Clinical and Experimental Dermatology最新文献

{"title":"Successful treatment of lupus miliaris disseminatus faciei with topical ivermectin: a case report.","authors":"Carmen Cánovas Seva, Cecilia Tejero García, Brais Chao Maseda, Jose Saez Padilla, Carlos Aliste-Santos, Elena Roson","doi":"10.1093/ced/llaf284","DOIUrl":"https://doi.org/10.1093/ced/llaf284","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unequal NHS wig provision: toupée or no toupée, that is the question?","authors":"Marianne de Brito, Amy Johnson, Sue Schilling, Leila Asfour, Nick J Levell","doi":"10.1093/ced/llaf282","DOIUrl":"https://doi.org/10.1093/ced/llaf282","url":null,"abstract":"<p><p>Wigs are a necessary medical orthotic for some with alopecia to participate in society. However, for those with limited incomes, government funded National Health Service (NHS) wig provision is of great help. Recent reports to Alopecia UK, a patient support group, suggest restrictions in this support. The availability of NHS wig provision by UK geographical region was assessed by surveying dermatology secondary care healthcare professionals. There were 75 responses from 48/136 (35%) of UK Trusts and Health Boards. It was difficult for clinicians at 24/48 (50%) institutions to prescribe wigs. Wig provision was impossible for 11%. There was regional variation; it was straightforward throughout Scotland and the South West of England but difficult in Northern Ireland and London, where 50% reported it was impossible or nearly impossible. This demonstrates unwarranted variation in wig prescription difficulty for patients across the UK.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Course of Atopic Dermatitis after Dupilumab Discontinuation: A Multicenter Real-World Study.","authors":"Francesca Barei, Stefano Macchi, Paolo Calzari, Simone Ribero, Michela Ortoncelli, Caterina Foti, Anna Balato, Eugenia Veronica Di Brizzi, Ketty Peris, Niccolò Gori, Elena Ippoliti, Carlotta Gurioli, Bianca Maria Piraccini, Ilaria Trave, Emanuele Cozzani, Elena Pezzolo, Laura Bonzano, Enzo Errichetti, Natale Schettini, Eustachio Nettis, Massimo Gola, Nicola Milanesi, Claudio Feliciani, Maria Beatrice De Felici Del Giudice, Anna Campanati, Helena Gioacchini, Armando Pisapia, Gianluca Avallone, Giuseppe Micali, Maria Letizia Musumeci, Romina Ortega, Flavia Manzo Margiotta, Marco Romanelli, Katharina Hansel, Luca Stingeni, Cataldo Patruno, Maria Esposito, Maria Concetta Fargnoli, Andrea De Berardinis, Caterina Ferreli, Laura Calabrese, Pietro Rubegni, Laura Lazzeri, Laura Grigolato, Benedetta Galli, Mariateresa Rossi, Martina Maurelli, Giampiero Girolomoni, Giuseppe Lauletta, Maddalena Napolitano, Angela Alfano, Luigi Gargiulo, Alessandra Narcisi, Angelo Valerio Marzano, Silvia Mariel Ferrucci","doi":"10.1093/ced/llaf275","DOIUrl":"https://doi.org/10.1093/ced/llaf275","url":null,"abstract":"<p><strong>Introduction: </strong>Limited data exist on the clinical course of atopic dermatitis (AD) after the discontinuation of dupilumab. This study aims to assess disease progression following dupilumab discontinuation.</p><p><strong>Methods: </strong>A multicenter, retrospective study was conducted on 208 patients with severe AD who discontinued dupilumab for reasons unrelated to inefficacy. The Eczema Area and Severity Index (EASI), Pruritus Numerical Rating Scale (P-NRS), Atopic Dermatitis Control Tool (ADCT), and Dermatology Life Quality Index (DLQI) were used to assess disease activity post-discontinuation. Kaplan-Meier analysis estimated the time and probability of disease worsening (defined as EASI >7.0, EASI increase ≥6.6, P-NRS ≥4, P-NRS increase ≥4, ADCT ≥7, ADCT increase ≥5, or DLQI increase ≥4), as well as the need to restart systemic treatment.</p><p><strong>Results: </strong>The main reasons for discontinuing dupilumab were clinical remission or good clinical control (43.3%), patient 'decision (11.1%), and pregnancy or pregnancy's desire (20.7%). Patients with a family history of AD or non-classical phenotypes had a significantly higher likelihood of disease worsening. A significant portion (42.8%) of patients resumed systemic treatment, within a median time of 47 weeks, and a baseline median EASI score of 10.0 and a median P-NRS of 6.0. The probability of resuming systemic treatment was 25% at 31 weeks and 50% at 94 weeks. Re-initiation of dupilumab significantly improved EASI and P-NRS scores within 16 weeks.</p><p><strong>Conclusion: </strong>Discontinuing dupilumab is associated with disease recurrence in some patients, especially those with a family history or non-classical AD. Dupilumab re-initiation is effective, leading to significant clinical improvements and supporting its use after treatment interruption.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Ten-year Retrospective Study of 103 Cases.","authors":"Lu Zhou, Yun Lu, Ya Zou, Hua Wei, Xirui Guo, Qinchuan Li, Yan Zhou, Xiaotian Zhao, Fangqing Xie, Liwen Zhang","doi":"10.1093/ced/llaf278","DOIUrl":"https://doi.org/10.1093/ced/llaf278","url":null,"abstract":"<p><strong>Background: </strong>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening conditions with high mortality, most frequently caused by drugs.</p><p><strong>Methods: </strong>A retrospective study was reviewed at a tertiary hospital in China during the period of 2013 to 2023. The aim of this study was to evaluate and compare the demographic, laboratory and clinical features, culprit drugs, complications, treatment and outcome of drug-induced SJS/TEN patients.</p><p><strong>Results: </strong>The study population included 54 SJS patients, 17 SJS-TEN overlap patients, and 32 TEN patients. The average age was 49.0±21.5 years (range: 1-90 years). Females were predominant, with a female to male ratio of 1.34:1. Antibiotics (34.0%), non-steroidal anti-inflammatory drugs (NSAIDs) (16.5%), and anticonvulsants (14.6%) were the most frequently implied drug categories, with carbamazepine, levofloxacin, ibuprofen, aspirin, amoxicillin, metronidazole and lamotrigine being the most common individual causative drugs. In addition to mucosal involvement, liver dysfunction, pneumonia, and heart involvement were the most common complications of SJS/TEN. Almost all patients except one were treated with the systemic corticosteroid treatment, and 47.6% of patients received intravenous immunoglobulin (IVIG) combined with steroid therapy. The mortality rate was 9.7% overall, with the highest mortality in the TEN group, at 15.6%. Moreover, there was no statistical difference between the predicted and actual mortality (12.6% vs. 9.7%) (P=0.507).</p><p><strong>Conclusions: </strong>In our study, carbamazepine, levofloxacin, ibuprofen, aspirin, amoxicillin, metronidazole and lamotrigine were the most common triggers for SJS/TEN. If combined with high-risk factors such as pneumonia, renal insufficiency, gastro-intestinal disorder, cardiac involvement and sepsis, SJS/TEN patients might have a higher risk of mortality.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-onset extensive seborrheic keratoses in the spectrum of familial acanthosis nigricans.","authors":"David Pesqué, Beatriz Bellosillo, Álvaro March-Rodríguez, Irene Abreu-Rodriguez, Luis A Pérez-Jurado, Ramon M Pujol","doi":"10.1093/ced/llaf273","DOIUrl":"https://doi.org/10.1093/ced/llaf273","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of alpha-HPV types in cutaneous squamous cell carcinoma associated with markers of carcinogenesis: a retrospective study.","authors":"Florence Brunet-Possenti, Morgane Weiss, Jean-Luc Prétet, Lydia Deschamps, Vincent Descamps, Caroline Halimi, Diane Descamps, Jade Ghosn, Romane Guilbaud, Charlotte Charpentier, Valentine Marie Ferré","doi":"10.1093/ced/llaf264","DOIUrl":"https://doi.org/10.1093/ced/llaf264","url":null,"abstract":"<p><strong>Background: </strong>While the role of oncogenic alpha (α)-HPVs in anogenital and oral mucosal cancers is well-established, their involvement in skin carcinogenesis remains unexplored.</p><p><strong>Objective: </strong>To investigate the role of α-HPV in cutaneous squamous cell carcinoma (cSCC).</p><p><strong>Methods: </strong>This retrospective study included 129 formalin-fixed, paraffin-embedded cSCC samples. The main outcomes were the proportion of α-HPV positive cSCC and the characterization of viral features, assessed through HPV typing and viral DNA integration analysis.</p><p><strong>Results: </strong>The study included 99 cases of invasive cSCCs and 30 Bowen's disease. HPV DNA was detected in 56.6% of samples. HPV from the α genus were identified in 25 samples, (19.4%), with only a single α-HPV type detected in each positive sample. HPV16 was the main type, detected in 10 samples. Peripheral healthy skin tested negative in 10 out of 11 α-HPV-positive samples. Viral DNA was integrated in host-cell DNA in 8 out of 9 HPV16-positive samples.</p><p><strong>Conclusions: </strong>This study highlights a significant prevalence of α-HPV-positive samples among both invasive and in situ cSCC. The virological findings support a carcinogenic role of α-HPV in cSCC.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bipolar Syndrome Among Patients with Psoriasis: A Nested Case-Control Propensity-Scored Study.","authors":"Amritpal Kooner, Rawle A Sekhon, Beniamin Zeka, Michelle Anthony","doi":"10.1093/ced/llaf283","DOIUrl":"https://doi.org/10.1093/ced/llaf283","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapidly Growing Neck mass in a young woman.","authors":"Bing-Sian Lin, Kuang-Ling Ou, Chien-Ping Chiang","doi":"10.1093/ced/llaf213","DOIUrl":"https://doi.org/10.1093/ced/llaf213","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cutaneous horn in a male patient with well-controlled HIV.","authors":"Charlotte Muehlschlegel, Aparna Vyas, Claire Martyn-Simmons, Nathan Asher, Evangelia Panagou","doi":"10.1093/ced/llaf277","DOIUrl":"https://doi.org/10.1093/ced/llaf277","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intralesional sodium thiosulfate is an effective treatment for non-uraemic calciphylaxis.","authors":"Wen Hao Tan, Joel Hua Liang Lim","doi":"10.1093/ced/llaf254","DOIUrl":"https://doi.org/10.1093/ced/llaf254","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}