Clinical and Experimental Dermatology最新文献

{"title":"A solitary cockade purpuric lesion in a pregnant woman.","authors":"Aravind Sivakumar, Siddhartha Siddeswara, Bhawana Badhe, Rashmi Kumari","doi":"10.1093/ced/llae496","DOIUrl":"10.1093/ced/llae496","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"888-890"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient information leaflet feedback on delusional infestation.","authors":"Parmis Vafapour, Anthony Bewley, Alia Ahmed, Padma Mohandas, Ruth Taylor, Jon Goulding","doi":"10.1093/ced/llae471","DOIUrl":"10.1093/ced/llae471","url":null,"abstract":"<p><strong>Background: </strong>Delusional infestation, also known as Ekbom syndrome and delusional parasitosis, is a poorly understood condition often surrounded by misinformation. Patients and their families frequently encounter scepticism regarding their experiences. This research aimed to create a patient information leaflet (PIL) with a patient-centred approach and to gather feedback on its usefulness for sharing information and validating their experiences.</p><p><strong>Objectives: </strong>To evaluate patient feedback on a newly developed PIL designed for individuals with delusional infestation, assessing its perceived usefulness and impact.</p><p><strong>Methods: </strong>A survey was administered to 18 patients before their appointments, incorporating the new PIL. The survey included questions on the leaflet's clarity, usefulness, ability to validate patient experiences and other pointers, measured on a 10-point Likert scale (0 = no comment, 1 = strongly disagree, 10 = strongly agree). Data were analysed using descriptive statistics and factor analysis. Additionally, the final question allowed for written feedback, which was examined through thematic analysis.</p><p><strong>Results: </strong>The survey results revealed that the majority of patients were satisfied with the new PIL. Specifically, 94% (17/18) agreed or strongly agreed that the leaflet was logical and easy to follow, 72% (13/18) found it useful for understanding their condition, and 78% (14/18) felt it validated their experiences. Mean scores for these concepts were 8.83 (SD 2.97), 7.61 (SD 1.93) and 7.78 (SD 1.91), respectively. Thematic analysis of written feedback highlighted themes of improved understanding but uncertainty around acknowledgement of experiences.</p><p><strong>Conclusions: </strong>This new patient-centred PIL for delusional parasitosis was well received, indicating its potential as a valuable tool for patients and their support networks. By addressing the specific needs and experiences of patients, the leaflet can improve communication and reduce the stigma associated with the condition. Future research should explore long-term impact and the effectiveness of similar resources in other patient populations.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"755-759"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"A not-so healthy glow: a qualitative analysis of sunbed content and viewer engagement on social media\".","authors":"Amy Long, Alison Long, Joseph Siby, Keavy Conroy, Geoff Hanley, Nasir Mughal, Zelmarie Beselaar, Sarah Fleming, Muireann Roche","doi":"10.1093/ced/llae474","DOIUrl":"10.1093/ced/llae474","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"871"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mobile subcutaneous tumour on the trapezius.","authors":"Hailey Konisky, Esperanza Villanueva-Siles, Kseniya Kobets","doi":"10.1093/ced/llae505","DOIUrl":"10.1093/ced/llae505","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"898-900"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent tuberculosis screening without chest X-ray: a single-centre experience.","authors":"Emily K Pender, Rosalind Hughes, Brian Kirby","doi":"10.1093/ced/llae483","DOIUrl":"10.1093/ced/llae483","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"876-877"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zoon balanitis: not a distinct clinicopathological entity?","authors":"Richard E Watchorn, Claire Doyle, Georgios Kravvas, Christopher B Bunker","doi":"10.1093/ced/llae457","DOIUrl":"10.1093/ced/llae457","url":null,"abstract":"<p><p>Zoon balanitis (ZB) was originally described in the 1950s in patients with clinical features resembling erythroplasia of Queyrat but with histology that demonstrated a plasma cell infiltrate without evidence of dysplasia. Subsequently, ZB has been extensively reported in the literature, reflecting widespread acknowledgement as an established distinct clinicopathological entity. However, its existence as such has been questioned, and there have been suggestions in the literature that ZB represents either a nonspecific irritant reaction pattern, or a part of the heterogeneous clinicopathological complex of male genital lichen sclerosus (MGLSc). In this study, the entire historical literature of published cases of ZB was subject to review to determine whether clinical or histological features of MGLSc had been present and been overlooked. In total, 101 papers were reviewed. Seventy-five contained images purporting to be of ZB. Images that were deemed to be of inadequate quality or to present uninformative anatomical views were excluded. The images in 66 papers were amenable to scrutiny; 98.5% of these images demonstrated clinical signs of MGLSc, such as adhesions, effacement of the coronal sulcus and the frenulum, tightening of the prepuce, constrictive posthitis, etiolation of the glans, lichenoid inflammation and sclerosis. These findings strongly suggest that ZB occurs in the vast majority of cases as a manifestation of MGLSc and that its recognition as a distinct clinicopathological entity should be questioned, if not discontinued.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"731-739"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary assessment of the accuracy of cutaneous T-cell lymphoma diagnosis through deep sequencing of the TRG gene.","authors":"Jin-Bon Hong, Tyng-Shiuan Hsieh, Tsen-Fang Tsai, Jau-Yu Liau, Hsien-Ching Chiu, Tung-Lung Lee, Tai-Chung Huang","doi":"10.1093/ced/llae413","DOIUrl":"10.1093/ced/llae413","url":null,"abstract":"<p><strong>Background: </strong>The diagnostic challenges in early mycosis fungoides (MF) and other cutaneous T-cell lymphomas (CTCLs) persist despite advancements in molecular methods.</p><p><strong>Objectives: </strong>To provide a preliminary assessment of next-generation sequencing (NGS) in analysing TRG (T-cell receptor gamma locus) sequences for distinguishing CTCLs from benign inflammatory skin disorders.</p><p><strong>Methods: </strong>NGS was used to assess TRG sequences in skin samples from clinicopathologically proven CTCLs and benign inflammatory skin disorders.</p><p><strong>Results: </strong>Our study analysed skin samples from a total of 36 participants, comprising 22 cases of CTCL, including 14 MF and 8 other CTCLs, alongside 14 cases of benign inflammatory skin disorders. According to LymphoTrack® criteria, monoclonality was detected in 16 (73%) of the 22 patients with CTCL. Specifically, in cases of MF, 10 of 14 (71%) were identified as monoclonal, with all 4 non-monoclonal cases being in the patch stage. For the other cases of CTCL, six of eight displayed monoclonality. Among the 22 patients with CTCL, 10 (45%) had multiple biopsies, with 8 (36%) displaying the same dominant clone across different sites. Among the 14 benign cases, only the case of erythrodermic psoriasis exhibited monoclonality. Our decision tree analysis suggests that a high frequency of the most abundant clone, its ratio to the third most abundant clone and TRG VγI segment usage are effective markers that can help in the diagnosis of CTCL.</p><p><strong>Conclusions: </strong>A combination of the clone frequencies and TRG V segment usage may enhance diagnosis of MF and other CTCLs, helping to differentiate them from benign conditions. However, molecular diagnosis for patch-stage MF remains challenging.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"788-794"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risk of candidiasis during treatment with bimekizumab for the management of plaque psoriasis: a 16-week multicentre real-world experience - IL PSO (Italian Landscape Psoriasis).","authors":"Matteo Megna","doi":"10.1093/ced/llae400","DOIUrl":"10.1093/ced/llae400","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"858-859"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genitourinary disorders and oral medicine.","authors":"Sree Yazhini Ramar, Sanjana Kotekar, Aravind Sivakumar, Sheetanshu Kumar","doi":"10.1093/ced/llae473","DOIUrl":"10.1093/ced/llae473","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"882-883"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assessed improved sun protection after diagnosis of melanoma is associated with improved survival.","authors":"Christoph Müller, Judith Wendt, Ichiro Okamoto","doi":"10.1093/ced/llae487","DOIUrl":"10.1093/ced/llae487","url":null,"abstract":"<p><strong>Background: </strong>Although ultraviolet radiation is the most important risk factor for skin cancer in general, its role in disease control after the diagnosis of melanoma remains to be elucidated.</p><p><strong>Objectives: </strong>To analyse the association between survival and self-assessed sun protection behaviour after a melanoma diagnosis.</p><p><strong>Methods: </strong>This was a questionnaire-based pilot study. We used patient data from the Molecular Markers of Melanoma Study programme to select patients with a histologically verified, invasive cutaneous melanoma, diagnosed at stage I or II according to the American Joint Committee on Cancer's AJCC Cancer Staging Manual 8th edition, between 1981 and 2014. In total, 843 patients with melanoma were asked whether their diagnosis had influenced their sun protection behaviour and, if 'Yes', they were asked to describe, in their own words, how the diagnosis affected their behaviour. We excluded 33 patients who were unable to answer and included 810 patient responses for analysis. Reports on sun protection behaviour before and after melanoma diagnosis were recorded.</p><p><strong>Results: </strong>We found a significant association of increased melanoma-specific survival (P = 0.001) with improved self-assessed sun protection behaviour. After adjusting for age, sex, AJCC stage, localization of the primary tumour and prior ultraviolet light exposure (outdoor occupation, solarium use and sun cream use), improved sun protecting behaviour after melanoma diagnosis resulted in a decreased hazard ratio (HR) for melanoma-specific survival (adjusted HR 0.491, 95% confidence interval 0.270-0.896; P = 0.020). Stratification showed that those who benefited from improved sun protection were, in particular, male patients, patients diagnosed with melanoma after 50 years of age, patients with stage II melanomas and those carrying an MC1R gene variant.</p><p><strong>Conclusions: </strong>Self-assessed improved sun protection after diagnosis was significantly associated with reduced mortality due to melanoma. These results highlight the importance of improved sun awareness for patients after melanoma diagnosis, not only for preventing further melanomas but also reducing mortality risk.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"812-817"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}