Clinical and Experimental Dermatology最新文献

{"title":"Shared Decision Making in Central Centrifugal Cicatricial Alopecia.","authors":"Elizabeth Swain, Renee Haughton, Victoria Palmer, Ivie Obeime, Amy McMichael","doi":"10.1093/ced/llae535","DOIUrl":"https://doi.org/10.1093/ced/llae535","url":null,"abstract":"<p><strong>Background: </strong>Central centrifugal cicatricial alopecia (CCCA) is a primary lymphocytic scarring alopecia which occurs predominantly in Black middle-aged women.1,2 The benefits and prevalence of shared decision-making (SDM) models for CCCA patients have yet to be studied. Our study investigates the role of SDM in the management of CCCA.</p><p><strong>Methods: </strong>SDM processes were measured by the SDM-Q9, the Decisional Regret Scale (DRS), and the Patient Control Preferences Scale (CPS). Members of the Scarring Alopecia Foundation (n=1192) were recruited between June and August of 2023 via a one-time email sent via the Scarring Alopecia Foundation listserv.</p><p><strong>Results: </strong>87 respondents were documented. The CPS (n=87) suggested that most patients (47.6% ; n=41) prefer to share responsibility with their doctor for treatment decisions. The SDM Q-9 (Scored 0-45) and DRS [scored 0-100] demonstrated mean scores of 27.5 (11.5) and 38.4 (19.4), with higher and lesser scores, respectively, demonstrating patient satisfaction with SDM.</p><p><strong>Discussion: </strong>SDM is useful in complex decision-making when there are several medically reasonable alternatives available for treatment. Patients with CCCA may benefit from this model, and investments in resources such as patient decision aids and SDM training for further dermatologists will aid integration into clinical practice.</p><p><strong>Limitation: </strong>There was no method of verifying the CCCA diagnosis for respondents. Additionally, most respondents had tertiary education, which limits generalizability to the wider population. Lastly, the low survey response rate (9.7%) predisposes to nonresponse bias.</p><p><strong>Conclusion: </strong>The CPS, SDM-Q-9, and DRS suggest that patients with CCCA prefer to be involved in management decisions.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study of tofacitinib citrate with 308-nm excimer laser for the treatment of vitiligo.","authors":"Jia Gao, Qiuting Li, Haiying Huang, Siguang Yu, Yanping Qiu, Yanping Liang, Lizhen Lan, Lili Li","doi":"10.1093/ced/llae532","DOIUrl":"https://doi.org/10.1093/ced/llae532","url":null,"abstract":"<p><strong>Background: </strong>Vitiligo is a clinically prevalent acquired skin disorder characterized by depigmentation. Currently, the therapeutic options for vitiligo are restricted, and numerous issues exist, such as a prolonged treatment course, unsatisfactory therapeutic efficacy, adverse reactions, and a high propensity for recurrence after treatment cessation.</p><p><strong>Aim: </strong>To assess the safety and efficacy of combined treatment involving oral tofacitinib citrate (TC) and a 308-nm excimer laser (EL), with the aim of discovering a rapid and effective treatment approach to minimize the side effects of various drugs.</p><p><strong>Methods: </strong>A total of 63 patients with progressive vitiligo and a Vitiligo Disease Activity Score (VIDA) score of four from January 2022 to January 2024 were enrolled and divided into three groups. The three groups were the TC combined with 308-nm EL and methylprednisolone treatment group, the TC and 308-nm EL treatment group, and the methylprednisolone treatment alone group. The treatment was continued for 24 weeks. Finally, assessment of therapy outcomes was performed.</p><p><strong>Results: </strong>When TC was combined with 308-nm EL and methylprednisolone treatment, the effect was more rapid. When TC was combined with 308-nm EL, it had a more favorable treatment effect than that of methylprednisolone alone, despite having a slower effect onset. After 24 weeks of treatment, there was no significant difference between the two groups in terms of the total response rate or significant efficiency. However, when only methylprednisolone treatment was applied, the effect is relatively slow and inefficient.</p><p><strong>Conclusion: </strong>This study confirmed the rapid and efficient treatment of vitiligo through the combination of TC and 308-nm EL, and no serious adverse reactions were reported, which could offer an optimal treatment plan for patients with vitiligo.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"I looked like a beetroot\": a patient's experience of dermatomyositis.","authors":"Fiona Sexton, Claire Doyle, Lesley Ann Murphy","doi":"10.1093/ced/llae533","DOIUrl":"https://doi.org/10.1093/ced/llae533","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate change and the role of dermatologists: a call to action.","authors":"Luca Potestio, Fabrizio Martora, Alessia Villani, Matteo Megna","doi":"10.1093/ced/llae526","DOIUrl":"https://doi.org/10.1093/ced/llae526","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effectiveness and safety of deucravacitinib in psoriasis: A 52-week real-world study of genital, scalp, and nail lesions.","authors":"Teppei Hagino, Hidehisa Saeki, Eita Fujimoto, Naoko Kanda","doi":"10.1093/ced/llae530","DOIUrl":"https://doi.org/10.1093/ced/llae530","url":null,"abstract":"<p><strong>Background: </strong>The long-term (around 1-year) effectiveness and safety of deucravacitinib for the treatment of psoriasis have not been extensively studied in real-world settings, particularly in difficult-to-treat areas, such as the genital, scalp, and nail regions.</p><p><strong>Objectives: </strong>To evaluate the 52-week real-world effectiveness and safety of deucravacitinib in patients with moderate-to-severe psoriasis of the genital, scalp, and nail regions.</p><p><strong>Methods: </strong>This prospective study analyzed 104 patients with moderate-to-severe plaque psoriasis treated with deucravacitinib. Clinical scores, psoriasis area and severity index (PASI), static or regional physician's global assessment (PGA), dermatology life quality index (DLQI), and laboratory inflammatory indices were assessed during a 52-week period.</p><p><strong>Results: </strong>Deucravacitinib decreased clinical severity scores, and the decrease was sustained for 52 weeks. At week 52, 86.0%, 62.8%, and 25.6% of patients achieved PASI 75, 90, and 100, respectively. Deucravacitinib reduced the PGA scores for the genital, scalp, and nail regions, as well as the DLQI. The 52-week treatment had no impact on laboratory inflammatory indices, and no severe or lethal adverse events were reported.</p><p><strong>Conclusions: </strong>Deucravacitinib may be a promising long-term treatment option for psoriasis, demonstrating sustained effectiveness and safety, including in difficult-to-treat areas, such as the genital, scalp, and nail regions, in real-world clinical practice.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Widespread imiquimod-induced psoriasis like eruption: case report and analysis of mast cell infiltration.","authors":"Tatsuya Katsumi, Ryota Hayashi, Shingo Takei, Manon Okamura, Yuka Tsutsui, Osamu Ansai, Akito Hasegawa, Yu Matsui, Tatsuya Takenouchi, Riichiro Abe","doi":"10.1093/ced/llae527","DOIUrl":"https://doi.org/10.1093/ced/llae527","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A donut-shaped plaque and pigmented papule on the cheek.","authors":"Wei-Yao Wang, Chieh-Hsun Chen","doi":"10.1093/ced/llae528","DOIUrl":"https://doi.org/10.1093/ced/llae528","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risk of malignancy in patients with psoriasis treated with long-term tumor necrosis factor-α inhibitor: a systematic review and meta-analysis.","authors":"Wen-Ting Wu, Ming-Che Chiang, Yu-Chen Huang","doi":"10.1093/ced/llae503","DOIUrl":"https://doi.org/10.1093/ced/llae503","url":null,"abstract":"<p><strong>Background: </strong>The relationship between tumor necrosis factor-α inhibitors (TNFi) and cancer risk is complex, given their pivotal role in managing chronic inflammatory conditions. Persistent concerns about TNFi therapy potentially increasing cancer risk necessitate a thorough understanding of its long-term effects on cancer development in patients with psoriasis to guide therapeutic decision-making.</p><p><strong>Objectives: </strong>This systematic review and meta-analysis aimed to evaluate the association between long-term TNFi therapy and cancer risk in patients with psoriasis.</p><p><strong>Methods: </strong>Data were collected from PubMed, Embase, and the Cochrane Library, from their inception to January 1, 2024. The studies included adults with psoriasis or psoriatic arthritis receiving TNFi, presenting standardized incidence ratio (SIR) data for cancer. Data extraction followed PRISMA guidelines, with independent extraction by two authors, and pooled data synthesis was conducted using a random-effects model. The primary outcomes were SIRs for all cancers excluding non-melanoma skin carcinoma (NMSC) and for NMSC itself. The secondary outcome was the SIR of specific cancer types.</p><p><strong>Results: </strong>The meta-analysis included eight studies with a total of 32,765 psoriasis patients. The pooled results showed no increased risk of cancers, including all cancers excluding NMSC, melanoma, lymphoma, prostate cancer, and breast cancer, among individuals receiving long-term TNFi therapy for psoriasis compared to the general population. However, subgroup analysis found an elevated risk of NMSC in patients with psoriatic arthritis and a significant increase in the risk of squamous cell carcinoma (SCC) among psoriasis patients treated with TNFi compared to the general population (SIR, 1.84; 95% CI, 1.16 - 2.92 and SIR, 2.84; 95% CI, 1.64 - 4.91, respectively).</p><p><strong>Conclusions: </strong>Our systematic review and meta-analysis indicate that most cancers examined did not demonstrate an increased risk following long-term TNFi therapy in psoriasis patients. However, for patients with psoriatic arthritis or those at high risk of SCC, these findings underscore the importance of personalized treatment strategies that weigh individual risks and benefits.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Hand Eczema in France: Occupational Impact and Work Absenteeism.","authors":"Bruno Halioua, Charbel Skayem, Stéphanie Merhand, Yaron BenHayoun, Charles Taieb, Marie Aleth Richard","doi":"10.1093/ced/llae522","DOIUrl":"https://doi.org/10.1093/ced/llae522","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerous tiny hyperkeratotic projections on bilateral soles and toes.","authors":"Yi-Shan Teng, Yng Sun","doi":"10.1093/ced/llae518","DOIUrl":"https://doi.org/10.1093/ced/llae518","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}