Clinical and Experimental Dermatology最新文献_第5页

'A hundred paper cuts over my vulva': a patient's experience of vulval lichen sclerosus. 我的外阴上有上百个纸片大小的伤口"：外阴硬皮病患者的经历。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-01-27 DOI: 10.1093/ced/llae423

Jaclyn Lanthier, Louise Clarke, Rosalind Simpson

引用次数: 0

A systematic review and meta-analysis of psychiatric diseases in individuals with primary hyperhidrosis. 对原发性多汗症患者精神疾病的系统回顾和荟萃分析。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-01-27 DOI: 10.1093/ced/llae389

Mattias A S Henning, Farnam Barati, Gregor B E Jemec

{"title":"A systematic review and meta-analysis of psychiatric diseases in individuals with primary hyperhidrosis.","authors":"Mattias A S Henning, Farnam Barati, Gregor B E Jemec","doi":"10.1093/ced/llae389","DOIUrl":"10.1093/ced/llae389","url":null,"abstract":"Primary hyperhidrosis is associated with a substantial mental burden. In this study, the objective was to compare the occurrence of psychiatric diseases in individuals with and without primary hyperhidrosis by systematically reviewing the literature and conducting a meta-analysis. The PRISMA statement and the MOOSE checklist were employed. Cochrane Library, Embase and PubMed were searched. The risk of bias was determined by the Newcastle-Ottawa Scale. A random effects model was employed in the meta-analysis. Fifteen studies met the eligibility criteria, encompassing 50 429 participants with hyperhidrosis and 182 464 control participants. Hyperhidrosis was associated with increased odds of anxiety (odds ratio 3.5, 95% confidence interval 1.0-11.8) and depression (odds ratio 2.4, 95% confidence interval 1.4-4.0). Studies using outcome definitions for anxiety and depression and not included in the meta-analysis showed similar results. Studies reporting on other morbidities (i.e. body dysmorphic disorder, social phobia and stress) found a higher occurrence of these outcomes in the individuals with hyperhidrosis than in the control participants. Primary hyperhidrosis is associated with anxiety and depression. These results acknowledge the psychiatric burden that patients with primary hyperhidrosis experience.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"323-330"},"PeriodicalIF":3.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world efficacy and safety of dupilumab for paediatric atopic dermatitis: a multicentre retrospective study. 杜匹单抗治疗儿童特应性皮炎的实际疗效和安全性：一项多中心回顾性研究。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-01-27 DOI: 10.1093/ced/llae406

Eitan Pirov, Vered Molho-Pessach, Eran Cohen-Barak, Jen A Barak Levitt, Aviv Barzilai, Jonathan Bar, Yael Renert-Yuval, Efrat Bar-Ilan, Rivka Friedland, Shoshana Greenberger

{"title":"Real-world efficacy and safety of dupilumab for paediatric atopic dermatitis: a multicentre retrospective study.","authors":"Eitan Pirov, Vered Molho-Pessach, Eran Cohen-Barak, Jen A Barak Levitt, Aviv Barzilai, Jonathan Bar, Yael Renert-Yuval, Efrat Bar-Ilan, Rivka Friedland, Shoshana Greenberger","doi":"10.1093/ced/llae406","DOIUrl":"10.1093/ced/llae406","url":null,"abstract":"Background: Real-world data regarding the use of dupilumab in children with atopic dermatitis (AD) are limited.Objectives: To evaluate the real-world efficacy of dupilumab in children with moderate-to-severe AD over an extended follow-up period.Methods: This was a retrospective study of patients (≤ 18 years) with moderate-to-severe AD treated with dupilumab in four Israeli tertiary centres. Efficacy and safety were assessed using descriptive statistics.Results: In total, 230 patients were included in the analysis [age 9.9 years (SD 4.3), male/female 1 : 1 ratio)]. Of them, 59.6% (137/230) had ≥ 1 atopic comorbidity. The follow-up duration ranged from 2 to 248 weeks, with a median of 52 weeks (interquartile range 24-96). Within 12 weeks of treatment, 41.7% (68/163) of patients had reached Investigator Global Assessment 0-1. The mean body surface area was reduced from 58.0% (SD 20.5%) at baseline to 27.8% (SD 20.2%) at 12 weeks. The average Pruritus Numeric Rating Scale score was reduced from 7.9 (SD 2.2) at baseline to 2.3 (SD 2.8) at 12 weeks. Adverse events, in 210 patients, included conjunctivitis in 34 patients (16.2%), injection-site reactions in 11 patients (5.2%) and dupilumab-associated head and neck dermatitis in 6 patients (2.9%). Overall, 26 of 210 patients (12.3%) discontinued the treatment: 9 of the 26 patients (35%) because of adverse events and 15 patients (58%) because of inadequate efficacy. The overall probability of dupilumab survival at 52 weeks was 94.0%.Conclusions: Real-world data presented here for 230 paediatric and adolescents with moderate-to-severe AD reinforce dupilumab's efficacy and safety and highlight dupilumab's high survival rate after 1 year of treatment in the paediatric population.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"372-379"},"PeriodicalIF":3.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pili annulati under the electron microscope: a case report and literature review. 电子显微镜下的环状韧带：病例报告和文献综述。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-01-27 DOI: 10.1093/ced/llae365

Shengzhao Chen, Xiaoshuang Yang, Zhongfa Lu

引用次数: 0

Repigmentation in facial vitiligo depends on the affected areas. 面部白癜风的色素沉着取决于受影响的部位。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-01-27 DOI: 10.1093/ced/llae350

Reinhart Speeckaert, Lu Wang, Nanja van Geel

引用次数: 0

Oncogenic genodermatoses in paediatric patients with skin of colour: a review. 有色人种儿科皮肤的致癌基因皮肤病：综述。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-01-27 DOI: 10.1093/ced/llae306

Sherwin Fazelpour, Sandhya C Deverapalli, Bichchau Nguyen

{"title":"Oncogenic genodermatoses in paediatric patients with skin of colour: a review.","authors":"Sherwin Fazelpour, Sandhya C Deverapalli, Bichchau Nguyen","doi":"10.1093/ced/llae306","DOIUrl":"10.1093/ced/llae306","url":null,"abstract":"Cutaneous neoplasms are relatively rare in children. Most commonly, skin cancers arise through environmental factors, particularly ultraviolet radiation; thus, age is the most predictive factor in developing cutaneous carcinomas. However, children born with certain genodermatoses are significantly more likely to develop malignancies and must be carefully monitored and treated. Most published data are based mainly on signs and symptoms present in White patients. Therefore, we aim to highlight the cutaneous presentations and relative differences of these genodermatoses among patients with skin of colour, who are underrepresented in medicine. We conducted a literature review of 504 patients presented in 236 published articles. Manuscripts with accessible case reports for children aged ≤ 17 years were included. Patients with skin of colour often present with fewer classical findings and have higher incidences of scarring and dyspigmentation. There is also a higher incidence of consanguinity in affected patients. Providers who are able to recognize nonclassical signs can provide proper management and treatment regimens, potentially bringing outcomes for patients with skin of colour more in line with those of White children.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"287-298"},"PeriodicalIF":3.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytomegalovirus complications in drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: importance of routine monitoring and early therapeutic intervention. DIHS/DRESS 中的 CMV 并发症：常规监测和早期治疗干预的重要性。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-01-27 DOI: 10.1093/ced/llae372

Shingo Takei, Ryota Hayashi, Natsumi Hama, Riichiro Abe

{"title":"Cytomegalovirus complications in drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: importance of routine monitoring and early therapeutic intervention.","authors":"Shingo Takei, Ryota Hayashi, Natsumi Hama, Riichiro Abe","doi":"10.1093/ced/llae372","DOIUrl":"10.1093/ced/llae372","url":null,"abstract":"Fatal outcomes in drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) are reported to be associated with cytomegalovirus (CMV) reactivation. However, CMV reactivation is observed not only in DIHS/DRESS but also in other diseases when high doses of corticosteroids are administered. Currently, it is difficult to distinguish whether CMV reactivation in DIHS/DRESS is caused by steroid-induced immunosuppression or the pathology of DIHS/DRESS. In this study, we describe the characteristic of CMV reactivation in patients with DIHS/DRESS (n = 22) by comparing the frequency of reactivation and its complications with those that occur in people with pemphigus vulgaris (PV) (n = 21) treated with high doses of corticosteroids. The frequency of CMV reactivation showed no difference between the DIHS/DRESS and PV groups. On the other hand, the frequency of CMV complications was higher in the DIHS than the PV group. Our data show the importance of monitoring for CMV complications, although CMV reactivation is not a unique consequence of DIHS/DRESS compared with other diseases treated with a high dose of corticosteroids.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"399-403"},"PeriodicalIF":3.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Not just another psoriasis…. 不只是另一种牛皮癣

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-01-27 DOI: 10.1093/ced/llae402

Vidette Wong, Matthew Costley, Nabla McLoone

引用次数: 0

Identification of a novel variant of LAMB3 in a patient with a distinct junctional epidermolysis bullosa laryngo-onycho-cutaneous syndrome phenotype. 在一名具有独特交界性表皮松解症喉音-皮肤综合征表型的患者身上发现 LAMB3 基因的新型变异体。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-01-27 DOI: 10.1093/ced/llae403

Aashka Suvarnakar, Michelle Schwartz Kahn, Kristina M Derrick, Soodeh Kabir, Sharon A Glick

引用次数: 0

Dermatopathology. 皮肤病理学。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-01-27 DOI: 10.1093/ced/llae369

Nicola Kearney, Rachel Lockhart, Cristina Grechin, Emily Orr, Li Jie Helena Yoo, Christian Gulmann, Marina O'Kane

引用次数: 0