Clinical and Experimental Dermatology最新文献

{"title":"Efficacy of abrocitinib and baricitinib on 'difficult-to-treat areas' in patients with atopic dermatitis: a multicentre study.","authors":"Maddalena Napolitano, Luca Potestio, Elena Pezzolo, Mariateresa Rossi, Raul Saboya, Benedetta Galli, Massimiliano Scalvenzi, Cataldo Patruno","doi":"10.1093/ced/llae415","DOIUrl":"10.1093/ced/llae415","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"863-865"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional analysis of TikTok content relating to sunscreen conspiracy theories and correlation with published evidence on sunscreen risks.","authors":"Nicola Kearney, Marion Leahy, Maria Stanciu, Aine O'Flynn, Mary Catherine Walsh, Mary Laing","doi":"10.1093/ced/llae456","DOIUrl":"10.1093/ced/llae456","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"867-869"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anifrolumab use in refractory dermatomyositis: a case report and literature review.","authors":"Alejandro Claudio-Oliva, Myriam Viedma-Martínez, Gonzalo Gallo-Pineda, Maria Prieto-Rozados, Isabel Villegas-Romero, David Jiménez-Gallo, Mario Linares-Barrios","doi":"10.1093/ced/llae476","DOIUrl":"10.1093/ced/llae476","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"874-876"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple purple-coloured plaques in a paediatric Asian patient with skin of colour.","authors":"Christian Schembri, Yana Marie Dimech, Alexandra Betts, Nathalie Galea, Charles Joseph Borg, Liam Mercieca, Mark Anthony Aquilina, Adriana Warrington","doi":"10.1093/ced/llae486","DOIUrl":"10.1093/ced/llae486","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"891-894"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and tolerability of 1.6% phenol-croton peeling vs. topical 5% imiquimod in the treatment of actinic cheilitis: a randomized controlled trial.","authors":"Luiz Eduardo Fabrício de Melo Garbers, Anna Carolina Miola, Vinicius de Souza, Christina de Castro Brommonschenkel, Flávio de Oliveira Lima, Eliana Maria Minicucci, Hélio Amante Miot","doi":"10.1093/ced/llae520","DOIUrl":"10.1093/ced/llae520","url":null,"abstract":"<p><strong>Background: </strong>Trials evaluating the effectiveness of topical treatments for actinic cheilitis (AC) are scarce. Despite no comparative data, phenol-croton peeling has been reported as effective in treating this condition.</p><p><strong>Objective: </strong>To assess for the treatment of AC the efficacy and tolerability of a single session of 1.6% phenol-croton peeling vs. topical 5% imiquimod cream applied for 30 days for the treatment of AC.</p><p><strong>Methods: </strong>An open, randomized controlled trial was conducted to compare the effectiveness and tolerability of 1.6% phenol-croton peeling vs. topical 5% imiquimod for the treatment of AC [protocol registered at ReBEC (Brazilian Registry of Clinical Trials) - RBR-1044sz68]. Thirty-six patients with biopsy-proven AC were allocated into two groups (1 : 1): the imiquimod group received 5% topical imiquimod three times a week for 30 days, and the croton group underwent one session of 1.6% phenol-croton peeling. The primary outcome was the clearance of AC after 56 days. Secondary outcomes included clinical and histological parameters, adverse effects and clinical results after 180 days.</p><p><strong>Results: </strong>Complete clinical clearance of AC (defined as clearance of both leukoplakia and hyperkeratosis) at day 56 and day 180 occurred in 17 of 18 (94%) participants from the croton group but in none of the 18 participants in the imiquimod group (P < 0.01). Improvement in all clinical parameters was more prominent in the croton group (P ≤ 0.01). Complete histological normalization at day 56 occurred in 72% of the croton group and only 17% in the imiquimod group (P < 0.01). Histological parameters such as atypia (keratinocyte intraepithelial neoplasia score), solar elastosis and hyperkeratosis reduced in intensity only in the croton group (P < 0.05). Adverse effects were most intense on day 7 in the croton group and persisted until day 21 in the imiquimod group. The study was prematurely terminated at the interim analysis.</p><p><strong>Conclusions: </strong>A single session of 1.6% phenol-croton peeling produced clinically and histologically superior results with a shorter recovery period compared with imiquimod for treating AC.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"826-835"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inpatient dermatology referrals: what is the burden? A retrospective review of 14 years of dermatology inpatient referrals.","authors":"Marie-Julie A M Cnudde, Charles Thomas, Christian Aldridge","doi":"10.1093/ced/llae498","DOIUrl":"10.1093/ced/llae498","url":null,"abstract":"<p><strong>Background: </strong>The lack of dermatological knowledge by nondermatologists is exposed by the increasing number of requests made for inpatient dermatological consultations. Patients have been commenced on inappropriate treatment because of poor dermatology training.</p><p><strong>Objectives: </strong>To determine the burden and accuracy of inpatient dermatology referrals.</p><p><strong>Methods: </strong>A retrospective cohort study using paper inpatient dermatology referrals from one health board (Cwm Taf Morgannwg University Health Board, Wales, UK) between June 2007 and July 2021. Data analysis included timing of referrals, referring specialty, diagnosis and treatment. Descriptive statistics, using Excel, were used for analyses.</p><p><strong>Results: </strong>The average number of referrals per year was 106 (range 79-166). The most frequent day of referral was Monday (26%). Most referrals were from medical teams (73%).Differential diagnosis was suggested by the referring team in 59% of referrals. In only 29% of referrals did the dermatology team agree with the differential diagnosis. There was a discrepancy in the correctness of diagnosis in all categories; however, paediatricians were most likely to offer a correct differential (44%). In 44% of referrals, treatment was commenced by the referring team, most commonly antibiotics.</p><p><strong>Conclusions: </strong>There is an extra burden on dermatology teams to cover inpatients. Our figures highlight two important issues. Firstly, the need for better dermatological education in medical schools to improve diagnostic accuracy and management of conditions. Secondly, the need for an inpatient dermatology service to review inpatient referrals and advise in the diagnosis and management of dermatology cases on the wards and to protect the service from being uncoupled from the main hospital.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"764-769"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of upadacitinib retreatment after withdrawal in moderate-to-severe atopic dermatitis: a retrospective study.","authors":"Teppei Hagino, Hidehisa Saeki, Eita Fujimoto, Naoko Kanda","doi":"10.1093/ced/llae410","DOIUrl":"10.1093/ced/llae410","url":null,"abstract":"<p><strong>Background: </strong>Upadacitinib, a Janus kinase 1 (JAK1) inhibitor, is effective for moderate-to-severe atopic dermatitis (AD). Upadacitinib treatment may be discontinued in some patients; however, the effectiveness and safety of retreatment after its withdrawal have not been examined in detail in real-world practice.</p><p><strong>Objectives: </strong>To evaluate the effectiveness and safety of upadacitinib retreatment after withdrawal in real-world clinical practice for Japanese patients with AD.</p><p><strong>Methods: </strong>This retrospective study included 62 Japanese patients with moderate-to-severe AD treated with upadacitinib 15 mg (n = 38) or 30 mg (n = 24). Effectiveness was assessed using the Eczema Area and Severity Index (EASI) and Peak Pruritus Numerical Rating Scale (PP-NRS) before treatment (baseline), at timepoints of discontinuation, at retreatment, and at week 12 after retreatment with upadacitinib. Safety was evaluated through the incidence of treatment-emergent adverse events (TEAEs).</p><p><strong>Results: </strong>EASI and PP-NRS scores significantly decreased at week 12 after upadacitinib retreatment compared with baseline in both the 15-mg and 30-mg groups (P = 0.01 for EASI and PP-NRS in both groups). At week 12 after retreatment, achievement rates of at least a 75%, 90% or 100% reduction in EASI from baseline (EASI 75, EASI 90 or EASI 100, respectively) were 84%, 57% and 19% in the 15-mg group, and 87%, 57% and 17% in the 30-mg group, respectively. TEAEs were mild or moderate, and no serious AEs or deaths were reported.</p><p><strong>Conclusions: </strong>Retreatment with upadacitinib after withdrawal effectively improved clinical signs and pruritus in patients with AD, with a manageable safety profile, supporting its use for long-term management of AD.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"770-778"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of suicide and suicidality in patients with moderate to severe psoriasis: results from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR).","authors":"Kerry Williams, Georgia Lada, Nick J Reynolds, Kathleen Mcelhone, Ian Evans, Richard B Warren, Shernaz Walton, Olivia Hughes, Anthony Bewley, Kayleigh Mason, C Elise Kleyn","doi":"10.1093/ced/llae449","DOIUrl":"10.1093/ced/llae449","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is associated with poor mental health and reduced quality of life. Although the high risk for depression in patients with psoriasis is well established, the suicidality risk among these patients is uncertain. Previous studies provide contrasting results and have not included patients with clinically confirmed severe disease.</p><p><strong>Objectives: </strong>To determine the risk of suicide among patients with moderate to severe psoriasis and to compare it with that of the general population, and to investigate if psychiatric comorbidity or history of suicidality increases future suicidality risk in psoriasis. We further estimated the incidence of suicidal and self-injurious behaviours in patients.</p><p><strong>Methods: </strong>Analysis was performed using the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR). General population mortality and suicide data were used as controls.</p><p><strong>Results: </strong>There were nine suicides in BADBIR. The incidence rate of suicide was 12.5 per 100 000 person-years [95% confidence interval (CI) 6.53-24.11] in BADBIR vs. 11.0 per 100 000 person-years (95% CI 10.7-11.3) in the general population in England and Wales. Among patients, psychiatric comorbidity or past suicidality was associated with a higher risk for suicidal ideation, suicide attempts and self-injurious behaviours.</p><p><strong>Conclusions: </strong>The suicide rate among patients with moderate to severe psoriasis was not significantly higher when compared with the general population. Suicide is a rare event and our results are limited by uncertainty about the reliability of the estimate. However, considering the high depression prevalence in psoriasis, our findings support the need for prompt assessment of patients for psychiatric comorbidities and suicidality history. Further research is required on suicidal behaviours and the role of psoriasis severity.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"804-811"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Findings of the British Association of Dermatologists career survey of dermatologists in training and new consultant dermatologists 2023.","authors":"Lauren Passby, Ajoy Bardhan, Tamara Griffiths, Mahbub M Chowdhury","doi":"10.1093/ced/llae467","DOIUrl":"10.1093/ced/llae467","url":null,"abstract":"<p><p>Previous surveys of UK dermatology trainees have identified key patterns regarding future career intentions that can help to inform workforce planning as the number of vacancies for dermatology consultants continues to increase. Over a 6-week period between September and October 2023, we invited all doctors currently training in dermatology, as well as all dermatology doctors who completed their training between 2018 and 2023, to complete separate surveys. These surveys explored career locations, working patterns, pull factors toward particular posts and push factors away from dermatology consultant posts in the National Health Service (NHS). The findings of these surveys confirm persisting trends toward less-than-full-time working, trainees' ongoing limited geographical mobility and a declining appetite for academic work, all identified in previous surveys. This survey offers the first insights into the working lives and factors influencing the career choices of consultants who completed their dermatology training between 2018 and 2023.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"845-849"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General dermatology and dermatology in primary healthcare.","authors":"Aneet Kaur, Chirantan S, Tanvi Dev, Pradeep Kanumilli, Pallavi Pallavi","doi":"10.1093/ced/llae488","DOIUrl":"10.1093/ced/llae488","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"886-887"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}