Clinical and Experimental Dermatology最新文献

{"title":"Paediatrics and Genetics.","authors":"Mai Shehab, Conn McGrath, Dany Tadfi, Kristina Semkova, Wisam Alwan","doi":"10.1093/ced/llaf393","DOIUrl":"https://doi.org/10.1093/ced/llaf393","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of endometriosis in adult female patients with hidradenitis suppurativa: a cross-sectional study using the All of Us Research Program.","authors":"Christine Hodelin, Jeffrey M Cohen, Anna Eisenstein","doi":"10.1093/ced/llaf395","DOIUrl":"https://doi.org/10.1093/ced/llaf395","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, dermoscopic and confocal microscopy features of multiple primary melanomas according to germline variant status: a retrospective, hospital-based study.","authors":"Marco Spadafora, Beatrice Melli, Jonida Bardhushi, Stefania Borsari, Simonetta Rosato, Stefano Giuseppe Caraffi, Chiara Cattani, Vincenza Ylenia Cusenza, Davide Nicoli, Shaniko Kaleci, Iris Zalaudek, Caterina Longo","doi":"10.1093/ced/llaf354","DOIUrl":"https://doi.org/10.1093/ced/llaf354","url":null,"abstract":"<p><strong>Background: </strong>Familial melanoma represents approximately 10% of cutaneous melanomas. Individuals with pathogenic germline variants have a higher risk of developing multiple primary melanomas (MPM). However, differences in clinical, dermoscopic, and reflectance confocal microscopy (RCM) features between variant carriers and non-carriers are not well established.</p><p><strong>Objective: </strong>To compare clinical, dermoscopic, and RCM characteristics of MPM patients with and without germline variants associated with familial melanoma.</p><p><strong>Methods: </strong>This retrospective study included 45 MPM patients who underwent Sanger sequencing and/or custom Next-Generation Sequencing (NGS) panels between 2020 and 2023. Clinical, dermoscopic, and RCM images were reviewed and compared between variant-positive and variant-negative groups.</p><p><strong>Results: </strong>Germline variants in moderate- to high-risk melanoma genes were found in 15 patients. Carriers were diagnosed at a younger age (41.8 ± 10.1 vs. 53.5 ± 10.4; P < .001), had a more frequent family history of melanoma (P = .015), more melanomas arising from pre-existing nevi (P < .001), and less actinic damage (P = .045). CDKN2A carriers were younger (38.9 ± 11.4 vs. 45.3 ± 7.8) and had fewer melanomas (2.7 ± 1.3 vs. 4.1 ± 1.2; P = .05) than MITF or POT1 carriers. CDKN2A carriers had low (n=5), medium (n=1), or high (n=2) nevus counts, while MITF carriers had medium (n=1) to high (n=4) counts. Dermoscopically, variant carriers showed fewer regression structures (8.3% vs. 39.8%; P = .010). RCM findings indicated a non-significant trend toward more dendritic cell-type melanomas in non-carriers (33.9% vs. 19.4%).</p><p><strong>Conclusion: </strong>MPM patients with germline variants demonstrate distinct clinical and imaging profiles compared to non-carriers. These findings support personalized surveillance in high-risk individuals and the integration of genetic testing into melanoma management. Further studies with larger cohorts are needed to refine genotype-phenotype associations.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General dermatology.","authors":"Vanessa Tran, Andrew Awad, Anne Howard","doi":"10.1093/ced/llaf387","DOIUrl":"https://doi.org/10.1093/ced/llaf387","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Displacement on Skin-Related Neglected Tropical Diseases in Sudan.","authors":"Alaa Abdelmonim Elsaeed Elhag, Iyas Dawood, Salma Ibrahim Mohammed Adam, Nusaiba A Y Ahmed, Rana Osman, Nayyrah Ahmed, Abdulhafiz Yaghoub Ali Abdulla, Rawa Badri","doi":"10.1093/ced/llaf392","DOIUrl":"https://doi.org/10.1093/ced/llaf392","url":null,"abstract":"<p><p>Displacement due to conflict and environmental crises in Sudan has intensified the burden of neglected tropical diseases (NTDs), particularly those with dermatologic manifestations. This narrative review explores the relationship between displacement and skin-related NTDs in Sudan by synthesizing epidemiological data, health infrastructure challenges, social impacts, and public health responses. Data were sourced from peer-reviewed literature, WHO reports, and humanitarian briefs published between 2000 and 2024. Findings reveal that overcrowded living conditions, malnutrition, and disruption of healthcare services have increased the transmission and severity of leishmaniasis, mycetoma, leprosy, lymphatic filariasis, onchocerciasis, and scabies among internally displaced persons (IDPs). Social stigma, financial hardship, and poor access to treatment further amplify the disease burden. While public health interventions, such as mass drug administration and mobile outreach programs, have shown effectiveness, ongoing conflict and inadequate resources continue to hamper these efforts. Strategic recommendations include scaling up surveillance, enhancing healthcare worker training through digital and in-person methods, improving medication access, and integrating NTD care into broader humanitarian responses.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'Potential role of leptin in Janus kinase 2 inhibitor-associated weight gain: a monocentric retrospective study'.","authors":"Luca Potestio, Cataldo Patruno, Maddalena Napolitano","doi":"10.1093/ced/llaf207","DOIUrl":"10.1093/ced/llaf207","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1875-1876"},"PeriodicalIF":2.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do atopic dermatitis trialists perceive the Harmonising Outcomes Measurement in Eczema (HOME) core outcome set? A survey study from the HOME initiative.","authors":"Yuval Gilad, Eric L Simpson, Christian Apfelbacher, Phyllis I Spuls, Kim S Thomas, Jochen Schmitt, Louise A A Gerbens, Michael E Jacobson, Norito Katoh, Hywel C Williams, Yael A Leshem","doi":"10.1093/ced/llaf191","DOIUrl":"10.1093/ced/llaf191","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1868-1871"},"PeriodicalIF":2.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acne vulgaris: considerations in darker skin types.","authors":"Chiedu E Ufodiama, Georgia Lada, Tamara W Griffiths, C Elise Kleyn","doi":"10.1093/ced/llaf220","DOIUrl":"10.1093/ced/llaf220","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1886-1887"},"PeriodicalIF":2.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse dermal angiomatosis of the breast masquerading as recurrent cellulitis, treated with Benelli's mastopexy: a case report.","authors":"Ankan Gupta, Vartika Singh, Atul Philipose, Nalini Sarah Newbigging, Supriya Sen","doi":"10.1093/ced/llaf235","DOIUrl":"10.1093/ced/llaf235","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1929-1932"},"PeriodicalIF":2.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of rapidly progressive, ulcerating nodules and plaques.","authors":"Conor Larney, Quynh Le, Louise Photiou, Michelle Goh, Edwin Tan","doi":"10.1093/ced/llaf157","DOIUrl":"10.1093/ced/llaf157","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1900-1902"},"PeriodicalIF":2.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}