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Clinical and Experimental Dermatology最新文献

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Metabolic syndrome and pigmentation: a review of the connecting link. 代谢综合征与色素沉着：相互联系的综述。
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-05-16 DOI: 10.1093/ced/llaf218
Abheek Sil, Shreya Poddar, Anupam Das, Diptarup Ray
{"title":"Metabolic syndrome and pigmentation: a review of the connecting link.","authors":"Abheek Sil, Shreya Poddar, Anupam Das, Diptarup Ray","doi":"10.1093/ced/llaf218","DOIUrl":"https://doi.org/10.1093/ced/llaf218","url":null,"abstract":"<p><p>There is an ongoing interest regarding the association of metabolic syndrome (MetS) and skin diseases. However, the link between MetS and pigmentation has not been extensively explored. In this review, we undertake a detailed discussion on the existing literature on this niche area, the various implicated pathomechanisms and/or molecular pathways, and highlight scope for further scientific exploration. A better understanding of the relationship between MetS and disorders of pigmentation contributes to early diagnosis and prevention, as well as providing clues for developing novel therapeutic strategies.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of cardiac screening in X-linked ichthyosis - a plea. 心脏筛查对x连锁鱼鳞病的重要性
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-05-16 DOI: 10.1093/ced/llaf221
William Davies
{"title":"The importance of cardiac screening in X-linked ichthyosis - a plea.","authors":"William Davies","doi":"10.1093/ced/llaf221","DOIUrl":"https://doi.org/10.1093/ced/llaf221","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing a Genital Disease Quality of Life Index Questionnaire for Male Genital Lichen Sclerosus: A Modification of the Vulvar Quality of Life Index (VQLI) - A Pilot Study. 编制男性生殖器硬化地衣疾病生活质量指数问卷：外阴生活质量指数（VQLI）的修改-一项试点研究。
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-05-16 DOI: 10.1093/ced/llaf219
Kashini Andrew, Danning Li, Nachammada Solomon Emmanuel, Tang Ngee Shim
{"title":"Developing a Genital Disease Quality of Life Index Questionnaire for Male Genital Lichen Sclerosus: A Modification of the Vulvar Quality of Life Index (VQLI) - A Pilot Study.","authors":"Kashini Andrew, Danning Li, Nachammada Solomon Emmanuel, Tang Ngee Shim","doi":"10.1093/ced/llaf219","DOIUrl":"https://doi.org/10.1093/ced/llaf219","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vulvar basal cell carcinoma treated with Mohs micrographic surgery: A case series and systematic review. Mohs显微手术治疗外阴基底细胞癌：一个病例系列和系统回顾。
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-05-16 DOI: 10.1093/ced/llaf203
Marie-Chantal Causssade, Rosario Aguero, Francisca Donoso, Hesham Alsheik, Juan C Castro, Consuelo Cardenas, Katherine Droppelmann, Pablo Uribe, Anthony M Rossi, Cristian Navarrete-Dechent
{"title":"Vulvar basal cell carcinoma treated with Mohs micrographic surgery: A case series and systematic review.","authors":"Marie-Chantal Causssade, Rosario Aguero, Francisca Donoso, Hesham Alsheik, Juan C Castro, Consuelo Cardenas, Katherine Droppelmann, Pablo Uribe, Anthony M Rossi, Cristian Navarrete-Dechent","doi":"10.1093/ced/llaf203","DOIUrl":"https://doi.org/10.1093/ced/llaf203","url":null,"abstract":"<p><p>Basal cell carcinoma (BCC) is the most common type of skin cancer. Vulvar BCC accounts for less than 1% of all BCCs but can be difficult to manage due to its functionally and cosmetically relevant anatomic location. Mohs micrographic surgery (MMS) is a tissue-sparing technique that ensures complete margin analysis, minimizing recurrence while preserving healthy tissue. In this study, we systematically reviewed the literature, searching for cases of vulvar BCC treated with MMS. Eight articles representing 17 cases of vulvar BCC treated with MMS have been published, and we added 3 extra cases of our own experience. The present study highlights the relevance of including BCC in the differential diagnosis of vulvar dermatosis, and the key role of MMS in the vulvar region, where tissue sparing and functionality preservation are vital.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal Relationship Between Juvenile Xanthogranuloma and Juvenile Myelomonocytic Leukemia: Insights from a PTPN11 Missense Variant. 幼年黄色肉芽肿与幼年粒细胞白血病的克隆关系：来自PTPN11错义变异的见解。
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-05-15 DOI: 10.1093/ced/llaf211
Inbar Kobal, Vered Molho-Pessach, Sigal Matza-Porges, Stephanie Benshushan, Oded Shamriz, Eve Finkelstein
{"title":"Clonal Relationship Between Juvenile Xanthogranuloma and Juvenile Myelomonocytic Leukemia: Insights from a PTPN11 Missense Variant.","authors":"Inbar Kobal, Vered Molho-Pessach, Sigal Matza-Porges, Stephanie Benshushan, Oded Shamriz, Eve Finkelstein","doi":"10.1093/ced/llaf211","DOIUrl":"https://doi.org/10.1093/ced/llaf211","url":null,"abstract":"<p><p>Juvenile xanthogranuloma (JXG) is typically a benign non-Langerhans cell histiocytosis but has been rarely associated with juvenile myelomonocytic leukemia (JMML). Mutations in the RAS-MAPK pathway are implicated in both conditions, suggesting a shared genetic basis; however, only one prior case has demonstrated a clonal relationship. We report a 21-month-old boy with a progressive yellow papulonodular rash, dusky plaques, and recurrent infections. Skin biopsy confirmed JXG, and exome sequencing revealed a somatic PTPN11 (c.226 G>A) variant in both peripheral blood (32.6%) and skin lesion (27.2%). The early identification of this mutation prompted urgent hemato-oncologic evaluation. Two weeks later, the patient developed overt JMML and was successfully treated with chemotherapy and bone marrow transplantation. The shared mutation supports a clonal relationship between JXG and JMML. This case highlights the value of early genetic testing in atypical JXG and represents the second documented case of clonally related, sequential JXG and JMML.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: The risk of candidiasis during treatment with bimekizumab for the management of plaque psoriasis: a 16-week multicentre real-world experience - IL PSO (Italian Landscape Psoriasis). 修正：比美珠单抗治疗斑块型银屑病期间念珠菌病的风险：一项为期16周的多中心真实世界经验- IL PSO（意大利景观银屑病）。
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-05-15 DOI: 10.1093/ced/llaf175
{"title":"Correction to: The risk of candidiasis during treatment with bimekizumab for the management of plaque psoriasis: a 16-week multicentre real-world experience - IL PSO (Italian Landscape Psoriasis).","authors":"","doi":"10.1093/ced/llaf175","DOIUrl":"https://doi.org/10.1093/ced/llaf175","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on 'Potential Role of Leptin in JAK2 Inhibitor-Associated Weight Gain: A Monocentric Retrospective Study'. “瘦素在JAK2抑制剂相关体重增加中的潜在作用：一项单中心回顾性研究”
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-05-14 DOI: 10.1093/ced/llaf207
Luca Potestio, Cataldo Patruno, Maddalena Napolitano
{"title":"Comment on 'Potential Role of Leptin in JAK2 Inhibitor-Associated Weight Gain: A Monocentric Retrospective Study'.","authors":"Luca Potestio, Cataldo Patruno, Maddalena Napolitano","doi":"10.1093/ced/llaf207","DOIUrl":"https://doi.org/10.1093/ced/llaf207","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chromoblastomycosis: a contemporary review of a neglected disease. 成色菌病：一种被忽视疾病的当代回顾。
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-05-14 DOI: 10.1093/ced/llaf201
William Tuckwell, Paul D Yesudian, David Chandler
{"title":"Chromoblastomycosis: a contemporary review of a neglected disease.","authors":"William Tuckwell, Paul D Yesudian, David Chandler","doi":"10.1093/ced/llaf201","DOIUrl":"https://doi.org/10.1093/ced/llaf201","url":null,"abstract":"<p><p>Of the melanised fungal infections affecting humans, chromoblastomycosis (CBM) remains the most prevalent. Also known as chromomycosis, this condition typically manifests as insidious onset cutaneous lesions that eventually progress to cause physical disability. CBM is considered a Neglected Tropical Disease (NTD) by the World Health Organisation (WHO) due to its significant impact on impoverished populations throughout tropical regions, the paucity of research, and the opportunity to improve treatment and prevention. In many cases, the diagnosis is delayed; this is thought to be due to the multitude of clinical mimics and the lack of general awareness. Furthermore, the subcutaneous invasion of this infection creates therapeutic challenges. A small number of studies have identified partially successful treatments and potential pharmacological targets. Herein we present an updated review of this condition to give a contemporary perspective on a neglected disease.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent Facial Rash. 持续性面部皮疹。
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-05-14 DOI: 10.1093/ced/llaf209
Hana El-Sbahi, Mohanad Aldiwani, Manisha Panchal, Marie O'Riordan, Karen Harman
{"title":"Persistent Facial Rash.","authors":"Hana El-Sbahi, Mohanad Aldiwani, Manisha Panchal, Marie O'Riordan, Karen Harman","doi":"10.1093/ced/llaf209","DOIUrl":"https://doi.org/10.1093/ced/llaf209","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A non-healing ulcer on the leg of a 26-year-old male. 一名26岁男性腿上的溃疡无法愈合。
IF 3.7 4区 医学
Clinical and Experimental Dermatology Pub Date : 2025-05-14 DOI: 10.1093/ced/llaf200
Víctor García-Rodríguez, Jorge Arandes-Marcocci, Mariona Pintiado I Gàmez, Rodolfo Andrés Posada-Caez
{"title":"A non-healing ulcer on the leg of a 26-year-old male.","authors":"Víctor García-Rodríguez, Jorge Arandes-Marcocci, Mariona Pintiado I Gàmez, Rodolfo Andrés Posada-Caez","doi":"10.1093/ced/llaf200","DOIUrl":"https://doi.org/10.1093/ced/llaf200","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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