Clinical and Experimental Dermatology最新文献

{"title":"Methodological concerns about the PRO-SCALP study: self-report bias, follow-up duration, and selection effects.","authors":"Emaan, Shahzeen Nasir, Faiqua Ahmed, Abeera Saleem Mughal","doi":"10.1093/ced/llag234","DOIUrl":"10.1093/ced/llag234","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1917-1918"},"PeriodicalIF":2.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic poikilodermatous patches in a 41-year-old man.","authors":"Alonso García-Núñez, Mercedes Morillo-Andújar, Juan M Liñán-Barroso, Ismael Khiar-Fernández, Teresa de Zulueta-Dorado, José J Pereyra-Rodríguez","doi":"10.1093/ced/llag277","DOIUrl":"10.1093/ced/llag277","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1962-1964"},"PeriodicalIF":2.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General dermatology and dermatology in primary healthcare.","authors":"Amy Barrett, Ilona Blee, Ali Alsaeed, Danning Li, Chamandeep Thind","doi":"10.1093/ced/llag204","DOIUrl":"10.1093/ced/llag204","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1940-1942"},"PeriodicalIF":2.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and demographic features of Behçets: a retrospective analysis of 4007 patients from a single centre in Turkey.","authors":"Nasim Behkami, Ömer Mangır, Zekayi Kutlubay","doi":"10.1093/ced/llag213","DOIUrl":"10.1093/ced/llag213","url":null,"abstract":"<p><strong>Background: </strong>Behçets is a multisystem inflammatory condition that can lead to severe vascular and neurological complications.</p><p><strong>Objectives: </strong>To evaluate the demographic and clinical characteristics of a large single-centre cohort of patients with Behçets and to investigate the associations of sex, age at onset and human leucocyte antigen B51 (HLA-B51) status with organ involvement patterns.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted on 4007 patients who had been followed-up since 2010 at the Behçet's Disease Research and Application Center at Istanbul University-Cerrahpaşa, Turkey. Demographic data and details of clinical features and organ involvement were extracted and analysed statistically based on sex, age of disease onset and HLA-B51 status.</p><p><strong>Results: </strong>The mean (SD) age of patients was 42.9 (11.4) years, with a male to female ratio of 1.1:1. Men exhibited higher rates of ocular, vascular and neurological involvement, while women had more joint involvement. HLA-B51 was associated with joint and ocular involvement and pathergy positivity. Early-onset disease (onset < 16 years) was observed in 11% (n = 448/4007) of patients and was associated with increased rates of systemic involvement. Joint involvement (n = 1553/4007, 39%) mostly appeared as arthralgia or arthritis. Gastrointestinal involvement (n = 115/4007, 2.9%) was associated with diabetes mellitus. Pathergy positivity was observed in 21% (n = 823/4007) of patients and was associated with early disease onset and smoking. Multivariable analyses showed that male sex and early disease onset were associated with ocular and neurological involvement, whereas vascular involvement was associated with male sex, early onset and smoking.</p><p><strong>Conclusions: </strong>Organ involvement in Behçets varies by sex, age at onset and HLA-B51 status, highlighting the importance of these factors in clinical evaluation.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1848-1854"},"PeriodicalIF":2.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient- and clinician-reported outcomes of calcipotriol/betamethasone dipropionate PAD-cream for the treatment of adult patients with scalp psoriasis under real-world conditions: results from the prospective, noninterventional, multicentre PRO-SCALP study.","authors":"Jose Luis López Estebaranz, Anthony Bewley, Andreas Pinter, Jordi Galván, Volker Koscielny","doi":"10.1093/ced/llag185","DOIUrl":"10.1093/ced/llag185","url":null,"abstract":"<p><strong>Background: </strong>The novel cream formulation of calcipotriol and betamethasone dipropionate based on polyaphron dispersion technology (CAL/BDP PAD-cream) has shown promising results on psoriasis in phase III clinical trials. However, real-world data on scalp psoriasis are limited.</p><p><strong>Objectives: </strong>To assess clinician-reported outcomes (ClinROs) and patient-reported outcomes (PROs) of CAL/BDP PAD-cream in adults with mild-to-moderate scalp psoriasis under real-world conditions in Europe.</p><p><strong>Methods: </strong>PRO-SCALP is a prospective, noninterventional, multicentre, cohort study conducted between June 2023 and October 2024 in Germany, Spain and the UK. Data were collected at baseline and week 8 (end of study, EOS). PROs included the Treatment Satisfaction Questionnaire for Medication Version 9 (TSQM-9), Scalpdex questionnaire, Worst Itch-Numerical Rating Scale (WI-NRS), sleep disturbances, the Psychosocial Effects of Scalp Psoriasis Questionnaire and adherence. ClinROs included treatment satisfaction, Physician's Global Assessment of scalp (scalp-PGA) and scalp-modified Psoriasis Area and Severity Index (S-mPASI). The trial was registered at ClinicalTrials.gov (NCT05811234).</p><p><strong>Results: </strong>In total, 253 patients had evaluable data (mean age 47.9 years; 65.2% female). Of them, 59.9% reported high adherence (visual analogue scale score 80-100). At EOS, the mean (SD) global satisfaction (TSQM-9) was 76.0 (21.6) and 77.6% of patients achieved a scalp-PGA score of 0/1 (clear/almost clear). Moreover, 68.4% achieved scalp-PGA success (scores of 0/1 and ≥ 2-point improvement). WI-NRS, S-mPASI and Scalpdex scores improved significantly (P < 0.001) from baseline to EOS. Sleep patterns and psychosocial outcomes also improved.</p><p><strong>Conclusions: </strong>CAL/BDP PAD-cream is associated with high treatment satisfaction and improved clinical outcomes and quality of life in the real-world management of scalp psoriasis.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1855-1864"},"PeriodicalIF":2.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ulcerated plaques on the trunk and genitalia in a patient with advanced HIV.","authors":"Sasitorn Yenyuwadee, Pattriya Jirawattanadon, Charussri Leeyaphan, Kamonlawat Sutthipool, Wittawat Turakit, Penvadee Pattanaprichakul","doi":"10.1093/ced/llag215","DOIUrl":"10.1093/ced/llag215","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1946-1949"},"PeriodicalIF":2.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin oncology.","authors":"Nicole Fagan, Liana Victory, Róisín Rynne, Amy Long, Caitriona Hackett, Kevin Molloy","doi":"10.1093/ced/llag175","DOIUrl":"10.1093/ced/llag175","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1937-1939"},"PeriodicalIF":2.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A second case of recessive mosaicism in ABCA12 causing a congenital unilateral epidermal naevus.","authors":"Madeleine Müller, Rebekka Salgo, Svenja Rademacher, Alrun Hotz, Judith Fischer","doi":"10.1093/ced/llag273","DOIUrl":"10.1093/ced/llag273","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1975-1978"},"PeriodicalIF":2.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148337951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eczema action plans: do they improve objective disease outcomes?","authors":"Priya Kadu, Chenan A Huang, Matthew Zirwas, Steven R Feldman","doi":"10.1093/ced/llag226","DOIUrl":"10.1093/ced/llag226","url":null,"abstract":"<p><p>Eczema action plans have emerged as a management tool for eczema. Recent studies investigated the efficacy of eczema action plans in improving quality of life and disease severity. This study aims to examine the effectiveness of eczema action plans in improving eczema. A search was conducted using the MEDLINE, Embase and Scopus databases for clinical trials evaluating eczema action plans in eczema management. Five studies (four randomized, one nonrandomized) showed no objective improvement in atopic dermatitis severity or quality of life with eczema action plans. Eczema action plans improved patient knowledge, confidence and satisfaction, but these did not translate to clinical outcomes, possibly due to complex regimens hindering adherence.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1819-1827"},"PeriodicalIF":2.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare professionals' confidence in recognizing different skin conditions presented in primary care: a cross-sectional survey.","authors":"Chandhini Suresh, Hannah E Wainman, Hywel C Williams, Philippa Bowes, Ramyya Sivanathan, Julian Peace, Sonia Gran","doi":"10.1093/ced/llag214","DOIUrl":"10.1093/ced/llag214","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1894-1897"},"PeriodicalIF":2.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}