Clinical and Experimental Dermatology最新文献_第8页

Association of Autoimmune Disease with Melanoma and Non-Melanoma Skin Cancers. 自身免疫性疾病与黑色素瘤和非黑色素瘤皮肤癌的关系

IF 2.8 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-09-09 DOI: 10.1093/ced/llaf409

Marina Z Joel, Saloni Patel, Jun Kang, Joel C Sunshine

{"title":"Association of Autoimmune Disease with Melanoma and Non-Melanoma Skin Cancers.","authors":"Marina Z Joel, Saloni Patel, Jun Kang, Joel C Sunshine","doi":"10.1093/ced/llaf409","DOIUrl":"https://doi.org/10.1093/ced/llaf409","url":null,"abstract":"This study examines the association between autoimmune diseases and melanoma and non-melanoma skin cancer using data from the All of Us Research Program. We conducted a cross-sectional analysis including 419,789 participants using multivariable logistic regression models adjusting for sociodemographic variables, comorbidities, and immunosuppressant use. We found significant associations between melanoma and Sjögren's syndrome, inflammatory bowel disease (IBD), vitiligo, and autoimmune thyroiditis. Non-melanoma skin cancer risk was elevated in Sjögren's, IBD, and Type 1 diabetes mellitus. Notably, our finding of increased melanoma and basal cell carcinoma risk in vitiligo contrasts with prior studies. These differences may reflect increased genetic diversity in our cohort or confounding by immune checkpoint inhibitor use. Our findings demonstrate increased risk of both melanoma and non-melanoma skin cancer in patients with select autoimmune diseases, highlighting the importance of heightened surveillance in high-risk autoimmune populations and the need for future research into immune-related mechanisms driving skin cancer susceptibility.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world effectiveness of lebrikizumab on pruritus in moderate-to-severe atopic dermatitis: preliminary data from a single-center, real-life experience. lebrikizumab治疗中度至重度特应性皮炎瘙痒的实际有效性：来自单中心真实经验的初步数据

IF 2.8 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-09-08 DOI: 10.1093/ced/llaf411

Luca Potestio, Cataldo Patruno, Francesca di Vico, Ludovica Lizzi, Maddalena Napolitano

引用次数: 0

Post inflammatory hyperpigmentation following cutaneous surgery in skin of colour. 皮肤手术后炎性色素沉着。

IF 2.8 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-09-08 DOI: 10.1093/ced/llaf410

Isobel R Okeah, Chawalpat K Siripanich, Yan C Chow, Faisal R Ali

引用次数: 0

Reflectance Confocal Microscopy for Monitoring Treatment Response in Superficial Basal Cell Carcinoma: Diagnostic Challenges Due to Scar Formation. 反射共聚焦显微镜监测浅表基底细胞癌的治疗反应：由于疤痕形成的诊断挑战。

IF 2.8 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-09-08 DOI: 10.1093/ced/llaf407

Marie Clark, John Wuennenberg, Jalal Maghfour, Brittani Jones, Jane M Grant-Kels, Manu Jain, David M Ozog, Indermeet Kohli

{"title":"Reflectance Confocal Microscopy for Monitoring Treatment Response in Superficial Basal Cell Carcinoma: Diagnostic Challenges Due to Scar Formation.","authors":"Marie Clark, John Wuennenberg, Jalal Maghfour, Brittani Jones, Jane M Grant-Kels, Manu Jain, David M Ozog, Indermeet Kohli","doi":"10.1093/ced/llaf407","DOIUrl":"https://doi.org/10.1093/ced/llaf407","url":null,"abstract":"Background: Reflectance confocal microscopy (RCM) criteria for in vivo diagnosis of unperturbed basal cell carcinoma (BCC) lesions have been validated and studies have reported high diagnostic sensitivity. However, a paucity of data remains regarding preservation or changes in RCM features after biopsy or treatment.Objective: Prospectively image biopsy proven superficial BCC (sBCC) with RCM at baseline and 12 weeks post-treatment to determine clearance and identify any associated RCM features.Methods: Ten subjects with biopsy proven sBCC completed this study. Clinical examination, dermoscopy, and RCM imaging were performed at baseline, prior to treatment, and 12 weeks post treatment with a 1064 Nd-YAG laser. Following treatment, RCM features were compared to clinical and histologic findings.Results: Statistically significant changes in RCM features at baseline and follow-up included: tumor islands with hyperreflective aggregates, dark silhouettes, peripheral palisading, peritumoral clefting, and dermal inflammatory cells. Changes in nuclear streaming, fibrosis, and vasculature were not significant.Limitations: A limitation of this study is the small sample size.Conclusions: The features of nuclear streaming, fibrosis and dilated vessels may be observed during RCM imaging of biopsy proven BCC at baseline and post treatment, and should be cautiously interpreted. Additional studies are needed to further validate these findings.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Challenges of Integrating Skin NTDs in Pakistan: A Gap Between Recommendations and Realities. 在巴基斯坦整合皮肤被忽视疾病的挑战：建议与现实之间的差距。

IF 2.8 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-09-06 DOI: 10.1093/ced/llaf415

Anil Fastenau, Matthew Willis, Priyanka Chahal, Fabian Schlumberger, Bushra Nadeem

引用次数: 0

Acute generalized exanthematous pustulosis: 15-year retrospective multicenter experience. 急性全身性脓疱病：15年回顾性多中心经验。

IF 2.8 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-09-06 DOI: 10.1093/ced/llaf412

Stefania Guida, Valentina Caputo, Aldo L Di Marco, Jan W Schroeder, Giovanni Paolino, Italo F Aromolo, Carlo A Maronese, Angelo V Marzano, Maria Teresa Fernández Figueras, Maribel Iglesias-Sancho, Emanuela Bonoldi, Franco Rongioletti

{"title":"Acute generalized exanthematous pustulosis: 15-year retrospective multicenter experience.","authors":"Stefania Guida, Valentina Caputo, Aldo L Di Marco, Jan W Schroeder, Giovanni Paolino, Italo F Aromolo, Carlo A Maronese, Angelo V Marzano, Maria Teresa Fernández Figueras, Maribel Iglesias-Sancho, Emanuela Bonoldi, Franco Rongioletti","doi":"10.1093/ced/llaf412","DOIUrl":"https://doi.org/10.1093/ced/llaf412","url":null,"abstract":"Background: Acute generalized exanthematous pustulosis (AGEP) is a rare skin condition often triggered by medications. Many case reports have been published but a few studies on large cohorts have been reported to date.Objectives: The aim of the current study is to provide correlation between AGEP EuroSCAR score and clinical, laboratory findings and histopathologic examination in a large cohort.Methods: This retrospective, multicenter study analyzed 51 AGEP cases across four academic institutions.Results: The study found that the majority of cases were drug-induced, particularly by antibiotics such as amoxicillin. The average time from drug exposure to symptom onset was 10.7 days, with hospitalization lasting an average of 14.5 days and recovery averaging 33.3 days. Key features included widespread itching, fever, and elevated inflammatory markers. Histopathological analysis frequently revealed spongiform pustules and eosinophilic infiltration. Importantly, this study is the first to demonstrate a significant association between higher EuroSCAR scores and elevated LDH levels, suggesting a more intense inflammatory response in cases with higher EuroSCAR scores. The findings underscore the need for early diagnosis and management of AGEP, with a particular focus on discontinuing the offending drug and administering corticosteroids.Conclusions: Despite its retrospective design, this study contributes valuable insights into the systemic implications and histopathological characteristics of AGEP, highlighting the possible role of LDH, and the importance of further research to refine diagnosis, treatment protocols and improve patient outcomes.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repurposing Follicular Unit Extraction Punches for Excision of Ice-pick Acne Scars. 重新利用滤泡单位提取器去除冰锥痤疮疤痕。

IF 2.8 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-09-03 DOI: 10.1093/ced/llaf401

Davin Lim, Xiaoshun Hang

引用次数: 0

Asymptomatic lesions on the lower limbs. 下肢无症状病变。

IF 2.8 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-09-03 DOI: 10.1093/ced/llaf406

Valerie Yii, Nicole Young, Daniella Kushnir-Grinbaum, Ragini Ghiya, Samantha Eisman

引用次数: 0

Podoconiosis: A Comprehensive clinical review and Strategies for Control and Elimination. 足癣病：全面的临床回顾和控制和消除策略。

IF 2.8 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-09-03 DOI: 10.1093/ced/llaf397

Wendemagegn Enbiale, Kebede Deribe

引用次数: 0

Antibiotics, analgesics, and antifungals are commonly implicated in acute generalized exanthematous pustulosis; a retrospective analysis of 1410 cases. 抗生素、镇痛药和抗真菌药通常与急性全身性脓疱病有关；回顾性分析1410例病例。

IF 2.8 4区医学

Clinical and Experimental Dermatology Pub Date : 2025-09-03 DOI: 10.1093/ced/llaf402

Gaurav N Pathak, Aryan Mahajan, Steven R Feldman

引用次数: 0