Clinical and Experimental Dermatology最新文献

{"title":"Efficacy and safety of switching from baricitinib to ritlecitinib in severe alopecia areata.","authors":"Ying Chen, Qiuyun Xu, Xiaoqing Lv, Zheyu Zhuang, Siyi Bao, Jing Mao, Ting Gong, Chao Ji","doi":"10.1093/ced/llae548","DOIUrl":"10.1093/ced/llae548","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1228-1230"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of secondary intention healing in dermatology and dermatological surgery: part 1.","authors":"Aparna Potluru, Olga Pawlik, Richard Barlow, David Veitch, Aaron Wernham","doi":"10.1093/ced/llaf018","DOIUrl":"10.1093/ced/llaf018","url":null,"abstract":"<p><p>Secondary intention healing (SIH) describes wounds healing from the base upwards, without direct closure. This starts with granulation of the wound, followed by re-epithelialization and contraction. The surgeon and patient need to weigh up the advantages and disadvantages of SIH vs. other reconstruction methods. There are limited studies directly comparing SIH with skin grafts; however, SIH looks to be a robust alternative in specific settings. Well-established sites for SIH include concave areas such as the nose, eye, ear and temple, as these areas give rise to the best cosmetic outcomes. However, SIH has proven to be a successful repair method in several convex locations, including the dorsa of the hands, digital extremities, scalp, lips and eyelids. SIH can be supplemented by other surgical techniques, including purse-string sutures and postoperative de-epithelialization.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1094-1100"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of large language model powered search tools reveals differences in output quality, information transparency and accessibility for Mohs micrographic surgery enquiries.","authors":"Neil K Jairath, Sumanth Chennareddy, Sophia Manduca, Adriana Lopez, Murad Alam, Nicholas Golda, Elise Ng, Vishal A Patel, Emily S Ruiz, Joshua W Trufant, Jesse M Lewin","doi":"10.1093/ced/llaf034","DOIUrl":"10.1093/ced/llaf034","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1244-1245"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated polymorphic mucocutaneous lesions in an immunocompetent 65-year-old man.","authors":"Rashmi K Vageshappa, Neeharika Verma, Anupama Bains, Divya Aggarwal","doi":"10.1093/ced/llaf038","DOIUrl":"10.1093/ced/llaf038","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1277-1280"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser hair depilation therapy for pilonidal sinus disease: a 5-year, retrospective experience in a university teaching hospital in the UK, 2017-2023.","authors":"Kashini Andrew, Maya Dyson, Pui Chi Lee, Pooja Sonigra, Rona Applewaite, Danning Li, Michelle Thomson, Alan Nevill","doi":"10.1093/ced/llaf035","DOIUrl":"10.1093/ced/llaf035","url":null,"abstract":"<p><strong>Background: </strong>Pilonidal sinus disease (PSD) is a chronic, debilitating condition predominantly affecting young men. Laser hair depilation is an established adjunct to surgical treatment for PSD. It can lead to reduced rates of recurrence and postsurgical interventions.</p><p><strong>Objectives: </strong>To assess the outcome of laser hair depilation therapy on disease progression in patients with PSD at the Birmingham Skin Regional Laser Centre.</p><p><strong>Methods: </strong>Patient demographics, PSD clinical stage, laser type, number of laser sessions, surgical intervention and treatment outcomes were extracted from electronic medical records of patients (n = 97) referred for laser hair depilation between 2017 and 2023. Statistical analysis was performed using Microsoft Excel and R. Treatment outcomes were categorized as improvement (healed, improved) or no improvement of underlying PSD. Disease severity was classified using the method of Guner et al. (BMC Surg 2016; 16:18).</p><p><strong>Results: </strong>Most patients affected were male (77%). The median age was 22 years (interquartile range 20-28). The median number of laser hair removal sessions was 8 (interquartile range 5.5-10). The number of laser hair removal sessions was the only predictive factor for symptom resolution (P < 0.001). Neither surgical intervention nor the type of surgery (incision, excision, modified flap, or endoscopic surgical intervention) showed a significant association with improvement in PSD (P = 0.47 and P = 0.65, respectively). In the subgroup of patients who did not undergo surgery (n = 32, 33%), 25 patients (78%) had improvement or healing in their PSD. There were no statistically significant associations between age, type of laser, disease severity and benefit from laser hair removal. No complications were reported and there was only one case of recurrence.</p><p><strong>Conclusions: </strong>Laser hair depilation is a safe and effective postoperative adjunct treatment for treating sacrococcygeal PSD. For early-stage disease it may offer curative treatment.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1132-1137"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An undifferentiated malignant tumour posing a diagnostic challenge.","authors":"Niovi Papalexopoulou, Lucy Melly, Elaine MacDuff, Clare May","doi":"10.1093/ced/llaf051","DOIUrl":"10.1093/ced/llaf051","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1288-1290"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A striking hand phenotype and guselkumab efficacy in NIPAL4-linked autosomal recessive congenital ichthyosis.","authors":"Henning Klapproth, Jonas Rauterberg, Philipp Koll, Lukas Soellner, Daniela Neumayer, Judith Fischer, Iliana Tantcheva-Poór","doi":"10.1093/ced/llae552","DOIUrl":"10.1093/ced/llae552","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1232-1234"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitiligo and associated comorbidities: A case-control study in the All of Us database.","authors":"Austin J Piontkowski, Celina Dubin, Sach Thakker, Jeremy Orloff, Camille Powers, Caroline Silver, Benjamin Ungar, Nicholas Gulati","doi":"10.1093/ced/llaf228","DOIUrl":"https://doi.org/10.1093/ced/llaf228","url":null,"abstract":"<p><p>Recent research has established an association between vitiligo and other autoimmune diseases. Given the systemic inflammation, there are likely other comorbidities with vitiligo that are not as well established. We identified 1,074 vitiligo patients and 4,296 matched controls in the All of Us database. Conditional logistic regression estimated the odds ratio (OR) and 95% confidence interval (CI) of 29 select comorbid conditions for vitiligo patients compared to matched controls. The Benjamini-Hochberg method was used to adjust p-values. On logistic regression, vitiligo patients had significantly increased likelihoods of atherosclerotic disease (OR 1.78, 95% CI 1.48-2.14, p<0.001), hypertension (OR 1.75, 95% CI 1.50-2.03, p<0.001), and hyperlipidemia (OR 2.32, 95% CI 1.99-2.72 p<0.001). Vitiligo patients additionally carried a significant bone and joint, autoimmune, endocrine, and psychiatric comorbidity burden. This convergence highlights the multifaceted nature of vitiligo, prompting a need for investigating therapeutic approaches capable of addressing both vitiligo and its varied comorbidities.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Modified Tissue-Saving Technique with Silver Nitrate to Obliterate Tunnels for Hidradenitis Suppurativa.","authors":"Hannah R Chang, Emily Murphy, Duaa Abdel Hameid, Madeline Ngo, Melissa M Mauskar","doi":"10.1093/ced/llaf216","DOIUrl":"https://doi.org/10.1093/ced/llaf216","url":null,"abstract":"<p><p>Hidradenitis suppurativa (HS) is a chronic inflammatory dermatosis characterized by recurrent nodules, abscesses, draining sinus tracts, and scar formation, predominantly affecting intertriginous areas. The associated pain, drainage, and scarring significantly diminish the quality of life of affected individuals. Surgical interventions for HS lesions include excision, traditional deroofing techniques, and a simpler mini-deroofing method (punch debridement). Here we present a further modification to mini-deroofing: the application of silver nitrate into the tunnel to achieve tunnel obliteration and expedite healing. A 41-year-old woman with Hurley stage 2 HS, despite multiple rounds of antibiotics and steroid injections, developed a nodule that progressed to form a tunnel, causing considerable discomfort. A mini-deroofing technique followed by silver nitrate application into the tunnel was performed with complete resolution of the tunnel at the 3-week follow-up. The application of silver nitrate offers several advantages over traditional deroofing methods, including reduced procedure time and faster healing due to a minimized wound surface area. Silver nitrate facilitates chemical debridement, promoting an expedited and less painful recovery. Moreover, this in-clinic procedure does not require a dedicated visit, making it a convenient and effective option for managing HS, particularly in patients with early-stage disease.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose ionizing radiation exposure and its impact on skin ageing among healthcare workers.","authors":"Huriye Aybüke Koç, Cansu Altınöz Güney","doi":"10.1093/ced/llae547","DOIUrl":"10.1093/ced/llae547","url":null,"abstract":"<p><strong>Background: </strong>Exposure to ionizing radiation (IR) is an occupational risk for healthcare professionals and can result in a range of health issues.</p><p><strong>Objectives: </strong>To assess the relationship between chronic low-dose IR exposure and the development of early ageing-related facial skin wrinkles in healthcare workers.</p><p><strong>Methods: </strong>Facial skin wrinkles present in 70 healthcare workers who had been exposed to low-dose IR for at least 5 years were compared with those of 70 nonexposed healthcare workers. Skin wrinkles were assessed using the Lemperle wrinkle assessment scale and the scores of the IR-exposed healthcare workers were compared with those of the nonexposed controls.</p><p><strong>Results: </strong>There were no statistically significant differences in sociodemographic factors and Fitzpatrick skin types between the IR-exposed healthcare workers and the control group. Analysis of the Lemperle wrinkle assessment scale scores revealed significant differences, with IR-exposed workers showing higher scores for all facial wrinkle categories evaluated (all P < 0.001) and for horizontal neck folds (P = 0.002).</p><p><strong>Conclusions: </strong>To our knowledge, this is the first study to assess healthcare workers with long-term exposure to low-dose IR for facial skin wrinkles, a visible consequence of skin ageing. Chronic low-dose IR exposure can lead to increased skin wrinkles, representative of advanced skin ageing in healthcare workers. These findings underscore the need for enhanced protective measures and regular monitoring for individuals exposed to occupational radiation.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1101-1106"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}