNP), 63.6 and 62.2 (PigA), 52.3 and 49.4 (PH).The average diagnostic delay was 3.0 (PNP), 9.5 (PIgA) and 2.0 months (PH). Mortality rate was 54.5% (PNP), 3.8% (PIgA) and 5.9% (PH). Cutaneous involvement was present in all cases of PIgA and PH, and in 83.3% of PNP cases. In contrast, oral mucosal involvement was observed in all PNP cases, but only in 7.7% of PigA and 21.1% of PH cases. Histology, DIF, IIF and ELISA data were variably consistent with the literature.Comorbidities included mainly solid malignancies for PNP while cardiovascular and metabolic disease were the most prevalent for PIgA and PH. Treatment mostly relied on systemic steroids and rituximab.</p><p><strong>Conclusions: </strong>The VARIANT_P study contributed to data collection relatively to atypical pemphigus variants in order to promote the development of specific therapeutical guidelines in the future.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical facial oedema in acrodermatitis chronica atrophicans: A potential clue for early diagnosis in Lyme disease.","authors":"Ane Carrera Gabilondo, Nerea Fernández Ros, José Ignacio Echeveste, Juan José Rosales Castillo, Guillermo Ramos, Agustín España","doi":"10.1093/ced/llaf450","DOIUrl":"https://doi.org/10.1093/ced/llaf450","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and clinical profile of leprosy patients in Lagos, Nigeria: a 17-year retrospective study.","authors":"Olufolakemi Cole-Adeife, Gbolahan Dairo, Luther Agaga, Frances Ajose","doi":"10.1093/ced/llaf442","DOIUrl":"https://doi.org/10.1093/ced/llaf442","url":null,"abstract":"<p><p>Nigeria continues to report over 2000 new leprosy cases annually. This retrospective study reviewed leprosy case records from 2006 to 2023 at a Teaching hospital (TH) and a Leprosy Treatment Referral Centre (LTRC) in Lagos, Nigeria. Demographic, clinical, and treatment data were analysed and challenges highlighted. At the TH, 96 leprosy patients (mean age 37.3 years; 63.5% male) were seen, and 75% had multibacillary disease. At the LTRC, 354 patients (mean age 42.5 years; 65% male) were seen, and 98.6% had multibacillary disease. Late presentation was common in both centres. Most patients received multi-drug therapy (MDT) at the LTRC, but 52 patients (19 from the TH; 33 from the LTRC) defaulted from care. Between 2017 and 2023, 25% of patients (including 2.1% aged <15 years) presented with Grade 2 disability. Leprosy cases have declined in Lagos, but delayed presentation, inadequate frontline diagnostic capacity and weak surveillance systems contribute to sustained morbidity. Strengthening health worker knowledge and surveillance in an integrated approach is essential for leprosy control.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underreporting of Patient Reported Outcomes in Hidradenitis Suppurativa Clinical Trials: A Scoping Review.","authors":"Grace Xiong, Christopher Shenouda, Dea Metko, Eric McMullen, Shireen Dumont, David Croitoru, Raed Alhusayen, Vincent Piguet","doi":"10.1093/ced/llaf447","DOIUrl":"https://doi.org/10.1093/ced/llaf447","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Quantification of Treatment Response to Low-Dose Oral Minoxidil in Non-Scarring Alopecia.","authors":"Jasmine Levine, Lillian Mo, Ross O'Hagan, Divija Sharma, Serena Morsia, Benjamin Ungar","doi":"10.1093/ced/llaf446","DOIUrl":"https://doi.org/10.1093/ced/llaf446","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linearly arranged nodules on the chin and neck.","authors":"Arun Somasundaram, Siddhartha Siddeswara, Laxmisha Chandrashekar, Sreerekha Jinkala, Aishwarya Karthikeyan","doi":"10.1093/ced/llaf449","DOIUrl":"https://doi.org/10.1093/ced/llaf449","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}