Clinical and Experimental Dermatology最新文献

{"title":"Chromoblastomycosis in northern Taiwan from 2017 to 2024: unique characteristics.","authors":"Ju-Shao Yen, I Hsin Shih, Wen-Hung Chung, Chun-Yu Cheng, Chau Yee Ng, Chun-Bing Chen, Yu-Huei Huang, Pei-Lun Sun","doi":"10.1093/ced/llaf329","DOIUrl":"10.1093/ced/llaf329","url":null,"abstract":"<p><strong>Background: </strong>Chromoblastomycosis (CBM) is an implantation mycosis caused by dematiaceous fungi in the tropical and subtropical regions. It is a neglected tropical disease that primarily affects populations living in poverty. Although located in tropical and subtropical regions, Taiwan is a highly industrialized country with an advanced healthcare system that offers a unique perspective on CBM.</p><p><strong>Objectives: </strong>To explore the epidemiology, clinical characteristics and treatment outcomes of patients with CBM in northern Taiwan.</p><p><strong>Methods: </strong>This study included 14 patients who were pathologically diagnosed with CBM at Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, between January 2017 and August 2024. The relevant clinical profiles were analysed. The pathogens were isolated by fungal culture and identified using sequence-based methods.</p><p><strong>Results: </strong>The mean age was 65.4 (SD 10.4) years, and 93% (13/14) of the patients were male. The median time between onset and diagnosis was 6.5 (interquartile range 3.0-36.0) months. In addition to the common comorbidities, we identified four hepatitis B carriers and two patients who were immunosuppressed. Although there were four patients who had occupations requiring physical labour, nine patients were either retired or engaged in sedentary work and their leisure activities included gardening (this information was not available for one patient). Pathogens were isolated from 13 patients, all of which were identified as Fonsecaea monophora. Treatments included systemic and topical antifungal agents, surgical excision, local thermotherapy and cryotherapy, with 71% (10/14) patients achieving complete response.</p><p><strong>Conclusions: </strong>Patients with CBM in Taiwan are characterized by older age and, in some, a history of gardening-related trauma or immunosuppression. We also report a shorter delay from disease onset to diagnosis and a good complete response rate, which may reflect better medical accessibility.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"821-830"},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythematous macules as an atypical presentation of paucibacillary leprosy.","authors":"Salma Baraz, Rime Baba, Mohammed Amraoui, Rachid Frikh, Naoufal Hjira","doi":"10.1093/ced/llaf363","DOIUrl":"10.1093/ced/llaf363","url":null,"abstract":"<p><p>Leprosy, caused by Mycobacterium leprae, remains a significant health concern in certain endemic regions despite global elimination efforts. This case describes a 53-year-old Moroccan woman presenting with a 1-year history of asymptomatic erythematous macules associated with sensory deficits. Initial diagnoses included common dermatological conditions, leading to delays in definitive treatment. A detailed clinical examination revealed hallmark sensory loss in the lesions, with dermoscopy and histopathology supporting a diagnosis of paucibacillary leprosy. While bacilloscopic findings were negative, histological analysis demonstrated lymphocytic infiltration around nerve fibres, consistent with leprosy criteria. The patient was successfully managed with multidrug therapy and educational reinforcement to promote adherence. Additionally, chemoprophylaxis with single-dose rifampicin was administered to household contacts, as recommended by the World Health Organization. This report underscores the diagnostic challenges in paucibacillary leprosy, where overlapping clinical features may mimic other dermatoses. It highlights the crucial roles of histopathology, dermoscopy and systematic neurological evaluations in confirming diagnoses, especially in resource-limited settings. Early diagnosis, effective treatment and preventive strategies, including chemoprophylaxis, remain essential to reducing transmission and minimizing stigma in leprosy-endemic regions. The case emphasizes the continued vigilance required of dermatologists to recognize rare presentations and contribute to global eradication efforts.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"867-870"},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging terbinafine resistance in Trichophyton spp.: 20 cases of recalcitrant dermatophytosis from Sarawak General Hospital, Malaysia.","authors":"Siti Ayesha Siddiqa Saifuddin, Xue Ting Tan, Min Moon Tang","doi":"10.1093/ced/llaf350","DOIUrl":"10.1093/ced/llaf350","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"891-894"},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of switching from original omalizumab to an intended-copy biosimilar in chronic urticaria: a case series highlighting global regulatory discrepancies.","authors":"Abhishek De, Disha Chakraborty, S K Shahriar Ahmed, Kiran Godse, Apeksha Singh","doi":"10.1093/ced/llaf377","DOIUrl":"10.1093/ced/llaf377","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"895-897"},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and clinical profile of patients with leprosy in Lagos, Nigeria: a 17-year retrospective study.","authors":"Olufolakemi Cole-Adeife, Gbolahan Dairo, Luther Agaga, Frances Ajose","doi":"10.1093/ced/llaf442","DOIUrl":"10.1093/ced/llaf442","url":null,"abstract":"<p><p>Nigeria continues to report over 2000 new leprosy cases annually. This retrospective study reviewed leprosy case records from 2006 to 2023 at a teaching hospital (TH) and a leprosy treatment referral centre (LTRC) in Lagos, Nigeria. Demographic, clinical and treatment data were analysed and challenges highlighted. At the TH, 96 patients with leprosy were seen. The median age was 34.6 years (range 11-79); 61 (64%) were male; and 75% had multibacillary disease. At the LTRC, 354 patients were seen. The median age was 39.8 years (range 7-85); 230 (65%) were male; and 349 (98.6%) had multibacillary disease. Late presentation was common in both centres. Most patients received multidrug therapy at the LTRC, but of 450 patient records overall, 52 defaulted from care (19 from the TH; 33 from the LTRC). Between 2017 and 2023, 25% of patients (37 of 149), including 2.7% aged < 15 years, presented with grade 2 disability. Leprosy cases have declined in Lagos, but delayed presentation, inadequate frontline diagnostic capacity and weak surveillance systems contribute to sustained morbidity. Strengthening health worker knowledge and surveillance in an integrated approach is essential for leprosy control. Teaser text.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"876-880"},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal neglected tropical diseases.","authors":"David J Chandler","doi":"10.1093/ced/llaf528","DOIUrl":"10.1093/ced/llaf528","url":null,"abstract":"<p><p>This article provides an overview of the neglected tropical diseases caused by fungi, which include mycetoma, chromoblastomycosis and sporotrichosis. These are chronic infections of the skin and subcutaneous tissue that can be locally destructive, leading to disfigurement and disability. Management of these conditions is challenging, often requiring prolonged antimicrobial therapy in combination with surgical treatment.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"768-778"},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145707642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding dermatology services in Ethiopia: insights and experiences from the national residency expansion programme.","authors":"Wendemagegn Enbiale, Annika Beate Wilder-Smith, Selamawit Girma, Mengistu Hiletwork, Nigussie Tegegne, Marlous L Grijsen, Karolyn Wanat, Esther Freema, L Claire Fuller, Dagnachew Shibeshi","doi":"10.1093/ced/llaf300","DOIUrl":"10.1093/ced/llaf300","url":null,"abstract":"<p><strong>Background: </strong>Postgraduate medical education is vital for addressing global health disparities, particularly in low- and middle-income countries (LMICs). Dermatology residency training programmes in Ethiopia commenced in 2006 to address a critical shortage of specialists and improve access to care for skin-related conditions, including neglected tropical diseases. This study explores the progress, achievements and challenges of Ethiopia's dermatology residency programmes.</p><p><strong>Objectives: </strong>To evaluate the development, outcomes and lessons learnt from dermatology residency training in Ethiopia, offering insights for scaling specialist training programmes in LMICs.</p><p><strong>Methods: </strong>A mixed-methods approach was employed, combining quantitative analysis of training outputs and regional distribution of dermatologists with qualitative key informant interviews. Data were collected through an online survey involving members from the Ethiopian Dermatovenerology Society. Semi-structured interviews were also conducted with senior dermatologists involved in programme development initiation. Thematic content analysis was performed to identify barriers, facilitators and recommendations for programme sustainability.</p><p><strong>Results: </strong>Between 2008 and 2023, Ethiopia graduated 194 dermatologists across five institutions. The annual output increased from 6 to 31 specialists trained each year. Overall, 78 of 108 (72%) dermatologist respondents worked full time in the public sector. There were 51 of the 108 (47%) respondents who were involved in academic institutions. However, 66 of 110 (60%) of dermatologists are concentrated in urban areas. Key facilitators of the residency programme included the Addis Ababa University commitment to expanding postgraduate education, partnerships with the All Africa Leprosy Rehabilitation and Training Center Hospital and full government sponsorship. Challenges included limited infrastructure, shortages in subspecialty training and an urban-centric workforce distribution. Interviewees highlighted the importance of thorough nationally coordinated planning and commitment to address these barriers.</p><p><strong>Conclusions: </strong>Ethiopia's dermatology training programmes have significantly strengthened the specialist workforce, but inequities in service distribution and gaps in training capacity remain. Strategies to enhance rural service incentives, expand subspecialty training and integrate telemedicine are critical for improving healthcare equity. Lessons from Ethiopia's experience underscore the value of Ministry of Health local leadership and ownership in postgraduate programme expansion.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"814-820"},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious disease.","authors":"YiXuan Goh, Ghufran Al-Bander, Garret O'Connell, Claire Doyle, Fiona Sexton, Orla McFeely, Orla O'Mahony, Sarah O'Connell, Sally O'Shea","doi":"10.1093/ced/llaf196","DOIUrl":"10.1093/ced/llaf196","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"904-905"},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vibriosis: a cause of bacterial skin infections to consider in returning travellers, especially in our world of climate change.","authors":"Su Ping Regina Lim, Jeannie Peng Lan Ong","doi":"10.1093/ced/llaf374","DOIUrl":"10.1093/ced/llaf374","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"898-899"},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediculosis capitis: a hidden threat in tropical regions.","authors":"Ramamoorthy Logamoorthy, Kaliaperumal Karthikeyan","doi":"10.1093/ced/llaf522","DOIUrl":"10.1093/ced/llaf522","url":null,"abstract":"<p><p>Pediculosis capitis, caused by Pediculus humanus var. capitis, is a common ectoparasitic infestation primarily affecting school-aged children worldwide. It is transmitted through direct head-to-head contact and occasionally via fomites. Although it is not a vector for diseases, it causes significant psychosocial and economic burdens, including scalp itching, parental anxiety, absenteeism and social stigma. The head louse life cycle includes egg, nymph and adult stages, with the entire cycle completed in 21-30 days. Diagnosis is based on identifying live lice or viable eggs, often aided by wet combing or dermoscopy. Differential diagnoses include dandruff, hair casts and fungal infections like piedra. Clinical features include pruritus, excoriations, secondary bacterial infections and, in severe cases, conditions like plica polonica (a severely matted mass of hair stuck together with dirt, discharge and infection, making combing impossible) or iron deficiency anaemia. Treatment involves topical pediculicides, wet combing, and oral therapies for resistant cases, with no established global guidelines specific to pediculosis capitis. The condition disproportionately affects resource-poor communities, exacerbated by poverty, overcrowding and limited access to treatment. Public health impacts include substantial healthcare costs and school absenteeism. Despite its prevalence, pediculosis capitis remains under-recognized as a neglected tropical disease, underscoring the need for integrated strategies to reduce its health and socioeconomic impacts. This review highlights the epidemiology, pathophysiology, clinical presentation, diagnosis, management and public health implications of pediculosis capitis, emphasizing the importance of awareness and effective interventions to mitigate its global burden.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"759-767"},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}