Clinical and Experimental Dermatology最新文献

{"title":"Viral infections in atopic dermatitis.","authors":"Nada Khalil, Joshua Walton, Nerys Roberts, Khawar Hussain","doi":"10.1093/ced/llae304","DOIUrl":"10.1093/ced/llae304","url":null,"abstract":"<p><p>Individuals with atopic dermatitis are susceptible to frequent viral skin infections due to compromised epidermal barrier function and immune dysregulation. The diagnosis and management of viral infections in atopic dermatitis can be challenging due to various clinical phenotypes and overlapping clinical features. We reviewed the literature for the diagnosis, aetiology, management, differential diagnoses and complications of these viral infections to provide an up-to-date clinical overview for clinicians involved in caring for patients with atopic dermatitis, including features specific to patients with skin of colour. Accurate diagnosis and appropriate management in cases of uncertainty are crucial due to the risk of life-threatening complications with some viral infections. The differing presentations of these infections in patients with skin of colour are highlighted, as this is an underrepresented area of research. Future research with greater diversity of patients is needed for patients with atopic dermatitis complicated by viral skin infections.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"46-55"},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatrics and genetics.","authors":"Seán O'Malley, Sinead Collins","doi":"10.1093/ced/llae314","DOIUrl":"10.1093/ced/llae314","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"194-195"},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding hair disorders through artificial intelligence: DALLE's role in image creation.","authors":"Eduardo P Deliyannis","doi":"10.1093/ced/llae302","DOIUrl":"10.1093/ced/llae302","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"165-167"},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effect of psoriasis and metabolic syndrome on risk of all-cause and cardiovascular mortality in US adults: a nationwide cohort study.","authors":"Xiufang Kong, Wei Wang","doi":"10.1093/ced/llae340","DOIUrl":"10.1093/ced/llae340","url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome (MetS) is a common comorbidity in psoriasis. However, the associations between MetS, psoriasis and mortality remain largely unclear.</p><p><strong>Objectives: </strong>To investigate the synergistic effect of MetS and psoriasis on total and cardiovascular disease (CVD) mortality in a representative sample of US adults.</p><p><strong>Methods: </strong>In total, 14 930 participants from the 2003-2006 and 2009-2014 National Health and Nutrition Examination Survey were included in this prospective, nationwide cohort study. Participants were stratified into the psoriasis-/MetS- (reference) group, psoriasis-/MetS+ group, psoriasis+/MetS- group and psoriasis+/MetS+ group.</p><p><strong>Results: </strong>Overall, 14 930 participants, 50.71% were male, with a mean age of 43 years, were included in the final analysis. The weighted percentages of participants in the psoriasis-/MetS-, psoriasis-/MetS+, psoriasis+/MetS- and psoriasis+/MetS+ groups were 72.77%, 24.36%, 1.94% and 0.93%, respectively. In total, 874 deaths (246 of which were related to CVD) occurred during a median follow-up of 110 months. Compared with the reference group, the hazard ratios in the psoriasis-/MetS+, psoriasis+/MetS- and psoriasis+/MetS+ groups were 1.788 [95% confidence interval (CI) 1.486-2.152], 0.858 (95% CI 0.431-1.707) and 2.050 (95% CI 1.028-4.092), respectively, for all-cause mortality, and 1.856 (1.350-2.552), 1.229 (95% CI 0.292-5.181) and 4.571 (95% CI 1.724-12.119), respectively, for CVD mortality. Subgroup analysis showed that this association was not influenced by participants' age, sex, physical activity, smoking, estimated glomerular filtration rate, or urinary albumin/creatinine ratio. Similar results were obtained in the sensitivity analysis of the main results.</p><p><strong>Conclusions: </strong>Presence of comorbid MetS significantly increases all-cause and CVD mortality in patients with psoriasis. Dermatologists can potentially aid in reducing mortality rates in patients with psoriasis through targeted screening for MetS.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"113-119"},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the psychological impact of childhood-onset psoriasis: a systematic review.","authors":"Veranca Shah, Allison Larson, Mohammad Jafferany","doi":"10.1093/ced/llae276","DOIUrl":"10.1093/ced/llae276","url":null,"abstract":"<p><p>Childhood-onset psoriasis is often associated with various psychological challenges. Numerous studies have delved into the connection between adult-onset psoriasis and its potential to heighten a patient's susceptibility to various psychological challenges. However, less has been written about the influence of childhood psoriasis on psychological disorders, particularly anxiety and depression, eating disorders and substance abuse. In this study, we delve into studies that shed light on these associated risks. A systematic literature review was conducted using PubMed, focusing on the psychological impacts of childhood-onset psoriasis. From an initial pool of 313 articles, we utilized Covidence, a specialized software designed for screening and selection, adhering to strict exclusion criteria such as psoriasis in adulthood and incorrect study designs. This process refined our focus to 12 relevant articles, which were critically analysed to understand the psychological comorbidities associated with childhood-onset psoriasis. Our review reveals a significant link between childhood-onset psoriasis and increased instances of depression and anxiety. Notably, children with psoriasis demonstrate higher frequencies of suicidal thoughts and behaviours, as well as a marked propensity for substance abuse and addiction. The study also uncovers a strong connection between psoriasis in children and the development of eating disorders such as anorexia nervosa and bulimia nervosa. Childhood-onset psoriasis significantly affects the psychological wellbeing of children, with heightened risks for depression, anxiety, suicidality, substance abuse and eating disorders. These findings underscore the need for comprehensive management strategies that encompass not only the physical symptoms but also mental health and psychological support for children with psoriasis. Early intervention and regular screenings are crucial in mitigating these risks and improving the quality of life of paediatric patients with psoriasis.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"29-37"},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genitourinary disorders and oral medicine.","authors":"Wei Qiang Chng, Choon Chiat Oh","doi":"10.1093/ced/llae273","DOIUrl":"10.1093/ced/llae273","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"192-193"},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tinea capitis in older people: clinical experience of 36 cases over 10 years.","authors":"Alexandro Bonifaz, María Alejandra Chacón-Ruiz, Javier Araiza, Leonel Fierro-Arias, Luis Miguel Moreno-López, David Chandler","doi":"10.1093/ced/llae354","DOIUrl":"10.1093/ced/llae354","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"182-184"},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary erythematous nodule on the breast.","authors":"Brandon R Block, Camille M Powers, Lisa Zhou, Austin J Piontkowski, Jeremy Orloff, Bruce E Petersen, Nicholas Gulati","doi":"10.1093/ced/llae379","DOIUrl":"10.1093/ced/llae379","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"223-226"},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eczematous dermatitis of knees after bilateral total knee replacement: a rare cause.","authors":"Jerene Mathews","doi":"10.1093/ced/llae256","DOIUrl":"10.1093/ced/llae256","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"234-236"},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The National Health Service 2-week-wait skin cancer referral pathway: analysis and recommendations for process improvement.","authors":"Vishal Madan","doi":"10.1093/ced/llae323","DOIUrl":"10.1093/ced/llae323","url":null,"abstract":"<p><strong>Background: </strong>Although pressures on the National Health Service skin cancer services pre-dated the COVID pandemic, the 2-week-wait (2WW) skin cancer standards that require hospitals to provide an appointment with a specialist within 2 weeks for anyone with symptoms that may indicate cancer have deteriorated post the pandemic.</p><p><strong>Objectives: </strong>To undertake process mapping of the current 2WW skin cancer pathways and provide recommendations to streamline and improve the pathway to meet the 2WW standards.</p><p><strong>Methods: </strong>The 2WW skin cancer pathway is analysed in this report utilizing 4 V typology encompassing the four dimensions of operations: volume, variety, variation and visibility, and a volume-variety matrix. A performance matrix of the 2WW skin cancer pathway and SIPOC (suppliers, inputs, processes, outputs and customers) analysis are also examined.</p><p><strong>Results: </strong>Process analysis enabled the identification of some of the limitations of the 2WW skin cancer pathway. Following analysis and redesign of the process map of the pathway, recommendations, including lesion assessment using artificial intelligence, single-lesion assessment clinics and direct access skin surgery, all of which aim to expedite patient care and increase capacity in 2WW clinics, are provided.</p><p><strong>Conclusions: </strong>The process analysis of the 2WW skin cancer pathway provides useful insights and helps identify bottlenecks in the system. Recommendations following remapping the process offer potential solutions to help reduce time to referral and to increase capacity. These recommendations should help reduce waiting times for patients receiving an initial diagnosis and subsequent definitive treatment for suspected skin cancers.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"88-96"},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}