Clinical and Experimental Dermatology最新文献_第10页

Living with Ichthyosis: A Journey through the Years. 与鱼鳞病共存：岁月之旅》。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-08-06 DOI: 10.1093/ced/llae301

Vidette Wong, Susannah Hoey

引用次数: 0

Paediatrics and Genetics. 儿科与遗传学

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-08-06 DOI: 10.1093/ced/llae314

Seán O'Malley, Sinead Collins

引用次数: 0

A Preliminary Exploration of DALL-E 2's Replication of Hair Disorders. 对《DALL-E 2》复制毛发疾病的初步探索。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-08-06 DOI: 10.1093/ced/llae302

Eduardo P Deliyannis

引用次数: 0

Expression of STAT3, IL-27p28, and IL-12p35 Is Deregulated and Linked to Autoimmune Markers in Chronic Spontaneous Urticaria. 慢性自发性荨麻疹患者STAT3、IL-27p28和IL-12p35的表达失调并与自身免疫标记物相关。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-08-06 DOI: 10.1093/ced/llae319

Sahar Rastgoo, Mojgan Mohammadi, Marcus Maurer, Mahdi Atabaki, Jalil Tavakkol-Afshari, Maryam Khoshkhui

{"title":"Expression of STAT3, IL-27p28, and IL-12p35 Is Deregulated and Linked to Autoimmune Markers in Chronic Spontaneous Urticaria.","authors":"Sahar Rastgoo, Mojgan Mohammadi, Marcus Maurer, Mahdi Atabaki, Jalil Tavakkol-Afshari, Maryam Khoshkhui","doi":"10.1093/ced/llae319","DOIUrl":"https://doi.org/10.1093/ced/llae319","url":null,"abstract":"Background: Chronic spontaneous urticaria (CSU) is a common inflammatory disorder characterized by wheals, angioedema, or both, for more than 6 weeks. Autoimmunity is held to be one of the most frequent causes, but little is known about the expression and relevance of autoimmunity-driving genes in CSU, such as STAT3, STAT1, IL-27p28, and IL-12p35.Objective: To investigate CSU patients or the expression of STAT3, STAT1, IL-27p28, and IL-12p35 and possible links to clinical features.Methods: Gene expression levels, in 26 CSU patients and 19 healthy controls (HCs), were determined by quantitative real-time PCR. CSU patients were assessed for total IgE and IgG-anti-TPO, markers of autoimmune CSU.Results: Patients with CSU showed significantly higher expression of STAT3, but not STAT1, and 17 and 10 of 26 CSU patients had elevated STAT3 expression and STAT3/STAT1 ratios, respectively, as compared to only 1 of 19 HCs. High STAT3 expression and STAT3/STAT1 ratios were linked to low IgE and elevated IgG-anti-TPO. As compared to HCs, CSU patients had markedly lower and correlated IL-27p28 and IL-12p35 mRNA expression levels. Low IL-27p28 and IL-12p35 expression levels were linked to higher STAT3/STAT1 ratios and low IgE.Conclusion: STAT3 upregulation, higher STAT3/STAT1 ratios, and IL-27p28 and IL-12p35 downregulation cluster with features of autoimmune CSU. The role of STAT3 as a potential pathogenic driver of autoimmune CSU and target of treatment should be explored further.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bullous Drug Eruption. 大疱性药疹

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-08-06 DOI: 10.1093/ced/llae294

Dora Mancha, Cláudia Brazão, Lanyu Sun, João Pedro de Vasconcelos, Teresa Correia, Luís Soares-de-Almeida, Paulo Filipe

{"title":"Bullous Drug Eruption.","authors":"Dora Mancha, Cláudia Brazão, Lanyu Sun, João Pedro de Vasconcelos, Teresa Correia, Luís Soares-de-Almeida, Paulo Filipe","doi":"10.1093/ced/llae294","DOIUrl":"https://doi.org/10.1093/ced/llae294","url":null,"abstract":"A 63-year-old woman presented at our emergency department with a disseminated dermatosis that developed after undergoing a cardiac catheterization procedure. Her past medical history included an end-stage renal disease undergoing hemodialysis. Clinical examination revealed erosions and hemorrhagic crusts located on her lips and along the arteriovenous fistula. Additionally, we observed five hyperpigmented macules on her left hand's dorsum and palm and multiple hypopigmented macules in the genital area. Upon medical record review, we discovered the occurrence of prior bullous eruptions following contrast administration. A fixed drug eruption (FDE) due to radiocontrast was diagnosed based on clinical history, clinical examination, eruption timeframe, and positive drug provocation test. Intravenous contrast media reactions can be immediate or delayed, with delayed hypersensitivity reactions (DHR) occurring one hour to seven days post-administration. DHRs often present as maculopapular rashes. FDEs are rare. Skin tests are used to identify culprit agents. Ideally, intradermal tests, with delayed readings, and patch tests are combined for optimal sensitivity. Despite lacking standardized protocols, premedication with corticosteroids may mitigate reaction severity.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatopathology. 皮肤病理学。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-08-06 DOI: 10.1093/ced/llae313

Vidette Wong, Claire Hunter, Helen Louise Hunter

引用次数: 0

Review of adjuvant Intravenous immunoglobulins in patients with refractory pyoderma gangrenosum: a single-centre experience. 难治性脓皮病患者静脉注射免疫球蛋白辅助治疗回顾：单中心经验。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-08-06 DOI: 10.1093/ced/llae318

Charlotte Krones, Gia T Tang, Laura Scardamaglia

引用次数: 0

Intravenous Low-Dose Cyclophosphamide Pulses Followed by Rituximab for Ocular Mucous Membrane Pemphigoid. 静脉注射小剂量环磷酰胺脉冲后使用利妥昔单抗治疗眼粘膜斑丘疹。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-08-05 DOI: 10.1093/ced/llae316

Myriam Viedma-Martínez, Ricardo Patricio Roman-Cheuque, Alejandro Claudio-Oliva, Antonio Jose Duran-Romero, Jose Francisco Millan-Cayetano, David Jimenez-Gallo, Mario Linares-Barrios

引用次数: 0

Oncogenic Genodermatoses in Pediatric Skin of Color: A Review. 有色人种儿科皮肤的致癌基因皮肤病：综述。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-08-04 DOI: 10.1093/ced/llae306

Sherwin Fazelpour, Sandhya C Deverapalli, Bichchau Nguyen

{"title":"Oncogenic Genodermatoses in Pediatric Skin of Color: A Review.","authors":"Sherwin Fazelpour, Sandhya C Deverapalli, Bichchau Nguyen","doi":"10.1093/ced/llae306","DOIUrl":"https://doi.org/10.1093/ced/llae306","url":null,"abstract":"Cutaneous neoplasms are relatively rare in children. Most commonly, skin cancers arise through environmental factors, particularly ultraviolet radiation; thus, age is the most predictive factor in developing cutaneous carcinomas. However, children born with certain genodermatoses are significantly more likely to develop malignancies and must carefully be monitored and treated. The preponderance of published data is based mainly on signs and symptoms present in White patients. Therefore, we aim to highlight the cutaneous presentations and relative differences of these genodermatoses among skin-of-color (SOC) patients, who are underrepresented in medicine. We conducted a literature review of 504 patients presented in 236 published articles. Manuscripts with accessible case reports for children aged 17 or younger were included. SOC patients often present with fewer classic findings and have a higher incidence of scarring and dyspigmentation. There is also a higher incidence of consanguinity in affected patients. Providers being able to recognize non-classical signs enable proper management and treatment regimens, potentially bringing SOC patient outcomes more in line with White children.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral infections in atopic dermatitis. 特应性皮炎的病毒感染。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-08-04 DOI: 10.1093/ced/llae304

Nada Khalil, Joshua Walton, Nerys Roberts, Khawar Hussain

引用次数: 0