Clinical and Experimental Dermatology最新文献

{"title":"Dark brown hair regrowth in a red-haired woman with alopecia areata.","authors":"Bevin Bhoyrul","doi":"10.1093/ced/llaf267","DOIUrl":"https://doi.org/10.1093/ced/llaf267","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of socioeconomic status and distance to dermatological clinic on the disease burden of keratinocyte carcinoma and precursors in Danish office-based dermatological practice.","authors":"Johan Sieborg, Merete Haedersdal, Ulrikke Lei, Henrik Sølvsten, Anne Braae Olesen, Gabrielle R Vinding, Anna Lei Lamberg, Alexander Egeberg, Emily Wenande","doi":"10.1093/ced/llaf262","DOIUrl":"https://doi.org/10.1093/ced/llaf262","url":null,"abstract":"<p><strong>Background: </strong>Socioeconomic status (SES) and access to dermatological care are thought to influence rates of keratinocyte carcinoma (KC). However, few studies examine these factors' impact on disease burden of specific KC subtypes.</p><p><strong>Objectives: </strong>To determine the impact of SES and distance to dermatologist on the burden of KC disease, determined by tumour incidence rate ratios (TIRRs) and tumour size, for nodular basal cell carcinoma (nBCC), superficial BCC (sBCC), squamous cell carcinoma (SCC), and the KC precursor, Bowen's disease (BD).</p><p><strong>Methods: </strong>Based on a nationwide registry (The Danish Skin Cancer Registry), the study included 100,705 patients with 190,468 histologically- or clinically verified KC/BD registered in state-funded office-based dermatology practice between 2013-2022. A negative binomial regression calculated TIRRs, while impact on lateral tumour size was estimated with log-linear quantile regression.</p><p><strong>Results: </strong>High SES, based on income, was associated with increased incidence and smaller tumours for all KC subtypes. Rates of nBCC and sBCC were 2.7 and 2.4 times higher among top-25% earners versus the lowest income category (nBCC: 2.74 (95%CI:2.69-2.79); sBCC: 2.38 (95%CI:2.30-2.47)). However, top earners had up to 9.7% smaller BCC tumours (e.g., BCC: 95%CI:8.5-11.0%). Similarly for SCC and BD, incidences were higher among the top-25% earners (e.g., SCC:2.08 (95%CI:1.94-2.22) but also 11.3% (95%CI:7.4-15.1%) and 13.9% (95% CI:9.9-17.7%) smaller in size.Impact of distance to dermatologist depended on KC subtype. For nBCC, rising incidence was noted with shorter distances, as reflected by a 15% decrease in TIRR with every 10 km increase (0.85(95%CI: 0.85-0.86)). The opposite trend was seen for SCC and BD, where respective incidence rates increased 7% and 14% with every 10 km (e.g., SCC: 1.07(95%CI:1.05-1.09). Individuals living further away had larger nBCCs and sBCCs, with an up to 8.1% (nBCC: 95%CI:7.5-8.7%) increase in tumour size per 10 km. No correlation between size and distance was found for SCC.</p><p><strong>Conclusions: </strong>High SES was associated with increased incidence and smaller tumours for all KC subtypes, reflecting either higher rates of detection or disease occurrence. Distance to dermatologist was an independent predictor of KC burden, with shorter distances leading to increased incidence but smaller nBCC tumours and decreased incidence of SCC.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scalp hair repigmentation after radiotherapy.","authors":"Andrew Maxwell, Christopher Yee-Min Chew, Ian Porter, Rodney Sinclair, Adam Sheridan","doi":"10.1093/ced/llaf261","DOIUrl":"https://doi.org/10.1093/ced/llaf261","url":null,"abstract":"<p><p>We report a rare case of scalp hair repigmentation after radiotherapy in a 76-year-old male. The patient had grey scalp hairs for over a decade, and was treated with radiotherapy, 45 Gy delivered over 25 fractions, for squamous cell carcinoma of the scalp and neck. He subsequently underwent a period of radiotherapy-induced alopecia and when his hair regrew four months later it was unexpectedly coloured orange to brown, his natural hair colour in his youth. There are limited reported cases of this phenomenon. This report adds to the limited literature, highlighting the role of hair follicle melanocytes and melanocyte stem cell plasticity in hair colour restoration, and how factors such as radiation may influence it.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriasis vulgaris in patients with a recent history of neoplasia: safety of interleukin-23 inhibitors. A multicentre retrospective study.","authors":"Francesca Satolli, Silvia Gerosa, Martina Burlando, Emanuele Claudio Cozzani, Claudia Lasagni, Marco Manfredini, Alessandra Narcisi, Angelo Valerio Marzano, Carlo Giovanni Carrera, Matteo Megna, Annalisa Cagni, Maria Esposito, Maria Concetta Fargnoli, Vito Di Lernia, Francesca Peccerillo, Marco Romanelli, Emanuele Trovato, Paolo Amerio, Andrea Carugno, Giovanna Brunasso, Giulia Rech, Riccardo Balestri, Luca Mastorino, Pietro Quaglino, Marco Brusasco, Claudio Feliciani","doi":"10.1093/ced/llaf184","DOIUrl":"https://doi.org/10.1093/ced/llaf184","url":null,"abstract":"<p><strong>Background: </strong>The management of psoriasis in patients with a history of cancer remains debated, especially for the limited literature available. Given the lack of large, well-designed studies focused on this patient group, real-world clinical experiences and expert insights serve as crucial resources for guiding informed treatment decisions. This issue particularly regards the newest anti-interleukin (IL) drugs available, such as those targeting IL-23.</p><p><strong>Objectives: </strong>To analyse a real-world population of patients with psoriasis undergoing biologic treatment with anti-IL-23 drugs who also have a concurrent cancer diagnosis.</p><p><strong>Methods: </strong>A retrospective, observational, multicentre study was conducted, enrolling adult patients with moderate-to-severe plaque psoriasis and a personal history of malignancy. The patients were undergoing any anti-IL-23 treatment approved for psoriasis (guselkumab, risankizumab or tildrakizumab).</p><p><strong>Results: </strong>In total, 198 patients were enrolled. Among these, 67 (33.8%) had a history of malignancy within the past 5 years, whereas 131 (66.2%) had been diagnosed with cancer prior to that time. During the period of the study, six patients (3.0%) experienced progression or recurrence of their existing neoplasia. Moreover, six (3.0%) were diagnosed with a new neoplasia during the study period, discontinuing biologic treatment in only two cases. A subanalysis investigating the relationship between comorbidities and the incidence of neoplastic progression or recurrence during therapy, as well as the development of a new neoplasia, did not show any statistically significant associations. Similarly, significant associations between previous treatments and increased risk of cancer recurrence, progression or development were not found.</p><p><strong>Conclusions: </strong>Our real-life experience is the largest study investigating the use of anti-IL-23 agents and the risk of cancer recurrence, progression and development in patients with a history of cancer. This study confirms their safety also in this cohort of patients.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin surgery and cosmetic dermatology.","authors":"Eimear Duff, Roisin Rynne, Cliona Feighery, Niamh Kearney","doi":"10.1093/ced/llaf251","DOIUrl":"https://doi.org/10.1093/ced/llaf251","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All pain, no gain: Porokeratosis ptychotropica remains a therapeutic challenge.","authors":"Sophie Bashall, Sarah Ryan, Justin Hau, Natalie Attard, Nastassia Nardini, Zidan Anoud, Natalia Castrejon DeAnta, David Chandler, Marieta Papanikolaou","doi":"10.1093/ced/llaf242","DOIUrl":"https://doi.org/10.1093/ced/llaf242","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic Dermatitis and Obsessive-Compulsive Disorder: A Systematic Review.","authors":"Sheila Sharifi, Isabella J Tan, Mohammad Jafferany","doi":"10.1093/ced/llaf259","DOIUrl":"https://doi.org/10.1093/ced/llaf259","url":null,"abstract":"<p><p>Atopic dermatitis (AD) is a prominent inflammatory skin disorder that significantly affects daily functioning and mental health in patients. Among its psychological repercussions, besides anxiety and depression, obsessive-compulsive disorder (OCD) has emerged with multiple studies indicating an increased risk of OCD in AD patients. This systematic review aims to synthesize and evaluate the current literature on the association between AD and OCD, with particular attention to mechanisms linking disease and integrative treatment approaches. A search of the PubMed, PsycINFO, and Web of Science databases was performed on September 12, 2024 to select peer-reviewed English studies relevant to our topic. Our results revealed the influences of demographic variables such as gender, age, and atopic severity as central to concomitant disease prevalence, with women and young adults posing the highest risk of comorbidity. The complex interaction between the two disease states is thought to be a bidirectional relationship characterized by immunological, behavioral, and genetic factors. Hence, an understanding of underlying pathophysiology is necessary for comprehensive management. Patients may benefit from a multifaceted approach including prescription of immunomodulatory agents and referral to psychiatry and psychology. Ultimately, we seek to inform clinical practice by advocating for interdisciplinary approaches to care and providing the framework for future investigations.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose modulation strategies in psoriatic patients: real-world comparison between secukinumab and brodalumab for up to one year after dose spacing.","authors":"Luca Mastorino, Paolo Dapavo, Michela Ortoncelli, Eleonora Bongiovanni, Yingying Liao, Margherita Pelucchi, Francesco Leo, Pietro Quaglino, Simone Ribero","doi":"10.1093/ced/llaf250","DOIUrl":"https://doi.org/10.1093/ced/llaf250","url":null,"abstract":"<p><strong>Introduction: </strong>Modulation of the regimen of biologics, including dose reduction (de-escalation) and dose augmentation (escalation), is of increasing interest in psoriatic patients.De-escalation strategies include reducing the single therapeutic dose, the mg/kg ratio or number of injections, and dose-spacing (D-S), i.e. extending the interval between administrations. Real-life data regarding dose de-escalation are lacking.</p><p><strong>Objectives: </strong>We aim to retrospectively analyse the effectiveness and drug survival of D-S of secukinumab and brodalumab in a real-world setting.</p><p><strong>Materials and methods: </strong>This is a cohort study with a retrospective analysis of the general characteristics and effectiveness of patients with psoriasis undergoing therapeutic biologic D-S with secukinumab or brodalumab.</p><p><strong>Results: </strong>Eighty patients, 38.75% treated with secukinumab and 61.25% treated with brodalumab, underwent dose modulation by D-S of 50% of the approved range. After a mean of 35 months the population underwent D-S. At D-S, the mean PASI was 0.1, ranging from 0.7 to 0.1 in the following year. PASI100 was achieved by 91% at the date of D-S, and remained stable over the following year. Similar trends were seen for PASI 90 and PASI≤1 with 99%, and 100% of achievement at the time of D-S, which were maintained at 12 months post-D-S. The 12-month drug survival of the D-S regimen was 66%, with 1 in 4 patients returning to standard dosage, and PASI 100 was regained in two-third of these cases. Secukinumab showed a drug survival after D-S of 78.3% vs 58.9% of brodalumab. No differences in mean and relative PASIs at any time point after D-S were found between the two treatments.</p><p><strong>Conclusions: </strong>Therapeutic modulation of IL-17 inhibitors in patients with psoriasis and controlled disease seems an effective therapeutic strategy that maintains efficacy for up to one year in 40% of patients. No differences were observed between secukinumab and brodalumab during the D-S regimen.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of the Cost and Carbon Footprint of Acne Treatments in the NHS.","authors":"Sarika Grover, William Hunt, Rachel A Abbott, David de Berker, Tamara Griffiths, Dennis Niebel, Simon Tso","doi":"10.1093/ced/llaf258","DOIUrl":"https://doi.org/10.1093/ced/llaf258","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Granulomatous reaction to red tattoo pigment successfully treated with topical allopurinol.","authors":"Marcial Álvarez-Salafranca, Itziar Muelas-Rives, Iranzu Barandika-Urrutia, Ignacio Hernández-Aragües, María Carmen Gómez-Mateo","doi":"10.1093/ced/llaf257","DOIUrl":"https://doi.org/10.1093/ced/llaf257","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}